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Volumn 3, Issue 2, 2012, Pages 227-244

Cancer stem cell targeting: The next generation of cancer therapy and molecular imaging

Author keywords

A subset of the bulk cancer that gives rise to all cell types found in a particular cancer. They are responsible for initiating and maintaining the cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CATUMAXOMAB; CD133 ANTIGEN; CD33 ANTIGEN; EPITHELIAL CELL ADHESION MOLECULE; GEMCITABINE; GEMTUZUMAB OZOGAMICIN; HERMES ANTIGEN; IPI 926; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SONIC HEDGEHOG PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; VISMODEGIB; WNT PROTEIN;

EID: 84863115835     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.11.148     Document Type: Review
Times cited : (34)

References (199)
  • 1
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumors and metastases
    • Klein CA. Parallel progression of primary tumors and metastases. Nat. Rev. Cancer 9, 202-212 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 202-212
    • Klein, C.A.1
  • 2
    • 0345059767 scopus 로고    scopus 로고
    • Applying the principles of stem-cell biology to cancer
    • Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat. Rev. Cancer 3, 895-902 (2003). (Pubitemid 37500174)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.12 , pp. 895-902
    • Pardal, R.1    Clarke, M.F.2    Morrison, S.J.3
  • 4
    • 77953810074 scopus 로고    scopus 로고
    • Cancer stem cells at the crossroads of current cancer therapy failures: Radiation oncology perspective
    • Koch U, Krause M, Baumann M. Cancer stem cells at the crossroads of current cancer therapy failures: radiation oncology perspective. Semin. Cancer Biol. 20, 116-124 (2010).
    • (2010) Semin. Cancer Biol. , vol.20 , pp. 116-124
    • Koch, U.1    Krause, M.2    Baumann, M.3
  • 5
    • 77953809918 scopus 로고    scopus 로고
    • Normal stem cells and cancer stem cells: Similar and different
    • Shackleton M. Normal stem cells and cancer stem cells: similar and different. Semin. Cancer Biol. 20, 85-92 (2010).
    • (2010) Semin. Cancer Biol. , vol.20 , pp. 85-92
    • Shackleton, M.1
  • 6
    • 77952275068 scopus 로고    scopus 로고
    • The cancer stem cell paradigm: A new understanding of tumor development and treatment
    • Ebben JD, Treisman DM, Zorniak M et al. The cancer stem cell paradigm: a new understanding of tumor development and treatment. Expert Opin Ther. Targets 14, 621-632 (2010).
    • (2010) Expert Opin Ther. Targets , vol.14 , pp. 621-632
    • Ebben, J.D.1    Treisman, D.M.2    Zorniak, M.3
  • 7
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • Visvader JE. Cells of origin in cancer. Nature 469, 314-322 (2011).
    • (2011) Nature. , vol.469 , pp. 314-322
    • Visvader, J.E.1
  • 8
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises promises and challenges
    • Clevers H. The cancer stem cell: premises, promises and challenges. Nat. Med. 17, 313-319 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 313-319
    • Clevers, H.1
  • 10
    • 77953663505 scopus 로고    scopus 로고
    • Antibodies targeting cancer stem cells: A new paradigm in immunotherapy
    • Deonarain MP, Kousparou CA, Epenetos AA. Antibodies targeting cancer stem cells: a new paradigm in immunotherapy? MAbs. 1, 12-25 (2009).
    • (2009) MAbs. , vol.1 , pp. 12-25
    • Deonarain, M.P.1    Kousparou, C.A.2    Epenetos, A.A.3
  • 12
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumors: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumors: accumulating evidence and unresolved questions. Nat. Rev. Cancer 8, 755-768 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 14
    • 44649107292 scopus 로고    scopus 로고
    • Mechanisms of Disease: Cancer stem cells-targeting the evil twin
    • DOI 10.1038/ncponc1110, PII NCPONC1110
    • Trumpp A, Wiestler OD. Mechanisms of disease: cancer stem cells: targeting the evil twin. Nat. Clin. Pract. Oncol. 5, 337-347 (2008). (Pubitemid 351780950)
    • (2008) Nature Clinical Practice Oncology , vol.5 , Issue.6 , pp. 337-347
    • Trumpp, A.1    Wiestler, O.D.2
  • 15
    • 79952993517 scopus 로고    scopus 로고
    • Multidrug efflux pumps and cancer stem cells: Insights into multidrug resistance and therapeutic development
    • Moitra K, Lou H, Dean M. Multidrug efflux pumps and cancer stem cells: insights into multidrug resistance and therapeutic development. Clin. Pharmacol. Ther. 89, 491-502 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 491-502
    • Moitra, K.1    Lou, H.2    Dean, M.3
  • 16
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • DOI 10.1038/nm0797-730
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3, 730-737 (1997). (Pubitemid 27298715)
    • (1997) Nature Medicine , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 17
    • 78149262994 scopus 로고    scopus 로고
    • Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models
    • USA
    • Liu H, Patel MR, Prescher JA et al. Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc. Natl Acad. Sci. USA 107, 18115-18120 (2010).
    • (2010) Proc. Natl Acad. Sci. , vol.107 , pp. 18115-18120
    • Liu, H.1    Patel, M.R.2    Prescher, J.A.3
  • 18
    • 12944288172 scopus 로고    scopus 로고
    • -/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis
    • Abraham BK, Fritz P, McClellan M et al. Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. Clin. Cancer Res. 11, 1154-1159 (2005). (Pubitemid 40175765)
    • (2005) Clinical Cancer Research , vol.11 , Issue.3 , pp. 1154-1159
    • Abraham, B.K.1    Fritz, P.2    McClellan, M.3    Hauptvogel, P.4    Athelogou, M.5    Brauch, H.6
  • 20
    • 79957891885 scopus 로고    scopus 로고
    • EZH2 and ALDH-1 mark breast epithelium at risk for breast cancer development
    • Kunju LP, Cookingham C, Toy KA et al. EZH2 and ALDH-1 mark breast epithelium at risk for breast cancer development. Mod. Pathol. 24(6), 786-793 (2011).
    • (2011) Mod. Pathol. , vol.24 , Issue.6 , pp. 786-793
    • Kunju, L.P.1    Cookingham, C.2    Toy, K.A.3
  • 21
    • 73449142873 scopus 로고    scopus 로고
    • Expression of CD133 PAX2 ESA and GPR30 in invasive ductal breast carcinomas
    • Liu Q, Li JG, Zheng XY, Jin F, Dong HT. Expression of CD133, PAX2, ESA and GPR30 in invasive ductal breast carcinomas. Chin. Med. J. 122, 2763-2769 (2009).
    • (2009) Chin. Med. J. , vol.122 , pp. 2763-2769
    • Liu, Q.1    Li, J.G.2    Zheng, X.Y.3    Jin, F.4    Dong, H.T.5
  • 22
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res. 10, R25 (2008).
    • (2008) Breast Cancer Res. , vol.10
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 23
    • 45749125992 scopus 로고    scopus 로고
    • Is CD133 a marker of metastatic colon cancer stem cells?
    • DOI 10.1172/JCI36046
    • LaBarge MA, Bissell MJ. Is CD133 a marker of metastatic colon cancer stem cells? J. Clin. Invest. 118, 2021-2024 (2008). (Pubitemid 351872322)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.6 , pp. 2021-2024
    • LaBarge, M.A.1    Bissell, M.J.2
  • 26
    • 77956302698 scopus 로고    scopus 로고
    • Distinct expression levels and patterns of stem cell marker aldehyde dehydrogenase isoform 1 ALDH1 in human epithelial cancers
    • Deng S, Yang X, Lassus H et al. Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 5, e10277 (2010).
    • (2010) PLoS One , vol.5
    • Deng, S.1    Yang, X.2    Lassus, H.3
  • 28
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P et al. Identification of pancreatic cancer stem cells. Cancer Res. 67, 1030-1037 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 29
    • 72549089933 scopus 로고    scopus 로고
    • Pancreatic cancer stem cells: New understanding of tumorigenesis clinical implications
    • Ischenko I, Seeliger H, Kleespies A et al. Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications. Langenbecks Arch. Surg. 395, 1-10 (2010).
