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Volumn 56, Issue 7, 2012, Pages 1058-1072

Effects of plant sterols and stanols on intestinal cholesterol metabolism: Suggested mechanisms from past to present

Author keywords

Cholesterol; Mechanism of action; Mixed micelles; Plant stanols; Plant sterols

Indexed keywords

ABC TRANSPORTER; CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LIVER X RECEPTOR; MEMBRANE PROTEIN; NPC1L1 PROTEIN, HUMAN; ORPHAN NUCLEAR RECEPTOR; PHYTOSTEROL; SITOSTEROL DERIVATIVE; STANOL ESTER;

EID: 84863550149     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100722     Document Type: Review
Times cited : (224)

References (100)
  • 1
    • 0033755730 scopus 로고    scopus 로고
    • AHA Dietary Guidelines: revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association
    • Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J. et al., AHA Dietary Guidelines: revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Stroke 2000, 31, 2751-2766.
    • (2000) Stroke , vol.31 , pp. 2751-2766
    • Krauss, R.M.1    Eckel, R.H.2    Howard, B.3    Appel, L.J.4
  • 2
    • 0035897687 scopus 로고    scopus 로고
    • Updated guidelines for cholesterol management
    • Lauer, M. S., Fontanarosa, P. B., Updated guidelines for cholesterol management. JAMA 2001, 285, 2508-2509.
    • (2001) JAMA , vol.285 , pp. 2508-2509
    • Lauer, M.S.1    Fontanarosa, P.B.2
  • 3
    • 0020972414 scopus 로고
    • Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis
    • Brown, M. S., Goldstein, J. L., Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu. Rev. Biochem. 1983, 52, 223-261.
    • (1983) Annu. Rev. Biochem. , vol.52 , pp. 223-261
    • Brown, M.S.1    Goldstein, J.L.2
  • 4
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials
    • Baigent, C., Blackwell, L., Emberson, J., Holland, L. E. et al., Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170, 000 participants in 26 randomised trials. Lancet 2010, 376, 1670-1681.
    • (2010) Lancet , vol.376 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2    Emberson, J.3    Holland, L.E.4
  • 5
    • 20844463066 scopus 로고    scopus 로고
    • Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans
    • Landmesser, U., Bahlmann, F., Mueller, M., Spiekermann, S. et al., Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. Circulation 2005, 111, 2356-2363.
    • (2005) Circulation , vol.111 , pp. 2356-2363
    • Landmesser, U.1    Bahlmann, F.2    Mueller, M.3    Spiekermann, S.4
  • 6
    • 34447281476 scopus 로고    scopus 로고
    • Low-density lipoprotein cholesterol reduction: the end is more important than the means
    • LaRosa, J. C., Low-density lipoprotein cholesterol reduction: the end is more important than the means. Am. J. Cardiol. 2007, 100, 240-242.
    • (2007) Am. J. Cardiol. , vol.100 , pp. 240-242
    • LaRosa, J.C.1
  • 7
    • 60249092628 scopus 로고    scopus 로고
    • Continuous dose-response relationship of the LDL-cholesterol-lowering effect of phytosterol intake
    • Demonty, I., Ras, R. T., van der Knaap, H. C., Duchateau, G. S. et al., Continuous dose-response relationship of the LDL-cholesterol-lowering effect of phytosterol intake. J. Nutr. 2009, 139, 271-284.
    • (2009) J. Nutr. , vol.139 , pp. 271-284
    • Demonty, I.1    Ras, R.T.2    van der Knaap, H.C.3    Duchateau, G.S.4
  • 8
    • 79957736833 scopus 로고    scopus 로고
    • A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: results of a meta-analysis of randomized, placebo-controlled trials
    • Musa-Veloso, K., Poon, T. H., Elliot, J. A., Chung, C., A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: results of a meta-analysis of randomized, placebo-controlled trials. Prostaglandins Leukot Essent. Fatty Acids 2011, 85, 9-28.
    • (2011) Prostaglandins Leukot Essent. Fatty Acids , vol.85 , pp. 9-28
    • Musa-Veloso, K.1    Poon, T.H.2    Elliot, J.A.3    Chung, C.4
  • 9
    • 53649086051 scopus 로고    scopus 로고
    • Effects of long-term plant sterol or stanol ester consumption on lipid and lipoprotein metabolism in subjects on statin treatment
    • de Jong, A., Plat, J., Lutjohann, D., Mensink, R. P., Effects of long-term plant sterol or stanol ester consumption on lipid and lipoprotein metabolism in subjects on statin treatment. Br. J. Nutr. 2008, 100, 937-941.
    • (2008) Br. J. Nutr. , vol.100 , pp. 937-941
    • de Jong, A.1    Plat, J.2    Lutjohann, D.3    Mensink, R.P.4
  • 10
    • 33746390405 scopus 로고    scopus 로고
    • The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease
    • Devaraj, S., Jialal, I., The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease. Nutr. Rev. 2006, 64, 348-354.
    • (2006) Nutr. Rev. , vol.64 , pp. 348-354
    • Devaraj, S.1    Jialal, I.2
  • 11
    • 0036895134 scopus 로고    scopus 로고
    • Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion
    • Sudhop, T., Sahin, Y., Lindenthal, B., Hahn, C. et al., Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion. Gut 2002, 51, 860-863.
    • (2002) Gut , vol.51 , pp. 860-863
    • Sudhop, T.1    Sahin, Y.2    Lindenthal, B.3    Hahn, C.4
  • 12
    • 0029035238 scopus 로고
    • Dietary phytosterols: a review of metabolism, benefits and side effects
    • Ling, W. H., Jones, P. J., Dietary phytosterols: a review of metabolism, benefits and side effects. Life Sci. 1995, 57, 195-206.
