Nicotine acts on growth plate chondrocytes to delay skeletal growth through the α7 neuronal nicotinic acetylcholine receptor

PLoS ONE

Volumn 3, Issue 12, 2008, Pages

  Kawakita, Atsuo ^a,b   Sato, Kazuki ^b   Makino, Hatsune ^a   Ikegami, Hiroyasu ^b   Takayama, Shinichiro ^c   Toyama, Yoshiaki ^b   Umezawa, Akihiro ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGAROSE; ALGINIC ACID; BUNGAROTOXIN RECEPTOR; CALCIUM ION; DRINKING WATER; METHYLLYCACONITINE; NICOTINE; ALPHA-BUNGAROTOXIN RECEPTOR; CALCIUM; GLUCURONIC ACID; HEXURONIC ACID; MICROSPHERE; NICOTINIC RECEPTOR; PROTEIN SUBUNIT; SEPHAROSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE GROWTH; CALCIUM SIGNALING; CARTILAGE CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; EXTRACELLULAR MATRIX; FEMALE; FINGER; GROWTH PLATE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSSIFICATION; OVULATION; PREGNANCY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BONE DEVELOPMENT; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; GEL; GENETICS; METABOLISM; MUTATION; PROTEIN TRANSPORT; TIME;

MURINAE; MUS;

ALGINATES; ANIMALS; BONE DEVELOPMENT; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; CHONDROCYTES; FEMALE; GELS; GLUCURONIC ACID; GROWTH PLATE; HEXURONIC ACIDS; HUMANS; MATERNAL EXPOSURE; MICE; MICROSPHERES; MUTATION; NICOTINE; PROTEIN SUBUNITS; PROTEIN TRANSPORT; RECEPTORS, NICOTINIC; SEPHAROSE; TIME FACTORS;

EID: 58049195704     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003945     Document Type: Article

References (28)

1. Davies DP, Abernethy M (1976) Cigarette smoking in pregnancy: Associations with maternal weight gain and fetal growth. Lancet 1: 385-387.
2. Hardy JB, Mellits ED (1972) Does maternal smoking during pregnancy have a long-term effect on the child? Lancet 2: 1332-1336.
3. Wingerd J, Schoen EJ (1974) Factors influencing length at birth and height at five years. Pediatrics 53: 737-741.
4. Karatza AA, Varvarigou A, Beratis NG (2003) Growth up to 2 years in relationship to maternal smoking during pregnancy. Clin Pediatr (Phila) 42: 533-541.
5. Sexton M, Hebel JR (1984) A clinical trial of change in maternal smoking and its effect on birth weight. Jama 251: 911-915.
6. Yerushalmy J (1971) The relationship of parents' cigarette smoking to outcome of pregnancy-implications as to the problem of inferring causation from observed associations. Am J Epidemiol 93: 443-456.
7. Olsen J, Pereira Ada C, Olsen SF (1991) Does maternal tobacco smoking modify the effect of alcohol on fetal growth? Am J Public Health 81: 69-73.
8. Trygg K, Lund-Larsen K, Sandstad B, Hoffman HJ, Jacobsen G, et al. (1995) Do pregnant smokers eat differently from pregnant non-smokers? Paediatr Perinat Epidemiol 9: 307-319.
9. Haddon W Jr, Nesbitt RE, Garcia R (1961) Smoking and pregnancy: carbon monoxide in blood during gestation and at term. Obstet Gynecol 18: 262-267.
10. Mochizuki M, Maruo T, Masuko K (1985) Mechanism of foetal growth retardation caused by smoking during pregnancy. Acta Physiol Hung 65: 295-304.
11. Nordstrom ML, Cnattingius S (1996) Effects on birthweights of maternal education, socio-economic status, and work-related characteristics. Scand J Soc Med 24: 55-61.
12. Mau G (1976) Letter: Smoking and the fetus. Lancet 1: 972.
13. Nelson E, Jodscheit K, Guo Y (1999) Maternal passive smoking during pregnancy and fetal developmental toxicity. Part 1: gross morphological effects. Hum Exp Toxicol 18: 252-256.
14. El-Zawawy HB, Gill CS, Wright RW, Sandell LJ (2006) Smoking delays chondrogenesis in a mouse model of closed tibial fracture healing. J Orthop Res 24: 2150-2158.
15. Olsen J (1992) Cigarette smoking in pregnancy and fetal growth. Does the type of tobacco play a role? Int J Epidemiol 21: 279-284.
16. Sharma G, Vijayaraghavan S (2002) Nicotinic receptor signaling in nonexcitable cells. J Neurobiol 53: 524-534.
17. Arneric SP, Brioni JD (1999) Neuronal nicotinic receptors : pharmacology and therapeutic opportunities. New York: Wiley-Liss, xii, 421 p.
18. Tacchetti C, Quarto R, Nitsch L, Hartmann DJ, Cancedda R (1987) In vitro morphogenesis of chick embryo hypertrophic cartilage. J Cell Biol 105: 999-1006.
19. Hauselmann HJ, Fernandes RJ, Mok SS, Schmid TM, Block JA, et al. (1994) Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads. J Cell Sci 107 (Pt1): 17-27.
20. Kurtoglu S, Gunes T, Koklu E, Bastug O, Canoz O, et al. (2007) Influence of maternal nicotine exposure on neonatal rat bone: protective effect of pentoxifylline. Exp Biol Med (Maywood) 232: 398-405.
21. Gullahorn L, Lippiello L, Karpman R (2005) Smoking and osteoarthritis: differential effect of nicotine on human chondrocyte glycosaminoglycan and collagen synthesis. Osteoarthritis Cartilage 13: 942-943.
22. Orr-Urtreger A, Goldner FM, Saeki M, Lorenzo I, Goldberg L, et al. (1997) Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. J Neurosci 17: 9165-9171.
23. Arredondo J, Nguyen VT, Chernyavsky AI, Bercovich D, Orr-Urtreger A, et al. (2002) Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. J Cell Biol 159: 325-336.
24. Luck W, Nau H, Hansen R, Steldinger R (1985) Extent of nicotine and cotinine transfer to the human fetus, placenta and amniotic fluid of smoking mothers. Dev Pharmacol Ther 8: 384-395.
25. Dempsey D, Jacob P 3rd, Benowitz NL (2000) Nicotine metabolism and elimination kinetics in newborns. Clin Pharmacol Ther 67: 458-465.
26. Sano M, Umezawa A, Abe H, Akatsuka A, Nonaka S, et al. (2001) EAT/mcl-1 expression in the human embryonal carcinoma cells undergoing differentiation or apoptosis. Exp Cell Res 266: 114-125.
27. Sano M, Umezawa A, Suzuki A, Shimoda K, Fukuma M, et al. (2000) Involvement of EAT/mcl-1, an anti-apoptotic bcl-2-related gene, in murine embryogenesis and human development. Exp Cell Res 259: 127-139.
28. Benya PD, Shaffer JD (1982) Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30: 215-224.