    • (2010) Langenbecks Arch. Surg. , vol.395 , pp. 1-10
    • Ischenko, I.1    Seeliger, H.2    Kleespies, A.3
  • 30
    • 76549120193 scopus 로고    scopus 로고
    • The AC133 epitope but not the CD133 protein is lost upon cancer stem cell differentiation
    • Kemper K, Sprick MR, de Bree M et al. The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation. Cancer Res. 70, 719-729 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 719-729
    • Kemper, K.1    Sprick, M.R.2    De Bree, M.3
  • 31
  • 32
    • 80052270628 scopus 로고    scopus 로고
    • Molecular pathology of tumor-initiating cells: Lessons from Philadelphia chromosome-positive leukemia
    • Naka K, Hoshii T, Tadokoro Y, Hirao A. Molecular pathology of tumor-initiating cells: lessons from Philadelphia chromosome-positive leukemia. Path. Int. 61, 501-508 (2011).
    • (2011) Path. Int. , vol.61 , pp. 501-508
    • Naka, K.1    Hoshii, T.2    Tadokoro, Y.3    Hirao, A.4
  • 33
    • 63649119820 scopus 로고    scopus 로고
    • Cancer stem cell-directed therapies: Recent data from the laboratory and clinic
    • Park CY, Tseng D, Weissman IL. Cancer stem cell-directed therapies: recent data from the laboratory and clinic. Mol. Ther. 17, 219-230 (2009).
    • (2009) Mol. Ther. , vol.17 , pp. 219-230
    • Park, C.Y.1    Tseng, D.2    Weissman, I.L.3
  • 34
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, Wu Q, McLendon RE et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756-762 (2006).
    • (2006) Nature. , vol.444 , pp. 756-762
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 35
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • Shackleton M, Quintana E, Fearon ER, Morrison SJ. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138, 822-829 (2009).
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 36
    • 77953811725 scopus 로고    scopus 로고
    • Cancer stem cells: Back to darwin
    • Greaves M. Cancer stem cells: back to Darwin? Semin. Cancer Biol. 20, 65-70 (2010).
    • (2010) Semin.Cancer Biol. , vol.20 , pp. 65-70
    • Greaves, M.1
  • 37
    • 77953722864 scopus 로고    scopus 로고
    • The difficulty of targeting cancer stem cell niches
    • LaBarge MA. The difficulty of targeting cancer stem cell niches. Clin. Cancer Res. 16, 3121-3129 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3121-3129
    • Labarge, M.A.1
  • 38
    • 74949090309 scopus 로고    scopus 로고
    • The therapeutic promise of the cancer stem cell concept
    • Frank NY, Schatton T, Frank MH. The therapeutic promise of the cancer stem cell concept. J. Clin. Invest. 120, 41-50 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 41-50
    • Frank, N.Y.1    Schatton, T.2    Frank, M.H.3
  • 39
    • 77953696850 scopus 로고    scopus 로고
    • Controversies in cancer stem cells: Targeting embryonic signaling pathways
    • Takebe N, Ivy SP. Controversies in cancer stem cells: targeting embryonic signaling pathways. Clin. Cancer Res. 16, 3106-3112 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3106-3112
    • Takebe, N.1    Ivy, S.P.2
  • 40
    • 57349143739 scopus 로고    scopus 로고
    • Efficient tumor formation by single human melanoma cells
    • Quintana E, Shackleton M, Sabel MS et al. Efficient tumor formation by single human melanoma cells. Nature 456, 593-598 (2008).
    • (2008) Nature. , vol.456 , pp. 593-598
    • Quintana, E.1    Shackleton, M.2    Sabel, M.S.3
  • 41
    • 77958152852 scopus 로고    scopus 로고
    • Delivering cargoes into cancer cells using DNA aptamers targeting internalized surface portals
    • Orava EW, Cicmil N, Gariepy J. Delivering cargoes into cancer cells using DNA aptamers targeting internalized surface portals. Biochim. Biophys. Acta 1798, 2190-2200 (2010).
    • (2010) Biochim. Biophys. Acta. , vol.1798 , pp. 2190-2200
    • Orava, E.W.1    Cicmil, N.2    Gariepy, J.3
  • 42
    • 79953113373 scopus 로고    scopus 로고
    • Therapeutics formulated to target cancer stem cells: Is it in our future
    • Clayton S, Mousa SA. Therapeutics formulated to target cancer stem cells: is it in our future? Cancer Cell Int. 11, 7 (2011).
    • (2011) Cancer Cell Int. , vol.11 , pp. 7
    • Clayton, S.1    Mousa, S.A.2
  • 43
    • 79956351015 scopus 로고    scopus 로고
    • Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    • Chaffer CL, Brueckmann I, Scheel C et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc. Natl Acad. Sci. USA 108, 7950-7955 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 7950-7955
    • Chaffer, C.L.1    Brueckmann, I.2    Scheel, C.3
  • 44
    • 79953701955 scopus 로고    scopus 로고
    • Breast cancer-initiating cells: Insights into novel treatment strategies
    • Santilli G, Binda M, Zaffaroni N, Daidone MG. Breast cancer-initiating cells: insights into novel treatment strategies. Cancers 3, 1405-1425 (2011).
    • (2011) Cancers , vol.3 , pp. 1405-1425
    • Santilli, G.1    Binda, M.2    Zaffaroni, N.3    Daidone, M.G.4
  • 45
    • 77955275498 scopus 로고    scopus 로고
    • Efficacy of anticancer agents in cell lines versus human primary tumor tissue
    • Cree IA, Glaysher S, Harvey AL. Efficacy of anticancer agents in cell lines versus human primary tumor tissue. Curr. Opin Pharmacol. 10, 375-379 (2010).
    • (2010) Curr. Opin Pharmacol. , vol.10 , pp. 375-379
    • Cree, I.A.1    Glaysher, S.2    Harvey, A.L.3
  • 47
    • 42549099061 scopus 로고    scopus 로고
    • The cancer stem cell hypothesis: In search of definitions, markers, and relevance
    • DOI 10.1038/labinvest.2008.14, PII LABINVEST200814
    • Shipitsin M, Polyak K. The cancer stem cell hypothesis: in search of definitions, markers and relevance. Lab. Invest. 88, 459-463 (2008). (Pubitemid 351581449)
    • (2008) Laboratory Investigation , vol.88 , Issue.5 , pp. 459-463
    • Shipitsin, M.1    Polyak, K.2
  • 48
    • 65349180755 scopus 로고    scopus 로고
    • Molecularly characterised xenograft tumor mouse models: Valuable tools for evaluation of new therapeutic strategies for secondary liver cancers
    • 2009
    • Mischek D, Steinborn R, Petznek H et al. Molecularly characterised xenograft tumor mouse models: valuable tools for evaluation of new therapeutic strategies for secondary liver cancers. J. Biomed. Biotechnol. 2009, 437284 (2009).
    • J. Biomed. Biotechnol. , vol.2009 , pp. 437284
    • Mischek, D.1    Steinborn, R.2    Petznek, H.3
  • 49
    • 77956686420 scopus 로고    scopus 로고
    • Xenograft models of head and neck cancers
    • Sano D, Myers JN. Xenograft models of head and neck cancers. Head Neck Oncol. 1, 32 (2009).
    • (2009) Head Neck Oncol. , vol.1 , pp. 32
    • Sano, D.1    Myers, J.N.2
  • 50
    • 75649116753 scopus 로고    scopus 로고
    • A reproducible brain tumor model established from human glioblastoma biopsies
    • Wang J, Miletic H, Sakariassen PO et al. A reproducible brain tumor model established from human glioblastoma biopsies. BMC Cancer 9, 465 (2009).
    • (2009) BMC Cancer , vol.9 , pp. 465
    • Wang, J.1    Miletic, H.2    Sakariassen, P.O.3
  • 51
    • 77957987999 scopus 로고    scopus 로고
    • Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation
    • de Plater L, Lauge A, Guyader C et al. Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation. Br. J. Cancer 103, 1192-1200 (2010).
    • (2010) Br. J. Cancer , vol.103 , pp. 1192-1200
    • De Plater, L.1    Lauge, A.2    Guyader, C.3
  • 52
    • 77956371555 scopus 로고    scopus 로고
    • The use of animal models for cancer chemoprevention drug development
    • Steele VE, Lubet RA. The use of animal models for cancer chemoprevention drug development. Semin. Oncol. 37, 327-338 (2010).
