Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat

Toxicology

Volumn 264, Issue 1-2, 2009, Pages 89-95

  Yoshikawa, Yukitaka ^a   Morita, Mayu ^a   Hosomi, Hiroko ^a   Tsuneyama, Koichi ^b   Fukami, Tatsuki ^a   Nakajima, Miki ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Acetaminophen; Hepatotoxicity; RNA interference; Superoxide dismutase 2

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBONYL DERIVATIVE; HEME OXYGENASE 1; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; PARACETAMOL; SHORT HAIRPIN RNA;

ADENOVIRUS INFECTION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; ENZYME ACTIVITY; LIPID PEROXIDATION; LIVER TOXICITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SINGLE DRUG DOSE; TOXICOKINETICS;

ACETAMINOPHEN; ADENOVIRIDAE; ANALGESICS, NON-NARCOTIC; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOTRANSFORMATION; BLOTTING, WESTERN; GENETIC VECTORS; HEME OXYGENASE-1; HEPATITIS, TOXIC; LIPID PEROXIDATION; LIVER FUNCTION TESTS; MALE; MITOCHONDRIA, LIVER; PROTEIN CARBONYLATION; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SUPEROXIDE DISMUTASE;

ADENOVIRIDAE; RATTUS;

EID: 69449098657     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.07.017     Document Type: Article

References (23)

1. Akai S., Hosomi H., Minami K., Tsuneyama K., Katoh M., Nakajima M., and Yokoi T. Knock down of γ-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity. J. Biol. Chem. 282 (2007) 23996-24003
2. Boelsterli U.A., and Lim P.L. Mitochondrial abnormalities-a link to idiosyncratic drug hepatotoxicity?. Toxicol. Appl. Pharmacol. 220 (2006) 92-107
3. Das K.C., Guo X.L., and White C.W. Protein kinase C delta-dependent induction of manganese superoxide dismutase gene expression by microtubule-active anticancer drugs. J. Biol. Chem. 273 (1998) 34639-34645
4. Ganey P.E., Luyendyk J.P., Newport S.W., Eagle T.M., Maddox J.F., Mackman N., and Roth R.A. Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology 46 (2007) 1177-1186
5. Gunawan B.K., Liu Z.X., Han D., Hanawa N., Gaarde W.A., and Kaplowitz N. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 131 (2006) 165-178
6. Hu Y., Ingelman-Sundberg M., and Lindros K.O. Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation. Biochem. Pharmacol. 50 (1995) 155-161
7. Jaeschke H., and Wendel A. Diurnal fluctuation and pharmacological alteration of mouse organ glutathione content. Biochem. Pharmacol. 34 (1985) 1029-1033
8. Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nat. Rev. Drug Discov. 4 (2005) 489-499
9. Kikkawa R., Fujikawa M., Yamamoto T., Hamada Y., Yamada H., and Horii I. In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system. J. Toxicol. Sci. 31 (2006) 23-34
10. Kim Y.W., Ki S.H., Lee J.R., Lee S.J., Kim C.W., Kim S.C., and Kim S.G. Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine. Chem. Biol. Interact. 161 (2006) 125-138
11. Lebovitz R.M., Zhang H., Vogel H., Cartwright Jr. J., Dionne L., Lu N., Huang S., and Matzuk M.M. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 9782-9787
12. Lei X.G., Zhu J.H., McClung J.P., Aregullin M., and Roneker C.A. Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity. Biochem. J. 399 (2006) 455-461
13. McConnachie L.A., Mohar I., Hudson F.N., Ware C.B., Ladiges W.C., Fernandez C., Chatterton-Kirchmeier S., White C.C., Pierce R.H., and Kavanagh T.J. Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice. Toxicol. Sci. 99 (2007) 628-636
14. Meister G., and Tuschl T. Mechanisms of gene silencing by double-stranded RNA. Nature 431 (2004) 343-349
15. Merrick B.A., Bruno M.E., Madenspacher J.H., Wetmore B.A., Foley J., Pieper R., Zhao M., Makusky A.J., McGrath A.M., Zhou J.X., Taylor J., and Tomer K.B. Alterations in the rat serum proteome during liver injury from acetaminophen exposure. J. Pharmacol. Exp. Ther. 318 (2006) 792-802
16. Morishita K., Mizukawa Y., Kasahara T., Okuyama M., Takashima K., Toritsuka N., Miyagishima T., Nagao T., and Urushidani T. Gene expression profile in liver of differing ages of rats after single oral administration of acetaminophen. J. Toxicol. Sci. 31 (2006) 491-507
17. Pessayre D., Wandscheer J.C., Cobert B., Level R., Degott C., Batt A.M., Martin N., and Benhamou J.P. Additive effects of inducers and fasting on acetaminophen hepatotoxicity. Biochem. Pharmacol. 29 (1980) 2219-2223
18. Tabata T., Katoh M., Tokudome S., Hosakawa M., Chiba K., Nakajima M., and Yokoi T. Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5′-deoxy-5-fluorocytidine formation. Drug Metab. Dispos. 32 (2004) 762-767
19. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 27 (1969) 502-522
20. Van Remmen H., Salvador C., Yang H., Huang T.T., Epstein C.J., and Richardson A. Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse. Arch. Biochem. Biophys. 363 (1999) 91-97
21. Visner G.A., Dougall W.C., Wilson J.M., Burr I.A., and Nick H.S. Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response. J. Biol. Chem. 265 (1990) 2856-2864
22. Yoshikawa, Y., Hosomi, H., Fukami, T., Nakajima, M., Yokoi, T., 2009. Establishment of knockdown of superoxide dismutase 2 and expression of CYP3A4 cell system to evaluate drug-induced cytotoxicity. Toxicol. In Vitro, 1179-1187.
23. Zelko I.N., Mariani T.J., and Folz R.J. Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic. Biol. Med. 33 (2002) 337-349