Oxidative stress in Alzheimer's and Parkinson's diseases: Insights from the yeast Saccharomyces cerevisiae

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Pimentel, Catarina ^a   Batista Nascimento, Liliana ^a   Rodrigues Pousada, Claudina ^a   Menezes, Regina A ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S; BIOLOGICAL PROCESS; DISEASE ETIOLOGY; EUKARYOTIC CELLS; GENETIC MANIPULATIONS; NEURODEGENERATION; NEURODEGENERATIVE DISORDERS; NEURONAL DEATH; PARKINSON'S DISEASE; YEAST SACCHAROMYCES CEREVISIAE;

NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS;

YEAST;

ALZHEIMER DISEASE; DEGENERATIVE DISEASE; FUNGAL GENETICS; GENETIC MANIPULATION; HUMAN; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; REVIEW; SACCHAROMYCES CEREVISIAE; BIOLOGICAL MODEL; GENETICS; METABOLISM; PATHOLOGY;

EUKARYOTA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN;

ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; HUMANS; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PARKINSON DISEASE; SACCHAROMYCES CEREVISIAE;

EID: 84863691708     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/132146     Document Type: Review

References (112)

1. Mao P., Reddy P. H., Is multiple sclerosis a mitochondrial disease? Biochimica et Biophysica Acta 2010 1802 1 66 79
2. Starkov A. A., Chinopoulos C., Fiskum G., Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury Cell Calcium 2004 36 3-4 257 264 (Pubitemid 38992351)
3. Valko M., Leibfritz D., Moncol J., Cronin M. T. D., Mazur M., Telser J., Free radicals and antioxidants in normal physiological functions and human disease International Journal of Biochemistry and Cell Biology 2007 39 1 44 84 (Pubitemid 44566469)
4. Ramalingam M., Kim S. J., Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases. Journal of Neural Transmission. In press
5. Jomova K., Valko M., Advances in metal-induced oxidative stress and human disease Toxicology 2011 283 2-3 65 87
6. Jomova K., Vondrakova D., Lawson M., Valko M., Metals, oxidative stress and neurodegenerative disorders Molecular and Cellular Biochemistry 2010 345 1-2 91 104
7. Hentze M. W., Muckenthaler M. U., Galy B., Camaschella C., Two to tango: regulation of mammalian iron metabolism Cell 2010 142 1 24 38
8. Kim B. E., Nevitt T., Thiele D. J., Mechanisms for copper acquisition, distribution and regulation Nature Chemical Biology 2008 4 3 176 185 (Pubitemid 351264130)
9. Jomova K., Valko M., Importance of iron chelation in free radical-induced oxidative stress and human disease Current Pharmaceutical Design 2011 17 31 3460 3473
10. Kakhlon O., Cabantchik Z. I., The labile iron pool: characterization, measurement, and participation in cellular processes Free Radical Biology and Medicine 2002 33 8 1037 1046
11. Meneghini R., Iron homeostasis, oxidative stress, and DNA damage Free Radical Biology and Medicine 1997 23 5 783 792 (Pubitemid 27364873)
12. Carreras M. C., Franco M. C., Peralta J. G., Poderoso J. J., Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease Molecular Aspects of Medicine 2004 25 1-2 125 139 (Pubitemid 38401937)
13. Shulman R. G., Rothman D. L., Behar K. L., Hyder F., Energetic basis of brain activity: implications for neuroimaging Trends in Neurosciences 2004 27 8 489 495 (Pubitemid 38951042)
14. Su B., Wang X., Nunomura A., Oxidative stress signaling in Alzheimer's disease Current Alzheimer Research 2008 5 6 525 532
15. Reed T. T., Lipid peroxidation and neurodegenerative disease Free Radical Biology Medicine 2011 51 7 1302 1319
16. Klein J. A., Ackerman S. L., Oxidative stress, cell cycle, and neurodegeneration Journal of Clinical Investigation 2003 111 6 785 793 (Pubitemid 37074950)
17. Palmieri B., Sblendorio V., Oxidative stress tests: overview on reliability and usePart I European Review for Medical and Pharmacological Sciences 2007 11 5 309 342 (Pubitemid 350213812)