    • (2010) Semin. Oncol. , vol.37 , pp. 327-338
    • Steele, V.E.1    Lubet, R.A.2
  • 53
    • 64349109459 scopus 로고    scopus 로고
    • Mouse models of human AML accurately predict chemotherapy response
    • Zuber J, Radtke I, Pardee TS et al. Mouse models of human AML accurately predict chemotherapy response. Genes Dev. 23, 877-889 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 877-889
    • Zuber, J.1    Radtke, I.2    Pardee, T.S.3
  • 54
    • 80053531658 scopus 로고    scopus 로고
    • Regulation of cancer stem cells by cytokine networks: Attacking cancers inflammatory roots
    • Korkaya H, Liu S, Wicha MS. Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots. Clin. Cancer Res. 17, 6125-6129 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6125-6129
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3
  • 55
    • 79959771576 scopus 로고    scopus 로고
    • Clinical trial design for testing the stem cell model for the prevention and treatment of cancer
    • Reddy RM, Kakarala M, Wicha MS. Clinical trial design for testing the stem cell model for the prevention and treatment of cancer. Cancers 2011, 2696-2708 (2011).
    • (2011) Cancers 2011 , pp. 2696-2708
    • Reddy, R.M.1    Kakarala, M.2    Wicha, M.S.3
  • 56
    • 79955016306 scopus 로고    scopus 로고
    • Circulating tumor cells: Not all detected cells are bad and not all bad cells are detected
    • Wicha MS, Hayes DF. Circulating tumor cells: not all detected cells are bad and not all bad cells are detected. J. Clin. Oncol. 29, 1508-1511 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1508-1511
    • Wicha, M.S.1    Hayes, D.F.2
  • 57
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 58
    • 77449088191 scopus 로고    scopus 로고
    • Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells
    • Fehm T, Hoffmann O, Aktas B et al. Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells. Breast Cancer Res. 11, R59 (2009).
    • (2009) Breast Cancer Res. , vol.11
    • Fehm, T.1    Hoffmann, O.2    Aktas, B.3
  • 59
    • 77955113469 scopus 로고    scopus 로고
    • Genetically abnormal circulating cells in lung cancer patients: An antigen-independent fluorescence in situ hybridization-based case-control study
    • Katz RL, He W, Khanna A et al. Genetically abnormal circulating cells in lung cancer patients: an antigen-independent fluorescence in situ hybridization-based case-control study. Clin. Cancer Res. 16, 3976-3987 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3976-3987
    • Katz, R.L.1    He, W.2    Khanna, A.3
  • 61
    • 58049201990 scopus 로고    scopus 로고
    • The stem cell-associated antigen CD133 Prominin-1 is a molecular therapeutic target for metastatic melanoma
    • Rappa G, Fodstad O, Lorico A. The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells 26, 3008-3017 (2008).
    • (2008) Stem. Cells , vol.26 , pp. 3008-3017
    • Rappa, G.1    Fodstad, O.2    Lorico, A.3
  • 64
    • 40749155451 scopus 로고    scopus 로고
    • Stemcell marker CD133 affects clinical outcome in glioma patients
    • Zeppernick F, Ahmadi R, Campos B et al. Stemcell marker CD133 affects clinical outcome in glioma patients. Clin. Cancer Res. 14, 123-139 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 123-139
    • Zeppernick, F.1    Ahmadi, R.2    Campos, B.3
  • 65
    • 51649111430 scopus 로고    scopus 로고
    • Single-cell cloning of colon cancer stem cells reveals a multilineage differentiation capacity
    • USA
    • Vermeulen L, Todaro M, de Sousa Mello F et al. Single-cell cloning of colon cancer stem cells reveals a multilineage differentiation capacity. Proc. Natl Acad. Sci. USA 105, 13427-13432 (2008).
    • (2008) Proc. Natl Acad. Sci , vol.105 , pp. 13427-13432
    • Vermeulen, L.1    Todaro, M.2    De Sousa Mello, F.3
  • 67
    • 53249113793 scopus 로고    scopus 로고
    • Pancreatic cancer stem cells: Implications for the treatment of pancreatic cancer
    • Simeone DM. Pancreatic cancer stem cells: implications for the treatment of pancreatic cancer. Clin. Cancer Res. 14, 5646-5648 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5646-5648
    • Simeone, D.M.1
  • 69
    • 79952236235 scopus 로고    scopus 로고
    • Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells
    • Gaviraghi M, Tunici P, Valensin S et al. Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells. Biosci. Rep. 31, 45-55 (2010).
    • (2010) Biosci. Rep. , vol.31 , pp. 45-55
    • Gaviraghi, M.1    Tunici, P.2    Valensin, S.3
  • 71
    • 79251610010 scopus 로고    scopus 로고
    • Cancer stem cells: Repair gone awry
    • doi:10.1155/2011/465343 Epub ahead of print
    • Rangwala F, Omenetti A, Diehl A. Cancer stem cells: repair gone awry? J. Oncol. doi:10.1155/2011/465343 (2011) (Epub ahead of print).
    • (2011) J. Oncol.
    • Rangwala, F.1    Omenetti, A.2    Diehl, A.3
  • 72
    • 33847649534 scopus 로고    scopus 로고
    • Tumor-initiating cells vs. cancer stem cells and CD133: Whats in the name
    • Neuzil J, Stantic M, Zobalova R et al. Tumor-initiating cells vs. cancer 'stem' cells and CD133: what's in the name? Biochem. Biophys. Res. Commun. 355, 855-859 (2007).
    • (2007) Biochem. Biophys. Res. Commun. , vol.355 , pp. 855-859
    • Neuzil, J.1    Stantic, M.2    Zobalova, R.3
  • 73
    • 71849094172 scopus 로고    scopus 로고
    • Potential for therapeutic targeting of tumor stem cells
    • Saini V, Shoemaker RH. Potential for therapeutic targeting of tumor stem cells. Cancer Sci. 101, 16-21 (2009).
    • (2009) Cancer Sci. , vol.101 , pp. 16-21
    • Saini, V.1    Shoemaker, R.H.2
  • 76
    • 57149142257 scopus 로고    scopus 로고
    • Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer
    • Saad M, Garbuzenko OB, Minko T. Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer. Nanomedicine 3, 761-776 (2008).
    • (2008) Nanomedicine , vol.3 , pp. 761-776
    • Saad, M.1    Garbuzenko, O.B.2    Minko, T.3
  • 77
    • 34548505716 scopus 로고    scopus 로고
    • Reversal of BCRP-mediated multidrug resistance by stable expression of small interfering RNAs
    • DOI 10.1002/jcb.21276
    • Lv H, He Z, Liu X et al. Reversal of BCRP-mediated multidrug resistance by stable expression of small interfering RNAs. J. Cell Biochem. 102, 75-81 (2007). (Pubitemid 47378912)
    • (2007) Journal of Cellular Biochemistry , vol.102 , Issue.1 , pp. 75-81
    • Lv, H.1    He, Z.2    Liu, X.3    Yuan, J.4    Yu, Y.5    Chen, Z.6
  • 78
    • 4444275386 scopus 로고    scopus 로고
    • Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal resistance in human ovarian cancer cells
    • Duan Z, Brakora KA, Seiden MV. Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human ovarian cancer cells. Mol. Cancer Ther. 3, 833-838 (2004). (Pubitemid 39193765)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.7 , pp. 833-838
    • Duan, Z.1    Brakora, K.A.2    Seiden, M.V.3
  • 79
    • 73949154406 scopus 로고    scopus 로고
    • Overcoming multidrug resistance by RNA interference
    • Stege A, Kruhn A, Lage H. Overcoming multidrug resistance by RNA interference. Methods Mol. Biol. 596, 447-465 (2010).
    • (2010) Methods Mol. Biol. , vol.596 , pp. 447-465
    • Stege, A.1    Kruhn, A.2    Lage, H.3
  • 80
    • 59249095556 scopus 로고    scopus 로고
    • Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells
    • Xia Z, Zhu Z, Zhang L et al. Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells. Oncol. Rep. 20, 1433-1439 (2008).
    • (2008) Oncol. Rep. , vol.20 , pp. 1433-1439
    • Xia, Z.1    Zhu, Z.2    Zhang, L.3
  • 81
    • 70350241634 scopus 로고    scopus 로고
    • Delivery of short hairpin RNAs by transkingdom RNA interference modulates the classical ABCB1-mediated multidrug-resistant phenotype of cancer cells
    • Kruhn A, Wang A, Fruehauf JH, Lage H. Delivery of short hairpin RNAs by transkingdom RNA interference modulates the classical ABCB1-mediated multidrug-resistant phenotype of cancer cells. Cell Cycle 8, 3349-3354 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 3349-3354
    • Kruhn, A.1    Wang, A.2    Fruehauf, J.H.3    Lage, H.4
  • 82
    • 36849084647 scopus 로고    scopus 로고
    • On future's doorstep: RNA interference and the pharmacopeia of tomorrow
    • DOI 10.1172/JCI34274
    • Gewirtz AM. On future's doorstep: RNA interference and the pharmacopeia of tomorrow. J. Clin. Invest. 117, 3612-3614 (2007). (Pubitemid 350224066)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.12 , pp. 3612-3614
    • Gewirtz, A.M.1
  • 83
    • 70350707597 scopus 로고    scopus 로고
    • The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
    • Patil YB, Swaminathan SK, Sadhukha T, Ma L, Panyam J. The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance. Biomaterials 31, 358-365 (2010).
