메뉴 건너뛰기




Volumn , Issue , 2007, Pages 483-518

Memory Changes with Age. Neurobiological Correlates

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84863394295     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012372540-0/50016-9     Document Type: Chapter
Times cited : (6)

References (201)
  • 1
    • 0022619046 scopus 로고
    • The effects of hippocampal lesions upon spatial and non-spatial tests of working memory
    • Aggleton JP, Hunt PR, Rawlins JN The effects of hippocampal lesions upon spatial and non-spatial tests of working memory. Behav Brain Res 1986, 19:133-146.
    • (1986) Behav Brain Res , vol.19 , pp. 133-146
    • Aggleton, J.P.1    Hunt, P.R.2    Rawlins, J.N.3
  • 2
    • 0031590580 scopus 로고    scopus 로고
    • The aging brain, Normal and abnormal memory
    • Albert MS The aging brain, Normal and abnormal memory. Phil Trans R Soc Lond B Biol Sci 1997, 352:1703-1709.
    • (1997) Phil Trans R Soc Lond B Biol Sci , vol.352 , pp. 1703-1709
    • Albert, M.S.1
  • 3
    • 2142640414 scopus 로고    scopus 로고
    • Aging and path integration skill, Kinesthetic and vestibular contributions to wayfinding
    • Allen GL, Kirasic KC, Rashotte MA, Huan DB Aging and path integration skill, Kinesthetic and vestibular contributions to wayfinding. Percept Psychophys 2004, 66:110-119.
    • (2004) Percept Psychophys , vol.66 , pp. 110-119
    • Allen, G.L.1    Kirasic, K.C.2    Rashotte, M.A.3    Huan, D.B.4
  • 4
    • 0020674589 scopus 로고
    • The effect of advanced old age on the neurone content of the cerebral cortex. Observations with an automatic image analyzer point counting method
    • Anderson JM, Hubbard BM, Coghill GR, Slidders W The effect of advanced old age on the neurone content of the cerebral cortex. Observations with an automatic image analyzer point counting method. J Neurol Sci 1983, 58:235-246.
    • (1983) J Neurol Sci , vol.58 , pp. 235-246
    • Anderson, J.M.1    Hubbard, B.M.2    Coghill, G.R.3    Slidders, W.4
  • 5
    • 0025764520 scopus 로고
    • Longitudinal study on age-related changes of working and reference memory in the rat
    • Ando S, Ohashi Y Longitudinal study on age-related changes of working and reference memory in the rat. Neurosci Lett 1991, 128:11-20.
    • (1991) Neurosci Lett , vol.128 , pp. 11-20
    • Ando, S.1    Ohashi, Y.2
  • 6
    • 0033389152 scopus 로고    scopus 로고
    • Silent synapses in neural plasticity, Current evidence
    • Atwood HL, Wojtowicz JM Silent synapses in neural plasticity, Current evidence. Learn Mem 1999, 6:511-542.
    • (1999) Learn Mem , vol.6 , pp. 511-542
    • Atwood, H.L.1    Wojtowicz, J.M.2
  • 7
    • 0033609045 scopus 로고    scopus 로고
    • Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs
    • Bach ME, Barad M, Son H, Zhuo M, Lu YF, Shih R, Mansuy I, Hawkins RD, Kandel ER Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs. Proc Natl Acad Sa USA 1999, 96:5280-5285.
    • (1999) Proc Natl Acad Sa USA , vol.96 , pp. 5280-5285
    • Bach, M.E.1    Barad, M.2    Son, H.3    Zhuo, M.4    Lu, Y.F.5    Shih, R.6    Mansuy, I.7    Hawkins, R.D.8    Kandel, E.R.9
  • 8
    • 0017358355 scopus 로고
    • Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study
    • Ball MJ Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta Neurophathol (Berl) 1977, 37:111-118.
    • (1977) Acta Neurophathol (Berl) , vol.37 , pp. 111-118
    • Ball, M.J.1
  • 9
    • 0032426667 scopus 로고    scopus 로고
    • Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates establishment of long-lasting long-term potentiation and memory
    • Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates establishment of long-lasting long-term potentiation and memory. Proceed Natl Acad Sci USA 1998, 95:15020-15025.
    • (1998) Proceed Natl Acad Sci USA , vol.95 , pp. 15020-15025
    • Barad, M.1    Bourtchouladze, R.2    Winder, D.G.3    Golan, H.4    Kandel, E.5
  • 10
    • 0018344553 scopus 로고
    • Memory deficits associated with senescence, A neurophysiological and behav-ioral study in the rat
    • Barnes CA Memory deficits associated with senescence, A neurophysiological and behav-ioral study in the rat. J Comp Physiol Psychol 1979, 93:14-104.
    • (1979) J Comp Physiol Psychol , vol.93 , pp. 14-104
    • Barnes, C.A.1
  • 11
    • 0002456663 scopus 로고
    • Memory changes with age, Neurobiological correlates
    • Academic Press, San Diego, J.L. Martinez, K. Kesner (Eds.)
    • Barnes CA Memory changes with age, Neurobiological correlates. Learning and Memory, A Biological View 1991, 259-296. Academic Press, San Diego. J.L. Martinez, K. Kesner (Eds.).
    • (1991) Learning and Memory, A Biological View , pp. 259-296
    • Barnes, C.A.1
  • 12
    • 0028107456 scopus 로고
    • Normal aging, Regionally spécifie changes in hippocampal synaptic trans-mission
    • Barnes CA Normal aging, Regionally spécifie changes in hippocampal synaptic trans-mission. Trends Neurosci 1994, 17:13-18.
    • (1994) Trends Neurosci , vol.17 , pp. 13-18
    • Barnes, C.A.1
  • 13
    • 0038222582 scopus 로고    scopus 로고
    • Long-term potentiation and the aging brain
    • Barnes CA Long-term potentiation and the aging brain. Philos Trans R Soc Lond B Biol Sci 2003, 358:112-165.
    • (2003) Philos Trans R Soc Lond B Biol Sci , vol.358 , pp. 112-165
    • Barnes, C.A.1
  • 14
    • 0024420493 scopus 로고
    • Selective improvement of aged rat short-term spatial memory by 3,4-diaminopyridine
    • Barnes CA, Eppich C, Rao G Selective improvement of aged rat short-term spatial memory by 3,4-diaminopyridine. Neurobiol Aging 1989, 10:331-341.
    • (1989) Neurobiol Aging , vol.10 , pp. 331-341
    • Barnes, C.A.1    Eppich, C.2    Rao, G.3
  • 15
    • 0023359255 scopus 로고
    • Behavioral and neurophysiological exam-ples of functional sparing in senescent rat
    • Barnes CA, Green EJ, Baldwin J, Johnson WE Behavioral and neurophysiological exam-ples of functional sparing in senescent rat. Can J Psychol 1987, 47:131-140.
    • (1987) Can J Psychol , vol.47 , pp. 131-140
    • Barnes, C.A.1    Green, E.J.2    Baldwin, J.3    Johnson, W.E.4
  • 16
    • 0019225823 scopus 로고
    • Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence
    • Barnes CA, McNaughton BL Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence. J Physiol (Lond) 1980, 309:413-485.
    • (1980) J Physiol (Lond) , vol.309 , pp. 413-485
    • Barnes, C.A.1    McNaughton, B.L.2
  • 17
    • 0002631245 scopus 로고
    • Spatial memory and hippocampal synaptic plasticity in senescent and middle-aged rats
    • Elsevier, New York, D. Stein (Ed.)
    • Barnes CA, McNaughton BL Spatial memory and hippocampal synaptic plasticity in senescent and middle-aged rats. The Psychobiology of Aging, Problems and Perspectives 1980, 253-272. Elsevier, New York. D. Stein (Ed.).
    • (1980) The Psychobiology of Aging, Problems and Perspectives , pp. 253-272
    • Barnes, C.A.1    McNaughton, B.L.2
  • 18
    • 0022403407 scopus 로고
    • An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses
    • Barnes CA, McNaughton BL An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses. Behav Neurosci 1985, 29:1040-1048.
    • (1985) Behav Neurosci , vol.29 , pp. 1040-1048
    • Barnes, C.A.1    McNaughton, B.L.2
  • 19
    • 0018988914 scopus 로고
    • Spatial memory deficit in senescent rats
    • Barnes CA, Nadel L, Honig WK Spatial memory deficit in senescent rats. Can Psychol 1980, 34:29-39.
    • (1980) Can Psychol , vol.34 , pp. 29-39
    • Barnes, C.A.1    Nadel, L.2    Honig, W.K.3
  • 20
    • 0026938051 scopus 로고
    • Region-specific age effects on AMPA sensitivity, Electrophysiological evidence for loss of synpatic contacts in hippocampal field CA1
    • Barnes CA, Rao G, Foster TC, McNaughton BL Region-specific age effects on AMPA sensitivity, Electrophysiological evidence for loss of synpatic contacts in hippocampal field CA1. Hippocampus 1992, 2:457-468.
    • (1992) Hippocampus , vol.2 , pp. 457-468
    • Barnes, C.A.1    Rao, G.2    Foster, T.C.3    McNaughton, B.L.4
  • 21
    • 0034282068 scopus 로고    scopus 로고
    • LTP induction threshold change in old rats at the per-forant path-granule cell synapse
    • Barnes CA, Rao G, Houston FP LTP induction threshold change in old rats at the per-forant path-granule cell synapse. Neurobiol Aging 2000, 21:613-620.
    • (2000) Neurobiol Aging , vol.21 , pp. 613-620
    • Barnes, C.A.1    Rao, G.2    Houston, F.P.3
  • 22
    • 0033757922 scopus 로고    scopus 로고
    • Age-related decrease in the Schaffer collateral-evoked EPSP in awake, freely behaving rats
    • Barnes CA, Rao G, Orr G Age-related decrease in the Schaffer collateral-evoked EPSP in awake, freely behaving rats. Neural Plast 2000, 7:167-178.
