메뉴 건너뛰기




Volumn 49, Issue 11, 2010, Pages 1755-1764

A Saccharomyces cerevisiae strain unable to store neutral lipids is tolerant to oxidative stress induced by α-synuclein

Author keywords

Synuclein; FASN; Free radicals; GSH; Lipid droplets; Neutral lipids; Oxidative stress; Parkinson disease; Saccharomyces cerevisiae; Squalene

Indexed keywords

ALPHA SYNUCLEIN; ESTER DERIVATIVE; FAT DROPLET; FATTY ACID SYNTHASE; LIPID; TRIACYLGLYCEROL;

EID: 78049386083     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.09.007     Document Type: Article
Times cited : (18)

References (55)
  • 1
    • 0028277520 scopus 로고
    • Identification of 2 distinct synucleins from human
    • Jakes R., Spillantini M.G., Goedert M. Identification of 2 distinct synucleins from human. FEBS Lett. 1994, 345:27-32.
    • (1994) FEBS Lett. , vol.345 , pp. 27-32
    • Jakes, R.1    Spillantini, M.G.2    Goedert, M.3
  • 2
    • 2642514788 scopus 로고    scopus 로고
    • Alpha-Synuclein: normal function and role in neurodegenerative diseases
    • Norris E.H., Giasson B.I., Lee V.M.Y. alpha-Synuclein: normal function and role in neurodegenerative diseases. Curr. Top. Dev. Biol. 2004, 60:17-54.
    • (2004) Curr. Top. Dev. Biol. , vol.60 , pp. 17-54
    • Norris, E.H.1    Giasson, B.I.2    Lee, V.M.Y.3
  • 3
    • 0031762949 scopus 로고    scopus 로고
    • Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia
    • Trojanowski J.Q., Goedert M., Iwatsubo T., Lee V.M.Y. Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia. Cell Death Differ. 1998, 5:832-837.
    • (1998) Cell Death Differ. , vol.5 , pp. 832-837
    • Trojanowski, J.Q.1    Goedert, M.2    Iwatsubo, T.3    Lee, V.M.Y.4
  • 4
    • 0032545154 scopus 로고    scopus 로고
    • Degenerative terminals of the perforant pathway are human alpha-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease
    • Iseki E., Marui W., Kosaka K., Akiyama H., Ueda K., Iwatsubo T. Degenerative terminals of the perforant pathway are human alpha-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease. Neurosci. Lett. 1998, 258:81-84.
    • (1998) Neurosci. Lett. , vol.258 , pp. 81-84
    • Iseki, E.1    Marui, W.2    Kosaka, K.3    Akiyama, H.4    Ueda, K.5    Iwatsubo, T.6
  • 5
    • 0032990543 scopus 로고    scopus 로고
    • Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease
    • Lippa C.F., Schmidt M.L., Lee V.M.Y., Trojanowski J.Q. Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann. Neurol. 1999, 45:353-357.
    • (1999) Ann. Neurol. , vol.45 , pp. 353-357
    • Lippa, C.F.1    Schmidt, M.L.2    Lee, V.M.Y.3    Trojanowski, J.Q.4
  • 6
    • 0032584686 scopus 로고    scopus 로고
    • Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
    • Spillantini M.G., Crowther R.A., Jakes R., Cairns N.J., Lantos P.L., Goedert M. Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci. Lett. 1998, 251:205-208.
    • (1998) Neurosci. Lett. , vol.251 , pp. 205-208
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Cairns, N.J.4    Lantos, P.L.5    Goedert, M.6
  • 12
    • 33749242234 scopus 로고    scopus 로고
    • Drosophila in the study of neurodegenerative disease
    • Marsh J.L., Thompson L.M. Drosophila in the study of neurodegenerative disease. Neuron 2006, 52:169-178.
    • (2006) Neuron , vol.52 , pp. 169-178
    • Marsh, J.L.1    Thompson, L.M.2
  • 13
    • 77949527336 scopus 로고    scopus 로고
    • Alpha-Synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans
    • Cao P.X., Yuan Y.Y., Pehek E.A., Moise A.R., Huang Y., Palczewski K., Feng Z.Y. alpha-Synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. PLoS ONE 2010, 5:e9312.
    • (2010) PLoS ONE , vol.5
    • Cao, P.X.1    Yuan, Y.Y.2    Pehek, E.A.3    Moise, A.R.4    Huang, Y.5    Palczewski, K.6    Feng, Z.Y.7
  • 16
    • 0345189364 scopus 로고    scopus 로고
    • Yeast cells provide insight into alpha-synuclein biology and pathobiology