    • (2010) Biomaterials , vol.31 , pp. 358-365
    • Patil, Y.B.1    Swaminathan, S.K.2    Sadhukha, T.3    Ma, L.4    Panyam, J.5
  • 84
    • 85157280707 scopus 로고    scopus 로고
    • Donnenberg VS Zimmerlin L Donnerberg AD Eds Springer Berlin Germany
    • Allan A. Cancer Stem Cells in Solid Tumors. Donnenberg VS, Zimmerlin L, Donnerberg AD (Eds). Springer, Berlin, Germany, 361-379 (2011).
    • (2011) Cancer Stem Cells in Solid Tumors , pp. 361-379
    • Allan, A.1
  • 85
    • 84857144607 scopus 로고    scopus 로고
    • Targeting cancer-initiating cell drug-resistance: A roadmap to a new-generation of cancer therapies
    • 10.1016/j.drudis.2011.02.005 Epub ahead of print
    • Alama A, Orengo AM, Ferrini S, Gangemi R. Targeting cancer-initiating cell drug-resistance: a roadmap to a new-generation of cancer therapies? Drug Discov. Today doi:10.1016/j.drudis.2011.02.005 (2011) (Epub ahead of print).
    • (2011) Drug Discov.Today
    • Alama, A.1    Orengo, A.M.2    Ferrini, S.3    Gangemi, R.4
  • 86
    • 35148888629 scopus 로고    scopus 로고
    • Cancer stem cells in radiation resistance
    • DOI 10.1158/0008-5472.CAN-07-0895
    • Rich JN. Cancer stem cells in radiation resistance. Cancer Res. 67, 8980-8984 (2007). (Pubitemid 47535877)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 8980-8984
    • Rich, J.N.1
  • 87
    • 78751640633 scopus 로고    scopus 로고
    • Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133+ glioma stem cells to temozolomide therapy
    • Ulasov IV, Nandi S, Dey M, Sonabend AM, Lesniak MS. Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy. Mol. Med. 17, 103-112 (2011)
    • (2011) Mol. Med. , vol.17 , pp. 103-112
    • Ulasov, I.V.1    Nandi, S.2    Dey, M.3    Sonabend, A.M.4    Lesniak, M.S.5
  • 88
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • DOI 10.1158/0008-5472.CAN-06-0858
    • Fan X, Matsui W, Khaki L et al. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res. 66, 7445-7452 (2006). (Pubitemid 44289197)
    • (2006) Cancer Research , vol.66 , Issue.15 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3    Stearns, D.4    Chun, J.5    Li, Y.-M.6    Eberhart, C.G.7
  • 90
    • 48549103124 scopus 로고    scopus 로고
    • Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
    • Rizzo P, Miao H, D'Souza G et al. Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res. 68, 5226-5235 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 5226-5235
    • Rizzo, P.1    Miao, H.2    D'Souza, G.3
  • 91
    • 62549096930 scopus 로고    scopus 로고
    • Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab
    • Magnifico A, Albano L, Campaner S et al. Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab. Clin. Cancer Res. 15, 2010-2021 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2010-2021
    • Magnifico, A.1    Albano, L.2    Campaner, S.3
  • 93
    • 33749515476 scopus 로고    scopus 로고
    • Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • DOI 10.1038/nm1483, PII NM1483
    • Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat. Med. 12, 1167-1174 (2006). (Pubitemid 44527352)
    • (2006) Nature Medicine , vol.12 , Issue.10 , pp. 1167-1174
    • Jin, L.1    Hope, K.J.2    Zhai, Q.3    Smadja-Joffe, F.4    Dick, J.E.5
  • 94
    • 79955778894 scopus 로고    scopus 로고
    • Breast cancer stem cells: Treatment resistance and therapeutic opportunities
    • Al-Ejeh F, Smart CE, Morrison BJ et al. Breast cancer stem cells: treatment resistance and therapeutic opportunities. Carcinogenesis 32, 650-658 (2011).
    • (2011) Carcinogenesis , vol.32 , pp. 650-658
    • Al-Ejeh, F.1    Smart, C.E.2    Morrison, B.J.3
  • 96
    • 3042678045 scopus 로고    scopus 로고
    • C-Myc and epidermal stem cell fate determination
    • Honeycutt KA, Roop DR. c-Myc and epidermal stem cell fate determination. J. Dermatol. 31, 368-375 (2004). (Pubitemid 38855794)
    • (2004) Journal of Dermatology , vol.31 , Issue.5 , pp. 368-375
    • Honeycutt, K.A.1    Roop, D.R.2
  • 97
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • Yamashita T, Ji J, Budhu A et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 136, 1012-1024 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3
  • 98
    • 77954922985 scopus 로고    scopus 로고
    • Stem cells in cancer: Instigators and propagators
    • Alison MR, Islam S, Wright NA. Stem cells in cancer: instigators and propagators? J. Cell Sci. 123, 2357-2368 (2010).
    • (2010) J. Cell Sci. , vol.123 , pp. 2357-2368
    • Alison, M.R.1    Islam, S.2    Wright, N.A.3
  • 99
    • 0034812866 scopus 로고    scopus 로고
    • Clinical experience with edrecolomab: A monoclonal antibody therapy for colorectal carcinoma
    • DOI 10.1016/S1040-8428(01)00131-7, PII S1040842800001317
    • Schwartzberg LS. Clinical experience with edrecolomab: a monoclonal antibody therapy for colorectal carcinoma. Crit. Rev. Oncol. Hematol. 40, 17-24 (2001). (Pubitemid 32923067)
    • (2001) Critical Reviews in Oncology/Hematology , vol.40 , Issue.1 , pp. 17-24
    • Schwartzberg, L.S.1
  • 100
    • 77956398731 scopus 로고    scopus 로고
    • EpCAM as a target in cancer therapy
    • author reply e241-e242
    • Gires O, Bauerle PA. EpCAM as a target in cancer therapy. J. Clin. Oncol. 28, e239-e240; author reply e241-e242 (2010).
    • (2010) J. Clin. Oncol. , vol.28
    • Gires, O.1    Bauerle, P.A.2
  • 101
    • 70349512496 scopus 로고    scopus 로고
    • EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins
    • Winkler J, Martin-Killias P, Pluckthun A, Zangemeister-Wittke U. EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins. Mol. Cancer Ther. 8, 2674-2683 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2674-2683
    • Winkler, J.1    Martin-Killias, P.2    Pluckthun, A.3    Zangemeister-Wittke, U.4
  • 102
    • 80052593787 scopus 로고    scopus 로고
    • Intraperitoneal treatment with the trifunctional bispecific antibody Catumaxomab in patients with platinum-resistant epithelial ovarian cancer: A Phase IIa study of the AGO Study Group
    • Baumann K, Pfisterer J, Wimberger P et al. Intraperitoneal treatment with the trifunctional bispecific antibody Catumaxomab in patients with platinum-resistant epithelial ovarian cancer: a Phase IIa study of the AGO Study Group. Gynecol. Oncol. 123, 27-32 (2011).
    • (2011) Gynecol. Oncol. , vol.123 , pp. 27-32
    • Baumann, K.1    Pfisterer, J.2    Wimberger, P.3
  • 103
    • 67650496215 scopus 로고    scopus 로고
    • A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer
    • DiMeo TA, Anderson K, Phadke P et al. A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res. 69, 5364-5373 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 5364-5373
    • Dimeo, T.A.1    Anderson, K.2    Phadke, P.3
  • 104
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signaling in cancer
    • Yauch RL, Gould SE, Scales SJ et al. A paracrine requirement for hedgehog signaling in cancer. Nature 455, 406-410 (2008).
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3
  • 105
    • 66049102512 scopus 로고    scopus 로고
    • Hedgehog signaling is dispensable for adult hematopoietic stem cell function
    • Gao J, Graves S, Koch U et al. Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell 4, 548-558 (2009).