    • (1995) Life Sci. , vol.57 , pp. 195-206
    • Ling, W.H.1    Jones, P.J.2
  • 13
    • 3042601466 scopus 로고    scopus 로고
    • A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
    • Klett, E. L., Lu, K., Kosters, A., Vink, E. et al., A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med. 2004, 2, 5.
    • (2004) BMC Med. , vol.2 , pp. 5
    • Klett, E.L.1    Lu, K.2    Kosters, A.3    Vink, E.4
  • 14
    • 0034712522 scopus 로고    scopus 로고
    • Plant sterol and stanol margarines and health
    • Law, M., Plant sterol and stanol margarines and health. BMJ 2000, 320, 861-864.
    • (2000) BMJ , vol.320 , pp. 861-864
    • Law, M.1
  • 15
    • 0042206849 scopus 로고    scopus 로고
    • Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels
    • Katan, M. B., Grundy, S. M., Jones, P., Law, M. et al., Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin. Proc. 2003, 78, 965-978.
    • (2003) Mayo Clin. Proc. , vol.78 , pp. 965-978
    • Katan, M.B.1    Grundy, S.M.2    Jones, P.3    Law, M.4
  • 16
    • 58749104741 scopus 로고    scopus 로고
    • Plant sterols/stanols as cholesterol lowering agents: a meta-analysis of randomized controlled trials
    • Abumweis, S. S., Barake, R., Jones, P. J., Plant sterols/stanols as cholesterol lowering agents: a meta-analysis of randomized controlled trials. Food Nutr. Res. 2008, 52-69.
    • (2008) Food Nutr. Res , pp. 52-69
    • Abumweis, S.S.1    Barake, R.2    Jones, P.J.3
  • 17
    • 77954573574 scopus 로고    scopus 로고
    • Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d
    • Mensink, R. P., de Jong, A., Lutjohann, D., Haenen, G. R. et al., Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d. Am. J. Clin. Nutr. 2010, 92, 24-33.
    • (2010) Am. J. Clin. Nutr. , vol.92 , pp. 24-33
    • Mensink, R.P.1    de Jong, A.2    Lutjohann, D.3    Haenen, G.R.4
  • 18
    • 77950861552 scopus 로고    scopus 로고
    • Very high plant stanol intake and serum plant stanols and non-cholesterol sterols
    • Gylling, H., Hallikainen, M., Nissinen, M. J., Simonen, P. et al., Very high plant stanol intake and serum plant stanols and non-cholesterol sterols. Eur. J. Nutr. 2009, 49, 111-117.
    • (2009) Eur. J. Nutr. , vol.49 , pp. 111-117
    • Gylling, H.1    Hallikainen, M.2    Nissinen, M.J.3    Simonen, P.4
  • 19
    • 0033794852 scopus 로고    scopus 로고
    • Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters
    • Plat, J., van Onselen, E. N., van Heugten, M. M., Mensink, R. P., Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters. Eur. J. Clin. Nutr. 2000, 54, 671-677.
    • (2000) Eur. J. Clin. Nutr. , vol.54 , pp. 671-677
    • Plat, J.1    van Onselen, E.N.2    van Heugten, M.M.3    Mensink, R.P.4
  • 20
    • 76949137856 scopus 로고
    • Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks
    • Peterson, D. W., Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks. Proc. Soc. Exp. Biol. Med. 1951, 78, 143-147.
    • (1951) Proc. Soc. Exp. Biol. Med. , vol.78 , pp. 143-147
    • Peterson, D.W.1
  • 21
    • 0004713793 scopus 로고
    • Some relationships among dietary sterols, plasma and liver cholesterol levels, and atherosclerosis in chicks
    • Peterson, D. W., Nichols, C. W., Jr., Shneour, E. A., Some relationships among dietary sterols, plasma and liver cholesterol levels, and atherosclerosis in chicks. J. Nutr. 1952, 47, 57-65.
    • (1952) J. Nutr. , vol.47 , pp. 57-65
    • Peterson, D.W.1    Nichols Jr, C.W.2    Shneour, E.A.3
  • 22
    • 84958699501 scopus 로고
    • Successive prevention of experimental hypercholesteremia and cholesterol atherosclerosis in the rabbit
    • Pollak, O. J., Successive prevention of experimental hypercholesteremia and cholesterol atherosclerosis in the rabbit. Circulation 1953, 7, 696-701.
    • (1953) Circulation , vol.7 , pp. 696-701
    • Pollak, O.J.1
  • 23
    • 33947253738 scopus 로고
    • Reduction of blood cholesterol in man
    • Pollak, O. J., Reduction of blood cholesterol in man. Circulation 1953, 7, 702-706.
    • (1953) Circulation , vol.7 , pp. 702-706
    • Pollak, O.J.1
  • 24
    • 0017688999 scopus 로고
    • Differential absorption of endogenous and exogenous cholesterol in the chick as affected by dietary oil level and phytosterols
    • Sklan, D., Dahan, M., Budowski, P., Hurwitz, S., Differential absorption of endogenous and exogenous cholesterol in the chick as affected by dietary oil level and phytosterols. J. Nutr. 1977, 107, 1996-2001.
    • (1977) J. Nutr. , vol.107 , pp. 1996-2001
    • Sklan, D.1    Dahan, M.2    Budowski, P.3    Hurwitz, S.4
  • 25
    • 0016153070 scopus 로고
    • Effect of soy sterols on intestinal absorption and secretion of cholesterol and bile acids in the chick
    • Sklan, D., Budowski, P., Hurwitz, S., Effect of soy sterols on intestinal absorption and secretion of cholesterol and bile acids in the chick. J. Nutr. 1974, 104, 1086-1090.
    • (1974) J. Nutr. , vol.104 , pp. 1086-1090
    • Sklan, D.1    Budowski, P.2    Hurwitz, S.3
  • 26
    • 0014147113 scopus 로고
    • Partition of lipids between emulsified oil and micellar phases of glyceride-bile salt dispersions
    • Borgstrom, B., Partition of lipids between emulsified oil and micellar phases of glyceride-bile salt dispersions. J. Lipid. Res. 1967, 8, 598-608.
