The role of stress in the regulation of drug metabolizing enzymes in mice

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 4, 1998, Pages 483-490

  Konstandi, M ^a   Marselos, M ^a   Radon Camus, A M ^b   Johnson, E ^a   Lang, M A ^c  

^a UNIVERSITY OF IOANNINA   (Greece)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Cytochromes; Mouse; P450; Restraint stress

Indexed keywords

ALDEHYDE DEHYDROGENASE; CYTOCHROME P450; DRUG METABOLIZING ENZYME; ETHOXYRESORUFIN DEETHYLASE; GLUTATHIONE; PENTOXYRESORUFIN DEALKYLASE;

ANIMAL EXPERIMENT; CONFERENCE PAPER; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME REGULATION; IMMOBILIZATION STRESS; MOUSE; NONHUMAN; NORTHERN BLOTTING;

EID: 0032432743     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03189999     Document Type: Conference Paper

References (31)

1. Yamazoe Y., Shimada M., Murayama N., Kato R. (1987): Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. J. Biol. Chem., 262(15), 7423-7428.
2. Coon M.J., Ding X., Perncky S.J., Vaz A.D.N. (1992): Cytochrome P450: progress and predictions. FASEB J., 6, 669-673
3. Gelboin H.V. (1980): Bemzo[a]pyrene metabolism, activation, and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. Physiol. Rev., 60, 1107-1166.
4. Waxman D.J. (1988): Interactions of hepatic cytochromes P-450 with steroid hormones. Biochem. Pharmacol., 37(1), 71-84.
5. Pelkonen O., Nebert D.W. (1982): Metabolism of polycyclic aromatic hydrocarbons:etiologic role in carcinogenesis. Pharmacol. Rev., 34, 189-222).
6. Boelsterli U.A. (1993): Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury. Drug Metab. Rev., 25(4), 395-451.
7. Pollack G.M., Browne J.L., Marton J., Haberer L.J. (1996): Chronic stress impairs oxidative metabolism and hepatic excretion of model xenobiotic substrates in the rat. Drug Metab. Dispos., 19, 130-134.
8. Riley V. (1981): Psychoneuroendocrine influences on immunocompetence and neoplasia.. Science, 212, 1100-1109.
9. Kelley M., Womack J., Safe S. (1990): Effects of cytochrome P-450 monoxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins, Biochem. Pharmacol., 39(12), 1991-1998.
10. Honkakoski P., Auriola S., Lang M.A. (1992): Distinct induction profiles of three phenobarbital-responsive mouse liver cytochrome P450 isozymes. Biochem. Pharmacol., 43(10), 2121-2128.
11. Smith G., Henderson C.J., Parker M.G., White R., Bars R.G., Wolf C.R. (1993): 1,4-Bis[2-(3,5- Dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P- 450 gene expression. Biochem J., 289, 807-813.
12. Diwan B.A., Lubet R.A., Ward J.M., Hrabie J.A., Rice J.M. (1992): Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-Dichloropyridyloxy))benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine. Carcinogenesis, 13(10),1893-1901.
13. Lang M.A., Gielen J.E., Nebert D.W. (1981): Genetic evidence for many unique liver microsomal P-450 mediated monoxygenase activities in heterogeneic stock mice J. Biol. Chem., 256(23), 12068-12075.
14. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. (1951): Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
15. Omura T., Sato R. (1964) The carbon monoxide-binding pigment of liver microsomes. II Solubilization, purification and properties. J. Biol. Chem., 239, 2379-2385.
16. Aitio A. (1978): A simple and sensitive assay of 7-ethoxycoumarin deethylation. Anal. Biochem., 85(2), 488-491.
17. Burke M.D. and Majer R.T. (1975): Inherent specificities of purified cytochromes P-450 and P-448 toward biphenyl hydroxylation and etkoxyresorufin deethylation. Drug Metab. Dispos., 3, 245-253.
18. Reinke L.A., Moyer M.J. (1985): p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol. Drug Metab. Dispos., 13(5), 548-552.
19. Dagani D., Archer M.C. (1978): Colorimetric determination of acetaldehyde in the presence of formaldehyde. Anal. Biochem., 87, 455-459.
20. Saville B. (1958): A scheme for the colorimetric determination of microgram amounts of thiols. Analyst, 83, 670-672.
21. Habig W.H., Pabst M.J., Jakoby W.B. (1974): Glutathione S-transferases. The first enzymatic step in mercapluric acid formation. J. Biol. Chem., 249, 7130-7139.
22. Anisman H., Kokkinidis L., Sklar L.S. (1985): Neurochemical consequences of stress. Contributions of adaptive processes. In: STRESS (Burchaeld S, Ed) Psychological and Physiological Interactions, NY, Hemispheke Publ. Co., ch.3.
23. Harbuz M.S., Lightman S.L.(1989): Responses of hypothalamic and pituitary mRNA to physical and physiological stress in the rat. J. Endocrinol., 122, 705-711.
24. Furner R.L., Stitzel R.E. (1968): Stress-induced alterations in microsomal drug metabolism in the adrenalectomized rat. Biochem. Pharmacol., 17, 121-127.
25. Capel I.D., Jenner M., Pinnock .M.H., Dorrell H.M., Williams D.C. (1980): The effect of isolation stress on some hepatic drug and carcinogen metabolizing enzymes in rats. J.Envir. Pathol. & Toxicol., 4(2-3), 337-44.
26. Nerurkar P.V., Park S.S., Thomas P.E., Nims R.W., Lubet R.A. (1993): Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochrome P4501A2 and 2B respectively, in the rat and mouse. Biochem. Pharmacol., 46, 933-943.
27. Hahnemann B., Salonpää P., Pasanen M., Mäenpää J., Honkakoski P., Juvonen R., Lang M.A., Pelkonen O., Raunio H. (1992): Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression. Biochem. J., 286, 289-294.
28. Thomas P.E., Bandiera S., Maines S.L., Ryan D.E., Levin W. (1987) Regulation of cytochrome P450j, a high-affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes. Biochemistry, 26, 2280-2289.
29. McManus M.E., Felton J.S., Knize M.G., Burgess W.M., Roberts-Thomson S., Pond S.M., Stupans T., Veronese M.E. (1989): Activation of the food derived mutagen 2-amino-3-methyl- 6- phenylimidazo(4,5,6)pyridine by rabbit and human liver microsomes and purified forms of cytochrome P-450. Carcinogenesis, 10, 357-364.
30. Gonzalez F.J. (1989): The molecular biology of cytochrome P450s. Pharmacol. Rev., 40(4), 243-287.
31. Gonzalez F.J., Gelboin H.V. (1994): Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab. Rev., 26(1,2),165-183.