    • (2009) Cell Stem. Cell , vol.4 , pp. 548-558
    • Gao, J.1    Graves, S.2    Koch, U.3
  • 106
    • 79954611501 scopus 로고    scopus 로고
    • Phase i trial of hedgehog pathway inhibitor vismodegib GDC-0449 in patients with refractory locally advanced or metastatic solid tumors
    • LoRusso PM, Rudin CM, Reddy JC et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin. Cancer Res. 17, 2502-2511 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2502-2511
    • Lorusso, P.M.1    Rudin, C.M.2    Reddy, J.C.3
  • 107
    • 77952541851 scopus 로고    scopus 로고
    • New developments in the discovery of small molecule Hedgehog pathway antagonists
    • Tremblay MR, McGovern K, Read MA, Castro AC. New developments in the discovery of small molecule Hedgehog pathway antagonists. Curr. Opin Chem. Biol. 14, 428-435 (2010).
    • (2010) Curr. Opin Chem. Biol. , vol.14 , pp. 428-435
    • Tremblay, M.R.1    McGovern, K.2    Read, M.A.3    Castro, A.C.4
  • 108
    • 79960223701 scopus 로고    scopus 로고
    • Updates on first-line treatment of metastatic pancreatic adenocarcinoma presented at: The 2011 ASCO Annual Meeting
    • Chicago, IL, USA, 3-7 June 2011.
    • Strimpakos AS, Syrigos KN, Saif MW. Updates on first-line treatment of metastatic pancreatic adenocarcinoma. Presented at: The 2011 ASCO Annual Meeting. Chicago, IL, USA, 3-7 June 2011. JOP 12, 339-342 (2011).
    • (2011) JOP , vol.12 , pp. 339-342
    • Strimpakos, A.S.1    Syrigos, K.N.2    Saif, M.W.3
  • 109
    • 33644560281 scopus 로고    scopus 로고
    • Cancer stem cells: An old idea - A paradigm shift
    • Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea - a paradigm shift. Cancer Res. 66(4), 1883-1890 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.4 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3
  • 110
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signaling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • Zhao C, Chen A, Jamieson CH et al. Hedgehog signaling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 458, 776-779 (2009).
    • (2009) Nature. , vol.458 , pp. 776-779
    • Zhao, C.1    Chen, A.2    Jamieson, C.H.3
  • 111
    • 34948837444 scopus 로고    scopus 로고
    • Selective targeting of cancer stem cells: A new concept in cancer therapeutics
    • DOI 10.2165/00063030-200721050-00002
    • Korkaya H, Wicha MS. Selective targeting of cancer stem cells: a new concept in cancer therapeutics. BioDrugs. 21, 299-310 (2007). (Pubitemid 47529469)
    • (2007) BioDrugs , vol.21 , Issue.5 , pp. 299-310
    • Korkaya, H.1    Wicha, M.S.2
  • 113
    • 58049198191 scopus 로고    scopus 로고
    • Brain cancer stem cells display preferential sensitivity to Akt inhibition
    • Eyler CE, Foo WC, LaFiura KM et al. Brain cancer stem cells display preferential sensitivity to Akt inhibition. Stem Cells 26, 3027-3036 (2008).
    • (2008) Stem. Cells , vol.26 , pp. 3027-3036
    • Eyler, C.E.1    Foo, W.C.2    Lafiura, K.M.3
  • 114
    • 40749150740 scopus 로고    scopus 로고
    • + HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    • DOI 10.1038/sj.onc.1210811, PII 1210811
    • Ma S, Lee TK, Zheng BJ, Chan KW, Guan XY. CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 27, 1749-1758 (2008). (Pubitemid 351380265)
    • (2008) Oncogene , vol.27 , Issue.12 , pp. 1749-1758
    • Ma, S.1    Lee, T.K.2    Zheng, B.-J.3    Chan, K.W.4    Guan, X.-Y.5
  • 116
    • 77956503727 scopus 로고    scopus 로고
    • Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres
    • Bar EE, Lin A, Mahairaki V, Matsui W, Eberhart CG. Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres. Am. J. Pathol. 177, 1491-1502 (2010).
    • (2010) Am. J. Pathol. , vol.177 , pp. 1491-1502
    • Bar, E.E.1    Lin, A.2    Mahairaki, V.3    Matsui, W.4    Eberhart, C.G.5
  • 117
    • 70449687092 scopus 로고    scopus 로고
    • Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1a
    • Soeda A, Park M, Lee D et al. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1a. Oncogene 28, 3949-3959 (2009).
    • (2009) Oncogene , vol.28 , pp. 3949-3959
    • Soeda, A.1    Park, M.2    Lee, D.3
  • 118
    • 77956224494 scopus 로고    scopus 로고
    • Oxygen in stem cell biology: A critical component of the stem cell niche
    • Mohyeldin A, Garzon-Muvdi T, Quinones- Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 7, 150-161 (2010).
    • (2010) Cell Stem. Cell , vol.7 , pp. 150-161
    • Mohyeldin, A.1    Garzon-Muvdi, T.2    Quinones- Hinojosa, A.3
  • 119
    • 79955475569 scopus 로고    scopus 로고
    • A Phase II, single-arm study of the anti-a5b1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer
    • Bell-McGuinn KM, Matthews CM, Ho SN et al. A Phase II, single-arm study of the anti-a5b1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer. Gynecol. Oncol. 121, 273-279 (2011).
    • (2011) Gynecol. Oncol. , vol.121 , pp. 273-279
    • Bell-Mcguinn, K.M.1    Matthews, C.M.2    Ho, S.N.3
  • 120
    • 77951667987 scopus 로고    scopus 로고
    • Mechanisms of resistance to antiangiogenesis therapy
    • Azam F, Mehta S, Harris AL. Mechanisms of resistance to antiangiogenesis therapy. Eur. J. Cancer. 46, 1323-1332 (2010).
    • (2010) Eur. J. Cancer. , vol.46 , pp. 1323-1332
    • Azam, F.1    Mehta, S.2    Harris, A.L.3
  • 121
    • 70349975991 scopus 로고    scopus 로고
    • Characterisation of normal and cancer stem cells: One experimental paradigm for two kinds of stem cells
    • Mayol JF, Loeuillet C, Herodin F, Wion D. Characterisation of normal and cancer stem cells: one experimental paradigm for two kinds of stem cells. Bioessays 31, 993-1001 (2009).
    • (2009) Bioessays , vol.31 , pp. 993-1001
    • Mayol, J.F.1    Loeuillet, C.2    Herodin, F.3    Wion, D.4
  • 122
    • 41149115123 scopus 로고    scopus 로고
    • The role of oxygen availability in embryonic development and stem cell function
    • DOI 10.1038/nrm2354, PII NRM2354
    • Simon MC, Keith B. The role of oxygen availability in embryonic development and stem cell function. Nat. Rev. Mol. Cell Biol. 9, 285-296 (2008). (Pubitemid 351430845)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.4 , pp. 285-296
    • Simon, M.C.1    Keith, B.2
  • 123
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat. Rev. Drug Discov. 10, 417-427 (2011).
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 125
    • 78649637459 scopus 로고    scopus 로고
    • Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy
    • Mishra P, Banerjee D, Ben-Baruch A. Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy. J. Leukoc. Biol. 89, 31-39 (2011).
    • (2011) J. Leukoc. Biol. , vol.89 , pp. 31-39
    • Mishra, P.1    Banerjee, D.2    Ben-Baruch, A.3
  • 126
    • 77953090345 scopus 로고    scopus 로고
    • CXCL12 SDF-1/ CXCR4 pathway in cancer
    • Teicher BA, Fricker SP. CXCL12 (SDF-1)/ CXCR4 pathway in cancer. Clin. Cancer Res. 16, 2927-2931 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2927-2931
    • Teicher, B.A.1    Fricker, S.P.2
  • 127
    • 33846959853 scopus 로고    scopus 로고
    • Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells
    • Ozpolat B, Akar U, Steiner M et al. Programmed. cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol. Cancer Res. 5, 95-108 (2007).
    • (2007) Mol. Cancer Res. , vol.5 , pp. 95-108
    • Ozpolat, B.1    Akar, U.2    Steiner, M.3
  • 128
    • 63349103376 scopus 로고    scopus 로고
    • A subset of patients with high-risk acute myelogenous leukemia shows improved peripheral blood cell counts when treated ith the combination of valproic acid theophylline and all-trans retinoic acid
    • Ryningen A, Stapnes C, Lassalle P et al. A subset of patients with high-risk acute myelogenous leukemia shows improved peripheral blood cell counts when treated ith the combination of valproic acid, theophylline and all-trans retinoic acid. Leuk. Res. 33, 779-787 (2009).
