Reversal of BCRP-mediated multidrug resistance by stable expression of small interfering RNAs

Journal of Cellular Biochemistry

Volumn 102, Issue 1, 2007, Pages 75-81

  Lv, Hui ^a   He, Zhimin ^a,b   Liu, Xiaorong ^a   Yuan, Jianhui ^a   Yu, Yanhui ^a   Chen, Zhuchu ^a  

^a Central South University   (China)

^b NONE   (China)

Author keywords

Breast cancer resistance (BCRP); Multidrug resistance; RNAi

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; MESSENGER RNA; MITOXANTRONE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RNA INTERFERENCE;

ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; MITOXANTRONE; NEOPLASM PROTEINS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 34548505716     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21276     Document Type: Article

References (22)

1. Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V, Dean M. 1998. Human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res 58:5337-5339.
2. Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB. 1986. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug resistant human cells. Cell 47:381-389.
3. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG. 1992. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science (Wash DC) 258:1650-1654.
4. Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD. 1998. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 95:15665-15670.
5. Ee PL, He X, Ross DD, Beck WT. 2004. Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference. Mol Cancer Ther 3:1577-1583.
6. Elbashir SM, Lendeckel W, Tuschl T. 2001. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15:188-200.
7. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. 1998. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806-811.
8. Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I. 1995. Genetic analysis of the multidrug transporter. Annu Rev Genet 29:607-649.
9. Hoffmann U, Materna V, Blohmer JU. 2001. Quantitative expression analysis of genes involved in the development of chemoresistance in ovarian carcinoma. Pathol Res Pract 96:235-238.
10. Kanzaki A, Toi M, Nakayama K, Bando H, Mutoh M, Uchida T, Fukumoto M, Takebayashi Y. 2001. Expression of multidrug resistance-related transporters in human breast carcinoma. Jpn J Cancer Res 92:452-458.
11. Kawabata S, Oka M, Shiozawa K, Tsukamoto K, Nakatomi K, Soda H, Fukuda M, Ikegami Y, Sugahara K, Yamada Y, Kamihira S, Doyle LA, Ross DD, Kohno S. 2001. Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells. Biochem Biophys Res Commun 280:1216-1223.
12. Maliepaard M, van Gastelen MA, de Jong LA, Pluim D, van Waardenburg RC, Ruevekamp-Helmers MC, Floot BG, Schellens JH. 1999. Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line. Cancer Res 59:4559-4563.
13. Minderman H, Suvannasankha A, O'Loughlin KL, Scheffer GL, Scheper RJ, Robey RW, Baer MR. 2002. Flow cytometric analysis of breast cancer resistance protein expression and function. Cytometry 48:59-65.
14. Miyake K, Mickley L, Litman T, Zhan Z, Robey R, Cristensen B, Brangi M, Greenberger L, Dean M, Fojo T, Bates SE. 1999. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes. Cancer Res 59:8-13.
15. Nieth C, Priebsch A, Stege A, Lage H. 2003. Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi). FEBS Lett 545:144-150.
16. Ozvegy C, Litman T, Sarkadi B. 2001. Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun 285:111-117.
17. Ozvegy C, Varadi A, Sarkadi B. 2002. Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation. J Biol Chem 277:47980-47990.
18. Ross DD, Karp JE, Chen TT, Doyle LA. 2000. Expression of breast cancer resistance protein in blast cells from patients with acute leukemia. Blood 96:365-368.
19. Stege A, Priebsch A, Nieth C, Lage H. 2004. Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference. Cancer Gene Ther 11:699-706.
20. Wu H, Hait WN, Yang JM. 2003. Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells. Cancer Res 63:1515-1519.
21. YagÜe E, Higgins CF, Raguz S. 2004. Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting M DR1. Gene Ther 11:1170-1174.
22. Yu JY, DeRuiter SL, Turner DL. 2002. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci USA 99:6047-6052.