    • (2000) Neural Plast , vol.7 , pp. 167-178
    • Barnes, C.A.1    Rao, G.2    Orr, G.3
  • 23
    • 0030854720 scopus 로고    scopus 로고
    • Multistability of cognitive maps in the hippocampus of old rats
    • Barnes CA, Suster MS, Shen J, McNaughton BL Multistability of cognitive maps in the hippocampus of old rats. Nature 1997, 388:272-275.
    • (1997) Nature , vol.388 , pp. 272-275
    • Barnes, C.A.1    Suster, M.S.2    Shen, J.3    McNaughton, B.L.4
  • 24
    • 0030755342 scopus 로고    scopus 로고
    • Age-related decrease in the N-methyl-d-aspartate-R-medi-ated excitatory postsynaptic potential in hippocampal region CA1
    • Barnes CA, Rao G, Shen J Age-related decrease in the N-methyl-d-aspartate-R-medi-ated excitatory postsynaptic potential in hippocampal region CA1. Neurobiol Aging 1997, 18:445-452.
    • (1997) Neurobiol Aging , vol.18 , pp. 445-452
    • Barnes, C.A.1    Rao, G.2    Shen, J.3
  • 25
    • 0018181655 scopus 로고
    • Aging in the rhesus monkey, Debilitating effects on short-term memory
    • Bartus RT, Fleming D, Johnson HR Aging in the rhesus monkey, Debilitating effects on short-term memory. J Gerontol 1978, 33:858-871.
    • (1978) J Gerontol , vol.33 , pp. 858-871
    • Bartus, R.T.1    Fleming, D.2    Johnson, H.R.3
  • 26
    • 0022395704 scopus 로고
    • Preservation of accurate spatial memory in aged rats
    • Beatty WW, Bierley RA, Boyd JG Preservation of accurate spatial memory in aged rats. Neurobiol Aging 1985, 5:219-225.
    • (1985) Neurobiol Aging , vol.5 , pp. 219-225
    • Beatty, W.W.1    Bierley, R.A.2    Boyd, J.G.3
  • 27
    • 0022919082 scopus 로고
    • Quantitative histochemistry of brain acetylcholines-terase and learning rate in the aged rat
    • Biegon A, Greenberger V, Segal M Quantitative histochemistry of brain acetylcholines-terase and learning rate in the aged rat. Neurobiol Aging 1986, 7:215-217.
    • (1986) Neurobiol Aging , vol.7 , pp. 215-217
    • Biegon, A.1    Greenberger, V.2    Segal, M.3
  • 28
    • 0042668324 scopus 로고    scopus 로고
    • Production of new cells in the rat dentate gyrus over the life span, Relation to cognitive decline
    • Bizon J, Gallagher M Production of new cells in the rat dentate gyrus over the life span, Relation to cognitive decline. Eur J Neurosci 2003, 18:215-218.
    • (2003) Eur J Neurosci , vol.18 , pp. 215-218
    • Bizon, J.1    Gallagher, M.2
  • 29
    • 13844257516 scopus 로고    scopus 로고
    • Neurogenesis in a rat model of age-related cognitive decline
    • Bizon JL, Lee HJ, Gallagher M Neurogenesis in a rat model of age-related cognitive decline. Aging Cell 2004, 3:227-234.
    • (2004) Aging Cell , vol.3 , pp. 227-234
    • Bizon, J.L.1    Lee, H.J.2    Gallagher, M.3
  • 30
    • 0038206578 scopus 로고    scopus 로고
    • Gene microarrays in hippocampal aging, Statistical profiling identifies novel processes corre-lated with cognitive impairment
    • Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, Foster TC, Landfield PW Gene microarrays in hippocampal aging, Statistical profiling identifies novel processes corre-lated with cognitive impairment. J Neurosci 2003, 23:3807-3819.
    • (2003) J Neurosci , vol.23 , pp. 3807-3819
    • Blalock, E.M.1    Chen, K.C.2    Sharrow, K.3    Herman, J.P.4    Porter, N.M.5    Foster, T.C.6    Landfield, P.W.7
  • 31
    • 0015850798 scopus 로고
    • Long-lasting potentiation of synaptic transmission in the dentate area of the unanaesthetised rabbit following stimulation of the perforant path
    • Bliss TVP, Gardner-Medwin AR Long-lasting potentiation of synaptic transmission in the dentate area of the unanaesthetised rabbit following stimulation of the perforant path. J Physiol (London) 1973, 232:357-374.
    • (1973) J Physiol (London) , vol.232 , pp. 357-374
    • Bliss, T.V.P.1    Gardner-Medwin, A.R.2
  • 32
    • 0015799240 scopus 로고
    • Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulus of perforant path
    • Bliss TVP, Lomo T Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulus of perforant path. J Physiol (London) 1973, 232:331-356.
    • (1973) J Physiol (London) , vol.232 , pp. 331-356
    • Bliss, T.V.P.1    Lomo, T.2
  • 33
    • 0017232487 scopus 로고
    • Loss of synapses in the dentate gyrus of the senescent rat
    • Bondareff W, Geinisman Y Loss of synapses in the dentate gyrus of the senescent rat. Am J Anat 1976, 145:129-136.
    • (1976) Am J Anat , vol.145 , pp. 129-136
    • Bondareff, W.1    Geinisman, Y.2
  • 35
    • 0028071507 scopus 로고
    • Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
    • Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva AJ Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 1994, 79:59-68.
    • (1994) Cell , vol.79 , pp. 59-68
    • Bourtchuladze, R.1    Frenguelli, B.2    Blendy, J.3    Cioffi, D.4    Schutz, G.5    Silva, A.J.6
  • 36
    • 0023804948 scopus 로고
    • Fimbria-fornix lesions in young rats impair acquisi-tion in a 14-unit T-maze similar to prior observed performance deficits in aged rats
    • Bresnahan EL, Wiser PR, Ingram DK Fimbria-fornix lesions in young rats impair acquisi-tion in a 14-unit T-maze similar to prior observed performance deficits in aged rats. Psycho-biology 1988, 16:243-250.
    • (1988) Psycho-biology , vol.16 , pp. 243-250
    • Bresnahan, E.L.1    Wiser, P.R.2    Ingram, D.K.3
  • 37
    • 0345118873 scopus 로고    scopus 로고
    • Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments
    • Brightwell JJ, Gallagher M, Colombo PJ Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments. Neurobiol Learn Mem 2004, 81:19-26.
    • (2004) Neurobiol Learn Mem , vol.81 , pp. 19-26
    • Brightwell, J.J.1    Gallagher, M.2    Colombo, P.J.3
  • 38
    • 0019291824 scopus 로고
    • Localization of cellular changes within multimodal sensory regions in aged monkey brain, Possible implications of age-related cognitive loss
    • Brizzee KR, Ordy JM, Bartus RT Localization of cellular changes within multimodal sensory regions in aged monkey brain, Possible implications of age-related cognitive loss. Neurobiol Aging 1980, 1:45-52.
    • (1980) Neurobiol Aging , vol.1 , pp. 45-52
    • Brizzee, K.R.1    Ordy, J.M.2    Bartus, R.T.3
  • 39
    • 77049202076 scopus 로고
    • Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex
    • Brody H Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex. J Comp Neurol 1955, 102:511-556.
    • (1955) J Comp Neurol , vol.102 , pp. 511-556
    • Brody, H.1
  • 41
    • 0142085283 scopus 로고
    • Paced and self-paced learning in young and elderly adults
    • Canestrari RE Paced and self-paced learning in young and elderly adults. J Gerontol 1963, 15:165-168.
    • (1963) J Gerontol , vol.15 , pp. 165-168
    • Canestrari, R.E.1
  • 42
    • 0026000977 scopus 로고
    • Spatial learning and memory in the radial maze, A longitudinal study in rats from 4 to 25 months of age
    • Caprioli A, Ghirardi O, Giuliani A, Ramacci MT, Angelucci L Spatial learning and memory in the radial maze, A longitudinal study in rats from 4 to 25 months of age. Neurobiol Aging 1991, 12:601-605.
    • (1991) Neurobiol Aging , vol.12 , pp. 601-605
    • Caprioli, A.1    Ghirardi, O.2    Giuliani, A.3    Ramacci, M.T.4    Angelucci, L.5
  • 44
  • 45
    • 0024403534 scopus 로고
    • Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation
    • Cole AJ, Saffen DW, Baraban JM, Worley PF Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature 1989, 340:474-476.
    • (1989) Nature , vol.340 , pp. 474-476
    • Cole, A.J.1    Saffen, D.W.2    Baraban, J.M.3    Worley, P.F.4
  • 46
    • 0023472509 scopus 로고
    • Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
    • Coleman PD, Flood DG Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiol Aging 1987, 8:521-545.
    • (1987) Neurobiol Aging , vol.8 , pp. 521-545
    • Coleman, P.D.1    Flood, D.G.2
  • 47
    • 0002276934 scopus 로고
    • Functional age, A conceptual and empirical critique
    • N.I.H. Pub. No. 80-969, U.S. Government Printing Office, Washington, DC, S.G. Haynes, M. Feinleib (Eds.)
    • Costa PT, McCrae RR Functional age, A conceptual and empirical critique. Epi-demiology of Aging 1980, 23-46. N.I.H. Pub. No. 80-969, U.S. Government Printing Office, Washington, DC. S.G. Haynes, M. Feinleib (Eds.).
    • (1980) Epi-demiology of Aging , pp. 23-46
    • Costa, P.T.1    McCrae, R.R.2
  • 49
    • 84927084331 scopus 로고
    • Age-associated memory impairment, Proposed diagnostic criteria and measures of clinical change. Report of a National Institute of Mental Health Work Group
    • Crook T, Bartus RT, Ferris SH, Whitehouse P, Cohen GD, Gershon S Age-associated memory impairment, Proposed diagnostic criteria and measures of clinical change. Report of a National Institute of Mental Health Work Group. Develop Neuropsychol 1986, 2:261-276.