18. Kannan K., Jain S. K., Oxidative stress and apoptosis Pathophysiology 2000 7 3 153 163
19. Du H., Yan S. S., Mitochondrial medicine for neurodegenerative diseases The International Journal of Biochemistry Cell Biology 2010 42 5 560 572
20. Braak H., Braak E., Yilmazer D., de Vos R. A. I., Jansen E. N. H., Bohl J., Pattern of brain destruction in Parkinson's and Alzheimer's diseases Journal of Neural Transmission 1996 103 4 455 490
21. Priller C., Bauer T., Mitteregger G., Krebs B., Kretzschmar H. A., Herms J., Synapse formation and function is modulated by the amyloid precursor protein The Journal of Neuroscience 2006 26 27 7212 7221
22. Turner P. R., O'Connor K., Tate W. P., Abraham W. C., Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory Progress in Neurobiology 2003 70 1 1 32 (Pubitemid 36966639)
23. O'Brien R. J., Wong P. C., Amyloid precursor protein processing and Alzheimer's disease Annual Review of Neuroscience 2011 34 185 204
24. Uversky V. N., Intrinsic disorder in proteins associated with neurodegenerative diseases Frontiers in Bioscience 2009 14 14 5188 5238
25. Lee V. M. Y., Goedert M., Trojanowski J. Q., Neurodegenerative tauopathies Annual Review of Neuroscience 2001 24 1121 1159 (Pubitemid 32695256)
26. Avramopoulos D., Genetics of Alzheimer's disease: recent advances Genome Medicine 2009 1 3 34
27. Hardy J., Allsop D., Amyloid deposition as the central event in the aetiology of Alzheimer's disease Trends in Pharmacological Sciences 1991 12 10 383 388
28. Iversen L. L., Mortishire-Smith R. J., Pollack S. J., Shearman M. S., The toxicity in vitro of -amyloid protein Biochemical Journal 1995 311 1 16
29. Kontush A., Amyloid- : an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease Free Radical Biology and Medicine 2001 31 9 1120 1131 (Pubitemid 33000134)
30. Tabner B. J., Turnbull S., El-Agnaf O., Allsop D., Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases Current Topics in Medicinal Chemistry 2001 1 6 507 517
31. Tabner B. J., Turnbull S., El-Agnaf O. M. A., Allsop D., Formation of hydrogen peroxide and hydroxyl radicals from A and -synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease Free Radical Biology and Medicine 2002 32 11 1076 1083 (Pubitemid 34603345)
32. Nunomura A., Hofer T., Moreira P. I., Castellani R. J., Smith M. A., Perry G., RNA oxidation in Alzheimer disease and related neurodegenerative disorders Acta Neuropathologica 2009 118 1 151 166
33. Premkumar D. R. D., Smith M. A., Richey P. L., Petersen R. B., Castellani R., Kutty R. K., Wiggert B., Perry G., Kalaria R. N., Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease Journal of Neurochemistry 1995 65 3 1399 1402
34. Dumont M., Beal M. F., Neuroprotective strategies involving ROS in Alzheimer disease Free Radical Biology and Medicine 2011 51 5 1014 1026
35. Molina-Holgado F., Hider R. C., Gaeta A., Williams R., Francis P., Metals ions and neurodegeneration BioMetals 2007 20 3-4 639 654 (Pubitemid 46776561)
36. Salvador G. A., Uranga R. M., Giusto N. M., Iron and mechanisms of neurotoxicity International Journal of Alzheimer's Disease 2011 2010 9
37. Hung Y. H., Bush A. I., Cherny R. A., Copper in the brain and Alzheimer's disease Journal of Biological Inorganic Chemistry 2010 15 1 61 76
38. Rajendran R., Minqin R., Ynsa M. D., Casadesus G., Smith M. A., Perry G., Halliwell B., Watt F., A novel approach to the identification and quantitative elemental analysis of amyloid deposits-Insights into the pathology of Alzheimer's disease Biochemical and Biophysical Research Communications 2009 382 1 91 95
39. Butterfield D. A., Bush A. I., Alzheimer's amyloid -peptide (142): Involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide Neurobiology of Aging 2004 25 5 563 568 (Pubitemid 38686475)
