Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment

European Journal of Clinical Nutrition

Volumn 62, Issue 2, 2008, Pages 263-273

  De Jong, A ^a   Plat, J ^a   Bast, A ^a   Godschalk, R W L ^a   Basu, S ^b   Mensink, R P ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPESTANOL; CAMPESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; PHYTOSTEROL; PLACEBO; RAPESEED OIL; SITOSTANOL; STANOL ESTER; STIGMASTEROL;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; INFLAMMATION; LIPID METABOLISM; MALE; NONHUMAN; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM;

ADOLESCENT; ADULT; AGED; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; C-REACTIVE PROTEIN; CHOLESTEROL, LDL; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; FOOD, FORTIFIED; HUMANS; LIPID METABOLISM; MALE; MARGARINE; MIDDLE AGED; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHYTOSTEROLS; SITOSTEROLS;

EID: 39049106458     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602733     Document Type: Article

References (37)

1. Aebi H (1984). Catalase in vitro. Methods Enzymol 105, 121-126.
2. Anderson TJ, Uehata A, Gerhard MD, Meredith IT, Knab S, Delagrange D et al. (1995). Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 26, 1235-1241.
3. Basu S (1998). Radioimmunoassay of 15-keto-13,14-dihydro-prostaglandin F2alpha: An index for inflammation via cyclooxygenase catalysed lipid piroxidation. Prostaglandins Leukot Essent Fatty Acids 58, 347-352.
4. Blair SN, Capuzzi DM, Gottlieb SO, Nguyen T, Morgan JM, Cater NB (2000). Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread to statin therapy. Am J Cardiol 86, 46-52.
5. Bouma M, Laan M, Deneter M, Buurman W (1997). Analysis of soluble adhesion molecules In: Johnstone A, Turner M (eds). Immunochemistry: A Practical Appproach. Oxford University Press: Oxford.
6. Briede JJ, Godschalk RW, Emans MT, De Kok TM, Van Agen E, Vah Maanen J et al. (2004): In vitro and in vivo studies on oxygen free radical and DNA adduct formation in rat lung and liver during benzo[a]pyrene metabolism. Free Radic Res 38, 995-1002.
7. Cines DB, Pollak ES, Bucle CA, Loscalzo J, Zimmermann GA, McEver R, et al. (1998). Endothelial cells in physlology and in the pathophysiology of vascular disorders. Blood, 91, 3527-3561.
8. Comparato C, Altana C, Bellosta S, Baetta R, Paoletti R, Corsini A (2001): Clinically relevant pleiotropic effectD of statins: drug properties or effects of profound cholesterol reduction? Nutr Metab Cardiovasc Dis 11, 328-343.
9. de Jongh S, Vissers MN, Rol P, Bakker HD, Kastelein JJ, Stroes ES (2003). Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia. J Inherit Metab Dis 26, 343-351.
10. Expert panel on detection (2001). Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). J Am Med Assoc 285, 2486-2497.
11. Flohe, L, Gunzler WA (1984). Assays of glutathione peroxidase. Methods Enzymol 105, 114-121.
12. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499-502.
13. Granger DN, Vowinkel T, Petnehazy T (2004). Modulation of the inflammatory response in cardiovascular disease. Hypertension 43, 924-931.
14. Guillen-Sans R, Guzman-Chozas M. (1998). The thiobarbituric acid (TBA) reaction in foods: A review. Crit Rev Food Sci Nutr 38, 315-330.
15. Hallikainen MA, Sarkkinen ES, Gylling H, Erkkila AT, Uusitupa MIJ. (2000). Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet. Eur J Clin Nutr 54, 715-725.
16. Holvoet P, Vanhaecke J, Janssens S, Van de Werf F, Collen D (1998). Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease. Circulation 98, 1487-1494.
17. Jones P, Kafonek S, Laurora I, Hunninghake D (1998). Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia. (the CURVES study). Am J Cardiol 81, 582-587.
18. Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R (2003). Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 78, 965-978.
19. Ketomaki A, Gylling H, Miettinen TA (2004). Effects of plant stanol and sterol esters on serum phytosterols in a family with familial hypercholesterolemia including a homozygous subject. J Lab Clin Med 143, 255-262.
20. Ketomaki A, Gylling H, Miettinen TA (3005). Non-cholesterol sterols in serum, lipoproteins, and red cells in statin-treated FH subjects off and on plant stanol and sterol ester spreads. Clin Chim Acta 353 75-86.
21. Kirkova M, Atanassova M, Russanov E (1999). Effects of cimetidine and its metal complexes on nitroblue tetrazolium and ferricytochrome c reduction by superoxide radicals. Gen Pharmacol 33, 271-276. Landmesser U, Hornigi B, Drexler H (2000). Endothelial dysfunction in hypercholesterolemia: Mechanisms, pathophysiological importance, and therapeutic interventions. Semin Thromb Hemost 26, 529-537.
22. Leeuwenberg JP, Smeets EF, Neefjes JJ, Shaffer MA, Cinek T, Jeunhomme TM et al. (1992). E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro. Immunology 77, 543-549.
23. Lepage G,Munoz G, Champagne J, Roy CC (1991). Preparative steps necessary for the accurate measurement of malondialdehyde by high-performance liquid chromatography. Anal Biochem 197, 277-283.
24. Liao JK, Laufs U (2005). Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 45, 89-118.
25. Normen L, Dutta P, Lia A, Andersson H (2000). Soy sterol esters and beta-Sitostanol ester as inhibitors of cholesterol absorption in human small bowel. Am J Clin Nutr 71, 908-913.
26. Paglia DE, Valentine WN (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70, 158-169.
27. Peter K, Nawroth P, Conradt C, Nordt T, Weiss T, Boehme M et al. (1997). Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin. Arterioscler Thromb Vasc Biol 17, 505-512.
28. Plat J, Mensink RP (2000). Vegetable oil based versus wood based stanol ester mixtures: Effects on serum lipids and hemostatic factors in non-hypercholesterolemic subjects. Atherosclerosis 148, 101-112.
29. Plat J, Mensink RP (2001). Effects of diets enriched with two different plant sterol ester mixtures on plasma ubiquinol-10 and fat-soluble antioxidant concentrations. Metabolism 50, 520-529.
30. Plat J, Mensink RP (2002a). Effects of plant stanol esters on LDL receptor protein expression and ap LDL receptor and HMG-CoA reductase mRNA expression in mononuclear blood cells of healthy men and women. FASEB 16, 258-260.
31. Plat J, Mensink RP (2002b). Increased intestinal ABCA1 expression contributes fo the decrease in cholesterol absorption after plant stanol consumption. FASEB J 16, 1248-1293.
32. Ridker PM, Hennekens CY, Buring JE, Rifai N (2000). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. New Engl J Med 342, 836-843.
33. Ross R (1999). Atherosclerosis - an inflammatory disease. New Engl J Med 340, 115-126.
34. Vasankari T, Ahotupa M, Viikari J, Nuotio I, Strandberg T, Vanhanen H et al. (2004). Effect of 12-month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations. Ann Med 36, 618-622.
35. West SG (2001). Effect of diet on vascular reactivity: An emerging marker for vascular risk. Curr Atheroscler Rep 3, 446-455.
36. Weststrate JA, Meijet GW (1998). Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 52, 334-343.
37. Zhao G, Etherton TD, Martin KR, West SG, Gillies PJ, Kris-Etherton PM (2004). Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J Nutr 134, 2991-2997.