    • Outeiro T.F., Lindquist S. Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 2003, 302:1772-1775.
    • (2003) Science , vol.302 , pp. 1772-1775
    • Outeiro, T.F.1    Lindquist, S.2
  • 17
    • 20444372698 scopus 로고    scopus 로고
    • Alpha-Synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast
    • Dixon C., Mathias N., Zweig R.M., Davis D.A., Gross D.S. alpha-Synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast. Genetics 2005, 170:47-59.
    • (2005) Genetics , vol.170 , pp. 47-59
    • Dixon, C.1    Mathias, N.2    Zweig, R.M.3    Davis, D.A.4    Gross, D.S.5
  • 19
    • 77952741735 scopus 로고    scopus 로고
    • Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?
    • Khurana V., Lindquist S. Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?. Nat. Rev. Neurosci. 2010, 11:436-449.
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 436-449
    • Khurana, V.1    Lindquist, S.2
  • 20
    • 0345189365 scopus 로고    scopus 로고
    • Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein
    • Willingham S., Outeiro T.F., DeVit M.J., Lindquist S.L., Muchowski P.J. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science 2003, 302:1769-1772.
    • (2003) Science , vol.302 , pp. 1769-1772
    • Willingham, S.1    Outeiro, T.F.2    DeVit, M.J.3    Lindquist, S.L.4    Muchowski, P.J.5
  • 24
    • 54449092523 scopus 로고    scopus 로고
    • A block in endoplasmic reticulum-to-Golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulation
    • Gaspar M.L., Jesch S.A., Viswanatha R., Antosh A.L., Brown W.J., Kohlwein S.D., Henry S.A. A block in endoplasmic reticulum-to-Golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulation. J. Biol. Chem. 2008, 283:25735-25751.
    • (2008) J. Biol. Chem. , vol.283 , pp. 25735-25751
    • Gaspar, M.L.1    Jesch, S.A.2    Viswanatha, R.3    Antosh, A.L.4    Brown, W.J.5    Kohlwein, S.D.6    Henry, S.A.7
  • 27
    • 71449102613 scopus 로고    scopus 로고
    • Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast
    • Petschnigg J., Wolinski H., Kolb D., Zellnig G., Kurat C.F., Natter K., Kohlwein S.D. Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast. J. Biol. Chem. 2009, 284:30981-30993.
    • (2009) J. Biol. Chem. , vol.284 , pp. 30981-30993
    • Petschnigg, J.1    Wolinski, H.2    Kolb, D.3    Zellnig, G.4    Kurat, C.F.5    Natter, K.6    Kohlwein, S.D.7
  • 28
    • 0344443670 scopus 로고    scopus 로고
    • Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase
    • Zhang Q., Chieu H.K., Low C.P., Zhang S.C., Heng C.K., Yang H.Y. Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. J. Biol. Chem. 2003, 278:47145-47155.
    • (2003) J. Biol. Chem. , vol.278 , pp. 47145-47155
    • Zhang, Q.1    Chieu, H.K.2    Low, C.P.3    Zhang, S.C.4    Heng, C.K.5    Yang, H.Y.6
  • 30
    • 76049083966 scopus 로고    scopus 로고
    • Reactive oxygen species, cellular redox systems, and apoptosis
    • Circu M.L., Aw T.Y. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic. Biol. Med. 2010, 48:749-762.
    • (2010) Free Radic. Biol. Med. , vol.48 , pp. 749-762
    • Circu, M.L.1    Aw, T.Y.2
  • 31
    • 0036278335 scopus 로고    scopus 로고
    • Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease
    • Xu J., Kao S.Y., Lee F.J.S., Song W.H., Jin L.W., Yankner B.A. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat. Med. 2002, 8:600-606.
    • (2002) Nat. Med. , vol.8 , pp. 600-606
    • Xu, J.1    Kao, S.Y.2    Lee, F.J.S.3    Song, W.H.4    Jin, L.W.5    Yankner, B.A.6
  • 32
    • 23644442282 scopus 로고    scopus 로고
    • Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease
    • Flower T.R., Chesnokova L.S., Froelich C.A., Dixon C., Witt S.N. Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. J. Mol. Biol. 2005, 351:1081-1100.
    • (2005) J. Mol. Biol. , vol.351 , pp. 1081-1100
    • Flower, T.R.1    Chesnokova, L.S.2    Froelich, C.A.3    Dixon, C.4    Witt, S.N.5
