Dietary vegetable oil and wood derived plant stanol esters reduce atherosclerotic lesion size and severity in apoE*3-Leiden transgenic mice

Atherosclerosis

Volumn 157, Issue 2, 2001, Pages 375-381

  Volger, O L ^a   Mensink, R P ^b   Plat, J ^b   Hornstra, G ^b   Havekes, L M ^a   Princen, H M G ^a  

^a TNO   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

ApoE*3 Leiden transgenic mice; Atherosclerosis; Plant sterols; Sitostanol

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E 3 LEIDEN; CAMPESTANOL; CHOLESTEROL; INTERMEDIATE DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; SITOSTANOL; STANOL ESTER; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VEGETABLE OIL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL ADHESION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG MECHANISM; FEMALE; FOAM CELL; FOOD INTAKE; HYPERLIPIDEMIA; HYPOLIPEMIA; LIPID COMPOSITION; MONOCYTE; MOUSE; NONHUMAN; PLANT; PRIORITY JOURNAL; TRANSGENIC MOUSE; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; VEGETARIAN DIET; WOOD;

ANIMALS; APOLIPOPROTEIN E3; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CHOLESTEROL; DIETARY FATS, UNSATURATED; FEMALE; MICE; MICE, TRANSGENIC; MUTATION; PLANT OILS; SEVERITY OF ILLNESS INDEX; SITOSTEROLS; TRIGLYCERIDES; WOOD;

EID: 0034900620     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(00)00750-4     Document Type: Article

References (28)

1. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population
2. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men
3. Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects
4. Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population
5. Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet
6. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects
7. Effects of variable dietary sitostanol concentrations on plasma lipid profile and phytosterol metabolism in hamsters
8. Enhanced efficacy of sitostanol-containing versus sitostanol- free phytosterol mixtures in altering lipoprotein cholesterol levels and synthesis in rats
9. Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans
10. Dietary sitostanol reciprocally influences cholesterol absorption and biosynthesis in hamsters and rabbits
11. Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol
12. Dietary sitostanol reduces plaque formation but not lecithin cholesterol acyl transferase activity in rabbits
13. 'Tall oil'-derived phytosterols reduce atherosclerosis in ApoE-deficient mice
14. Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia
15. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice
16. Effects of dietary fish oil on serum lipids and VLDL kinetics in hyperlipidemic apolipoprotein E*3-Leiden transgenic mice
17. Lipoproteins in familial dysbetalipoproteinemia. Variation of serum cholesterol level associated with VLDL concentration
18. Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1
19. Cafestol, the cholesterol-raising factor in boiled coffee, increases serum cholesterol levels in apolipoprotein E*3-Leiden transgenic mice by suppression of bile acid synthesis
20. Quantitative assessment of aortic atherosclerosis in APOE*3 Leiden transgenic mice and its relationship to serum cholesterol exposure
21. Characterization of atherosclerotic lesions in apo E3-Leiden transgenic mice
22. Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice: An immunohistochemical study
23. Effect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia
24. Quantitative assessment of atherosclerotic lesions in mice
25. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association
26. Vegetable oil based versus wood based stanol ester mixtures: Effects on serum lipids and hemostatic factors in non-hypercholesterolemic subjects
27. The cholesterol-lowering action of plant stanol esters
28. Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment