Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer

American Journal of Respiratory Cell and Molecular Biology

Volumn 40, Issue 2, 2009, Pages 135-146

  Zhang, Jingmei ^a   Kamdar, Opal ^a   Le, Wei ^a   Rosen, Glenn D ^a   Upadhyay, Daya ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Chemotherapy; Lung cancer; Mitochondria; Nicotine

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CASPASE 9; CISPLATIN; ETOPOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; NICOTINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; X LINKED INHIBITOR OF APOPTOSIS; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CARCINOGEN; CASP9 PROTEIN, HUMAN; NICOTINIC AGENT; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LUNG CANCER; MITOCHONDRIAL MEMBRANE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; LUNG TUMOR; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PATHOLOGY; PROTEIN TRANSPORT; SMOKING; TUMOR CELL LINE;

NICOTIANA TABACUM;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOGENS; CASPASE 9; CELL LINE, TUMOR; CISPLATIN; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; HUMANS; LUNG NEOPLASMS; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NICOTINE; NICOTINIC AGONISTS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SMOKING;

EID: 59149087660     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2007-0277OC     Document Type: Article

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