    • (1986) Develop Neuropsychol , vol.2 , pp. 261-276
    • Crook, T.1    Bartus, R.T.2    Ferris, S.H.3    Whitehouse, P.4    Cohen, G.D.5    Gershon, S.6
  • 50
    • 0026560290 scopus 로고
    • Age associated memory impairment
    • Crook TH, Ferris SH Age associated memory impairment. BMJ 1992, 304:714.
    • (1992) BMJ , vol.304 , pp. 714
    • Crook, T.H.1    Ferris, S.H.2
  • 51
    • 0022273980 scopus 로고
    • Electrophysiological markers of aging and memory loss in rats
    • de Toledo-Morrell L, Morrell F Electrophysiological markers of aging and memory loss in rats. Ann NY Acad Sci 1985, 444:296-311.
    • (1985) Ann NY Acad Sci , vol.444 , pp. 296-311
    • de, T.M.L.1    Morrell, F.2
  • 52
    • 0021721209 scopus 로고
    • Pentoxifylline reverses age-related deficits in spatial memory
    • de Toledo-Morrell L, Morrell F, Fleming S, Cohen MM Pentoxifylline reverses age-related deficits in spatial memory. Behav Neural Biol 1984, 42:1-8.
    • (1984) Behav Neural Biol , vol.42 , pp. 1-8
    • de, T.M.L.1    Morrell, F.2    Fleming, S.3    Cohen, M.M.4
  • 54
    • 0027193830 scopus 로고
    • Age-related alterations in potentiation in the CA1 region in F344 rats
    • Deupree DL, Bradley J, Turner DA Age-related alterations in potentiation in the CA1 region in F344 rats. Neurobiol Aging 1993, 14:249-258.
    • (1993) Neurobiol Aging , vol.14 , pp. 249-258
    • Deupree, D.L.1    Bradley, J.2    Turner, D.A.3
  • 55
    • 0030567767 scopus 로고    scopus 로고
    • Calcium-dependent afterhyper-polarization and learning in young and aging hippocampus
    • Disterhoft JF, Thompson LT, Moyer JR, Mogul DJ Calcium-dependent afterhyper-polarization and learning in young and aging hippocampus. Life Sci 1996, 59:413-420.
    • (1996) Life Sci , vol.59 , pp. 413-420
    • Disterhoft, J.F.1    Thompson, L.T.2    Moyer, J.R.3    Mogul, D.J.4
  • 56
    • 0015069575 scopus 로고
    • Frontal lobe system and spatial reversal in the rat
    • Divac I Frontal lobe system and spatial reversal in the rat. Neuropsychologia 1971, 9:175-183.
    • (1971) Neuropsychologia , vol.9 , pp. 175-183
    • Divac, I.1
  • 57
    • 13544276192 scopus 로고    scopus 로고
    • Virtual navigation in humans, The impact of age, sex, and hormones on place learning
    • Driscoll I, Hamilton DA, Yeo RA, Brooks WM, Sutherland RJ Virtual navigation in humans, The impact of age, sex, and hormones on place learning. Horm Behav 2005, 47:326-335.
    • (2005) Horm Behav , vol.47 , pp. 326-335
    • Driscoll, I.1    Hamilton, D.A.2    Yeo, R.A.3    Brooks, W.M.4    Sutherland, R.J.5
  • 58
    • 0021236206 scopus 로고
    • Cognitive mapping and elderly adults, Verbal and location memory for urban landmarks
    • Evans GW, Brennan PL, Skorpanich MA, Held D Cognitive mapping and elderly adults, Verbal and location memory for urban landmarks. J Gerontol 1984, 39:432-457.
    • (1984) J Gerontol , vol.39 , pp. 432-457
    • Evans, G.W.1    Brennan, P.L.2    Skorpanich, M.A.3    Held, D.4
  • 59
    • 0029959314 scopus 로고    scopus 로고
    • Commentary on age-associated memory impairment, age-related cognitive decline and mild cognitive impairment
    • Ferris SH, Kluger A Commentary on age-associated memory impairment, age-related cognitive decline and mild cognitive impairment. Aging, Neuropsychol Cognition 1996, 3:148-153.
    • (1996) Aging, Neuropsychol Cognition , vol.3 , pp. 148-153
    • Ferris, S.H.1    Kluger, A.2
  • 60
    • 0026032513 scopus 로고
    • Region-specific stability of dendritic extent in normal aging and regression in Alzheimer's disease. II. Subiculum
    • Flood DG Region-specific stability of dendritic extent in normal aging and regression in Alzheimer's disease. II. Subiculum. Brain Res 1991, 540:83-95.
    • (1991) Brain Res , vol.540 , pp. 83-95
    • Flood, D.G.1
  • 61
    • 0023214421 scopus 로고
    • Dendritic extent in human CA2-3 hippocampal pyramidal neurons in normal aging and senile dementia
    • Flood DG, Guarnaccia M, Coleman PD Dendritic extent in human CA2-3 hippocampal pyramidal neurons in normal aging and senile dementia. Brain Res 1987, 409:88-96.
    • (1987) Brain Res , vol.409 , pp. 88-96
    • Flood, D.G.1    Guarnaccia, M.2    Coleman, P.D.3
  • 62
    • 0023156372 scopus 로고
    • Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia
    • Flood DG, Buell SJ, Horwitz GJ, Coleman PD Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia. Brain Res 1987, 402:205-216.
    • (1987) Brain Res , vol.402 , pp. 205-216
    • Flood, D.G.1    Buell, S.J.2    Horwitz, G.J.3    Coleman, P.D.4
  • 65
    • 0028954228 scopus 로고
    • Age-related spatial reference and working memory deficits assessed in the water maze
    • Frick KM, Baxter MG, Markowska AL, Olton DS, Price DL Age-related spatial reference and working memory deficits assessed in the water maze. Neurobiol Aging 1995, 16:149-160.
    • (1995) Neurobiol Aging , vol.16 , pp. 149-160
    • Frick, K.M.1    Baxter, M.G.2    Markowska, A.L.3    Olton, D.S.4    Price, D.L.5
  • 67
    • 0022364561 scopus 로고
    • Effects of opiate antagonists on spatial memory in young and aged rats
    • Gallagher M, Bostock E, King R Effects of opiate antagonists on spatial memory in young and aged rats. Behav Neural Biol 1985, 44:374-385.
    • (1985) Behav Neural Biol , vol.44 , pp. 374-385
    • Gallagher, M.1    Bostock, E.2    King, R.3
  • 68
    • 0027214025 scopus 로고
    • Severity of spatial learning impairment in aging, Development of a learning index for performance in the Morris water maze
    • Gallagher M, Burwell R, Burchinal M Severity of spatial learning impairment in aging, Development of a learning index for performance in the Morris water maze. Behav Neurosci 1993, 207:618-626.
    • (1993) Behav Neurosci , vol.207 , pp. 618-626
    • Gallagher, M.1    Burwell, R.2    Burchinal, M.3
  • 69
    • 0024160442 scopus 로고
    • Spatial learning deficits in old rats, A model for memory decline in the aged
    • Gallagher M, Pelleymounter MA Spatial learning deficits in old rats, A model for memory decline in the aged. Neurobiol Aging 1988, 2:549-556.
    • (1988) Neurobiol Aging , vol.2 , pp. 549-556
    • Gallagher, M.1    Pelleymounter, M.A.2
  • 70
    • 0018392518 scopus 로고
    • Loss of axosomatic synapses in the dentate gyrus of aged rats
    • Geinisman Y Loss of axosomatic synapses in the dentate gyrus of aged rats. Brain Res 1979, 168:485-492.
    • (1979) Brain Res , vol.168 , pp. 485-492
    • Geinisman, Y.1
  • 71
    • 0023026672 scopus 로고
    • Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory
    • Geinisman Y, de Toledo-Morrell L, Morrell F Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory. Brain Res 1986, 398:266-275.
    • (1986) Brain Res , vol.398 , pp. 266-275
    • Geinisman, Y.1    de, T.M.L.2    Morrell, F.3
  • 72
    • 0026938047 scopus 로고
    • Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique
    • Geinisman Y, de Toledo-Morrell L, Morrell F, Persina IS, Rossi M Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique. Hippocampus 1992, 2:437-444.
    • (1992) Hippocampus , vol.2 , pp. 437-444
    • Geinisman, Y.1    de, T.M.L.2    Morrell, F.3    Persina, I.S.4    Rossi, M.5
  • 75
    • 0000292303 scopus 로고
    • Circuitry of the primate prefrontal cortex and the regulation of behavior by representational memory
    • American Physiological Society, Bethesda, MD, F. Plum (Ed.)
    • Goldman-Rakic PS Circuitry of the primate prefrontal cortex and the regulation of behavior by representational memory. Handbook of Physiology, the Nervous System, Higher Functions of the Brain 1987, 373-417. American Physiological Society, Bethesda, MD. F. Plum (Ed.).
    • (1987) Handbook of Physiology, the Nervous System, Higher Functions of the Brain , pp. 373-417
    • Goldman-Rakic, P.S.1
  • 76
    • 0014309561 scopus 로고
    • Learning, retention, and extinction of a complex maze habit for mature-young and senescent Wistar albino rats
    • Goodrick C Learning, retention, and extinction of a complex maze habit for mature-young and senescent Wistar albino rats. J Gerontol 1968, 23:294-304.
    • (1968) J Gerontol , vol.23 , pp. 294-304
    • Goodrick, C.1
  • 77
    • 21244447302 scopus 로고    scopus 로고
    • Task-related activity in prefrontal cortex and its rela-tion to recognition memory performance in young and old adults
    • Grady CL, Mclntosh AR, Craik FI Task-related activity in prefrontal cortex and its rela-tion to recognition memory performance in young and old adults. Neuropsychologia 2005, 43:1466-1481.