    • (1967) J. Lipid. Res. , vol.8 , pp. 598-608
    • Borgstrom, B.1
  • 27
    • 0024452728 scopus 로고
    • Effects of sitosterol and sitostanol on micellar solubility of cholesterol
    • Ikeda, I., Tanabe, Y., Sugano, M., Effects of sitosterol and sitostanol on micellar solubility of cholesterol. J. Nutr. Sci. Vitaminol. (Tokyo) 1989, 35, 361-369.
    • (1989) J. Nutr. Sci. Vitaminol. (Tokyo) , vol.35 , pp. 361-369
    • Ikeda, I.1    Tanabe, Y.2    Sugano, M.3
  • 28
    • 0017688818 scopus 로고
    • Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholesterolemia and studies of sterol balance
    • Lees, A. M., Mok, H. Y., Lees, R. S., McCluskey, M. A. et al., Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis 1977, 28, 325-338.
    • (1977) Atherosclerosis , vol.28 , pp. 325-338
    • Lees, A.M.1    Mok, H.Y.2    Lees, R.S.3    McCluskey, M.A.4
  • 29
    • 77957566143 scopus 로고    scopus 로고
    • Phyto-sterol ester constituents affect micellar cholesterol solubility in model bile
    • Brown, A. W., Hang, J., Dussault, P. H., Carr, T. P., Phyto-sterol ester constituents affect micellar cholesterol solubility in model bile. Lipids 2010, 45, 855-862.
    • (2010) Lipids , vol.45 , pp. 855-862
    • Brown, A.W.1    Hang, J.2    Dussault, P.H.3    Carr, T.P.4
  • 30
    • 0023433133 scopus 로고
    • Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles
    • Armstrong, M. J., Carey, M. C., Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles. J. Lipid Res. 1987, 28, 1144-1155.
    • (1987) J. Lipid Res. , vol.28 , pp. 1144-1155
    • Armstrong, M.J.1    Carey, M.C.2
  • 31
    • 0017753145 scopus 로고
    • A comparison of hypo-cholesterolemic activity of beta-sitosterol and beta-sitostanol in rats
    • Sugano, M., Morioka, H., Ikeda, I., A comparison of hypo-cholesterolemic activity of beta-sitosterol and beta-sitostanol in rats. J. Nutr. 1977, 107, 2011-2019.
    • (1977) J. Nutr. , vol.107 , pp. 2011-2019
    • Sugano, M.1    Morioka, H.2    Ikeda, I.3
  • 32
    • 0018742240 scopus 로고
    • Intestinal absorption and lymphatic transport of cholesterol and beta-sitostanol in the rat
    • Hassan, A. S., Rampone, A. J., Intestinal absorption and lymphatic transport of cholesterol and beta-sitostanol in the rat. J. Lipid Res. 1979, 20, 646-653.
    • (1979) J. Lipid Res. , vol.20 , pp. 646-653
    • Hassan, A.S.1    Rampone, A.J.2
  • 33
    • 0025963444 scopus 로고
    • Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol
    • Heinemann, T., Kullak-Ublick, G. A., Pietruck, B., von Bergmann, K., Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol. Eur. J. Clin. Pharmacol. 1991, 40, S59-S63.
    • (1991) Eur. J. Clin. Pharmacol. , vol.40
    • Heinemann, T.1    Kullak-Ublick, G.A.2    Pietruck, B.3    von Bergmann, K.4
  • 34
    • 0031745196 scopus 로고    scopus 로고
    • Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects
    • Weststrate, J. A., Meijer, G. W., Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur. J. Clin. Nutr. 1998, 52, 334-343.
    • (1998) Eur. J. Clin. Nutr. , vol.52 , pp. 334-343
    • Weststrate, J.A.1    Meijer, G.W.2
  • 35
    • 0036291210 scopus 로고    scopus 로고
    • A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men
    • Matvienko, O. A., Lewis, D. S., Swanson, M., Arndt, B. et al., A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men. Am. J. Clin. Nutr. 2002, 76, 57-64.
    • (2002) Am. J. Clin. Nutr. , vol.76 , pp. 57-64
    • Matvienko, O.A.1    Lewis, D.S.2    Swanson, M.3    Arndt, B.4
  • 36
    • 58149388493 scopus 로고    scopus 로고
    • Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal
    • Rudkowska, I., Abumweis, S. S., Nicolle, C., Jones, P. J., Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal. J. Am. Coll. Nutr. 2008, 27, 588-595.
    • (2008) J. Am. Coll. Nutr. , vol.27 , pp. 588-595
    • Rudkowska, I.1    Abumweis, S.S.2    Nicolle, C.3    Jones, P.J.4
  • 37
    • 33644816753 scopus 로고    scopus 로고
    • Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects
    • Doornbos, A. M., Meynen, E. M., Duchateau, G. S., van der Knaap, H. C. et al., Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects. Eur. J. Clin. Nutr. 2006, 60, 325-333.
    • (2006) Eur. J. Clin. Nutr. , vol.60 , pp. 325-333
    • Doornbos, A.M.1    Meynen, E.M.2    Duchateau, G.S.3    van der Knaap, H.C.4
  • 38
    • 0017344010 scopus 로고
    • Determination of cholesterol absorption in man by intestinal perfusion
    • Grundy, S. M., Mok, H. Y., Determination of cholesterol absorption in man by intestinal perfusion. J. Lipid Res. 1977, 18, 263-271.
    • (1977) J. Lipid Res. , vol.18 , pp. 263-271
    • Grundy, S.M.1    Mok, H.Y.2
  • 39
    • 0345493907 scopus 로고    scopus 로고
    • Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans
    • Ostlund, R. E., Jr., Spilburg, C. A., Stenson, W. F., Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans. Am. J. Clin. Nutr. 1999, 70, 826-831.
