Evidence of α2-adrenoceptor involvement in B[α]P induction processes of drug-metabolizing enzymes: The effect of stress

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 4, 1998, Pages 491-495

  Konstandi, M ^a   Kostakis, D ^a   Johnson, E ^a   Lang, M A ^b   Marselos, M ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

B P; Rat; Stress; 2 adrenoceptor

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BENZO[A]PYRENE; CYTOCHROME P450; DEXMEDETOMIDINE; DRUG METABOLIZING ENZYME; LIVER ENZYME; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; IMIDAZOLE DERIVATIVE; MEDETOMIDINE; METHOXYRESORUFIN O DEMETHYLASE; METHOXYRESORUFIN-O-DEMETHYLASE; OXIDOREDUCTASE;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; IMMOBILIZATION STRESS; MALE; NONHUMAN; NORADRENERGIC SYSTEM; PATHOPHYSIOLOGY; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; ANIMAL; ARTICLE; DRUG EFFECT; DRUG POTENTIATION; MENTAL STRESS; METABOLISM; WISTAR RAT;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BENZO(A)PYRENE; CARCINOGENS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; IMIDAZOLES; MALE; MEDETOMIDINE; OXIDOREDUCTASES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2; STRESS, PSYCHOLOGICAL;

EID: 0032216747     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190000     Document Type: Conference Paper

References (26)

1. Williams G.M., Weisburger J.H. (1986) Chemical carcinogens. In: Gasarett and Doull?s Toxicology. New York, MacMillan, pp. 99-173.
2. Gonzalez F.J. and Gelboin H.V. (1994): Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab. Rev. 26(1,2), 165-183.
3. Ioannides C., Parke D.V. (1990): The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metab. Rev., 22(1), 1-85.
4. Gelboin H.V. (1980): Bemzo[ÿ]pyrene metabolism, activation, and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. Physiol. Rev., 60, 1107-1166.
5. Gonzalez F.J. (1989): The molecular biology of cytochrome P450s. Pharmacol. Rev., 40(4), 243-287.
6. Boelsterli U.A. (1993): Specific targets oof covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury. Drug Metab. Rev. 25(4), 395-451.
7. Matamoros R.A., Levine B.S. (1996): Stress response and drug metabolism in mice. Fundam. Appl.Toxicol. 30, 255-263.
8. Pollack G.M., Browne J.L., Marton J., Haberer L.J. (1996) :Chronic stress impairs oxidative metabolism and hepatic excretion of model xenobiotic substrates in the rat. Drug Metab. Dispos., 19, 130-134.
9. Capel I.D., Jenner M., Pinnock .M.H., Dorrell H.M., Williams D.C. (1980): The effect of isolation stress on some hepatic drug and carcinogen metabolizing enzymes in rats. J. Envir. Pathol. Toxicol., 4(2-3), 337-344.
10. Riley V. (1981): Psychoneuroendocrine influences on immunocompetence and neoplasia. Science, 212, 1100-1109.
11. Sourkes T. L. (1983): Pathways of stress in the CNS. Prog. Neuro-Psychopharmacol. & Biol. Psychiat., 7, 389-411.
12. Anisman H., Kokkinidis L., Sklar L.S. (1985): Neurochemical consequences of stress. Contributions of adaptive processes. In: Burchaeld S. (Ed.) STRESS: Psychological and Physiological Interactions, NY, Hemisphere Publ., Co., ch. 3.
13. Glavin G.B. (1985): Stress and noradrenaline: a review. Neurosci. Biobehav. Rev. 9, 233-243.
14. Waxman D.J. (1988): Interactions of hepatic cytochromes P-450 with steroid hormones. Biochem. Pharmacol., 37(1), 71-84.
15. Sherratt A.J., Banet D.E., Prough R.A. (1990): Glucocorticoid regulation of polycyclic aromatic hydrocarbon induction of cytochrome P4501A1, glutathione S-transferases and NAD(P)H: quinone oxidoreductase in cultured fetal rat hepatocytes. Mol. Pharmacol., 37,198-205.
16. Seltzer A. M., Donoso A.O., Podesta E. (1986): Restraint stress stimulation of prolactin and ACTH secretion: role of brain histamine. Physiol. Behav. 36, 251-255.
17. Virtanen R. (1989): Pharmacological profiles of medetomidine and its antagonist, atipamezole. Acta Vet. Scand., 85, 29-37.
18. Harbuz M.S., Lightman S.L. (1989): Responses of hypothalamic and pituitary mRNA to physical and physiological stress in the rat. J. Endocrinol., 122, 705-711.
19. Lang M.A., Gielen J.E., Nebert D.W. (1981): Genetic evidence for many unique liver microsomal P-450 mediated monoxygenase activities in heterogeneic stock mice J. Biol. Chem., 256(23),12068-12075.
20. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. (1951): Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
21. Omura T., Sato R. (1964): The carbon monoxide-binding pigment of liver microsomes. II Solubilization, purification and properties. J. Biol. Chem., 239, 2379-2385.
22. Burke M.D., Majer R.T. (1975): Inherent specificities of purified cytochromes P-450 and P- 448 toward biphenyl hydroxylation and ethoxyresorufin deethylation. Drug Metab. Dispos., 3, 245-253.
23. Nerurkar P.V., Park S.S., Thomas P.E., Nims R.W., Lubet R.A. (1993):Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochrome P4501A2 and 2B respectively, in the rat and mouse. Biochem. Pharmacol., 46, 933-943.
24. Honkakoski P., Auriola S., Lang M.A. (1992): Distinct induction profiles of three phenobarbital- responsive mouse liver cytochrome P450 isozymes. Biochem. Pharmacol., 43(10), 2121-2128.
25. McManus M.E., Felton J.S., Knize M.G., Burgess W.M., Roberts-Thomson S., Pond S.M., Stupans T., Veronese M.E. (1989): Activation of the food derived mutagen 2-amino-3-methyl-6-phenylimidazo(4,5,6)pyridine by rabbit and human liver microsomes and purified forms of cytochrome P-450. Carcinogenesis, 10, 357-364.
26. Yamazoe Y., Shimada M., Murayama N. and Kato R. (1987): Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. J. Biol. Chem., 262(15), 7423-7428.