    • (2005) Neuropsychologia , vol.43 , pp. 1466-1481
    • Grady, C.L.1    Mclntosh, A.R.2    Craik, F.I.3
  • 78
    • 0034648705 scopus 로고    scopus 로고
    • Impaired spatial learning in aged rats is associated with loss of p75-positive neurons in the basal forebrain
    • Greferath U, Bennie A, Kourakis A, Barrett GL Impaired spatial learning in aged rats is associated with loss of p75-positive neurons in the basal forebrain. Neuroscience 2000, 100:363-373.
    • (2000) Neuroscience , vol.100 , pp. 363-373
    • Greferath, U.1    Bennie, A.2    Kourakis, A.3    Barrett, G.L.4
  • 79
    • 0031051731 scopus 로고    scopus 로고
    • Complex patterns of immediate-early gene induction in rat brain following brightness discrimination training and pseudotraining
    • Grimm R, Tischmeyer W Complex patterns of immediate-early gene induction in rat brain following brightness discrimination training and pseudotraining. Behav Brain Res 1997, 84:109-166.
    • (1997) Behav Brain Res , vol.84 , pp. 109-166
    • Grimm, R.1    Tischmeyer, W.2
  • 80
    • 12544253120 scopus 로고    scopus 로고
    • Aging and the neural correlates of successful picture encoding, Frontal activations compensate for decreased medial-temporal activity
    • Gutchess AH, Welsh RC, Hedden T, Bangert A, Minear M, Liu LL, Park DC Aging and the neural correlates of successful picture encoding, Frontal activations compensate for decreased medial-temporal activity. J Cogn Neurosci 2005, 27:84-96.
    • (2005) J Cogn Neurosci , vol.27 , pp. 84-96
    • Gutchess, A.H.1    Welsh, R.C.2    Hedden, T.3    Bangert, A.4    Minear, M.5    Liu, L.L.6    Park, D.C.7
  • 81
    • 0034213297 scopus 로고    scopus 로고
    • Inhibition of activity-dependent Arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long
    • Guzowski JF, Lyford GL, Stevenson GD, Houston FP, McGaugh JL, Worley PF, Barnes CA Inhibition of activity-dependent Arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long. J Neurosci 2000, 20:3993-4001.
    • (2000) J Neurosci , vol.20 , pp. 3993-4001
    • Guzowski, J.F.1    Lyford, G.L.2    Stevenson, G.D.3    Houston, F.P.4    McGaugh, J.L.5    Worley, P.F.6    Barnes, C.A.7
  • 82
    • 0030956323 scopus 로고    scopus 로고
    • Antisense oligodeoxynucleotide-mediated disruption of hip-pocampal cAMP response element binding protein levels impairs consolidation of memory for water maze
    • Guzowski JF, McGaugh JL Antisense oligodeoxynucleotide-mediated disruption of hip-pocampal cAMP response element binding protein levels impairs consolidation of memory for water maze. Proc Natl Acad Sci USA 1997, 94:2693-2698.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2693-2698
    • Guzowski, J.F.1    McGaugh, J.L.2
  • 83
    • 0035879067 scopus 로고    scopus 로고
    • Experience-dependent gene expression in the rat hippocampus after spatial learning, A comparison of the immediate-early genes Arc, c-fos, and zif268
    • Guzowski JF, Setlow B, Wagner EK, McGaugh JL Experience-dependent gene expression in the rat hippocampus after spatial learning, A comparison of the immediate-early genes Arc, c-fos, and zif268. J Neurosci 2001, 22:5089-5098.
    • (2001) J Neurosci , vol.22 , pp. 5089-5098
    • Guzowski, J.F.1    Setlow, B.2    Wagner, E.K.3    McGaugh, J.L.4
  • 85
    • 0026082894 scopus 로고
    • Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. I. CA1 of hippocampus
    • Hanks SD, Flood DG Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. I. CA1 of hippocampus. Brain Res 1991, 540:63-82.
    • (1991) Brain Res , vol.540 , pp. 63-82
    • Hanks, S.D.1    Flood, D.G.2
  • 86
    • 84981795349 scopus 로고
    • Recall and recognition in elderly and young subjects
    • Harwood E, Naylor GFK Recall and recognition in elderly and young subjects. Australian J Psychol 1969, 21:251-257.
    • (1969) Australian J Psychol , vol.21 , pp. 251-257
    • Harwood, E.1    Naylor, G.F.K.2
  • 87
    • 0742323532 scopus 로고    scopus 로고
    • Insights into the ageing mind, A view from cognitive neuro-science
    • Hedden T, Gabrieli JD Insights into the ageing mind, A view from cognitive neuro-science. Nat Rev Neurosci 2004, 5:87-96.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 87-96
    • Hedden, T.1    Gabrieli, J.D.2
  • 88
    • 27944491521 scopus 로고    scopus 로고
    • Healthy and pathological processes in adult development, new evidence from neuroimaging of the aging brain
    • Hedden T, Gabrieli JD Healthy and pathological processes in adult development, new evidence from neuroimaging of the aging brain. Curr Opin Neurol 2005, 15:740-747.
    • (2005) Curr Opin Neurol , vol.15 , pp. 740-747
    • Hedden, T.1    Gabrieli, J.D.2
  • 89
    • 1242316182 scopus 로고    scopus 로고
    • Prominent decline of newborn cell prolifera-tion, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituita
    • Heine VM, Maslam S, Joels M, Lucassen PJ Prominent decline of newborn cell prolifera-tion, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituita. Neurobiol Aging 2004, 25:361-375.
    • (2004) Neurobiol Aging , vol.25 , pp. 361-375
    • Heine, V.M.1    Maslam, S.2    Joels, M.3    Lucassen, P.J.4
  • 90
    • 0029010263 scopus 로고
    • Changes in c-fos mRNA expression in rat brain during odor discrimination learning, Differential involvement of hippocampal subfields CA1 and CA3
    • Hess US, Gary L, Gall CM Changes in c-fos mRNA expression in rat brain during odor discrimination learning, Differential involvement of hippocampal subfields CA1 and CA3. J Neurosci 1995, 75:4786-4795.
    • (1995) J Neurosci , vol.75 , pp. 4786-4795
    • Hess, U.S.1    Gary, L.2    Gall, C.M.3
  • 91
    • 0029619060 scopus 로고
    • Regional patterns of c-fos mRNA expression in rat hip-pocampus following exploration of a novel environment versus performance of a well-learned discriminatio
    • Hess US, Lynch G, Gall CM Regional patterns of c-fos mRNA expression in rat hip-pocampus following exploration of a novel environment versus performance of a well-learned discriminatio. J Neurosci 1995, 25:7796-7809.
    • (1995) J Neurosci , vol.25 , pp. 7796-7809
    • Hess, U.S.1    Lynch, G.2    Gall, C.M.3
  • 92
    • 4544322402 scopus 로고    scopus 로고
    • The aging brain, Morphomolecular senescence of cortical circuits
    • Hof PR, Morrison JH The aging brain, Morphomolecular senescence of cortical circuits. Trends Neurosci 2004, 27:607-613.
    • (2004) Trends Neurosci , vol.27 , pp. 607-613
    • Hof, P.R.1    Morrison, J.H.2
  • 93
    • 0035200169 scopus 로고    scopus 로고
    • Understanding aging. An evaluation of research designs for assessing the interdependence of ageing-related changes
    • Hofer SM, Sliwinski MJ Understanding aging. An evaluation of research designs for assessing the interdependence of ageing-related changes. Gerontology 2001, 47:341-352.
    • (2001) Gerontology , vol.47 , pp. 341-352
    • Hofer, S.M.1    Sliwinski, M.J.2
  • 94
    • 0029042370 scopus 로고
    • Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system
    • Hughes P, Dragunow M Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol Rev 1995, 47:133-178.
    • (1995) Pharmacol Rev , vol.47 , pp. 133-178
    • Hughes, P.1    Dragunow, M.2
  • 95
    • 0032904489 scopus 로고    scopus 로고
    • Activity-and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous systems
    • Hughes PE, Alexi T, Walton M, Williams CE, Dragunow M, Clark RG, Gluckman PD Activity-and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous systems. Prog Neurobiol 1999, 57:421-450.
    • (1999) Prog Neurobiol , vol.57 , pp. 421-450
    • Hughes, P.E.1    Alexi, T.2    Walton, M.3    Williams, C.E.4    Dragunow, M.5    Clark, R.G.6    Gluckman, P.D.7
  • 96
    • 0021145680 scopus 로고
    • Alzheimer's disease, Cell-specific pathology isolates the hippocampal formation
    • Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL Alzheimer's disease, Cell-specific pathology isolates the hippocampal formation. Science 1984, 225:1168-1170.
    • (1984) Science , vol.225 , pp. 1168-1170
    • Hyman, B.T.1    Van, H.G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 97
    • 0022273981 scopus 로고
    • Analysis of age-related impairments in learning and memory in rodent models
    • Ingram D Analysis of age-related impairments in learning and memory in rodent models. Ann NY Acad Sci 1985, 444:312-331.
    • (1985) Ann NY Acad Sci , vol.444 , pp. 312-331
    • Ingram, D.1
  • 98
    • 0021080969 scopus 로고
    • Toward the behavioral assessment of biological aging in the laboratory mouse, concepts, terminology, and objectives
    • Ingram DK Toward the behavioral assessment of biological aging in the laboratory mouse, concepts, terminology, and objectives. Exp Aging Res 1983, 9:225-238.
    • (1983) Exp Aging Res , vol.9 , pp. 225-238
    • Ingram, D.K.1
  • 99
    • 0024157751 scopus 로고    scopus 로고
    • Complex maze learning in rodents as models of age-related memory impair-ment
    • Ingram DK Complex maze learning in rodents as models of age-related memory impair-ment. Neurobiol Aging 1998, 9:475-485.
    • (1998) Neurobiol Aging , vol.9 , pp. 475-485
    • Ingram, D.K.1
  • 100
    • 13244254290 scopus 로고    scopus 로고
    • Rodent models of age-related memory impairments
    • Academic Press, San Diego, P.R. Hof, C.V. Mobbs (Eds.)