    • (1999) Am. J. Clin. Nutr. , vol.70 , pp. 826-831
    • Ostlund Jr, R.E.1    Spilburg, C.A.2    Stenson, W.F.3
  • 40
    • 0020472048 scopus 로고
    • Optimizing the effect of plant sterols on cholesterol absorption in man
    • Mattson, F. H., Grundy, S. M., Crouse, J. R., Optimizing the effect of plant sterols on cholesterol absorption in man. Am. J. Clin. Nutr. 1982, 35, 697-700.
    • (1982) Am. J. Clin. Nutr. , vol.35 , pp. 697-700
    • Mattson, F.H.1    Grundy, S.M.2    Crouse, J.R.3
  • 42
    • 47549105306 scopus 로고    scopus 로고
    • Comparison of effects of dietary unesterified and esterified plant sterols on cholesterol absorption in rats
    • Kobayashi, M., Hamada, T., Goto, H., Imaizumi, K. et al., Comparison of effects of dietary unesterified and esterified plant sterols on cholesterol absorption in rats. J. Nutr. Sci. Vitaminol. (Tokyo) 2008, 54, 210-214.
    • (2008) J. Nutr. Sci. Vitaminol. (Tokyo) , vol.54 , pp. 210-214
    • Kobayashi, M.1    Hamada, T.2    Goto, H.3    Imaizumi, K.4
  • 43
    • 0034012947 scopus 로고    scopus 로고
    • Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine
    • Miettinen, T. A., Vuoristo, M., Nissinen, M., Jarvinen, H. J. et al., Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. Am. J. Clin. Nutr. 2000, 71, 1095-1102.
    • (2000) Am. J. Clin. Nutr. , vol.71 , pp. 1095-1102
    • Miettinen, T.A.1    Vuoristo, M.2    Nissinen, M.3    Jarvinen, H.J.4
  • 44
    • 33645127162 scopus 로고    scopus 로고
    • Phytosterol and phytostanol esters are effectively hydrolysed in the gut and do not affect fat digestion in ileostomy subjects
    • Normen, L., Ellegard, L., Janssen, H. G., Steenbergen, H. et al., Phytosterol and phytostanol esters are effectively hydrolysed in the gut and do not affect fat digestion in ileostomy subjects. Eur. J. Nutr. 2006, 45, 165-170.
    • (2006) Eur. J. Nutr. , vol.45 , pp. 165-170
    • Normen, L.1    Ellegard, L.2    Janssen, H.G.3    Steenbergen, H.4
  • 46
    • 3042824879 scopus 로고    scopus 로고
    • Both free and esterified plant sterols reduce cholesterol absorption and the bioavailability of beta-carotene and alpha-tocopherol in normocholesterolemic humans
    • Richelle, M., Enslen, M., Hager, C., Groux, M. et al., Both free and esterified plant sterols reduce cholesterol absorption and the bioavailability of beta-carotene and alpha-tocopherol in normocholesterolemic humans. Am. J. Clin. Nutr. 2004, 80, 171-177.
    • (2004) Am. J. Clin. Nutr. , vol.80 , pp. 171-177
    • Richelle, M.1    Enslen, M.2    Hager, C.3    Groux, M.4
  • 47
    • 0037769471 scopus 로고    scopus 로고
    • Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol absorption and LDL cholesterol
    • Spilburg, C. A., Goldberg, A. C., McGill, J. B., Stenson, W. F. et al., Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol absorption and LDL cholesterol. J. Am. Diet Assoc. 2003, 103, 577-581.
    • (2003) J. Am. Diet Assoc. , vol.103 , pp. 577-581
    • Spilburg, C.A.1    Goldberg, A.C.2    McGill, J.B.3    Stenson, W.F.4
  • 48
    • 84862132861 scopus 로고    scopus 로고
    • The effect of high-fiber rye bread enriched with nonesterified plant sterols on major serum lipids and apolipoproteins in normocholesterolemic individuals
    • DOI:10.1016/j.numecd.2010.09.011.
    • Soderholm, P. P., Alfthan, G., Koskela, A. H., Adlercreutz, H. et al., The effect of high-fiber rye bread enriched with nonesterified plant sterols on major serum lipids and apolipoproteins in normocholesterolemic individuals. Nutr. Metab. Cardiovasc. Dis. 2010, DOI:10.1016/j.numecd.2010.09.011.
    • (2010) Nutr. Metab. Cardiovasc. Dis
    • Soderholm, P.P.1    Alfthan, G.2    Koskela, A.H.3    Adlercreutz, H.4
  • 49
    • 27044447065 scopus 로고
    • Sterol metabolism. 3. The distribution and transport of sterols across the intestinal mucosa of the guinea pig
    • Glover, J., Green, C., Sterol metabolism. 3. The distribution and transport of sterols across the intestinal mucosa of the guinea pig. Biochem. J. 1957, 67, 308-316.
    • (1957) Biochem. J. , vol.67 , pp. 308-316
    • Glover, J.1    Green, C.2
  • 50
    • 0024210833 scopus 로고
    • Inhibition of cholesterol absorption in rats by plant sterols
    • Ikeda, I., Tanaka, K., Sugano, M., Vahouny, G. V. et al., Inhibition of cholesterol absorption in rats by plant sterols. J. Lipid Res. 1988, 29, 1573-1582.
    • (1988) J. Lipid Res. , vol.29 , pp. 1573-1582
    • Ikeda, I.1    Tanaka, K.2    Sugano, M.3    Vahouny, G.V.4
  • 51
    • 0024264706 scopus 로고
    • Discrimination between cholesterol and sitosterol for absorption in rats
    • Ikeda, I., Tanaka, K., Sugano, M., Vahouny, G. V. et al., Discrimination between cholesterol and sitosterol for absorption in rats. J. Lipid Res. 1988, 29, 1583-1591.