  • 33
    • 0035869341 scopus 로고    scopus 로고
    • Evidence for redox regulation of cytochrome c release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition
    • Kirkland R., Franklin J. Evidence for redox regulation of cytochrome c release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition. J. Neurosci. 2001, 21:1949.
    • (2001) J. Neurosci. , vol.21 , pp. 1949
    • Kirkland, R.1    Franklin, J.2
  • 34
    • 0018085511 scopus 로고
    • Quantitation of submicrogram quantities of protein by an improved protein-dye binding assay
    • Bearden J. Quantitation of submicrogram quantities of protein by an improved protein-dye binding assay. Biochim. Biophys. Acta Protein Struct. 1978, 533:525-529.
    • (1978) Biochim. Biophys. Acta Protein Struct. , vol.533 , pp. 525-529
    • Bearden, J.1
  • 35
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.1
  • 36
    • 64549089737 scopus 로고    scopus 로고
    • Heterologous expression of AtClo1, a plant oil body protein, induces lipid accumulation in yeast
    • Froissard M., D'Andrea S., Boulard C., Chardot T. Heterologous expression of AtClo1, a plant oil body protein, induces lipid accumulation in yeast. FEMS Yeast Res. 2009, 9:428-438.
    • (2009) FEMS Yeast Res. , vol.9 , pp. 428-438
    • Froissard, M.1    D'Andrea, S.2    Boulard, C.3    Chardot, T.4
  • 37
    • 38149090417 scopus 로고    scopus 로고
    • SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion
    • Desfougeres T., Ferreira T., Berges T., Regnacq M. SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion. Biochem. J. 2008, 409:299-309.
    • (2008) Biochem. J. , vol.409 , pp. 299-309
    • Desfougeres, T.1    Ferreira, T.2    Berges, T.3    Regnacq, M.4
  • 38
    • 34548851693 scopus 로고    scopus 로고
    • Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method
    • Rahman I., Kode A., Biswas S. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat. Protoc. 2007, 1:3159-3165.
    • (2007) Nat. Protoc. , vol.1 , pp. 3159-3165
    • Rahman, I.1    Kode, A.2    Biswas, S.3
  • 39
    • 0020065656 scopus 로고
    • Size control models of Saccharomyces cerevisiae cell proliferation
    • Wheals A.E. Size control models of Saccharomyces cerevisiae cell proliferation. Mol. Cell. Biol. 1982, 2:361-368.
    • (1982) Mol. Cell. Biol. , vol.2 , pp. 361-368
    • Wheals, A.E.1
  • 40
    • 0035371184 scopus 로고    scopus 로고
    • Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    • Schafer F.Q., Buettner G.R. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic. Biol. Med. 2001, 30:1191-1212.
    • (2001) Free Radic. Biol. Med. , vol.30 , pp. 1191-1212
    • Schafer, F.Q.1    Buettner, G.R.2
  • 41
    • 0015340462 scopus 로고
    • The action mechanism of cerulenin. I. Effect of cerulenin on sterol and fatty acid biosynthesis in yeast
    • Nomura S., Omura S., Hata T., Horiuchi T. The action mechanism of cerulenin. I. Effect of cerulenin on sterol and fatty acid biosynthesis in yeast. J. Biochem. 1972, 71:783-796.
    • (1972) J. Biochem. , vol.71 , pp. 783-796
    • Nomura, S.1    Omura, S.2    Hata, T.3    Horiuchi, T.4
  • 42
    • 0029619396 scopus 로고
    • Adaptive response of Schizosaccharomyces pombe to hydrogen peroxide and menadione
    • Lee J., Dawes I.W., Roe J.H. Adaptive response of Schizosaccharomyces pombe to hydrogen peroxide and menadione. Microbiology 1995, 141:3127-3132.
    • (1995) Microbiology , vol.141 , pp. 3127-3132
    • Lee, J.1    Dawes, I.W.2    Roe, J.H.3
  • 43
    • 67149094723 scopus 로고    scopus 로고
    • Genome-wide fitness and expression profiling implicate Mga2 in adaptation to hydrogen peroxide
    • Kelley R., Ideker T. Genome-wide fitness and expression profiling implicate Mga2 in adaptation to hydrogen peroxide. PLoS Genet. 2009, 5.
    • (2009) PLoS Genet. , vol.5
    • Kelley, R.1    Ideker, T.2
  • 44
    • 3843131947 scopus 로고    scopus 로고