    • (2009) Leuk. Res. , vol.33 , pp. 779-787
    • Ryningen, A.1    Stapnes, C.2    Lassalle, P.3
  • 129
    • 85157044310 scopus 로고    scopus 로고
    • Piccirillo S, Vescovi A (Eds) Springer Berlin, Heidelberg, Germany
    • Wiestler O, Haendler B, Mumberg D. Cancer Stem Cells. Piccirillo S, Vescovi A (Eds). Springer Berlin, Heidelberg, Germany 59-81 (2007).
    • (2007) Cancer Stem Cells. , pp. 59-81
    • Wiestler, O.1    Haendler, B.2    Mumberg, D.3
  • 130
    • 33847786883 scopus 로고    scopus 로고
    • A proof-of-principle study of epigenetic therapy added to neoadjuvant doxorubicin cyclophosphamide for locally advanced breast cancer
    • Arce C, Perez-Plasencia C, Gonzalez-Fierro A et al. A proof-of-principle study of epigenetic therapy added to neoadjuvant doxorubicin cyclophosphamide for locally advanced breast cancer. PLoS One 1, e98 (2006).
    • (2006) PLoS One , vol.1
    • Arce, C.1    Perez-Plasencia, C.2    Gonzalez-Fierro, A.3
  • 134
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel AP, Lievre M, Thomas C et al. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 3, e2888 (2008).
    • (2008) PLoS One , vol.3
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3
  • 135
    • 44049100934 scopus 로고    scopus 로고
    • Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
    • Li X, Lewis MT, Huang J et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J. Natl Cancer Inst. 100, 672-679 (2008).
    • (2008) J. Natl Cancer Inst. , vol.100 , pp. 672-679
    • Li, X.1    Lewis, M.T.2    Huang, J.3
  • 136
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
    • DOI 10.1111/j.1349-7006.2007.00550.x
    • Moustakas A, Heldin CH. Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci. 98, 1512-1520 (2007). (Pubitemid 47308444)
    • (2007) Cancer Science , vol.98 , Issue.10 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.-H.2
  • 137
    • 62549111693 scopus 로고    scopus 로고
    • The epithelial-to-mesenchymal transition and cancer stem cells: A coalition against cancer therapies
    • Hollier BG, Evans K, Mani SA. The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies. J. Mammary Gland Biol. Neoplasia 14, 29-43 (2009).
    • (2009) J. Mammary Gland Biol. Neoplasia , vol.14 , pp. 29-43
    • Hollier, B.G.1    Evans, K.2    Mani, S.A.3
  • 139
    • 62349116134 scopus 로고    scopus 로고
    • Imaging tracking and targeting of cancer stem cells
    • Vlashi E, Kim K, Lagadec C et al. imaging, tracking, and targeting of cancer stem cells. J. Natl Cancer Inst. 101, 350-359 (2009).
    • (2009) J. Natl Cancer Inst. , vol.101 , pp. 350-359
    • Vlashi, E.1    Kim, K.2    Lagadec, C.3
  • 140
    • 79551607425 scopus 로고    scopus 로고
    • Comparison of FLT-PET and FDG-PET for visualization of head and neck squamous cell cancers
    • Hoshikawa H, Nishiyama Y, Kishino T et al. Comparison of FLT-PET and FDG-PET for visualization of head and neck squamous cell cancers. Mol. Imaging Biol. 13, 172-177 (2011).
    • (2011) Mol. Imaging Biol. , vol.13 , pp. 172-177
    • Hoshikawa, H.1    Nishiyama, Y.2    Kishino, T.3
  • 142
    • 79953249129 scopus 로고    scopus 로고
    • Molecular imaging and stem cell research
    • Jang YY, Ye Z, Cheng L. Molecular imaging and stem cell research. Mol. Imaging. 10, 111-122 (2011).
    • (2011) Mol. Imaging. , vol.10 , pp. 111-122
    • Jang, Y.Y.1    Ye, Z.2    Cheng, L.3
  • 143
    • 79551563626 scopus 로고    scopus 로고
    • In vivo imaging for stem cell therapy: Enew developments and future challenges
    • Lucignani G, Rodriguez-Porcel M. In vivo imaging for stem cell therapy: new developments and future challenges. Eur. J. Nucl. Med. Mol. Imaging 38, 400-405 (2011).
    • (2011) Eur. J. Nucl. Med. Mol. Imaging , vol.38 , pp. 400-405
    • Lucignani, G.1    Rodriguez-Porcel, M.2
  • 144
    • 45849089879 scopus 로고    scopus 로고
    • Exploring the role of cancer stem cells in radioresistance
    • DOI 10.1038/nrc2419, PII NRC2419
    • Baumann M, Krause M, Hill R. Exploring the role of cancer stem cells in radioresistance. Nat. Rev. Cancer 8, 545-554 (2008). (Pubitemid 351881850)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.7 , pp. 545-554
    • Baumann, M.1    Krause, M.2    Hill, R.3
  • 146
    • 33645276597 scopus 로고    scopus 로고
    • Contrast-enhanced in vivo imaging of breast and prostate cancer cells by MRI
    • Rodriguez O, Fricke S, Chien C et al. Contrast-enhanced in vivo imaging of breast and prostate cancer cells by MRI. Cell Cycle 5, 113-119 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 113-119
    • Rodriguez, O.1    Fricke, S.2    Chien, C.3
  • 147
    • 77049102608 scopus 로고    scopus 로고
    • An approach to molecular imaging of atherosclerosis thrombosis and vascular inflammation using microparticles of iron oxide
    • McAteer MA, Akhtar AM, von Zur Muhlen C, Choudhury RP. An approach to molecular imaging of atherosclerosis, thrombosis, and vascular inflammation using microparticles of iron oxide. Atherosclerosis 209, 18-27 (2010).
    • (2010) Atherosclerosis , vol.209 , pp. 18-27
    • McAteer, M.A.1    Akhtar, A.M.2    Von Zur Muhlen, C.3    Choudhury, R.P.4
  • 148
    • 80955175430 scopus 로고    scopus 로고
    • BRCAA1 monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo targeted magnetofluorescent imaging of gastric cancer
    • Wang K, Ruan J, Qian Q et al. BRCAA1 monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo targeted magnetofluorescent imaging of gastric cancer. J. Nanobiotechnology 9, 23 (2011).
    • (2011) J. Nanobiotechnology , vol.9 , pp. 23
    • Wang, K.1    Ruan, J.2    Qian, Q.3
  • 149
    • 79960847763 scopus 로고    scopus 로고
    • Dual docetaxel/superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy
    • Ling Y, Wei K, Luo Y, Gao X, Zhong S. Dual docetaxel/superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy. Biomaterials 32(29), 7139-7150 (2011).
    • (2011) Biomaterials , vol.32 , Issue.29 , pp. 7139-7150
    • Ling, Y.1    Wei, K.2    Luo, Y.3    Gao, X.4    Zhong, S.5
  • 150
    • 80455131883 scopus 로고    scopus 로고
    • PET imaging of CXCR4 using copper-64 labeled peptide antagonist
    • Jacobson O, Weiss ID, Szajek LP et al. PET imaging of CXCR4 using copper-64 labeled peptide antagonist. Theranostics 1, 251-262 (2011).
    • (2011) Theranostics , vol.1 , pp. 251-262
    • Jacobson, O.1    Weiss, I.D.2    Szajek, L.P.3
  • 151
    • 78650905948 scopus 로고    scopus 로고
    • Non-invasive in vivo imaging of tumor-associated CD133/prominin
    • Tsurumi C, Esser N, Firat E et al. Non-invasive in vivo imaging of tumor-associated CD133/prominin. PLoS One 5, e15605 (2010).
    • (2010) PLoS One , vol.5
    • Tsurumi, C.1    Esser, N.2    Firat, E.3
  • 153
    • 80051682063 scopus 로고    scopus 로고
    • Immuno-PET of cancer: A revival of antibody imaging
    • Boerman OC, Oyen WJ. Immuno-PET of cancer: a revival of antibody imaging. J. Nucl. Med. 52, 1171-1172 (2011).