40. Butterfield D. A., Sultana R., Methionine-35 of A (142): importance for oxidative stress in Alzheimer disease Journal of Amino Acids 2011 2011 10
41. Naslund J., Schierhorn A., Hellman U., Lannfelt L., Roses A. D., Tjernberg L. O., Silberring J., Gandy S. E., Winblad B., Greengard P., Nordstedt C., Terenius L., Relative abundance of Alzheimer A amyloid peptide variants in Alzheimer disease and normal aging Proceedings of the National Academy of Sciences of the United States of America 1994 91 18 8378 8382 (Pubitemid 24273667)
42. Hirai K., Aliev G., Nunomura A., Fujioka H., Russell R. L., Atwood C. S., Johnson A. B., Kress Y., Vinters H. V., Tabaton M., Shimohama S., Cash A. D., Siedlak S. L., Harris P. L. R., Jones P. K., Petersen R. B., Perry G., Smith M. A., Mitochondrial abnormalities in Alzheimer's disease Journal of Neuroscience 2001 21 9 3017 3023 (Pubitemid 32323483)
43. Silva D. F. F., Esteves A. R., Oliveira C. R., Cardoso S. M., Mitochondria: the common upstream driver of amyloid- and tau pathology in Alzheimer's disease Current Alzheimer Research 2011 8 5 563 572
44. Cameron B., Landreth G. E., Inflammation, microglia, and Alzheimer's disease Neurobiology of Disease 2010 37 3 503 509
45. Eikelenboom P., van Exel E., Hoozemans J. J. M., Veerhuis R., Rozemuller A. J. M., Van Gool W. A., Neuroinflammationan early event in both the history and pathogenesis of Alzheimer's disease Neurodegenerative Diseases 2010 7 13 38 41
46. Eikelenboom P., Veerhuis R., The role of complement and activated microglia in the pathogenesis of Alzheimer's disease Neurobiology of Aging 1996 17 5 673 680 (Pubitemid 26348867)
47. Jenner P., Hunot, Olanow, Beal, Kordower, Tatton, Schapira, Oxidative stress in Parkinson's disease Annals of Neurology 2003 53 supplement 3 S26 S38
48. Spillantini M. G., Schmidt M. L., Lee V. M. Y., Trojanowski J. Q., Jakes R., Goedert M., -synuclein in Lewy bodies Nature 1997 388 6645 839 840
49. Irizarry M. C., Growdon W., Gomez-Isla T., Newell K., George J. M., Clayton D. F., Hyman B. T., Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain -synuclein immunoreactivity Journal of Neuropathology and Experimental Neurology 1998 57 4 334 337 (Pubitemid 28182631)
50. Polymeropoulos M. H., Lavedan C., Leroy E., Ide S. E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E. S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W. G., Lazzarini A. M., Duvoisin R. C., Di Iorio G., Golbe L. I., Nussbaum R. L., Mutation in the -synuclein gene identified in families with Parkinson's disease Science 1997 276 5321 2045 2047 (Pubitemid 27443610)
51. Jo E., McLaurin J., Yip C. M., George-Hyslop P. St., Fraser P. E., -synuclein membrane interactions and lipid specificity Journal of Biological Chemistry 2000 275 44 34328 34334
52. Auluck P. K., Caraveo G., Lindquist S., -synuclein: membrane interactions and toxicity in parkinson's disease Annual Review of Cell and Developmental Biology 2010 26 211 233
53. McNulty B. C., Young G. B., Pielak G. J., Macromolecular crowding in the Escherichia coli periplasm maintains -synuclein disorder Journal of Molecular Biology 2006 355 5 893 897 (Pubitemid 43012748)
54. Uversky V. N., Li J., Fink A. L., Evidence for a partially folded intermediate in -synuclein fibril formation Journal of Biological Chemistry 2001 276 14 10737 10744 (Pubitemid 38089246)
55. Uversky V. N., Neuropathology, biochemistry, and biophysics of -synuclein aggregation Journal of Neurochemistry 2007 103 1 17 37 (Pubitemid 47407730)
56. Jenner P., Olanow C. W., Oxidative stress and the pathogenesis of Parkinson's disease Neurology 1996 47 supplement 6 S161 S170
57. Perry G., Avila J., Espey M. G., Wink D. A., Atwood C. S., Smith M. A., Ishiropoulos H., Giasson B., Duda J. E., Trojanowski J. Q., Lee V. M. Y., Biochemistry of neurodegeneration Science 2001 291 5504 595 597