    • Ingram DK Rodent models of age-related memory impairments. Functional Neurobiology of Aging 2001, 373-386. Academic Press, San Diego. P.R. Hof, C.V. Mobbs (Eds.).
    • (2001) Functional Neurobiology of Aging , pp. 373-386
    • Ingram, D.K.1
  • 101
    • 0031281553 scopus 로고    scopus 로고
    • Place learning in virtual space I, Acquisition, overshadowing, and transfer
    • Jacobs WJ, Laurance HE, Thomas KGF Place learning in virtual space I, Acquisition, overshadowing, and transfer. Learn Motiv 1997, 25:521-541.
    • (1997) Learn Motiv , vol.25 , pp. 521-541
    • Jacobs, W.J.1    Laurance, H.E.2    Thomas, K.G.F.3
  • 102
    • 0001140811 scopus 로고    scopus 로고
    • Place learning in virtual space II, Topo-graphical relations as one dimension of stimulus control
    • Jacobs WJ, Thomas KGF, Laurance HE Nadel L Place learning in virtual space II, Topo-graphical relations as one dimension of stimulus control. Learn Motiv 1998, 29:288-308.
    • (1998) Learn Motiv , vol.29 , pp. 288-308
    • Jacobs, W.J.1    Thomas, K.G.F.2    Laurance, H.E.N.L.3
  • 103
    • 0035852759 scopus 로고    scopus 로고
    • The effects of aging on gene expression in the hypothalamus and cortex of mice
    • Jiang CH, Tsien JZ, Schultz PG, Hu Y The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc Natl Acad Sci USA 2001, 95:1930-1934.
    • (2001) Proc Natl Acad Sci USA , vol.95 , pp. 1930-1934
    • Jiang, C.H.1    Tsien, J.Z.2    Schultz, P.G.3    Hu, Y.4
  • 105
    • 0036325981 scopus 로고    scopus 로고
    • Neuroplasticity in old age, Sustained fivefold induc-tion of hippocampal neurogenesis by long-term environmental enrichment
    • Kempermann G, Gast D, Gage FH Neuroplasticity in old age, Sustained fivefold induc-tion of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol 2002, 52:135-143.
    • (2002) Ann Neurol , vol.52 , pp. 135-143
    • Kempermann, G.1    Gast, D.2    Gage, F.H.3
  • 106
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian ZS Diagnosis of Alzheimer's disease. Arch Neurol 1985, 42:1097-1105.
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 107
    • 0017763929 scopus 로고
    • A morphometric study of the neocortex of young adult and old maze-differentiated rats
    • Klein QW, Michel ME A morphometric study of the neocortex of young adult and old maze-differentiated rats. Mechanisms Aging Devel 1977, 6:441-452.
    • (1977) Mechanisms Aging Devel , vol.6 , pp. 441-452
    • Klein, Q.W.1    Michel, M.E.2
  • 108
    • 33748188974 scopus 로고    scopus 로고
    • Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
    • Kronenberg G, Bick-Sander A, Bunk E, Wolf C, Ehninger D, Kempermann G Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus. Neurobiol Aging 2006, 27:1505-1513.
    • (2006) Neurobiol Aging , vol.27 , pp. 1505-1513
    • Kronenberg, G.1    Bick-Sander, A.2    Bunk, E.3    Wolf, C.4    Ehninger, D.5    Kempermann, G.6
  • 109
    • 23944460541 scopus 로고    scopus 로고
    • Age-related disturbance of memory and CREB phosphorylation in CA1 area of hippocampal of rats
    • Kudo K, Wati H, Qiao C, Arita J, Kanba S Age-related disturbance of memory and CREB phosphorylation in CA1 area of hippocampal of rats. Brain Res 2005, 1054:30-37.
    • (2005) Brain Res , vol.1054 , pp. 30-37
    • Kudo, K.1    Wati, H.2    Qiao, C.3    Arita, J.4    Kanba, S.5
  • 110
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat, Age-related decrease of neuronal progenitor proliferation
    • Kuhn HG, Dickinson-Anson H, Gage FH Neurogenesis in the dentate gyrus of the adult rat, Age-related decrease of neuronal progenitor proliferation. J Neurosci 1996, 16:2027-2033.
    • (1996) J Neurosci , vol.16 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 111
    • 0030988498 scopus 로고    scopus 로고
    • Selective alteration of LTP-induced transcriptional response in hippocampus of aged, memory-impaired rats
    • Lanahan A, Lyford G, Stevenson GS, Worley PF, Barnes CA Selective alteration of LTP-induced transcriptional response in hippocampus of aged, memory-impaired rats. J Neurosci 1997, 17:2876-2885.
    • (1997) J Neurosci , vol.17 , pp. 2876-2885
    • Lanahan, A.1    Lyford, G.2    Stevenson, G.S.3    Worley, P.F.4    Barnes, C.A.5
  • 112
    • 0017669091 scopus 로고
    • Impaired monosynaptic potentiation in in vitro hippocampal slices from aged, memory-deficient rats. J
    • Landfield PW, Lynch G Impaired monosynaptic potentiation in in vitro hippocampal slices from aged, memory-deficient rats. J. Gerontol 1977, 32:523-533.
    • (1977) Gerontol , vol.32 , pp. 523-533
    • Landfield, P.W.1    Lynch, G.2
  • 113
    • 0018146937 scopus 로고
    • Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats
    • Landfield PW, McGaugh JL, Lynch G Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats. Brain Res 1978, 150:85-101.
    • (1978) Brain Res , vol.150 , pp. 85-101
    • Landfield, P.W.1    McGaugh, J.L.2    Lynch, G.3
  • 114
    • 0021645626 scopus 로고
    • 2+-dependent after hyperpolarizations in hippo-campal neurons of aged rats
    • 2+-dependent after hyperpolarizations in hippo-campal neurons of aged rats. Science 1984, 22(5):1089-1092.
    • (1984) Science , vol.22 , Issue.5 , pp. 1089-1092
    • Landfield, P.W.1    Pitler, T.A.2
  • 115
    • 0022558769 scopus 로고
    • 2+ ratios on frequency potentiation in hippocampal slices of young and aged rats
    • 2+ ratios on frequency potentiation in hippocampal slices of young and aged rats. J Neurophysiol 1986, 56:797-811.
    • (1986) J Neurophysiol , vol.56 , pp. 797-811
    • Landfield, P.W.1    Pitler, T.A.2    Applegate, M.D.3
  • 116
    • 76549192548 scopus 로고
    • The historical developments in the biological aspects of aging and the aged
    • Lawton AH The historical developments in the biological aspects of aging and the aged. Gerontologist 1965, 5:25-32.
    • (1965) Gerontologist , vol.5 , pp. 25-32
    • Lawton, A.H.1
  • 117
    • 0000847978 scopus 로고    scopus 로고
    • Gene-expression profile of the ageing brain in mice
    • Lee CK, Weindruch R, Prolla TA Gene-expression profile of the ageing brain in mice. Nat Genet 2000, 25:294-297.
    • (2000) Nat Genet , vol.25 , pp. 294-297
    • Lee, C.K.1    Weindruch, R.2    Prolla, T.A.3
  • 118
    • 2442507983 scopus 로고    scopus 로고
    • Independent cellular processes for hippocampal memory consolidation and reconsolidation
    • Lee JL, Everitt BJ, Thomas KL Independent cellular processes for hippocampal memory consolidation and reconsolidation. Science 2004, 304:839-843.
    • (2004) Science , vol.304 , pp. 839-843
    • Lee, J.L.1    Everitt, B.J.2    Thomas, K.L.3
  • 119
    • 0034992099 scopus 로고    scopus 로고
    • The effect of 1-carnitine on T-maze learning ability in aged rats
    • Lohninger S, Strasser A, Bubna-Littitz H The effect of 1-carnitine on T-maze learning ability in aged rats. Arch Gerontol Geriatr 2001, 32:245-253.
    • (2001) Arch Gerontol Geriatr , vol.32 , pp. 245-253
    • Lohninger, S.1    Strasser, A.2    Bubna-Littitz, H.3
  • 120
    • 9644265444 scopus 로고    scopus 로고
    • Short-and long-term spatial delayed response performance across the life span
    • Lyons-Warren A, Lillie R, Hershey T Short-and long-term spatial delayed response performance across the life span. Dev Neuropsychol 2004, 26:661-678.
    • (2004) Dev Neuropsychol , vol.26 , pp. 661-678
    • Lyons-Warren, A.1    Lillie, R.2    Hershey, T.3
  • 123
    • 0035430282 scopus 로고    scopus 로고
    • Transcriptional regulation by the phosphorylation-dependent factor CREB
    • Mayr B, Montminy M Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2001, 2:599-609.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 599-609
    • Mayr, B.1    Montminy, M.2
  • 124
    • 0032961182 scopus 로고    scopus 로고
    • Tests used to assess the cognitive abilities of aged rats, Their relation to each other and to hippocampal morphology and neurotrophin expression
    • McLay RN, Freeman SM, Harlan RE, Kastin AJ, Zadina JE Tests used to assess the cognitive abilities of aged rats, Their relation to each other and to hippocampal morphology and neurotrophin expression. Gerontology 1999, 45:143-155.
    • (1999) Gerontology , vol.45 , pp. 143-155
    • McLay, R.N.1    Freeman, S.M.2    Harlan, R.E.3    Kastin, A.J.4    Zadina, J.E.5
  • 125
    • 0024407258 scopus 로고
    • Hippocampal granule cells are necessary for normal spatial learning but not for spatially-selective pyramidal cell discharge
    • McNaughton BL, Barnes CA, Meltzer J, Sutherland RJ Hippocampal granule cells are necessary for normal spatial learning but not for spatially-selective pyramidal cell discharge. Exp Brain Res 1989, 76:485-496.