    • (1988) J. Lipid Res. , vol.29 , pp. 1583-1591
    • Ikeda, I.1    Tanaka, K.2    Sugano, M.3    Vahouny, G.V.4
  • 52
    • 77956821591 scopus 로고    scopus 로고
    • Apolipoprotein B-containing lipoprotein assembly in microsomal triglyceride transfer protein-deficient McA-RH7777 cells
    • Liu, Y., Manchekar, M., Sun, Z., Richardson, P. E. et al., Apolipoprotein B-containing lipoprotein assembly in microsomal triglyceride transfer protein-deficient McA-RH7777 cells. J. Lipid Res. 2010, 51, 2253-2264.
    • (2010) J. Lipid Res. , vol.51 , pp. 2253-2264
    • Liu, Y.1    Manchekar, M.2    Sun, Z.3    Richardson, P.E.4
  • 53
    • 0024514551 scopus 로고
    • Inhibition of acylcoenzyme A: cholesterol acyltransferase activity in CaCo-2 cells results in intracellular triglyceride accumulation
    • Kam, N. T., Albright, E., Mathur, S. N., Field, F. J., Inhibition of acylcoenzyme A: cholesterol acyltransferase activity in CaCo-2 cells results in intracellular triglyceride accumulation. J. Lipid Res. 1989, 30, 371-377.
    • (1989) J. Lipid Res. , vol.30 , pp. 371-377
    • Kam, N.T.1    Albright, E.2    Mathur, S.N.3    Field, F.J.4
  • 54
    • 0021367211 scopus 로고
    • Reduced cholesterol transmucosal transport in rats with inhibited mucosal acyl CoA: cholesterol acyltransferase and normal pancreatic function
    • Clark, S. B., Tercyak, A. M., Reduced cholesterol transmucosal transport in rats with inhibited mucosal acyl CoA: cholesterol acyltransferase and normal pancreatic function. J. Lipid Res. 1984, 25, 148-159.
    • (1984) J. Lipid Res. , vol.25 , pp. 148-159
    • Clark, S.B.1    Tercyak, A.M.2
  • 55
    • 0020581405 scopus 로고
    • Beta-sitosterol: esterification by intestinal acylcoenzyme A: cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification
    • Field, F. J., Mathur, S. N., Beta-sitosterol: esterification by intestinal acylcoenzyme A: cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification. J. Lipid Res. 1983, 24, 409-417.
    • (1983) J. Lipid Res. , vol.24 , pp. 409-417
    • Field, F.J.1    Mathur, S.N.2
  • 56
    • 0030993910 scopus 로고    scopus 로고
    • Effect of micellar beta-sitosterol on cholesterol metabolism in CaCo-2 cells
    • Field, F. J., Born, E., Mathur, S. N., Effect of micellar beta-sitosterol on cholesterol metabolism in CaCo-2 cells. J. Lipid Res. 1997, 38, 348-360.
    • (1997) J. Lipid Res. , vol.38 , pp. 348-360
    • Field, F.J.1    Born, E.2    Mathur, S.N.3
  • 57
    • 0028800470 scopus 로고
    • Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies
    • Chang, C. C., Chen, J., Thomas, M. A., Cheng, D. et al., Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies. J. Biol. Chem. 1995, 270, 29532-29540.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29532-29540
    • Chang, C.C.1    Chen, J.2    Thomas, M.A.3    Cheng, D.4
  • 58
    • 80053002735 scopus 로고    scopus 로고
    • Effect of phytosterols and their oxidation products on lipoprotein profiles and vascular function in hamster fed a high cholesterol diet
    • Liang, Y. T., Wong, W. T., Guan, L., Tian, X. Y. et al., Effect of phytosterols and their oxidation products on lipoprotein profiles and vascular function in hamster fed a high cholesterol diet. Atherosclerosis 2011, 219, 124-133.
    • (2011) Atherosclerosis , vol.219 , pp. 124-133
    • Liang, Y.T.1    Wong, W.T.2    Guan, L.3    Tian, X.Y.4
  • 59
    • 77952374152 scopus 로고    scopus 로고
    • Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice
    • Rideout, T. C., Harding, S. V., Jones, P. J., Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice. Mol. Nutr. Food Res. 2010, 54, S7-S13.
    • (2010) Mol. Nutr. Food Res. , vol.54
    • Rideout, T.C.1    Harding, S.V.2    Jones, P.J.3
  • 60
    • 4043124013 scopus 로고    scopus 로고
    • Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis
    • Davis, H. R., Jr., Zhu, L. J., Hoos, L. M., Tetzloff, G. et al., Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. J. Biol. Chem. 2004, 279, 33586-33592.
    • (2004) J. Biol. Chem. , vol.279 , pp. 33586-33592
    • Davis Jr, H.R.1    Zhu, L.J.2    Hoos, L.M.3    Tetzloff, G.4
  • 61
    • 34547915561 scopus 로고    scopus 로고
    • Differential intestinal mucosal protein expression in hypercholesterolemic mice fed a phytosterol-enriched diet
    • Calpe-Berdiel, L., Escola-Gil, J. C., Julve, J., Zapico-Muniz, E. et al., Differential intestinal mucosal protein expression in hypercholesterolemic mice fed a phytosterol-enriched diet. Proteomics 2007, 7, 2659-2666.
