Lentiviral-mediated gene delivery to synovium: Potent intra-articular expression with amplification by inflammation

Molecular Therapy

Volumn 7, Issue 4, 2003, Pages 460-466

  Gouze, Elvire ^a   Pawliuk, Robert ^b,c   Gouze, Jean Noel ^a,d   Pilapil, Carmencita ^a   Fleet, Christina ^b   Palmer, Glyn D ^a   Evans, Christopher H ^a   Leboulch, Philippe ^a,b,c   Ghivizzani, Steven C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Genetix Pharmaceuticals Inc   (United States)

^c HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Arthritis; Gene therapy; IL 1Ra; Lentivirus; Synovium

Indexed keywords

COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LENTIVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CARTILAGE; CELL COUNT; CELL INFILTRATION; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DNA MODIFICATION; DRUG EFFICACY; FIBROBLAST; GENE AMPLIFICATION; GENE EXPRESSION; GENE OVEREXPRESSION; MALE; NONHUMAN; RAT; SYNOVIUM; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS DNA CELL DNA INTERACTION;

ANIMALIA; LENTIVIRUS;

EID: 0037689517     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1525-0016(03)00024-8     Document Type: Article

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