58. Sayre L. M., Moreira P. I., Smith M. A., Perry G., Metal ions and oxidative protein modification in neurological disease Annali dell'Istituto Superiore di Sanita 2005 41 2 143 164 (Pubitemid 43169859)
59. Castellani R., Smith M. A., Richey P. L., Perry G., Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease Brain Research 1996 737 1-2 195 200 (Pubitemid 26366614)
60. Jellinger K., Kienzl E., Rumpelmair G., Riederer P., Stachelberger H., Ben- Shachar D., Youdim M. B. H., Iron-melanin complex in substantia nigra of Parkinsonian brains: an x-ray microanalysis Journal of Neurochemistry 1992 59 3 1168 1171
61. Castellani R. J., Siedlak S. L., Perry G., Smith M. A., Sequestration of iron by Lewy bodies in Parkinson's disease Acta Neuropathologica 2000 100 2 111 114 (Pubitemid 30456131)
62. Ben-Shachar D., Youdim M. B. H., Iron, melanin and dopamine interaction: relevance to Parkinson's disease Progress in Neuro-Psychopharmacology and Biological Psychiatry 1993 17 1 139 150
63. Lin M. T., Beal M. F., Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 2006 443 7113 787 795 (Pubitemid 44622683)
64. Zhou C., Huang Y., Przedborski S., Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance Annals of the New York Academy of Sciences 2008 1147 93 104
65. Langston J. W., Ballard P., Tetrud J. W., Irwin I., Chronic parkinsonism in humans due to a product of meperidine-analog synthesis Science 1983 219 4587 979 980 (Pubitemid 13189531)
66. Testa C. M., Sherer T. B., Greenamyre J. T., Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures Molecular Brain Research 2005 134 1 109 118 (Pubitemid 40403643)
67. Sherer T. B., Betarbet R., Testa C. M., Seo B. B., Richardson J. R., Kim J. H., Miller G. W., Yagi T., Matsuno-Yagi A., Greenamyre J. T., Mechanism of toxicity in rotenone models of Parkinson's disease Journal of Neuroscience 2003 23 34 10756 10764 (Pubitemid 37499681)
68. Hglinger G. U., Oertel W. H., Hirsch E. C., The rotenone model of Parkinsonismthe five years inspection Journal of Neural Transmission, Supplement 2006 70 269 272 (Pubitemid 44622210)
69. Sherer T. B., Kim J. H., Betarbet R., Greenamyre J. T., Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and -synuclein aggregation Experimental Neurology 2003 179 1 9 16 (Pubitemid 36062614)
70. Martin H. L., Teismann P., Glutathionea review on its role and significance in Parkinson's disease The FASEB Journal 2009 23 10 3263 3272
71. Winklhofer K. F., Haass C., Mitochondrial dysfunction in Parkinson's disease Biochimica et Biophysica Acta 2010 1802 1 29 44
72. Chinta S. J., Andersen J. K., Redox imbalance in Parkinson's disease Biochimica et Biophysica Acta 2008 1780 11 1362 1367
73. Schapira A. H., Mitochondria in the aetiology and pathogenesis of Parkinson's disease The Lancet Neurology 2008 7 1 97 109 (Pubitemid 350251942)
74. Schapira A. H. V., Cooper J. M., Dexter D., Jenner P., Clark J. B., Marsden C. D., Mitochondrial complex I deficiency in Parkinson's disease The Lancet 1989 1 8649 1269 (Pubitemid 19140359)
75. Chinta S. J., Mallajosyula J. K., Rane A., Andersen J. K., Mitochondrial -synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo Neuroscience Letters 2010 486 3 235 239
76. Gibson G. E., Starkov A., Blass J. P., Ratan R. R., Beal M. F., Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases Biochimica et Biophysica Acta 2010 1802 1 122 134
77. Alvarez-Castelao B., Muoz C., Snchez I., Goethals M., Vandekerckhove J., Castao J. G., Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome Biochimica et Biophysica Acta 2012 1823 2 524 533
