Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation

Journal of Cellular Biochemistry

Volumn 109, Issue 1, 2010, Pages 152-161

  Nishioka, Takashi ^a   Guo, Jinjin ^a   Yamamoto, Daisuke ^a   Chen, Lihua ^a   Huppi, Petra ^b   Chen, Chang Yan ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Lung cells; Mitogenic pathways; Nicotine acetylcholine receptor; Nitrosamines

Indexed keywords

[4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE]; CARCINOGEN; CISPLATIN; MECAMYLAMINE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINE; NICOTINIC RECEPTOR; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL GROWTH; CELL PROTECTION; CELL SURVIVAL; CELL TRANSFORMATION; CIGARETTE SMOKING; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ASSAY; EXPOSURE; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOGENS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CISPLATIN; DNA FRAGMENTATION; HUMANS; IMMUNOBLOTTING; MICE; NICOTINE; NICOTINIC AGONISTS; NITROSAMINES; RATS; RECEPTORS, NICOTINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UP-REGULATION;

NICOTIANA TABACUM;

EID: 73849130392     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22392     Document Type: Article

References (43)

1. Adrain C, Martin SJ. 2001. The mitochondrial apoptosome: A killer unleashed by the cytochrome seas. Trends Biochem Sci 26:390-397.
2. Arredondo J, Nguyen VT, Chernyavsky AI, Jolkovsky DL, Pinkerton KE, Grando SA. 2001. A receptor-mediated mechanism of nicotine toxicity in oral keratinocytes. Lab Invest 81:1653-1668.
3. Arredondo J, Chernyavsky AI, Marubio LM, Beaudet AL, Jolkovsky DL, Pinkerton KE, Grando SA. 2005. Receptor-mediated tobacco toxicity: Regulation of gene expression through alpha3beta2 nicotinic receptor in oral epithelial cells. Am J Pathol 166:597-613.
4. Arredondo J, Chernyavsky AI, Grando SA. 2006. Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells. Cancer Biol Ther 5:511-517.
5. Assis GF, Ceolin DS, Marques ME, Salvadori DM, Ribeiro DA. 2005. Cigarette smoke affects apoptosis in rat tongue mucosa: Role of bcl-2 gene family. J Mol Histol 36:483-489.
6. Bose C, Zhang H, Udupa KB, Chowdhury P. 2005. Activation of p-EKR1/2 by nicotine in pancreatic tumor cell line AR42J: Effects on proliferation and secretion. Am J Physiol Gastrointest Liver Physiol 289:G926-G934.
7. Castro NG, Albuquerque EX. 1995. alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability. Biophys J 68:516-524.
8. Colin J, Gaumer S, Guenal I, Mignotte B. 2009. Mitochondria, Bcl-2 family proteinand apoptosomes: Ofworms, flies and men. Front Biosci 14:4127-4137.
9. Cotter TG. 2009. Apoptosis and cancer: The genesis of a research field. Nat Rev Cancer 9:501-507.
10. Dasgupta P, Rizwani W, Pilai S, Kinkade R, Kovacs M, Rastogi S, Banerjee S, Carless M, Kim E, Coppola D, Haura E, Chellappan S. 2009. Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. Int J Cancer 124:36-45.
11. Dasgupta P, Rastogi S, Pillai S, Ordonez-Ercan D, Morris M, Haura E, Chellappan S. 2006. Nicotine induces cell proliferation by beta-arrestin- mediated activation of Src and Rb-Raf-1 pathways. J Clin Invest 116:2208-2217.
12. Denis GV, Yu Q, Ma P, Deeds L, Faller DV, Chen CY. 2003. Bcl-2, via its BH4 domain, blocks apoptotic signaling mediated by mitochondrial Ras. J Biol Chem 278:5775-5782.
13. Gallo O, Bianchi S, Porfirio B. 1995. Bcl-2 overexpression and smoking history in head and neck cancer. J Natl Cancer Inst 87:1024-1025.
14. Gomez DE, Skilton G, Alonso DF, Kazanietz MG. 1999. The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review). Oncol Rep 6:1363-1370.
15. Gottlieb RA. 2009. Mitochondria: Execution central. FEBS Lett 482:6-12.
16. Guo J, Chu M, Abbeyquaye T, Chen CY. 2005. Persistent nicotine treatment potentiates DHFR amplification in rat lung epithelial cells as a consequence of Ras activation. J Biol Chem 280:30422-30431.
17. Guo J, Ibaragi S, Zhu T, Luo LY, Hu GF, Huppi PS, Chen CY. 2008. Nicotine promotes mammary tumor migration via a signaling cascade involving protein kinase C and CDC42. Cancer Res 68:8473-8478.
18. Hata Y, Rook SL, Aiello LP. 1999. Basic fibroblast growth factor induces expression of VEGF receptor KDR through a protein kinase C and p44/p42 mitogen-activated protein kinase-dependent pathway. Diabetes 48:1145-1155.
