Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific α2-adrenoceptor antagonist atipamezole. A pharmacodynamic and kinetic study in healthy volunteers

Anesthesiology

Volumn 89, Issue 3, 1998, Pages 574-584

  Scheinin, Harry ^b   Aantaa, Riku ^c   Anttila, Markku ^c   Hakola, Pasi ^c   Helminen, Antti ^c   Karhuvaara, Sakari ^a  

^a Pharmadocs   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c NONE

Author keywords

Antidote; Receptors; Sympathomimetics

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ATIPAMEZOLE; CATECHOLAMINE; DEXMEDETOMIDINE; PLACEBO; SODIUM CHLORIDE;

ADRENERGIC ACTIVITY; ADULT; ALERTNESS; ANXIETY; ARTICLE; BRADYCARDIA; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; FLUSHING; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; SALIVATION; SEDATION; SIDE EFFECT; SINUS ARREST; SWEATING; TREMOR; XEROSTOMIA;

ADRENERGIC ALPHA-ANTAGONISTS; ADULT; BLOOD PRESSURE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HEART RATE; HUMANS; HYPNOTICS AND SEDATIVES; IMIDAZOLES; MALE; MEDETOMIDINE; NOREPINEPHRINE; RECEPTORS, ADRENERGIC, ALPHA-2; SYMPATHOLYTICS;

EID: 0031668941     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199809000-00005     Document Type: Article

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