    • (2011) J. Nucl. Med. , vol.52 , pp. 1171-1172
    • Boerman, O.C.1    Oyen, W.J.2
  • 155
    • 58249084323 scopus 로고    scopus 로고
    • Molecular imaging as a tool for translating breast cancer science
    • Mankoff DA. Molecular imaging as a tool for translating breast cancer science. Breast Cancer Res. 10(Suppl. 1), S3 (2008).
    • (2008) Breast Cancer Res. , vol.10 , Issue.1
    • Mankoff, D.A.1
  • 156
    • 82755193795 scopus 로고    scopus 로고
    • Engineering antibodies and proteins for molecular in vivo imaging
    • Romer T, Leonhardt H, Rothbauer U. Engineering antibodies and proteins for molecular in vivo imaging. Curr. Opin Biotechnol. 22(6), 882-887 (2011).
    • (2011) Curr. Opin Biotechnol. , vol.22 , Issue.6 , pp. 882-887
    • Romer, T.1    Leonhardt, H.2    Rothbauer, U.3
  • 157
    • 77953927395 scopus 로고    scopus 로고
    • Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In- or 68Ga-labeled affibody molecules
    • Baum RP, Prasad V, Muller D et al. Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In- or 68Ga-labeled affibody molecules. J. Nucl. Med. 51, 892-897 (2010).
    • (2010) J. Nucl. Med. , vol.51 , pp. 892-897
    • Baum, R.P.1    Prasad, V.2    Muller, D.3
  • 159
    • 27944452698 scopus 로고    scopus 로고
    • 3 expression in living mice
    • DOI 10.1021/bc0501698
    • Cheng Z, Wu Y, Xiong Z, Gambhir SS, Chen X. Near-infrared fluorescent RGD peptides for optical imaging of integrin avb3 expression in living mice. Bioconjug. Chem. 16, 1433-1441 (2005). (Pubitemid 41681509)
    • (2005) Bioconjugate Chemistry , vol.16 , Issue.6 , pp. 1433-1441
    • Cheng, Z.1    Wu, Y.2    Xiong, Z.3    Gambhir, S.S.4    Chen, X.5
  • 160
    • 48749104610 scopus 로고    scopus 로고
    • PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic RGD-conjugated radiolabeled iron oxide nanoparticles
    • Lee HY, Li Z, Chen K et al. PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. J. Nucl. Med. 49, 1371-1379 (2008).
    • (2008) J. Nucl. Med. , vol.49 , pp. 1371-1379
    • Lee, H.Y.1    Li, Z.2    Chen, K.3
  • 163
    • 33646582037 scopus 로고    scopus 로고
    • Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
    • USA
    • Farokhzad OC, Cheng J, Teply BA et al. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc. Natl Acad. Sci. USA 103, 6315-6320 (2006).
    • (2006) Proc. Natl Acad. Sci. , vol.103 , pp. 6315-6320
    • Farokhzad, O.C.1    Cheng, J.2    Teply, B.A.3
  • 165
    • 79954858874 scopus 로고    scopus 로고
    • RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule
    • Shigdar S, Lin J, Yu Y et al. RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci. 102, 991-998 (2011).
    • (2011) Cancer Sci. , vol.102 , pp. 991-998
    • Shigdar, S.1    Lin, J.2    Yu, Y.3
  • 166
    • 58949100319 scopus 로고    scopus 로고
    • Targeted Herceptin-dextran iron oxide nanoparticles for noninvasive imaging of HER2/neu receptors using MRI
    • Chen TJ, Cheng TH, Chen CY et al. Targeted Herceptin-dextran iron oxide nanoparticles for noninvasive imaging of HER2/neu receptors using MRI. J. Biol. Inorg. Chem. 14, 253-260 (2009).
    • (2009) J. Biol. Inorg. Chem. , vol.14 , pp. 253-260
    • Chen, T.J.1    Cheng, T.H.2    Chen, C.Y.3
  • 167
    • 81855218276 scopus 로고    scopus 로고
    • Chimeric aptamers in cancer cell-targeted drug delivery
    • Kanwar JR, Roy K, Kanwar RK. Chimeric aptamers in cancer cell-targeted drug delivery. Crit. Rev. Biochem. Mol. Biol. 46(6), 459-477 (2011).
    • (2011) Crit. Rev. Biochem. Mol. Biol. , vol.46 , Issue.6 , pp. 459-477
    • Kanwar, J.R.1    Roy, K.2    Kanwar, R.K.3
  • 170
    • 34648831012 scopus 로고    scopus 로고
    • Cancer stem cells in leukemia, recent advances
    • DOI 10.1002/jcp.21140
    • Zou G-M. Cancer stem cells in leukemia, recent advances. J. Cell Physiol. 213, 440-444 (2007). (Pubitemid 47509725)
    • (2007) Journal of Cellular Physiology , vol.213 , Issue.2 , pp. 440-444
    • Zou, G.-M.1
  • 171
    • 79951670098 scopus 로고    scopus 로고
    • Leukemia stem cells
    • Testa U. Leukemia stem cells. Ann Hematol. 90, 245-271 (2011).
    • (2011) Ann Hematol. , vol.90 , pp. 245-271
    • Testa, U.1
  • 172
    • 77954064420 scopus 로고    scopus 로고
    • Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers
    • Hwang-Verslues WW, Kuo WH, Chang PH et al. Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers. PLoS One 4, e8377 (2009).
    • (2009) PLoS One , vol.4
    • Hwang-Verslues, W.W.1    Kuo, W.H.2    Chang, P.H.3
  • 173
    • 79955929967 scopus 로고    scopus 로고
    • Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis
    • Ishiwata T, Matsuda Y, Naito Z. Nestin in gastrointestinal and other cancers: effects on cells and tumor angiogenesis. World J. Gastroenterol. 17, 409-418 (2011).
    • (2011) World J. Gastroenterol. , vol.17 , pp. 409-418
    • Ishiwata, T.1    Matsuda, Y.2    Naito, Z.3
  • 174
    • 72449210651 scopus 로고    scopus 로고
    • Cancer stem cells: Cell culture markers and targets for new therapies
    • Gilbert CA, Ross AH. Cancer stem cells: cell culture, markers, and targets for new therapies. J. Cell Biochem. 108, 1031-1038 (2009).
    • (2009) J. Cell Biochem. , vol.108 , pp. 1031-1038
    • Gilbert, C.A.1    Ross, A.H.2
  • 175
    • 71549129570 scopus 로고    scopus 로고
    • A2B5 cells from human glioblastoma have cancer stem cell properties
    • Tchoghandjian A, Baeza N, Colin C et al. A2B5 cells from human glioblastoma have cancer stem cell properties. Brain Pathol. 20, 211-221 (2010).
    • (2010) Brain Pathol. , vol.20 , pp. 211-221
    • Tchoghandjian, A.1    Baeza, N.2    Colin, C.3
  • 176
    • 80053119731 scopus 로고    scopus 로고
    • The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas
    • Kim K-J, Lee K-H, Kim H-S et al. The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas. Neuropathology. 31(5), 494-502 (2011).
    • (2011) Neuropathology. , vol.31 , Issue.5 , pp. 494-502
    • Kim, K.-J.1    Lee, K.-H.2    Kim, H.-S.3
  • 177
    • 84863143391 scopus 로고    scopus 로고
    • Liver cancer stem cells
    • 2011
    • Mikhail S, He AR. Liver cancer stem cells. Int. J. Hepatol. 2011, 486954 (2011).
    • Int. J. Hepatol. , vol.2011 , pp. 486954
    • Mikhail, S.1    He, A.R.2
  • 178
    • 79251641963 scopus 로고    scopus 로고
    • Lung cancer stem cell: New insights on experimental models and preclinical data
    • Epub 2011
    • Rivera C, Rivera S, Loriot Y, Vozenin MC, Deutsch E. Lung cancer stem cell: new insights on experimental models and preclinical data. J. Oncol. 2011:549181 (2011) (Epub).
    • J. Oncol. , vol.2011 , pp. 549181
    • Rivera, C.1    Rivera, S.2    Loriot, Y.3    Vozenin, M.C.4    Deutsch, E.5
  • 179
    • 36148991764 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumors
    • DOI 10.1016/j.copbio.2007.10.007, PII S0958166907001292, Expression Technologies / Tissue and Cell Engineering
    • Ailles LE, Weissman IL. Cancer stem cells in solid tumors. Curr. Opin Biotechnol. 18, 460-466 (2007). (Pubitemid 350116595)
    • (2007) Current Opinion in Biotechnology , vol.18 , Issue.5 , pp. 460-466
    • Ailles, L.E.1    Weissman, I.L.2
  • 180
    • 77958478367 scopus 로고    scopus 로고
    • Targeting the osteosarcoma cancer stem cell
    • Siclari VA, Qin L. Targeting the osteosarcoma cancer stem cell. J. Orthop. Surg. Res. 5, 78 (2010).
