Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration

Journal of Neuroscience

Volumn 32, Issue 3, 2012, Pages 1020-1034

  Sundaram, Jeyapriya R ^a,b   Chan, Elizabeth S ^a,b   Poore, Charlene P ^a,b   Pareek, Tej K ^c   Cheong, Wei Fun ^a,b   Shui, Guanghou ^a,b   Tang, Ning ^a,b   Low, Chian Ming ^a,b   Wenk, Markus R ^a,b   Kesavapany, Sashi ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CYCLIN DEPENDENT KINASE 5; CYTOSOLIC PHOSPHOLIPASE A2; LENTIVIRUS VECTOR; LYSOPHOSPHATIDYLCHOLINE; PROTEIN P25; TAU PROTEIN;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; GENE SILENCING; GENETIC TRANSDUCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LIPID ANALYSIS; MASS SPECTROMETRY; MOUSE; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROGENIC INFLAMMATION; NICK END LABELING; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

AGE FACTORS; AMYLOID BETA-PEPTIDES; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; CEREBRAL CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYTOKINES; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; GREEN FLUORESCENT PROTEINS; HUMANS; IN SITU NICK-END LABELING; INFLAMMATION; LYSOPHOSPHATIDYLCHOLINES; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROGLIA; NEURONS; PEPTIDE FRAGMENTS; PHOSPHOLIPASES A2, CYTOSOLIC; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TAU PROTEINS; TIME FACTORS; TRANSDUCTION, GENETIC;

EID: 84856007240     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5177-11.2012     Document Type: Article

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