Cytochromes P450 and experimental models of drug metabolism

Journal of Cellular and Molecular Medicine

Volumn 6, Issue 2, 2002, Pages 189-198

  Zuber, Roman ^a   Anzenbacherová, Eva ^a   Anzenbacher, P ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Cytochrome P450; Drug metabolism; Inter species differences

Indexed keywords

ANIMALIA; CANIS FAMILIARIS; SUS SCROFA;

BIOLOGICAL MARKER; CYTOCHROME P450; DRUG;

ANIMAL; ANIMAL MODEL; DOG; ENZYME SPECIFICITY; ENZYMOLOGY; HUMAN; LIVER MICROSOME; MACACA; METABOLISM; RAT; REVIEW; SPECIES DIFFERENCE; SWINE;

ANIMALS; BIOLOGICAL MARKERS; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; HUMANS; MACACA FASCICULARIS; MACACA MULATTA; MICROSOMES, LIVER; MODELS, ANIMAL; PHARMACEUTICAL PREPARATIONS; RATS; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY; SWINE;

EID: 0036548404     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2002.tb00186.x     Document Type: Short Survey

References (46)

1. Ortiz de Montellano P.R. (ed.), Cytochromes P450, Plenum Press, New York 1995
2. Anzenbacher P., Anzenbacherová E., Cytochromes P450 and metabolism of xeno-biotics, Cell. Mol. Life Sci., 58: 737, 2001
3. McLean M.A., Maves S.A., Weiss K.E., Krepich S., Sligar S.G., Characterization of a cytochrome P450 from the acidothermophilic archaea Sulfolobus solfataricus, Biochem. Biophys. Res. Commun., 252: 166, 1998
4. Nelson D.R., Cytochrome P450 and the individuality of species, Arch. Biochem. Biophys., 369: 1-10, 1999
5. For P450 pages on Internet, start e.g. with the http://mhc.com/ cytochromes/links.HTML or with http://dmelson.utmem.edu/cytochromeP450.html
6. Krishna D., Klotz U., Exrtahepatic metabolism of drugs in humans, Clin. Pharmacokinet., 26: 144, 1994
7. Mandelbaum A., Pertyborn F., Martin/Facklam M., Wiesel M., Unexplained decrease of cyclosporin trough levels in a compliant renal transplant patient, Nephrol. Dialysis Transplantation, 15: 1473, 2000
8. Mai I., Krüger H., Budde K., Johne A., Brockmöller J., Neumayer H.H., Roots I., Hazardous pharmacokinetic interaction of Saint John's wort (Hypericum perforatum) with the immunosuppressant cyclosporin, Int. J. Clin. Pharmacol. Therapeutics, 38: 500, 2000
9. Thummel K.E., Wilkinson G.R., In vitro and in vivo drug interactions involving human CYP3A, Annual Rev. Pharmacol. Toxicol., 38: 389, 1998
10. Mullins M.E., Horowitz B.Z., Linden D.H., Smith G.W., Norton R.L., Stump J., Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers, JAMA, 280: 157, 1998
11. Dresser G.K., Spencer D.J., Bailey D.G., Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition, Clin. Pharmacokinet., 38: 41, 2000
12. Bertz R.J., Granneman G.R., Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions, Clin. Pharmacokinet. 32: 210, 1997
13. Guengerich F.P., Human cytochrome P450 enzymes. In: Ref. 1, pp. 473-535
14. Cooper D.J., Gollackner B., Sachs D.H., Will the pig solve the transplantation backlog?, Annu. Rev. Med., 53: 133, 2002
15. Guengerich F.P., Comparisons on catalytic selectivity of cytochrome P450 subfamily enzymes from different species, Chem.-Biol. Interact., 106: 161, 1997
16. Smith D.A., Species differences in metabolism and pharmacokinetics: Are we close to an understanding?, Drug Metabol. Revs., 23: 355, 1991
17. Aleynik M.K., Lieber C.S., Dilinoleylphosphatidylcholine decreases ethanol-induced cytochrome P450 2E1, Biochem. Biophys. Res. Commun., 288: 1047, 2001
18. Lu C., Li A.P., Species comparison in cytochrome P450 induction: Effects of dexamethasone, omeprazole, and rifampine on P450 isoforms 1A and 3A in primary cultured hepatocytes form man, Sprague-Dawley rat, minipig, and Beagle dog, Chem.-Biol. Interact. 134: 271, 2001
19. Nedelcheva V., Gut I., P450 in the rat and man: Methods of investigation, substrate specifities and relevance to cancer, Xenobiotica, 24: 1151, 1994
20. Strobl G.R., von Kruedener S., Stockigt J., Guengerich F.P., Wolff T., Development of a pharmacophore for inhibition of human liver cytochrome P450 2D6: Molecular modelling and inhibition studies, J. Med. Chem., 36: 1136, 1993
21. Kobayashi K., Urashima K., Shimada T., Chiba K., Substrate specificity for rat cytochrome P450 (CYP) isoforms: Screening with cDNA-expressed system of the rat, Biochem. Pharmacol., 63: 889, 2002