    • A yeast strain lacking lipid particles bears a defect in ergosterol formation
    • Sorger D., Athenstaedt K., Hrastnik C., Daum G. A yeast strain lacking lipid particles bears a defect in ergosterol formation. J. Biol. Chem. 2004, 279:31190-31196.
    • (2004) J. Biol. Chem. , vol.279 , pp. 31190-31196
    • Sorger, D.1    Athenstaedt, K.2    Hrastnik, C.3    Daum, G.4
  • 47
    • 0034193399 scopus 로고    scopus 로고
    • Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
    • Murphy D., Rueter S., Trojanowski J., Lee V. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J. Neurosci. 2000, 20:3214.
    • (2000) J. Neurosci. , vol.20 , pp. 3214
    • Murphy, D.1    Rueter, S.2    Trojanowski, J.3    Lee, V.4
  • 48
    • 62149134185 scopus 로고    scopus 로고
    • Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer
    • Menendez J.A., Vazquez-Martin A., Ortega F.J., Fernandez-Real J.M. Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer. Clin. Chem. 2009, 55:425-438.
    • (2009) Clin. Chem. , vol.55 , pp. 425-438
    • Menendez, J.A.1    Vazquez-Martin, A.2    Ortega, F.J.3    Fernandez-Real, J.M.4
  • 49
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • Menendez J.A., Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat. Rev. Cancer 2007, 7:763-777.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 50
    • 39949084153 scopus 로고    scopus 로고
    • Adaptation to hydrogen peroxide in Saccharomyces cerevisiae: the role of NADPH-generating systems and the SKN7 transcription factor
    • Ng C.H., Tan S.X., Perrone G.G., Thorpe G.W., Higgins V.J., Dawes I.W. Adaptation to hydrogen peroxide in Saccharomyces cerevisiae: the role of NADPH-generating systems and the SKN7 transcription factor. Free Radic. Biol. Med. 2008, 44:1131-1145.
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 1131-1145
    • Ng, C.H.1    Tan, S.X.2    Perrone, G.G.3    Thorpe, G.W.4    Higgins, V.J.5    Dawes, I.W.6
  • 51
    • 42549160157 scopus 로고    scopus 로고
    • Loss of tafazzin in yeast leads to increased oxidative stress during respiratory growth
    • Chen S., He Q., Greenberg M.L. Loss of tafazzin in yeast leads to increased oxidative stress during respiratory growth. Mol. Microbiol. 2008, 68:1061-1072.
    • (2008) Mol. Microbiol. , vol.68 , pp. 1061-1072
    • Chen, S.1    He, Q.2    Greenberg, M.L.3
  • 53
    • 54249135351 scopus 로고    scopus 로고
    • Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth
    • Das B., Antoon R., Tsuchida R., Lotfi S., Morozova O., Farhat W., Malkin D., Koren G., Yeger H., Baruchel S. Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth. Neoplasia 2008, 10:1105-1153.
    • (2008) Neoplasia , vol.10 , pp. 1105-1153
    • Das, B.1    Antoon, R.2    Tsuchida, R.3    Lotfi, S.4    Morozova, O.5    Farhat, W.6    Malkin, D.7    Koren, G.8    Yeger, H.9    Baruchel, S.10
  • 54
    • 77649192253 scopus 로고    scopus 로고
    • Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells
    • Warleta F., Campos M., Allouche Y., Sanchez-Quesada C., Ruiz-Mora J., Beltran G., Gaforio J.J. Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells. Food Chem. Toxicol. 2010, 48:1092-1100.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 1092-1100
    • Warleta, F.1    Campos, M.2    Allouche, Y.3    Sanchez-Quesada, C.4    Ruiz-Mora, J.5    Beltran, G.6    Gaforio, J.J.7
  • 55
    • 0028913277 scopus 로고
    • Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squalene in n-butanol
    • Kohno Y., Egawa Y., Itoh S., Nagaoka S., Takahashi M., Mukai K. Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squalene in n-butanol. Biochim. Biophys. Acta Lipids Lipid Metab. 1995, 1256:52-56.
    • (1995) Biochim. Biophys. Acta Lipids Lipid Metab. , vol.1256 , pp. 52-56
    • Kohno, Y.1    Egawa, Y.2    Itoh, S.3    Nagaoka, S.4    Takahashi, M.5    Mukai, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.