Stress is a critical player in CYP3A, CYP2C, and CYP2D regulation: Role of adrenergic receptor signaling pathways

American Journal of Physiology - Endocrinology and Metabolism

Volumn 303, Issue 1, 2012, Pages

  Daskalopoulos, Evangelos P ^a   Malliou, Foteini ^a   Rentesi, Georgia ^a   Marselos, Marios ^a   Lang, Matti A ^b   Konstandi, Maria ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Cytochrome P 450s; Drug metabolism; Epinephrine; Glucocorticoids; Rat

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME P450 2C; CYTOCHROME P450 2C11; CYTOCHROME P450 2D; CYTOCHROME P450 2D1; CYTOCHROME P450 2D2; CYTOCHROME P450 3A; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; DEXMEDETOMIDINE; GLUCOCORTICOID; ISOPRENALINE; PHENYLEPHRINE; STAT5B PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STRESS; UPREGULATION;

ADRENERGIC AGONISTS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; CORTICOSTERONE; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; EPINEPHRINE; HEPATOCYTES; ISOENZYMES; MALE; MATERNAL DEPRIVATION; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC; RESTRAINT, PHYSICAL; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEROID 16-ALPHA-HYDROXYLASE; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL;

EID: 84863638072     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00545.2011     Document Type: Article

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