19. Hecht SS. 2002. Cigarette smoking and lung cancer: Chemical mechanisms and approaches to prevention. Lancet Oncol 3:461-469.
20. Hecht SS, Abbaspour A, Hoffman D. 1988, A study of tobacco carcinogenesis. XLII. Bioassay in A/J mice of some structural analogues of tobacco-specific nitrosamines. Cancer Lett 42:141-145.
21. Heeschen C, Jang JJ, Weis M, Pathak A, Kaji S, Hu RS, Tsao PS, Johnson FL, Cooke JP. 2001. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med 7:833-839.
22. Heeschen C, Weis M, Aicher A, Dimmeler S, Cooke JP. 2002. A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J Clin Invest 110:527-536.
23. Heeschen C, Weis M, Cooke JP. 2003. Nicotine promotes arteriogenesis. J Am Coll Cardiol 41:489-496.
24. Heusch WL, Maneckjee R. 1998. Signaling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis 19:551-556.
25. Karnath B. 2002. Smoking cessation. Am J Med 112:399-405.
26. Kurinna S, Konopleva M, Palla SL, Chen W, Kornblau S, Contractor R, Deng X, May WS, Andreeff M, Ruvolo PP. 2006. Bcl2 phosphorylation and active PKC alpha are associated with poor survival in AML. Leukemia 20:1316-1319.
27. Mai H, May WS, Gao F, Jin Z, Deng X. 2003. A functional role for nicotine in Bcl-2 phosphorylation and suppression of apoptosis. J Biol Chem 278:6369-6379.
28. Minna JD. 2003. Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. J Clin Invest 111:31-90.
29. Nakayama H, Numakawa T, Ikeuchi T. 2002. Nicotine-induced phosphorylation of Akt through epidermal growth factor receptor and Src in PC12h cells. J Neurochem 83:1372-1379.
30. Newton AC. 1995. Protein kinase C: Structure, function, and regulation. J Biol Chem 270:28495-28498.
31. Nguyen VT, Hall LL, Gallacher G, Ndoye A, Jolkovsky DL, Webber RJ, Buchli R, Grando SA. 2000. Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia. J Dent Res 79:939-949.
32. Plummer HK, Sheppard BJ, Schuller HM. 2000. Interaction of tobacco-specific toxicants with nicotinic cholinergic regulation of fetal pulmonary neuroendocrine cells: Implications for pediatric lung disease. Exp Lung Res 26:121-135.
33. Ruvolo PP, Deng X, Carr BK, May WS. 1998. A functional role for mitochondrial protein kinase Calpha in Bcl-2 phosphorylation and suppression of apoptosis. J Biol Chem 273:25436-25442.
34. Sánchez-Elsner T, Botella LM, Velasco B, Corbí A, Attisano L, Bernabéu C. 2001. Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem 276:38527-38535.
35. Sato T, Abe T, Nakamoto N, Tomaru Y, Koshikiya N, Nojima J, Kokabu S, Sakata Y, Kobayashi A, Yoda T. 2008. Nicotine induces cell proliferation in association with cyclin D1 up-regulation and inhibits cell differentiation in association with p53 regulation in a murine pre-osteoblastic cell line. Biochem Biophys Res Commun 377:126-130.
36. Schuller HM, Orloff M. 1998. Tobacco-specific carcinogenic nitrosamines. Biochem Pharmacol 55:1377-1384.
37. Schuller HM, Jull BA, Sheppard BJ, Plummer HK. 2000. Interaction of tobacco-specific toxicants with the neuronal alpha 7 nictoinic acetylcholine receptor and its associated mitogenic signal transduction pathway: Potential role in lung carcinogenesis and pediatric lung disorders. Eur J Pharmacol 393:265-277.
38. Sckido Y, Fong KM, Minna JD. 2003. Molecular genetics of lung cancer. Annu Rev Med 54:73-87.
39. Seguela P, Wadiche J, Dineley-Miller K, Dani JA, Patrick JW. 1993. Molecular cloning, functional properties, and distribution of rat brain alpha 7: A nicotinic cation channel highly permeable to calcium. J Neurosci 13:596-604.
40. Shin VY, Wu WK, Ye YN, So WH, Koo MW, Liu ES, Luo JC, Cho CH. 2004. Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2. Carcinogenesis 25:2487-2495.
41. Shin VY, Wu WK, Chu KM, Wong HP, Lam EK, Tai EK, Koo MW, Cho CH. 2005. Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Mol Cancer Res 3:607-615.
42. Xin M, Deng X. 2005. Nicotine inactivation of the proapoptotic function of Bax through phosphorylation. J Biol Chem 280:10781-10789.
43. Xu L, Deng X. 2006. Protein kianse Cτ promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of μ and τ-calpains. J Biol Chem 281:4457-4466.