Novel protective mechanisms for S-adenosyl-l-methionine against acetaminophen hepatotoxicity: Improvement of key antioxidant enzymatic function

Toxicology Letters

Volumn 212, Issue 3, 2012, Pages 320-328

  Michael Brown, James ^a   Ball, John G ^a   Wright, Michael Scott ^a   Van Meter, Stephanie ^a   Valentovic, Monica A ^a  

^a MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; Antioxidant; Hepatotoxicity; Nitrotyrosine; Oxidative stress; S adenosyl l methionine

Indexed keywords

3 NITROTYROSINE; ACETYLCYSTEINE; ANTIOXIDANT; CARBONYL DERIVATIVE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C; CYTOCHROME P450 2E1; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MANGANESE SUPEROXIDE DISMUTASE; PARACETAMOL; POLYAMINE; S ADENOSYLMETHIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; ENZYME ACTIVITY; LIVER PROTECTION; LIVER TOXICITY; MALE; MITOCHONDRION SWELLING; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; WESTERN BLOTTING;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; CYTOCHROME P-450 CYP2E1; DRUG ANTAGONISM; DRUG-INDUCED LIVER INJURY; LIVER; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; OXIDATIVE STRESS; OXIDOREDUCTASES; PROTEIN CARBONYLATION; S-ADENOSYLMETHIONINE;

MUS;

EID: 84863445073     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.05.018     Document Type: Article

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