78. Canet-Avilés R. M., Wilson M. A., Miller D. W., Ahmad R., McLendon C., Bandyopadhyay S., Baptista M. J., Ringe D., Petsko G. A., Cookson M. R., The Parkinson's disease DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization Proceedings of the National Academy of Sciences of the United States of America 2004 101 24 9103 9108 (Pubitemid 38781618)
79. Kwon H. J., Heo J. Y., Shim J. H., Park J. H., Seo K. S., Ryu M. J., Han J. S., Shong M., Son J. H., Kweon G. R., DJ-1 mediates paraquat-induced dopaminergic neuronal cell death Toxicology Letters 2011 202 2 85 92
80. Thomas K. J., McCoy M. K., Blackinton J., Beilina A., van der Brug M., Sandebring A., Miller D., Maric D., Cedazo-Minguez A., Cookson M. R., DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy Human Molecular Genetics 2011 20 1 40 50
81. Hunot S., Boissire F., Faucheux B., Brugg B., Mouatt-Prigent A., Agid Y., Hirsch E. C., Nitric oxide synthase and neuronal vulnerability in Parkinson's disease Neuroscience 1996 72 2 355 363 (Pubitemid 26111202)
82. Boka G., Anglade P., Wallach D., Javoy-Agid F., Agid Y., Hirsch E. C., Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease Neuroscience Letters 1994 172 1-2 151 154 (Pubitemid 24178765)
83. Botstein D., Fink G. R., Yeast: an experimental organism for 21st century biology Genetics 2011 189 3 695 704
84. Miller-Fleming L., Giorgini F., Outeiro T. F., Yeast as a model for studying human neurodegenerative disorders Biotechnology Journal 2008 3 3 325 338 (Pubitemid 351460791)
85. Heinicke S., Livstone M. S., Lu C., Oughtred R., Kang F., Angiuoli S. V., White O., Botstein D., Dolinski K., The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists PLoS ONE 2007 2 8 e766
86. Tenreiro S., Outeiro T. F., Simple is good: yeast models of neurodegeneration FEMS Yeast Research 2010 10 8 970 979
87. Khurana V., Lindquist S., Modelling neurodegeneration in Saccharomyces cerevisiae why cook with baker's yeast? Nature Reviews Neuroscience 2010 11 6 436 449
88. Bharadwaj P., Martins R., Macreadie I., Yeast as a model for studying Alzheimer's disease FEMS Yeast Research 2010 10 8 961 969
89. Walsh D. M., Tseng B. P., Rydel R. E., Podlisny M. B., Selkoe D. J., The oligomerization of amyloid -protein begins intracellularly in cells derived from human brain Biochemistry 2000 39 35 10831 10839
90. Shankar G. M., Li S., Mehta T. H., Garcia-Munoz A., Shepardson N. E., Smith I., Brett F. M., Farrell M. A., Rowan M. J., Lemere C. A., Regan C. M., Walsh D. M., Sabatini B. L., Selkoe D. J., Amyloid- protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory Nature Medicine 2008 14 8 837 842
91. Lee E. B., Leng L. Z., Zhang B., Kwong L., Trojanowski J. Q., Abel T., Lee V. M. Y., Targeting amyloid- peptide (A ) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in A precursor protein (APP) transgenic mice Journal of Biological Chemistry 2006 281 7 4292 4299 (Pubitemid 43847859)
92. Knobloch M., Konietzko U., Krebs D. C., Nitsch R. M., Intracellular A and cognitive deficits precede -amyloid deposition in transgenic arcA mice Neurobiology of Aging 2007 28 9 1297 1306 (Pubitemid 47081235)
93. Hughes S. R., Goyal S., Sun J. E., Two-hybrid system as a model to study the interaction of -amyloid peptide monomers Proceedings of the National Academy of Sciences of the United States 1996 93 5 2065 2070 (Pubitemid 26079881)
94. Bagriantsev S., Liebman S., Modulation of A 42 low-n oligomerization using a novel yeast reporter system BMC Biology 2006 4, article 32
95. von der Haar T., Jossé L., Wright P., Zenthon J., Tuite M. F., Development of a novel yeast cell-based system for studying the aggregation of Alzheimer's disease-associated A peptides in vivo Neurodegenerative Diseases 2007 4 2-3 136 147 (Pubitemid 47000407)
96. Tuite M. F., Cox B. S., The [ PSI + ] prion of yeast: a problem of inheritance Methods 2006 39 1 9 22 (Pubitemid 43994489)
97. Williams A. D., Portelius E., Kheterpal I., Guo J. T., Cook K. D., Xu Y., Wetzel R., Mapping A amyloid fibril secondary structure using scanning proline mutagenesis Journal of Molecular Biology 2004 335 3 833 842 (Pubitemid 38352823)
98. Krobitsch S., Lindquist S., Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins Proceedings of the National Academy of Sciences of the United States of America 2000 97 4 1589 1594 (Pubitemid 30118486)
99. Chernoff Y. O., Lindquist S. L., Ono B. I., Inge-Vechtomov S. G., Liebman S. W., Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [ PSI + ] Science 1995 268 5212 880 884
100. Caine J., Sankovich S., Antony H., Waddington L., Macreadie P., Varghese J., Macreadie I., Alzheimer's A fused to green fluorescent protein induces growth stress and a heat shock response FEMS Yeast Research 2007 7 8 1230 1236 (Pubitemid 47622047)
101. Treusch S., Hamamichi S., Goodman J. L., Functional links between A toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast Science 2011 334 6060 1241 1245
102. Outeiro T. F., Lindquist S., Yeast cells provide insight into -synuclein biology and pathobiology Science 2003 302 5651 1772 1775 (Pubitemid 37505742)
103. Gitler A. D., Bevis B. J., Shorter J., Strathearn K. E., Hamamichi S., Su L. J., Caldwell K. A., Caldwell G. A., Rochet J. C., McCaffery J. M., Barlowe C., Lindquist S., The Parkinson's disease protein -synuclein disrupts cellular Rab homeostasis Proceedings of the National Academy of Sciences of the United States of America 2008 105 1 145 150
104. Cooper A. A., Gitler A. D., Cashikar A., Haynes C. M., Hill K. J., Bhullar B., Liu K., Xu K., Strathearn K. E., Liu F., Cao S., Caldwell K. A., Caldwell G. A., Marsischky G., Kolodner R. D., LaBaer J., Rochet J. C., Bonini N. M., Lindquist S., -synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models Science 2006 313 5785 324 328 (Pubitemid 44480951)
105. Lewandowski N. M., Ju S., Verbitsky M., Polyamine pathway contributes to the pathogenesis of Parkinson disease Proceedings of the National Academy of Sciences of the United States 2010 107 39 16970 16975
106. Yeger-Lotem E., Riva L., Su L. J., Gitler A. D., Cashikar A. G., King O. D., Auluck P. K., Geddie M. L., Valastyan J. S., Karger D. R., Lindquist S., Fraenkel E., Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity Nature Genetics 2009 41 3 316 323
107. Su L. J., Auluck P. K., Outeiro T. F., Yeger-Lotem E., Kritzer J. A., Tardiff D. F., Strathearn K. E., Liu F., Cao S., Hamamichi S., Hill K. J., Caldwell K. A., Bell G. W., Fraenkel E., Cooper A. A., Caldwell G. A., Michael McCaffery J., Rochet J. C., Lindquist S., Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models Disease Models and Mechanisms 2010 3 3-4 194 208
108. Lee Y. J., Wang S., Slone S. R., Yacoubian T. A., Witt S. N., Defects in very long chain fatty acid synthesis enhance -synuclein toxicity in a yeast model of Parkinson's disease PLoS ONE 2011 6 1
109. Sere Y. Y., Regnacq M., Colas J., Berges T., A Saccharomyces cerevisiae strain unable to store neutral lipids is tolerant to oxidative stress induced by -synuclein Free Radical Biology and Medicine 2010 49 11 1755 1764
110. Lee H. G., Zhu X., Nunomura A., Perry G., Smith M. A., Amyloid : the alternate hypothesis Current Alzheimer Research 2006 3 1 75 80
111. Kontush A., Berndt C., Weber W., Akopyan V., Arlt S., Schippling S., Beisiegel U., Amyloid- is an antioxidant for lipoproteins in cerebrospinal fluid and plasma Free Radical Biology and Medicine 2001 30 1 119 128 (Pubitemid 32008095)
112. Macreadie I., Lotfi-Miri M., Mohotti S., Shapira D., Bennett L., Varghese J., Validation of folate in a convenient yeast assay suited for identification of inhibitors of Alzheimer's amyloid- aggregation Journal of Alzheimer's Disease 2008 15 3 391 396