Complex maze learning in rodents as a model of age-related memory impairment

Neurobiology of Aging

Volumn 9, Issue C, 1988, Pages 475-485

  Ingram, Donald K ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Aging; Animal models; Cholinergic system; Fimbria fornix; Hippocampus; Learning; Memory; Mice; Rats; Rigidity; Scopolamine

Indexed keywords

SCOPOLAMINE;

AGE; ANIMAL MODEL; CHOLINERGIC SYSTEM; HIPPOCAMPUS; LEARNING; MEMORY; MOUSE; NONHUMAN; PSYCHOLOGICAL ASPECT; RAT; REVIEW;

AGING; ANIMAL; DISEASE MODELS, ANIMAL; LEARNING DISORDERS; MALE; MEMORY DISORDERS; RATS; RATS, INBRED F344; RATS, INBRED STRAINS;

EID: 0024157751     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(88)80101-5     Document Type: Review

References (64)

1. Spatial memory of children and adults assessed in the radial maze
2. Comparison of the effects of nucleus basalis, diagonal band and septal lesions on learning and memory in Sprague-Dawley rats
3. Spatial memory deficit in senescent rats
4. Age-related changes in passive avoidance retention: Modulation with dietary choline
5. The cholinergic hypothesis of geriatric memory dysfunction
6. Logical principles for the development of animal models of age-related memory impairments
7. The need for common perspectives on the development and use of animal models for age-related neurodegenerative disorders
8. Preservation of accurate spatial memory in aged rats
9. Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats
10. Impaired regulation of arousal in old age and the consequences for learning and memory: Replacement of brain norepinephrine via neuron transplants improves memory performance in aged F-344 rats
11. Cognitive mapping elderly adults: Verbal location memory for urban landmarks
12. Intracerebral grafting in the aging brain
13. Intrahippocampal septal grafts ameliorate learning impairments in aged rats
14. Spatial learning and motor deficits in aged rats
15. Effects of opiate antagonists on spatial memory in young and aged rats
16. Spatial learning deficits in old rats: A model for memory decline in the aged
17. Influence of the goal on children's exploration and memory of large-scale space
18. Learning, retention, and extinction of a complex maze habit for mature-young and senescent Wistar albino rats
19. Learning by mature-young and aged Wistar rats as a function of test complexity
20. Maze teaming of mature-young and aged rats as a function of distribution of practice
21. Behavioral rigidity as a mechanism for facilitation of problem solving for aged rats
22. Problem solving and age: A critique of rodent research
23. Effects of lifelong restricted feeding on complex maze performance in rats
24. Cholinergic neurons, learning, and recovery of function
25. Toward the behavioral assessment of biological aging in the laboratory mouse: Concepts, terminology, and objectives
26. Biological age: A strategy for assessment
27. Analysis of age-related impairments in learning and memory in rodent models
28. Motor performance variability during aging in rodents Assessment of reliability and validity of individual differences
29. Assessing the predictive validity of psychomotor tests as measures of biological age in mice
30. Dietary restriction benefits learning and motor performance of aged mice
31. Neurobiological views of memory
32. Basal forebrain lesions produce a dissociation of trial-dependent and trial-independent memory performance
33. Age differences of response strategy in radial maze performance of Fischer-344 rats
34. Principles of spatial problem solving
35. Conformational changes in muscarinic receptors may produce diminished cholinergic neurotransmission and memory deficits in aged rats
36. Discrimination learning requiring different memory components in rats: Age and neurochemical comparisons
37. Fiber systems of the forebrain
38. Performance differences in a complex maze between young and aged rats
39. Hippocampus, space, and memory
40. Hippocampal function: Working memory or cognitive mapping?
41. Dementia: Animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system
42. Differences in human memory with aging: Nature, causes, and clinical implications
43. Memory for object locations in young and elderly adults
44. Scopolamine impairs learning performance of rats in a 14-unit T-maze
45. Scopolamine in rats impairs acquisition but not retention in a 14-unit T-maze
46. Age-related impairment in complex maze learning in rats Relationship to neophobia and cholinergic antagonism
47. The age factor in animal learning: I. Rats in the problem box and the maze
48. Memory: Time binding in organisms
49. Differential effects of posterior septal lesions on dispositional and representational memory
50. Studies in learning and memory in ageing rats
51. Effect of contextual organization on spatial memory of middle-aged and older women
52. Animal models of declining memory in the aged: Short-term and spatial memory in aged rat
53. Co-dergocrine, cerebral glucose utilization and maze performance in middle-aged rats
54. Effects of scopolamine on radial maze performance in rats
55. Dietary restriction and the aging process
56. Pharmacological manipulations of the substantia innominatacortical cholinergic pathway
57. The hippocampus and cue-utilization
58. Cue-dependent behavior of hippocampally damaged rats in a complex maze
59. Catecholamine system involvement in age-related memory dysfunction