Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-α-mediated improvement of hepatic lipid profile

Journal of Biological Chemistry

Volumn 284, Issue 10, 2009, Pages 6218-6226

  Dang, Huaixin ^a   Liu, Yan ^a   Pang, Wei ^a   Li, Chenghong ^a   Wang, Nanping ^b   Shyy, John Y J ^c   Zhu, Yi ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL LEVELS; CHOLESTEROL METABOLISM; DOWN-REGULATION; FATTY ACID SYNTHESIS; HEPATOCYTES; HIGH-FAT DIET; LIPID METABOLISMS; LIPID PROFILE; LIVER X RECEPTORS; OXIDOSQUALENE CYCLASE; OXYSTEROLS; STEROL REGULATORY ELEMENT-BINDING PROTEINS; UNDERLYING MECHANISM;

ACIDS; BIOCHEMISTRY; CHOLESTEROL; ECOLOGY; FATTY ACIDS; GENES; LAWS AND LEGISLATION; LIGANDS; LIVER; METABOLISM;

NUTRITION;

22 HYDROXYCHOLESTEROL; CHOLESTEROL; FATTY ACID; LANOSTEROL SYNTHASE; LIVER X RECEPTOR ALPHA; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; CELL RECEPTOR; DNA BINDING PROTEIN; INSIG2 PROTEIN, HUMAN; INSIG2 PROTEIN, MOUSE; LIVER X RECEPTOR; MEMBRANE PROTEIN; MUTASE; SIGNAL PEPTIDE; SREBF1 PROTEIN, HUMAN; SREBF1 PROTEIN, MOUSE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENZYME REPRESSION; FATTY ACID SYNTHESIS; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; LIPID DIET; LIPID METABOLISM; LIVER CELL CULTURE; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; UPREGULATION; ADENOVIRUS; ANIMAL; BIOSYNTHESIS; DIET; DRUG EFFECT; ENZYMOLOGY; FAT INTAKE; GENETICS; LIVER; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ADENOVIRIDAE; MUS;

ADENOVIRIDAE; ANIMALS; CELL LINE, TUMOR; DIET; DIETARY FATS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; INTRAMOLECULAR TRANSFERASES; LIPID METABOLISM; LIVER; MALE; MEMBRANE PROTEINS; MICE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 65249180182     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803702200     Document Type: Article

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