    • (1989) Exp Brain Res , vol.76 , pp. 485-496
    • McNaughton, B.L.1    Barnes, C.A.2    Meltzer, J.3    Sutherland, R.J.4
  • 126
    • 0029974070 scopus 로고    scopus 로고
    • Redistribution of spatial representation in the hippo-campus of aged rats performing a spatial memory task
    • Mizumori SJ, Lavoie AM, Kalyani A Redistribution of spatial representation in the hippo-campus of aged rats performing a spatial memory task. Behav Neurosci 1996, 770:1006-1016.
    • (1996) Behav Neurosci , vol.770 , pp. 1006-1016
    • Mizumori, S.J.1    Lavoie, A.M.2    Kalyani, A.3
  • 127
    • 33646504470 scopus 로고    scopus 로고
    • Age differences in the neural systems supporting human allocentric spatial navigation
    • Moffat SD, Elkins W, Resnick SM Age differences in the neural systems supporting human allocentric spatial navigation. Neurobiol Aging 2006, 27:965-972.
    • (2006) Neurobiol Aging , vol.27 , pp. 965-972
    • Moffat, S.D.1    Elkins, W.2    Resnick, S.M.3
  • 128
    • 0035164805 scopus 로고    scopus 로고
    • Age differences in spatial memory in a virtual environment navigation task
    • Moffat SD, Zonderman AB, Resnick SM Age differences in spatial memory in a virtual environment navigation task. Neurobiol Aging 2001, 22:787-796.
    • (2001) Neurobiol Aging , vol.22 , pp. 787-796
    • Moffat, S.D.1    Zonderman, A.B.2    Resnick, S.M.3
  • 129
    • 0015044784 scopus 로고
    • Paired-associate learning as a function of adult age and the length of the anticipation and inspection intervals. J
    • Monge R, Hultsch D Paired-associate learning as a function of adult age and the length of the anticipation and inspection intervals. J. Gerontol 1971, 26:157-162.
    • (1971) Gerontol , vol.26 , pp. 157-162
    • Monge, R.1    Hultsch, D.2
  • 130
    • 30344438257 scopus 로고    scopus 로고
    • Dysregulation of memory-related proteins in the hippocampus of aged rats and their relation with cognitive impairment
    • Monti B, Berteotti C, Contestabile A Dysregulation of memory-related proteins in the hippocampus of aged rats and their relation with cognitive impairment. Hippocampus 2005, 75:1041-1049.
    • (2005) Hippocampus , vol.75 , pp. 1041-1049
    • Monti, B.1    Berteotti, C.2    Contestabile, A.3
  • 131
    • 0027298841 scopus 로고
    • Hippocampal plasticity induced by primed burst, but not long-term potentiation, stimulation is impaired in area CA1 of aged Fischer 344 rats
    • Moore CI, Browning MD, Rose GM Hippocampal plasticity induced by primed burst, but not long-term potentiation, stimulation is impaired in area CA1 of aged Fischer 344 rats. Hippocampus 1993, 3:57-66.
    • (1993) Hippocampus , vol.3 , pp. 57-66
    • Moore, C.I.1    Browning, M.D.2    Rose, G.M.3
  • 133
    • 0005535917 scopus 로고
    • Spatial localization does not require the presence of local cues
    • Morris R Spatial localization does not require the presence of local cues. Learn Motiv 1981, 12:239-261.
    • (1981) Learn Motiv , vol.12 , pp. 239-261
    • Morris, R.1
  • 134
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris RG, Garrud P, Rawlins JN, O'Keefe J Place navigation impaired in rats with hippocampal lesions. Nature 1982, 297:681-683.
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.1    Garrud, P.2    Rawlins, J.N.3    O'Keefe, J.4
  • 135
    • 0030698871 scopus 로고    scopus 로고
    • Life and death of neurons in the aging brain
    • Morrison JH, Hof PR Life and death of neurons in the aging brain. Science 1997, 278:412-419.
    • (1997) Science , vol.278 , pp. 412-419
    • Morrison, J.H.1    Hof, P.R.2
  • 136
    • 0024156833 scopus 로고    scopus 로고
    • Effects of aging on visual recognition memory in the rhesus monkey
    • Moss MB, Rosene DL, Peters A Effects of aging on visual recognition memory in the rhesus monkey. Neurobiol Aging 1998, 9:495-502.
    • (1998) Neurobiol Aging , vol.9 , pp. 495-502
    • Moss, M.B.1    Rosene, D.L.2    Peters, A.3
  • 138
    • 0033835539 scopus 로고    scopus 로고
    • Spatial memory and aging, Performance on a human analog of the Morris water maze
    • Newman M, Kaszniak A Spatial memory and aging, Performance on a human analog of the Morris water maze. Aging Neuropsychol Cogn 2000, 7:86-93.
    • (2000) Aging Neuropsychol Cogn , vol.7 , pp. 86-93
    • Newman, M.1    Kaszniak, A.2
  • 139
    • 0842330769 scopus 로고    scopus 로고
    • Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases
    • Nguyen PV, Woo NH Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. Prog Neurobiol 2003, 77:401-437.
    • (2003) Prog Neurobiol , vol.77 , pp. 401-437
    • Nguyen, P.V.1    Woo, N.H.2
  • 140
    • 4444293175 scopus 로고    scopus 로고
    • Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and age-related spatial learning impairments
    • Nicholson DA, Yoshida R, Berry RW, Gallagher M, Geinisman Y Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and age-related spatial learning impairments. J Neurosci 2004, 24:7648-7653.
    • (2004) J Neurosci , vol.24 , pp. 7648-7653
    • Nicholson, D.A.1    Yoshida, R.2    Berry, R.W.3    Gallagher, M.4    Geinisman, Y.5
  • 141
    • 0026530379 scopus 로고
    • Induction of expres-sion of genes encoding transcription factors in the rat brain elicited by behavioral training
    • Nikolaev E, Kaminska B, Tischmeyer W, Matthies H, Kaczmarek L Induction of expres-sion of genes encoding transcription factors in the rat brain elicited by behavioral training. Brain Res Bull 1992, 25:479-484.
    • (1992) Brain Res Bull , vol.25 , pp. 479-484
    • Nikolaev, E.1    Kaminska, B.2    Tischmeyer, W.3    Matthies, H.4    Kaczmarek, L.5
  • 142
    • 0015145985 scopus 로고
    • The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely moving rat
    • O'Keefe J, Dostrovsky J The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely moving rat. Brain Res 1971, 34:171-175.
    • (1971) Brain Res , vol.34 , pp. 171-175
    • O'Keefe, J.1    Dostrovsky, J.2
  • 143
    • 0141500732 scopus 로고
    • Experimental strategies to identify the neurobiological bases of memory, Lesions
    • Academic Press, San Diego, J.L. Martinez, K. Kesner (Eds.)
    • Olton DS Experimental strategies to identify the neurobiological bases of memory, Lesions. Learning and Memory, A Biological View 1991, 441-446. Academic Press, San Diego. J.L. Martinez, K. Kesner (Eds.).
    • (1991) Learning and Memory, A Biological View , pp. 441-446
    • Olton, D.S.1
  • 144
    • 0017919285 scopus 로고
    • Hippocampal connections and spatial discrimination
    • Olton DS, Walker JA, Gage FH Hippocampal connections and spatial discrimination. Brain Res 1978, 139:295-308.
    • (1978) Brain Res , vol.139 , pp. 295-308
    • Olton, D.S.1    Walker, J.A.2    Gage, F.H.3
  • 145
    • 0027205322 scopus 로고
    • Distributed changes in c-Fos and c-Jun immunoreactivity in the rat brain associated with arousal and habituation to novelty
    • Papa M, Pellicano MP, Welzl H, Sadile AG Distributed changes in c-Fos and c-Jun immunoreactivity in the rat brain associated with arousal and habituation to novelty. Brain Res Bull 1993, 32:509-515.
    • (1993) Brain Res Bull , vol.32 , pp. 509-515
    • Papa, M.1    Pellicano, M.P.2    Welzl, H.3    Sadile, A.G.4
  • 147
    • 0000724791 scopus 로고
    • Spatial learning impairments in aged rats trained with a salient configuration of stimuli
    • Pelleymounter MA, Smith MY, Gallagher M Spatial learning impairments in aged rats trained with a salient configuration of stimuli. Psychobiology 1987, 15:248-254.
    • (1987) Psychobiology , vol.15 , pp. 248-254
    • Pelleymounter, M.A.1    Smith, M.Y.2    Gallagher, M.3
  • 148
    • 9644270708 scopus 로고    scopus 로고
    • Dementia-free centenarians
    • Perls T Dementia-free centenarians. Exp Gerontol 2004, 39:1587-1593.
    • (2004) Exp Gerontol , vol.39 , pp. 1587-1593
    • Perls, T.1
  • 151
    • 0035854504 scopus 로고    scopus 로고
    • Upregulation of the immediate early gene arc in the brains of rats exposed to environmental enrichment, Implications for molecu-lar plasticity
    • Pinaud R, Penner MR, Robertson HA, Currie RW Upregulation of the immediate early gene arc in the brains of rats exposed to environmental enrichment, Implications for molecu-lar plasticity. Brain Res Mol Brain Res 2001, 91:50-56.
    • (2001) Brain Res Mol Brain Res , vol.91 , pp. 50-56
    • Pinaud, R.1    Penner, M.R.2    Robertson, H.A.3    Currie, R.W.4
  • 152
    • 0029812884 scopus 로고    scopus 로고
    • Increased dendritic extent in hippocampal CA1 neurons from aged F344 rats
    • Pyapali GK, Turner DA Increased dendritic extent in hippocampal CA1 neurons from aged F344 rats. Neurobiol Aging 1996, 17:601-611.