    • (2007) Proteomics , vol.7 , pp. 2659-2666
    • Calpe-Berdiel, L.1    Escola-Gil, J.C.2    Julve, J.3    Zapico-Muniz, E.4
  • 62
    • 1542618335 scopus 로고    scopus 로고
    • Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport
    • Smart, E. J., De Rose, R. A., Farber, S. A., Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport. Proc. Natl. Acad. Sci. USA 2004, 101, 3450-3455.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3450-3455
    • Smart, E.J.1    De Rose, R.A.2    Farber, S.A.3
  • 63
    • 23044498557 scopus 로고    scopus 로고
    • Caveolin-1 is not required for murine intestinal cholesterol transport
    • Valasek, M. A., Weng, J., Shaul, P. W., Anderson, R. G. et al., Caveolin-1 is not required for murine intestinal cholesterol transport. J. Biol. Chem. 2005, 280, 28103-28109.
    • (2005) J. Biol. Chem. , vol.280 , pp. 28103-28109
    • Valasek, M.A.1    Weng, J.2    Shaul, P.W.3    Anderson, R.G.4
  • 64
    • 33746660272 scopus 로고    scopus 로고
    • Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter
    • Plosch, T., Kruit, J. K., Bloks, V. W., Huijkman, N. C. et al., Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter. J. Nutr. 2006, 136, 2135-2140.
    • (2006) J. Nutr. , vol.136 , pp. 2135-2140
    • Plosch, T.1    Kruit, J.K.2    Bloks, V.W.3    Huijkman, N.C.4
  • 65
    • 0034669171 scopus 로고    scopus 로고
    • Role of LXRs in control of lipogenesis
    • Schultz, J. R., Tu, H., Luk, A., Repa, J. J. et al., Role of LXRs in control of lipogenesis. Genes. Dev. 2000, 14, 2831-2838.
    • (2000) Genes. Dev. , vol.14 , pp. 2831-2838
    • Schultz, J.R.1    Tu, H.2    Luk, A.3    Repa, J.J.4
  • 66
    • 0037072732 scopus 로고    scopus 로고
    • Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
    • Grefhorst, A., Elzinga, B. M., Voshol, P. J., Plosch, T. et al., Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles. J. Biol. Chem. 2002, 277, 34182-34190.
    • (2002) J. Biol. Chem. , vol.277 , pp. 34182-34190
    • Grefhorst, A.1    Elzinga, B.M.2    Voshol, P.J.3    Plosch, T.4
  • 67
    • 78651346813 scopus 로고    scopus 로고
    • Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis
    • Lo Sasso, G., Murzilli, S., Salvatore, L., D'Errico, I. et al., Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis. Cell. Metab. 2010, 12, 187-193.
    • (2010) Cell. Metab. , vol.12 , pp. 187-193
    • Lo Sasso, G.1    Murzilli, S.2    Salvatore, L.3    D'Errico, I.4
  • 68
    • 33846421597 scopus 로고    scopus 로고
    • Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells
    • Yamanashi, Y., Takada, T., Suzuki, H., Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells. J. Pharmacol. Exp. Ther. 2007, 320, 559-564.
    • (2007) J. Pharmacol. Exp. Ther. , vol.320 , pp. 559-564
    • Yamanashi, Y.1    Takada, T.2    Suzuki, H.3
  • 69
    • 79960143049 scopus 로고    scopus 로고
    • The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake
    • Zhang, J. H., Ge, L., Qi, W., Zhang, L. et al., The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. J. Biol. Chem. 2011, 286, 25088-25097.
    • (2011) J. Biol. Chem. , vol.286 , pp. 25088-25097
    • Zhang, J.H.1    Ge, L.2    Qi, W.3    Zhang, L.4
  • 70
    • 30844437481 scopus 로고    scopus 로고
    • Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels
    • Jakulj, L., Trip, M. D., Sudhop, T., von Bergmann, K. et al., Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels. J. Lipid Res. 2005, 46, 2692-2698.
    • (2005) J. Lipid Res. , vol.46 , pp. 2692-2698
    • Jakulj, L.1    Trip, M.D.2    Sudhop, T.3    von Bergmann, K.4
  • 71
    • 80051547747 scopus 로고    scopus 로고
    • Combined effects of ezetimibe and phytosterols on cholesterol metabolism: a randomized, controlled feeding study in humans
    • Lin, X., Racette, S. B., Lefevre, M., Ma, L. et al., Combined effects of ezetimibe and phytosterols on cholesterol metabolism: a randomized, controlled feeding study in humans. Circulation 2011, 124, 596-601.
    • (2011) Circulation , vol.124 , pp. 596-601
    • Lin, X.1    Racette, S.B.2    Lefevre, M.3    Ma, L.4
  • 72
    • 30544438067 scopus 로고    scopus 로고
    • Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine
    • Duval, C., Touche, V., Tailleux, A., Fruchart, J. C. et al., Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine. Biochem. Biophys. Res. Commun. 2006, 340, 1259-1263.
    • (2006) Biochem. Biophys. Res. Commun. , vol.340 , pp. 1259-1263
    • Duval, C.1    Touche, V.2    Tailleux, A.3    Fruchart, J.C.4
  • 73
    • 60949112151 scopus 로고    scopus 로고
    • New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
    • Calpe-Berdiel, L., Escola-Gil, J. C., Blanco-Vaca, F., New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism. Atherosclerosis 2009, 203, 18-31.
    • (2009) Atherosclerosis , vol.203 , pp. 18-31
    • Calpe-Berdiel, L.1    Escola-Gil, J.C.2    Blanco-Vaca, F.3
  • 74
    • 65249180182 scopus 로고    scopus 로고
    • Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile
    • Dang, H., Liu, Y., Pang, W., Li, C. et al., Suppression of 2, 3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. J. Biol. Chem. 2009, 284, 6218-6226.
    • (2009) J. Biol. Chem. , vol.284 , pp. 6218-6226
    • Dang, H.1    Liu, Y.2    Pang, W.3    Li, C.4
  • 75
    • 27444436469 scopus 로고    scopus 로고
    • Plant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation
    • Plat, J., Nichols, J. A., Mensink, R. P., Plant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation. J. Lipid Res. 2005, 46, 2468-2476.
