Upregulation of the immediate early gene arc in the brains of rats exposed to environmental enrichment: Implications for molecular plasticity

Molecular Brain Research

Volumn 91, Issue 1-2, 2001, Pages 50-56

  Pinaud, Raphael ^a   Penner, Marsha R ^b   Robertson, Harold A ^b   Currie, R William ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Arc; Dendrite; Enriched environment; NGFI A; Plasticity; Transcription factor

Indexed keywords

MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CORPUS STRIATUM; DENTATE GYRUS; ENVIRONMENT; ENVIRONMENTAL EXPOSURE; GENE CONTROL; GENE EXPRESSION; HIPPOCAMPUS; IMMEDIATE EARLY GENE; IN SITU HYBRIDIZATION; MALE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN CHEMISTRY; CEREBRAL CORTEX; CORPUS STRIATUM; CYTOSKELETAL PROTEINS; DENDRITES; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; ENVIRONMENT; GENE EXPRESSION; GENES, IMMEDIATE-EARLY; HIPPOCAMPUS; IMMEDIATE-EARLY PROTEINS; IN SITU HYBRIDIZATION; MALE; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0035854504     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00121-8     Document Type: Article

References (25)

1. Long-term potentiation of synaptic transmission in the hippocampus: Properties and mechanisms
2. Dendritic reorganization in the denervated dentate gyrus of the rat following entorhinal cortical lesions: A Golgi and electron microscopic analysis
3. Neural activity mapping with inducible transcription factors
4. Possible ways in which synaptic mechanisms participate in learning, remembering and forgetting
5. Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment
6. Neonatal handling and environmental enrichment effects on emotionality, novelty/reward seeking, and age-related cognitive and hippocampal impairments: Focus on the Roman rat lines
7. Effects of differential experience on dendritic spine counts in rat cerebral cortex
8. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory
9. Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: Evidence for changes in length and orientation associated with chemically induced LTP
10. Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain
11. Activation of arc gene, a dendritic immediate early gene, by middle cerebral artery occlusion in rat brain
12. Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites
13. Spine loss and regrowth in hippocampus following deafferentation
14. Brief exposure to an enriched environment improves performance on the Morris water task and increases hippocampal cytosolic protein kinase C activity in young rats
15. The human synapsin II gene promoter. Possible role for the transcription factor zif268/egr-1, polyoma enhancer activator 3, and AP2
16. Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year
17. Environmental enrichment from birth enhances visual acuity but not place learning in mice
18. Brain changes in relation to experience
19. Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites
20. Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1
21. Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus
22. Rearing complexity affects branching of dendrites in the visual cortex of the rat
23. Correspondence between sites of NGFI-A induction and sites of morphological plasticity following exposure to environmental complexity
24. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective