Functional RNA interference (RNAi) screen identifies System a Neutral Amino Acid Transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress

Journal of Biological Chemistry

Volumn 287, Issue 8, 2012, Pages 6025-6034

  Oh, Raymond S ^a   Pan, Wen Chi ^a   Yalcin, Abdullah ^a   Zhang, Hong ^b   Guilarte, Tomás R ^c   Hotamisligil, Gökhan S ^a   Christiani, David C ^a   Lu, Quan ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; ADAPTIVE RESPONSE; AMINO ACID TRANSPORTER; CELL MODEL; CELL SORTING; CELLULAR LEVELS; CELLULAR MECHANISMS; ENDOPLASMIC RETICULUM STRESS; ENVIRONMENTAL TOXINS; ER STRESS; HUMAN DISEASE; HUMAN GENES; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); PROTEOTOXICITY; RNA INTERFERENCE; STRESS RESPONSE; TUNICAMYCIN;

AMINO ACIDS; ANTIBIOTICS; CELL MEMBRANES; CHEMICAL ACTIVATION; DISEASES; FLOW CYTOMETRY; GENES; RNA; SODIUM; TRANSCRIPTION FACTORS;

ARSENIC;

AMINO ACID TRANSPORTER; ARSENIC; ARSENIC TRIOXIDE; GLUTAMINE; MAMMALIAN TARGET OF RAPAMYCIN; SHORT HAIRPIN RNA; SODIUM DEPENDENT NEUTRAL AMINO ACID TRANSPORTER 2; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVITY; CELL ISOLATION; CELL SELECTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; MEDIATOR; MOLECULAR LIBRARY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID TRANSPORT SYSTEM A; ARSENIC; ARSENITES; ENDOPLASMIC RETICULUM STRESS; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION; GENOMICS; HEK293 CELLS; HUMANS; RNA INTERFERENCE; TOR SERINE-THREONINE KINASES;

EID: 84863117098     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.311217     Document Type: Article

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