    • (1996) Neurobiol Aging , vol.17 , pp. 601-611
    • Pyapali, G.K.1    Turner, D.A.2
  • 153
    • 0242460552 scopus 로고    scopus 로고
    • Dys-regulation of protein kinase a signaling in the aged prefrontal cortex, New strategy for treating age-related cognitive decline
    • Ramos BP, Birnbaum SG, Lindenmayer I, Newton SS, Duman RS, Arnsten AF Dys-regulation of protein kinase a signaling in the aged prefrontal cortex, New strategy for treating age-related cognitive decline. Neuron 2003, 40:835-845.
    • (2003) Neuron , vol.40 , pp. 835-845
    • Ramos, B.P.1    Birnbaum, S.G.2    Lindenmayer, I.3    Newton, S.S.4    Duman, R.S.5    Arnsten, A.F.6
  • 155
    • 0024439790 scopus 로고
    • Evidence for task-dependent memory dysfunction in the aged monkey
    • Rapp PR, Amaral DG Evidence for task-dependent memory dysfunction in the aged monkey. J Neurosci 1989, 9:3568-3576.
    • (1989) J Neurosci , vol.9 , pp. 3568-3576
    • Rapp, P.R.1    Amaral, D.G.2
  • 156
    • 0029821150 scopus 로고    scopus 로고
    • Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
    • Rapp PR, Gallagher M Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc Natl Acad Sci USA 1996, 93:9926-9930.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9926-9930
    • Rapp, P.R.1    Gallagher, M.2
  • 157
    • 0023139908 scopus 로고
    • An evaluation of spatial information processing in aged rats
    • Rapp PR, Rosenberg RA, Gallagher M An evaluation of spatial information processing in aged rats. Behav Neurosci 1987, 101:3-12.
    • (1987) Behav Neurosci , vol.101 , pp. 3-12
    • Rapp, P.R.1    Rosenberg, R.A.2    Gallagher, M.3
  • 158
    • 84882502860 scopus 로고    scopus 로고
    • Memory impaired aged rats, No loss of principal hippocampal and subicular neurons
    • Rasmussen T, Schliemann T, Sorensen JC, Zimmer J, West MJ Memory impaired aged rats, No loss of principal hippocampal and subicular neurons. Neurobiol Aging 1996, 27:1443-1447.
    • (1996) Neurobiol Aging , vol.27 , pp. 1443-1447
    • Rasmussen, T.1    Schliemann, T.2    Sorensen, J.C.3    Zimmer, J.4    West, M.J.5
  • 160
    • 4344695179 scopus 로고    scopus 로고
    • Age-related differences in performance on the Wisconsin card sorting test, A meta-analytic review
    • Rhodes MG Age-related differences in performance on the Wisconsin card sorting test, A meta-analytic review. Psychol Aging 2004, 19:482-494.
    • (2004) Psychol Aging , vol.19 , pp. 482-494
    • Rhodes, M.G.1
  • 161
    • 0037936789 scopus 로고    scopus 로고
    • Impact of aging on hippocampal function, Plasticity, network dynamics, and cognition
    • Rosenzweig ES, Barnes CA Impact of aging on hippocampal function, Plasticity, network dynamics, and cognition. Prog Neurobiol 2003, 69:143-179.
    • (2003) Prog Neurobiol , vol.69 , pp. 143-179
    • Rosenzweig, E.S.1    Barnes, C.A.2
  • 162
    • 0030686555 scopus 로고    scopus 로고
    • Role of temporal summation in age-related long-term potentiation-induction deficits
    • Rosenzweig ES, Rao G, McNaughton BL, Barnes CA Role of temporal summation in age-related long-term potentiation-induction deficits. Hippocampus 1997, 7:549-558.
    • (1997) Hippocampus , vol.7 , pp. 549-558
    • Rosenzweig, E.S.1    Rao, G.2    McNaughton, B.L.3    Barnes, C.A.4
  • 163
    • 10044297404 scopus 로고    scopus 로고
    • Spatial memory in aged rats is related to PKCgamma-dependent G-protein coupling of the Ml receptor
    • Rossi MA, Mash DC, deToledo-Morrell L Spatial memory in aged rats is related to PKCgamma-dependent G-protein coupling of the Ml receptor. Neurobiol Aging 2005, 26:53-68.
    • (2005) Neurobiol Aging , vol.26 , pp. 53-68
    • Rossi, M.A.1    Mash, D.C.2    deToledo-Morrell, L.3
  • 164
    • 0036181523 scopus 로고    scopus 로고
    • An examination of the Hofer and Sliwinski evaluation
    • Salthouse TA, Nesselroade JR An examination of the Hofer and Sliwinski evaluation. Gerontology 2002, 48:18-21.
    • (2002) Gerontology , vol.48 , pp. 18-21
    • Salthouse, T.A.1    Nesselroade, J.R.2
  • 165
    • 0029972070 scopus 로고    scopus 로고
    • The role of the hippo-campus and frontal cortex in age-related memory changes, A PET study
    • Schacter DL, Savage CR, Alpert NM, Rauch SL, Albert MS The role of the hippo-campus and frontal cortex in age-related memory changes, A PET study. Neuroreport 1996, 7:1165-1169.
    • (1996) Neuroreport , vol.7 , pp. 1165-1169
    • Schacter, D.L.1    Savage, C.R.2    Alpert, N.M.3    Rauch, S.L.4    Albert, M.S.5
  • 167
    • 0021918196 scopus 로고
    • Strain comparison of synaptic density in hippo-campal CA1 of aged rats
    • Scheff SW, Anderson KJ, DeKosky ST Strain comparison of synaptic density in hippo-campal CA1 of aged rats. Neurobiol Aging 1985, 6:29-34.
    • (1985) Neurobiol Aging , vol.6 , pp. 29-34
    • Scheff, S.W.1    Anderson, K.J.2    DeKosky, S.T.3
  • 168
    • 0018218935 scopus 로고
    • The hippocampus, Organizational patterns in health and senescence
    • Scheibel AB The hippocampus, Organizational patterns in health and senescence. Mech Aging Dev 1979, 9:89-102.
    • (1979) Mech Aging Dev , vol.9 , pp. 89-102
    • Scheibel, A.B.1
  • 171
    • 33747775155 scopus 로고    scopus 로고
    • Hippo-campal volume is preserved and fails to predict recognition memory impairment in aged rhesus monkeys (Macaca mulatta)
    • in press
    • Shamy JL, Buonocore MH, Makaron LM, Amaral DG, Barnes CA, Rapp PR Hippo-campal volume is preserved and fails to predict recognition memory impairment in aged rhesus monkeys (Macaca mulatta). Neurobiol Aging 2006, in press.
    • (2006) Neurobiol Aging
    • Shamy, J.L.1    Buonocore, M.H.2    Makaron, L.M.3    Amaral, D.G.4    Barnes, C.A.5    Rapp, P.R.6
  • 172
    • 16944363524 scopus 로고    scopus 로고
    • The effect of aging on experience-dependent plasticity of hippocampal place cells
    • Shen J, Barnes CA, McNaughton BL, Skaggs WE, Weaver KL The effect of aging on experience-dependent plasticity of hippocampal place cells. J Neurosci 1997, 77:6769-6782.
    • (1997) J Neurosci , vol.77 , pp. 6769-6782
    • Shen, J.1    Barnes, C.A.2    McNaughton, B.L.3    Skaggs, W.E.4    Weaver, K.L.5
  • 173
    • 0025267015 scopus 로고
    • The regulation and function of c-Fos and other immediate-early genes in the nervous system
    • Sheng M, Greenberg ME The regulation and function of c-Fos and other immediate-early genes in the nervous system. Neuron 1990, 4:477-485.
    • (1990) Neuron , vol.4 , pp. 477-485
    • Sheng, M.1    Greenberg, M.E.2
  • 174
    • 0021751688 scopus 로고
    • The influence of persistent crowding on the age changes in behavioral parameters and survival characteristics of rats
    • Skalicky M, Bubna-Littitz H, Hofecker G The influence of persistent crowding on the age changes in behavioral parameters and survival characteristics of rats. Mech Aging Dev 1984, 28:325-336.
    • (1984) Mech Aging Dev , vol.28 , pp. 325-336
    • Skalicky, M.1    Bubna-Littitz, H.2    Hofecker, G.3
  • 175
    • 2342557824 scopus 로고    scopus 로고
    • Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging
    • Small SA, Chawla MK, Buonocore M, Rapp PR, Barnes CA Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging. Proc Natl Acad Sci USA 2004, 101:7181-7186.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7181-7186
    • Small, S.A.1    Chawla, M.K.2    Buonocore, M.3    Rapp, P.R.4    Barnes, C.A.5
  • 176
    • 2342612629 scopus 로고    scopus 로고
    • Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons
    • Smith DE, Rapp PR, McKay HM, Roberts JA, Tuszynski MH Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J Neurosci 2004, 24:4373-4381.
    • (2004) J Neurosci , vol.24 , pp. 4373-4381
    • Smith, D.E.1    Rapp, P.R.2    McKay, H.M.3    Roberts, J.A.4    Tuszynski, M.H.5
  • 177
    • 0035174076 scopus 로고    scopus 로고
    • Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus
    • Smith DR, Hoyt EC, Gallagher M, Schwabe RF, Lund PK Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus. Neurobiol Aging 2001, 22:773-786.
    • (2001) Neurobiol Aging , vol.22 , pp. 773-786
    • Smith, D.R.1    Hoyt, E.C.2    Gallagher, M.3    Schwabe, R.F.4    Lund, P.K.5
  • 178
    • 0036881893 scopus 로고    scopus 로고
    • Local synthesis of proteins at synaptic sites on dendrites, Role in synaptic plasticity and memory consolidation?
    • Steward O, Worley P Local synthesis of proteins at synaptic sites on dendrites, Role in synaptic plasticity and memory consolidation?. Neurobiol Learn Mem 2002, 75:508-527.
    • (2002) Neurobiol Learn Mem , vol.75 , pp. 508-527
    • Steward, O.1    Worley, P.2
  • 179
    • 0002675721 scopus 로고
    • The age factor in animal learning, I. Rats in the problem box and the maze
    • Stone CP The age factor in animal learning, I. Rats in the problem box and the maze. Gen Psychol Monog 1929, 5:1-130.