    • (2005) J. Lipid Res. , vol.46 , pp. 2468-2476
    • Plat, J.1    Nichols, J.A.2    Mensink, R.P.3
  • 76
    • 66749118878 scopus 로고    scopus 로고
    • A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients
    • Plat, J., Brufau, G., Dallinga-Thie, G. M., Dasselaar, M. et al., A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients. J. Nutr. 2009, 139, 1143-1149.
    • (2009) J. Nutr. , vol.139 , pp. 1143-1149
    • Plat, J.1    Brufau, G.2    Dallinga-Thie, G.M.3    Dasselaar, M.4
  • 77
    • 71149093699 scopus 로고    scopus 로고
    • Plant stanol esters lower serum triacylglycerol concentrations via a reduced hepatic VLDL-1 production
    • Plat, J., Mensink, R. P., Plant stanol esters lower serum triacylglycerol concentrations via a reduced hepatic VLDL-1 production. Lipids 2009, 44, 1149-1153.
    • (2009) Lipids , vol.44 , pp. 1149-1153
    • Plat, J.1    Mensink, R.P.2
  • 78
    • 71149119184 scopus 로고    scopus 로고
    • Plant stanol supplementation decreases serum triacylglycerols in subjects with overt hypertriglyceridemia
    • Theuwissen, E., Plat, J., van der Kallen, C. J., van Greevenbroek, M. M. et al., Plant stanol supplementation decreases serum triacylglycerols in subjects with overt hypertriglyceridemia. Lipids 2009, 44, 1131-1140.
    • (2009) Lipids , vol.44 , pp. 1131-1140
    • Theuwissen, E.1    Plat, J.2    van der Kallen, C.J.3    van Greevenbroek, M.M.4
  • 79
    • 20444398521 scopus 로고    scopus 로고
    • Changes in intestinal and liver global gene expression in response to a phytosterol-enriched diet
    • Calpe-Berdiel, L., Escola-Gil, J. C., Ribas, V., Navarro-Sastre, A. et al., Changes in intestinal and liver global gene expression in response to a phytosterol-enriched diet. Atherosclerosis 2005, 181, 75-85.
    • (2005) Atherosclerosis , vol.181 , pp. 75-85
    • Calpe-Berdiel, L.1    Escola-Gil, J.C.2    Ribas, V.3    Navarro-Sastre, A.4
  • 81
    • 11144257009 scopus 로고    scopus 로고
    • Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice
    • Kruit, J. K., Plosch, T., Havinga, R., Boverhof, R. et al., Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. Gastroenterology 2005, 128, 147-156.
    • (2005) Gastroenterology , vol.128 , pp. 147-156
    • Kruit, J.K.1    Plosch, T.2    Havinga, R.3    Boverhof, R.4
  • 82
    • 77956642596 scopus 로고    scopus 로고
    • Biliary sterol secretion is not required for macrophage reverse cholesterol transport
    • Temel, R. E., Sawyer, J. K., Yu, L., Lord, C. et al., Biliary sterol secretion is not required for macrophage reverse cholesterol transport. Cell. Metab 2010, 12, 96-102.
    • (2010) Cell. Metab , vol.12 , pp. 96-102
    • Temel, R.E.1    Sawyer, J.K.2    Yu, L.3    Lord, C.4
  • 83
    • 34548492458 scopus 로고    scopus 로고
    • Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice
    • van der Velde, A. E., Vrins, C. L., van den Oever, K., Kunne, C. et al., Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice. Gastroenterology 2007, 133, 967-975.
    • (2007) Gastroenterology , vol.133 , pp. 967-975
    • van der Velde, A.E.1    Vrins, C.L.2    van den Oever, K.3    Kunne, C.4
  • 84
    • 44849100003 scopus 로고    scopus 로고
    • Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss
    • Brown, J. M., Bell, T. A., 3rd, Alger, H. M., Sawyer, J. K. et al., Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss. J. Biol. Chem. 2008, 283, 10522-10534.
    • (2008) J. Biol. Chem. , vol.283 , pp. 10522-10534
    • Brown, J.M.1    Bell 3rd, T.A.2    Alger, H.M.3    Sawyer, J.K.4
  • 85
    • 79959747253 scopus 로고    scopus 로고
    • A reappraisal of the mechanism by which plant sterols promote neutral sterol loss in mice
    • Brufau, G., Kuipers, F., Lin, Y., Trautwein, E. A. et al., A reappraisal of the mechanism by which plant sterols promote neutral sterol loss in mice. PLoS One 2011, 6, e21576.
    • (2011) PLoS One , vol.6
    • Brufau, G.1    Kuipers, F.2    Lin, Y.3    Trautwein, E.A.4
  • 86
    • 67749110331 scopus 로고    scopus 로고
    • Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol
    • van der Veen, J. N., van Dijk, T. H., Vrins, C. L., van Meer, H. et al., Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol. J. Biol. Chem. 2009, 284, 19211-19219.
    • (2009) J. Biol. Chem. , vol.284 , pp. 19211-19219
    • van der Veen, J.N.1    van Dijk, T.H.2    Vrins, C.L.3    van Meer, H.4
  • 87
    • 0037059047 scopus 로고    scopus 로고
    • Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross
    • Sehayek, E., Duncan, E. M., Lutjohann, D., Von Bergmann, K. et al., Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross. Proc. Natl. Acad. Sci. USA 2002, 99, 16215-16219.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16215-16219
    • Sehayek, E.1    Duncan, E.M.2    Lutjohann, D.3    Von Bergmann, K.4
  • 88
    • 0036194113 scopus 로고    scopus 로고
    • Improvement of vascular dysfunction and blood lipids of insulin-resistant rats by a marine oil-based phytosterol compound
    • Russell, J. C., Ewart, H. S., Kelly, S. E., Kralovec, J. et al., Improvement of vascular dysfunction and blood lipids of insulin-resistant rats by a marine oil-based phytosterol compound. Lipids 2002, 37, 147-152.