22. Gonzalez F.J., Matsunaga Y., Nagata K., Meyer U.A., Nebert D.W., Pastewka J., Kozak C.A., Gillette J., Gelboin H.W., Hardwick J.P., Debrisoquine 4-hydroxylase: Characterization of a new P450 gene subfamily., DNA, 6: 149, 1987
23. Quattrochi L.C., Tukey R.H., The human CYP1A2 gene and induction by 3-methylcholanthrene, J. Biol. Chem., 269: 6949, 1994
24. Haugen D.A., Coon M.J., Properties of electrophoretically homogenous phenobarbital-inducible and beta naphthoflavone-inducible forms of liver microsomal cytochrome P-450, J. Biol. Chem., 251: 7929, 1976
25. Ding X., Pernecky S.J., Coon M.J., Purification and characterization of cytochrome P450 2E2 from hepatic microsomes of neonatal rabbits, Arch. Biochem. Bioiphys., 291: 270, 1991
26. Schwartz P.S., Waxman D.J., Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells, Mol. Pharmacol., 60: 1268, 2001
27. Waxman D.J., Attisano C., Guengerich F.P., Lapenson D.P., Cytochrome P450 steroid hormone metabolism catalyzed by human liver microsomes, Arch. Biochem. Biophys., 263: 424, 1988
28. Yamamoto Y., Ishizuka M., Takada A., Fujita S., Cloning, tissue distribution, and functional expression of two novel rabbit cytochrome P450 isozymes, CYP2D23 and CYP2D24, J. Biochem. (Tokyo), 124: 503, 1998
29. Bogaards J.J.P., Bertrand M., Jackson P., Oudshoorn M.J., Weaver R.J., van Bladeren P.J., Walther B., Determining the best animal model for human cytochrome P450 activities: Comparison of mouse, rat, rabbit, dog, micropig, monkey and man, Xenobiotica, 30: 1131, 2000
30. Jayyosi Z., Muc M., Erick J., Thomas P.E., Kelley M., Catalytic and immunochemical characterization of cytochrome P450 isozyme induction in dog liver, Fundam. Appl. Toxicol., 31: 95, 1996
31. Roussel F., Duignan D.B., Lawton M.P., Obach R.S., Strick C.S., Tweedie D.J., Expression and characterization of canine cytochrome P450 2D15, Arch. Biochem. Biophys., 357: 27, 1998
32. Chauret N., Gauthier A., Martin J., Nicoll-Griffith D.A., In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse, Drug Metab. Disposition, 25: 1130, 1997
33. Sharer J.E., Shipley L.A., Vandenbranden M.R., Binkley S.N., Wrighton S.A., Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey, Drug Metab. Disposition, 23: 1231, 1995
34. Edwards R.J., Murray S., Schulz T., Neubert D., Gant T. W., Thorgeirsson S.S., Boobis A.R., Davis D.S., Contribution of CYP1A1 and CYP1A2 on the activation of heterocyclic amines in monkeys and human, Carcinogenesis, 15: 829, 1994
35. Komori M., Kikuchi O., Sakuma T., Funaki J., Kitada M., Kamataki T., Molecular cloning of monkey liver cytochromes P-450 cDNAs: Similarity of the primary sequences to human cytochromes P-450, Biochim. Biophys. Acta, 1171: 141, 1992
36. Anzenbacher P., Souèek P., Anzenbacherová E., Gut I., Hrubý K., Svoboda Z., Kvìtina J., Presence and activity of cytochrome P450 isoforms in minipig liver microsomes, Drug Metab. Disposition, 26: 56, 1998
37. Skaanild M.T., Friis C., Characterization of the P450 system in Goettingen minipigs, Pharmacol. Toxicol., 80 (Suppl. 2): 28, 1997
38. Monshouwer M., van't Klooster G.A.E., Nijmeijer S.M., Witkamp R.F., van Miert A.S.J.P.A.M., Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes, Toxicol. In Vitro, 12: 715, 1998
39. Myers M.J., Farrell D.E., Howard K.D., Kawalek J.C., Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine, Drug Metab. Disposition, 29: 908, 2001
40. 3 25-hydroxylase (CYP2D25), J. Biol. Chem., 275: 34650, 2000
41. 2-insensitive NADH-benzamidoxime reductase, J. Biol. Chem., 272: 19615, 1997
42. Nissen P.H., Wintero A.K., Fredholm M., Mapping of porcine genes belonging to two different cytochrome P450 subfamilies, Animal Genetics, 29: 7, 1998
43. Souèek P., Zuber R., Anzenbacherová E., Anzenbacher P., Guengerich F.P., Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs, BMC Pharmacology, 1: 11, 2001
44. Olsen A., Hansen K.T., Friis C., Pig hepatocytes as an in vitro model to study the regulation of human CYP3A4: prediction of drug-drug interactions with 17β-ethynylestradiol, Chem.-Biol. Interact., 107: 93, 1997
45. Anzenbacher P., Anzenbacherová E., Zuber R., Souèek P., Guengerich F.P., Pig and minipig cytochromes P450, Drug Metab. Disposition, 30: 100, 2002
46. Takemori S., Kominami S., The role of cytochromes P450 in adrenal steroidogenesis, Trends Biochem. Sci., 9: 393, 1984