    • (2010) J. Orthop. Surg. Res. , vol.5 , pp. 78
    • Siclari, V.A.1    Qin, L.2
  • 181
    • 79957917044 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival
    • Silva IA, Bai S, McLean K et al. Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res. 71, 3991-4001 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 3991-4001
    • Silva, I.A.1    Bai, S.2    McLean, K.3
  • 182
    • 77955599004 scopus 로고    scopus 로고
    • Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas
    • May R, Sureban SM, Lightfoot SA et al. Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas. Am. J. Physiol. Gastrointest. Liver Physiol. 299, G303-G310 (2010).
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.299
    • May, R.1    Sureban, S.M.2    Lightfoot, S.A.3
  • 183
    • 57149090285 scopus 로고    scopus 로고
    • The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cells
    • Griend DJV, Karthaus WL, Dalrymple S et al. The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cells. Cancer Res. 68, 9703-9711 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 9703-9711
    • Griend, D.J.V.1    Karthaus, W.L.2    Dalrymple, S.3
  • 184
    • 34548218695 scopus 로고    scopus 로고
    • Cancer stem-like cells in human prostate carcinoma cells DU145: The seeds of the cell line?
    • Wei C, Guomin W, Yujun L, Ruizhe Q. Cancer stem-like cells in human prostate carcinoma cells DU145: the seeds of the cell line? Cancer Biol. Ther. 6, 763-768 (2007). (Pubitemid 47328359)
    • (2007) Cancer Biology and Therapy , vol.6 , Issue.5 , pp. 763-768
    • Wei, C.1    Guomin, W.2    Yujun, L.3    Ruizhe, Q.4
  • 185
    • 33645026803 scopus 로고    scopus 로고
    • Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells
    • Patrawala L, Calhoun T, Schneider-Broussard R et al. Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 25, 1696-1708 (2006).
    • (2006) Oncogene , vol.25 , pp. 1696-1708
    • Patrawala, L.1    Calhoun, T.2    Schneider-Broussard, R.3
  • 186
    • 75949101677 scopus 로고    scopus 로고
    • ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients outcome
    • Li T, Su Y, Mei Y et al. ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab. Invest. 90, 234-244 (2010).
    • (2010) Lab. Invest. , vol.90 , pp. 234-244
    • Li, T.1    Su, Y.2    Mei, Y.3
  • 187
    • 78650620820 scopus 로고    scopus 로고
    • PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis
    • Zhang K, Waxman DJ. PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis. Mol. Cancer. 29, 319 (2010).
    • (2010) Mol. Cancer. , vol.29 , pp. 319
    • Zhang, K.1    Waxman, D.J.2
  • 188
    • 77953472807 scopus 로고    scopus 로고
    • CD133 trop-2 and a2b1 integrin surface receptors as markers of putative human prostate cancer stem cells
    • Trerotola M, Rathore S, Goel HL et al. CD133, Trop-2 and a2b1 integrin surface receptors as markers of putative human prostate cancer stem cells. Am. J. Transl. Res. 2, 135-144 (2010).
    • (2010) Am. J. Transl. Res. , vol.2 , pp. 135-144
    • Trerotola, M.1    Rathore, S.2    Goel, H.L.3
  • 189
    • 78449281896 scopus 로고    scopus 로고
    • Tumorigenic and metastatic activity of human thyroid cancer stem cells
    • Todaro M, Iovino F, Eterno V et al. Tumorigenic and metastatic activity of human thyroid cancer stem cells. Cancer Res. 70, 8874-8885 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 8874-8885
    • Todaro, M.1    Iovino, F.2    Eterno, V.3
  • 190
    • 80155167997 scopus 로고    scopus 로고
    • The potential role of CD133 in immune surveillance and apoptosis: A mitochondrial connection
    • Zobalova R, Prokopova K, Stantic M et al. The potential role of CD133 in immune surveillance and apoptosis: a mitochondrial connection? Antioxid. Redox Signal. 15(12), 2989-3002 (2011).
    • (2011) Antioxid.Redox Signal. , vol.15 , Issue.12 , pp. 2989-3002
    • Zobalova, R.1    Prokopova, K.2    Stantic, M.3
  • 191
    • 70349638289 scopus 로고    scopus 로고
    • Tumor-initiating cells: Challenges and opportunities for anticancer drug discovery
    • Zhou BB, Zhang H, Damelin M et al. Tumor-initiating cells: challenges and opportunities for anticancer drug discovery. Nat. Rev. Drug Discov. 8, 806-823 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 806-823
    • Zhou, B.B.1    Zhang, H.2    Damelin, M.3
  • 192
    • 59749103834 scopus 로고    scopus 로고
    • Nuclear signaling by tumor-associated antigen EpCAM
    • Maetzel D, Denzel S, Mack B et al. Nuclear signaling by tumor-associated antigen EpCAM. Nat. Cell Biol. 11, 162-171 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 162-171
    • Maetzel, D.1    Denzel, S.2    MacK, B.3
  • 193
    • 80053040376 scopus 로고    scopus 로고
    • Phase i trial of MK-0752 in children with refractory CNS malignancies: A pediatric brain tumor consortium study
    • Fouladi M, Stewart CF, Olson J et al. Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study. J. Clin. Oncol. 29, 3529-3534 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3529-3534
    • Fouladi, M.1    Stewart, C.F.2    Olson, J.3
  • 194
    • 84855869440 scopus 로고    scopus 로고
    • Therapeutic promise and challenges of targeting DLL4/NOTCH1
    • Yan M. Therapeutic promise and challenges of targeting DLL4/NOTCH1. Vasc. Cell 3, 17 (2011).
    • (2011) Vasc. Cell , vol.3 , pp. 17
    • Yan, M.1
  • 195
    • 80053206941 scopus 로고    scopus 로고
    • Therapeutic approaches to target cancer stem cells
    • Diaz A, Leon K. Therapeutic approaches to target cancer stem cells. Cancers 3, 3331-3352 (2011).
    • (2011) Cancers , vol.3 , pp. 3331-3352
    • Diaz, A.1    Leon, K.2
  • 196
    • 79957989939 scopus 로고    scopus 로고
    • Drug discovery approaches to target Wnt signaling in cancer stem cells
    • Curtin JC, Lorenzi MV. Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget 1, 563-577 (2010).
    • (2010) Oncotarget , vol.1 , pp. 563-577
    • Curtin, J.C.1    Lorenzi, M.V.2
  • 197
    • 67349260705 scopus 로고    scopus 로고
    • Targeting cancer stem cells for more effective therapies: Taking out cancer's locomotive engine
    • Winquist RJ, Boucher DM, Wood M, Furey BF. Targeting cancer stem cells for more effective therapies: taking out cancer's locomotive engine. Biochem. Pharmacol. 78, 326-334 (2009).
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 326-334
    • Winquist, R.J.1    Boucher, D.M.2    Wood, M.3    Furey, B.F.4
  • 198
    • 79960266140 scopus 로고    scopus 로고
    • Novel agents for the treatment of pancreatic adenocarcinoma
    • Chicago IL USA 3-7 June 2011. JOP
    • Cheng H, Merika E, Syrigos KN, Saif MW. Novel agents for the treatment of pancreatic adenocarcinoma. Presented at: The 2011 ASCO Annual Meeting. Chicago, IL, USA 3-7 June 2011. JOP 12, 334-338 (2011).
    • (2011) Presented At: The 2011 ASCO Annual Meeting , vol.12 , pp. 334-338
    • Cheng, H.1    Merika, E.2    Syrigos, K.N.3    Saif, M.W.4
  • 199
    • 79957622341 scopus 로고    scopus 로고
    • Concise review: Emerging concepts in clinical targeting of cancer stem cells
    • Rasheed ZA, Kowalski J, Smith BD, Matsui W. Concise review: emerging concepts in clinical targeting of cancer stem cells. Stem Cells 29, 883-887 (2011)
    • (2011) Stem Cells , vol.29 , pp. 883-887
    • Rasheed, Z.A.1    Kowalski, J.2    Smith, B.D.3    Matsui, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.