    • (2002) Lipids , vol.37 , pp. 147-152
    • Russell, J.C.1    Ewart, H.S.2    Kelly, S.E.3    Kralovec, J.4
  • 89
    • 0036173210 scopus 로고    scopus 로고
    • Supplementation of plant sterols and minerals benefits obese Zucker rats fed an atherogenic diet
    • Vaskonen, T., Mervaala, E., Krogerus, L., Karppanen, H., Supplementation of plant sterols and minerals benefits obese Zucker rats fed an atherogenic diet. J. Nutr. 2002, 132, 231-237.
    • (2002) J. Nutr. , vol.132 , pp. 231-237
    • Vaskonen, T.1    Mervaala, E.2    Krogerus, L.3    Karppanen, H.4
  • 90
    • 0037116573 scopus 로고    scopus 로고
    • Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    • Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D. et al., Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J. Am. Coll. Cardiol. 2002, 39, 257-265.
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 257-265
    • Corretti, M.C.1    Anderson, T.J.2    Benjamin, E.J.3    Celermajer, D.4
  • 91
    • 0032076318 scopus 로고    scopus 로고
    • Dietary sitostanol reduces plaque formation but not lecithin cholesterol acyl transferase activity in rabbits
    • Ntanios, F. Y., Jones, P. J., Frohlich, J. J., Dietary sitostanol reduces plaque formation but not lecithin cholesterol acyl transferase activity in rabbits. Atherosclerosis 1998, 138, 101-110.
    • (1998) Atherosclerosis , vol.138 , pp. 101-110
    • Ntanios, F.Y.1    Jones, P.J.2    Frohlich, J.J.3
  • 92
    • 33845563662 scopus 로고    scopus 로고
    • Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols
    • Plat, J., Beugels, I., Gijbels, M. J., de Winther, M. P. et al., Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols. J. Lipid Res. 2006, 47, 2762-2771.
    • (2006) J. Lipid Res. , vol.47 , pp. 2762-2771
    • Plat, J.1    Beugels, I.2    Gijbels, M.J.3    de Winther, M.P.4
  • 93
    • 0034900620 scopus 로고    scopus 로고
    • Dietary vegetable oil and wood derived plant stanol esters reduce atherosclerotic lesion size and severity in apoE*3-Leiden transgenic mice
    • Volger, O. L., Mensink, R. P., Plat, J., Hornstra, G. et al., Dietary vegetable oil and wood derived plant stanol esters reduce atherosclerotic lesion size and severity in apoE*3-Leiden transgenic mice. Atherosclerosis 2001, 157, 375-381.
    • (2001) Atherosclerosis , vol.157 , pp. 375-381
    • Volger, O.L.1    Mensink, R.P.2    Plat, J.3    Hornstra, G.4
  • 94
  • 95
    • 0028134614 scopus 로고
    • Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction
    • Celermajer, D. S., Sorensen, K. E., Bull, C., Robinson, J. et al., Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J. Am. Coll. Cardiol. 1994, 24, 1468-1474.
    • (1994) J. Am. Coll. Cardiol. , vol.24 , pp. 1468-1474
    • Celermajer, D.S.1    Sorensen, K.E.2    Bull, C.3    Robinson, J.4
  • 96
    • 0041418271 scopus 로고    scopus 로고
    • Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia
    • de Jongh, S., Vissers, M. N., Rol, P., Bakker, H. D. et al., Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia. J. Inherit. Metab. Dis. 2003, 26, 343-351.
    • (2003) J. Inherit. Metab. Dis , vol.26 , pp. 343-351
    • de Jongh, S.1    Vissers, M.N.2    Rol, P.3    Bakker, H.D.4
  • 97
    • 33748086019 scopus 로고    scopus 로고
    • Endothelial function in hypercholesterolemic subjects: effects of plant stanol and sterol esters
    • Hallikainen, M., Lyyra-Laitinen, T., Laitinen, T., Agren, J. J. et al., Endothelial function in hypercholesterolemic subjects: effects of plant stanol and sterol esters. Atherosclerosis 2006, 188, 425-432.
    • (2006) Atherosclerosis , vol.188 , pp. 425-432
    • Hallikainen, M.1    Lyyra-Laitinen, T.2    Laitinen, T.3    Agren, J.J.4
  • 98
    • 33646529852 scopus 로고    scopus 로고
    • Plant stanols do not restore endothelial function in pre-pubertal children with familial hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels
    • Jakulj, L., Vissers, M. N., Rodenburg, J., Wiegman, A. et al., Plant stanols do not restore endothelial function in pre-pubertal children with familial hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels. J. Pediatr. 2006, 148, 495-500.
    • (2006) J. Pediatr. , vol.148 , pp. 495-500
    • Jakulj, L.1    Vissers, M.N.2    Rodenburg, J.3    Wiegman, A.4
  • 99
    • 41949092417 scopus 로고    scopus 로고
    • Plant stanol ester consumption and arterial elasticity and endothelial function
    • Raitakari, O. T., Salo, P., Gylling, H., Miettinen, T. A., Plant stanol ester consumption and arterial elasticity and endothelial function. Br. J. Nutr. 2008, 100, 603-608.
    • (2008) Br. J. Nutr. , vol.100 , pp. 603-608
    • Raitakari, O.T.1    Salo, P.2    Gylling, H.3    Miettinen, T.A.4
  • 100
    • 39049106458 scopus 로고    scopus 로고
    • Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment
    • De Jong, A., Plat, J., Bast, A., Godschalk, R. W. et al., Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment. Eur. J. Clin. Nutr. 2008, 62, 263-273.
    • (2008) Eur. J. Clin. Nutr. , vol.62 , pp. 263-273
    • De Jong, A.1    Plat, J.2    Bast, A.3    Godschalk, R.W.4


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