    • (1929) Gen Psychol Monog , vol.5 , pp. 1-130
    • Stone, C.P.1
  • 180
    • 0002675723 scopus 로고
    • The age factor in animal learning, II. Rats in a multiple light discrimination box and a difficult maze
    • Stone CP The age factor in animal learning, II. Rats in a multiple light discrimination box and a difficult maze. Gen Psychol Monog 1929, 6:125-201.
    • (1929) Gen Psychol Monog , vol.6 , pp. 125-201
    • Stone, C.P.1
  • 181
    • 0029782113 scopus 로고    scopus 로고
    • Increase in single L-type calcium channels in hippocampal neurons during aging
    • Thibault O, Landfield PW Increase in single L-type calcium channels in hippocampal neurons during aging. Science 1996, 272:1017-1020.
    • (1996) Science , vol.272 , pp. 1017-1020
    • Thibault, O.1    Landfield, P.W.2
  • 182
    • 0033395289 scopus 로고    scopus 로고
    • Age-related changes in a human cognitive mapping system, Data from a computer-generated environment
    • Thomas KGF, Laurance HE, Luczak SE, Jacobs WJ Age-related changes in a human cognitive mapping system, Data from a computer-generated environment. CyberPsychol Beh 1999, 2:545-566.
    • (1999) CyberPsychol Beh , vol.2 , pp. 545-566
    • Thomas, K.G.F.1    Laurance, H.E.2    Luczak, S.E.3    Jacobs, W.J.4
  • 183
    • 0025174797 scopus 로고
    • Long-term stability of place-field activity of single units recorded from the dorsal hippocampus of freely behaving rats
    • Thompson LT, Best PJ Long-term stability of place-field activity of single units recorded from the dorsal hippocampus of freely behaving rats. Brain Res 1990, 509:299-308.
    • (1990) Brain Res , vol.509 , pp. 299-308
    • Thompson, L.T.1    Best, P.J.2
  • 184
    • 14944380610 scopus 로고    scopus 로고
    • The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats
    • Tombaugh GC, Rowe WB, Rose GM The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats. J Neurosci 2005, 25:2609-2616.
    • (2005) J Neurosci , vol.25 , pp. 2609-2616
    • Tombaugh, G.C.1    Rowe, W.B.2    Rose, G.M.3
  • 185
    • 0037327648 scopus 로고    scopus 로고
    • Fos imaging reveals ageing-related changes in hip-pocampal response to radial maze discrimination testing in mice
    • Touzani K, Marighetto A, Jaffard R Fos imaging reveals ageing-related changes in hip-pocampal response to radial maze discrimination testing in mice. Bur J Neurosci 2003, 17:628-640.
    • (2003) Bur J Neurosci , vol.17 , pp. 628-640
    • Touzani, K.1    Marighetto, A.2    Jaffard, R.3
  • 186
    • 0027615883 scopus 로고
    • Episodic spatial memory in adulthood
    • Uttl B, Graf P Episodic spatial memory in adulthood. Psychol Aging 1993, 5:257-273.
    • (1993) Psychol Aging , vol.5 , pp. 257-273
    • Uttl, B.1    Graf, P.2
  • 187
    • 0022399751 scopus 로고
    • Spatial memory and visual evoked potentials in young and old rats after housing in an enriched environment
    • van Gool WA, Mirmiran M, van Haaren F Spatial memory and visual evoked potentials in young and old rats after housing in an enriched environment. Behav Neural Biol 1985, 44:454-469.
    • (1985) Behav Neural Biol , vol.44 , pp. 454-469
    • van, G.W.A.1    Mirmiran, M.2    van, H.F.3
  • 188
    • 2942572946 scopus 로고    scopus 로고
    • Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan, A review and meta-analysis
    • Van Petten C Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan, A review and meta-analysis. Neuropsychologia 2004, 42:1394-1413.
    • (2004) Neuropsychologia , vol.42 , pp. 1394-1413
    • Van, P.C.1
  • 189
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • van Praag H, Shubert T, Zhao C, Gage FH Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 2005, 25:8680-8685.
    • (2005) J Neurosci , vol.25 , pp. 8680-8685
    • van, P.H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.4
  • 190
    • 2542637241 scopus 로고    scopus 로고
    • Altered hip-pocampal transcript profile accompanies an age-related spatial memory deficit in mice
    • Verbitsky M, Yonan AL, Malleret G, Kandel ER, Gilliam TC, Pavlidis P Altered hip-pocampal transcript profile accompanies an age-related spatial memory deficit in mice. Learn Mem 2004, 11:253-260.
    • (2004) Learn Mem , vol.11 , pp. 253-260
    • Verbitsky, M.1    Yonan, A.L.2    Malleret, G.3    Kandel, E.R.4    Gilliam, T.C.5    Pavlidis, P.6
  • 191
    • 84882537647 scopus 로고
    • Studies in learning and memory in ageing rats
    • Verzar-McDougall E Studies in learning and memory in ageing rats. Gerontologia 1957, 35:355-363.
    • (1957) Gerontologia , vol.35 , pp. 355-363
    • Verzar-McDougall, E.1
  • 192
    • 0029146583 scopus 로고
    • Corre-spondence between sites of NGFI-A induction and sites of morphological plasticity following exposure to environmental complexity
    • Wallace CS, Withers GS, Weiler IJ, George JM, Clayton DF, Greenough WT Corre-spondence between sites of NGFI-A induction and sites of morphological plasticity following exposure to environmental complexity. Brain Res Mol Brain Res 1995, 32:211-220.
    • (1995) Brain Res Mol Brain Res , vol.32 , pp. 211-220
    • Wallace, C.S.1    Withers, G.S.2    Weiler, I.J.3    George, J.M.4    Clayton, D.F.5    Greenough, W.T.6
  • 193
    • 0018852193 scopus 로고
    • Animal models of declining memory in the aged, Short-term and spatial memory in the aged rat
    • Wallace JE, Krauter EE, Campbell BA Animal models of declining memory in the aged, Short-term and spatial memory in the aged rat. J Gerontol 1980, 35:355-363.
    • (1980) J Gerontol , vol.35 , pp. 355-363
    • Wallace, J.E.1    Krauter, E.E.2    Campbell, B.A.3
  • 194
    • 0027164617 scopus 로고
    • Regionally specific loss of neurons in the aging human hippocampus
    • West MJ Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 1993, 14:287-293.
    • (1993) Neurobiol Aging , vol.14 , pp. 287-293
    • West, M.J.1
  • 195
    • 0012684884 scopus 로고
    • Preserved hippocampal cell number in aged monkeys with recognition memory deficits
    • West MJ, Amaral DJ, Rapp PR Preserved hippocampal cell number in aged monkeys with recognition memory deficits. Soc Neurosci Abst 1993, 19:599.
    • (1993) Soc Neurosci Abst , vol.19 , pp. 599
    • West, M.J.1    Amaral, D.J.2    Rapp, P.R.3
  • 196
    • 0030239808 scopus 로고    scopus 로고
    • An application of prefrontal cortex function theory to cognitive aging
    • West RL An application of prefrontal cortex function theory to cognitive aging. Psychol Bull 1996, 120:272-292.
    • (1996) Psychol Bull , vol.120 , pp. 272-292
    • West, R.L.1
  • 197
    • 22544475288 scopus 로고    scopus 로고
    • Age-associated alterations of hippocampal place cells are subregion specific
    • Wilson IA, Ikonen S, Gallagher M, Eichenbaum H, Tanila H Age-associated alterations of hippocampal place cells are subregion specific. J Neurosci 2005, 25:6877-6886.
    • (2005) J Neurosci , vol.25 , pp. 6877-6886
    • Wilson, I.A.1    Ikonen, S.2    Gallagher, M.3    Eichenbaum, H.4    Tanila, H.5
  • 198
    • 0027440875 scopus 로고
    • Dynamics of the hippocampal ensemble code for space
    • Wilson MA, McNaughton BL Dynamics of the hippocampal ensemble code for space. Science 1993, 261:1055-1058.
    • (1993) Science , vol.261 , pp. 1055-1058
    • Wilson, M.A.1    McNaughton, B.L.2
  • 199
    • 0027443739 scopus 로고
    • Thresholds for synpatic activation of transcription factors in hippocampus, Correlation with long-term enhancement
    • Worley PF, Bhat RV, Baraban JM, Erickson CA, McNaughton BL, Barnes CA Thresholds for synpatic activation of transcription factors in hippocampus, Correlation with long-term enhancement. J Neurosci 1993, 13:4776-4786.
    • (1993) J Neurosci , vol.13 , pp. 4776-4786
    • Worley, P.F.1    Bhat, R.V.2    Baraban, J.M.3    Erickson, C.A.4    McNaughton, B.L.5    Barnes, C.A.6
  • 200
    • 0030477815 scopus 로고    scopus 로고
    • Decreased NGFI-A gene expression in the hippocampus of cognitively impaired aged rats
    • Yau JL, Olsson T, Morris RG, Noble J, Seckl JR Decreased NGFI-A gene expression in the hippocampus of cognitively impaired aged rats. Brain Res Mol Brain Res 1996, 42:354-357.
    • (1996) Brain Res Mol Brain Res , vol.42 , pp. 354-357
    • Yau, J.L.1    Olsson, T.2    Morris, R.G.3    Noble, J.4    Seckl, J.R.5
  • 201
    • 0028934097 scopus 로고
    • CREB as a memory modulator, Induced expression of a CREB2 activator isoform enhances long-term memory in
    • Yin JC, Del Vecchio M, Zhou H, Tully T CREB as a memory modulator, Induced expression of a CREB2 activator isoform enhances long-term memory in. Drosophila. Cell 1995, 81:107-115.
    • (1995) Drosophila. Cell , vol.81 , pp. 107-115
    • Yin, J.C.1    Del, V.M.2    Zhou, H.3    Tully, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.