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Volumn 117, Issue 12, 2007, Pages 3612-3614

On future's doorstep: RNA interference and the pharmacopeia of tomorrow

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; MESSENGER RNA; MICRORNA; NUCLEIC ACID; RIBONUCLEASE H; SMALL INTERFERING RNA;

EID: 36849084647     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34274     Document Type: Review
Times cited : (57)

References (63)
  • 1
    • 0028802141 scopus 로고
    • Expression of differentiation-related phenotypes and apoptosis are independently regulated during myeloid cell differentiation
    • Terui, Y., et al. 1995. Expression of differentiation-related phenotypes and apoptosis are independently regulated during myeloid cell differentiation. J. Biochem. (Tokyo) 117:77-84.
    • (1995) J. Biochem. (Tokyo) , vol.117 , pp. 77-84
    • Terui, Y.1
  • 2
    • 0035976571 scopus 로고    scopus 로고
    • Research on resistance to cancer drug Gleevec
    • Sawyers, C.L. 2001. Research on resistance to cancer drug Gleevec. Science. 294:1834.
    • (2001) Science , vol.294 , pp. 1834
    • Sawyers, C.L.1
  • 3
    • 33745878287 scopus 로고    scopus 로고
    • Unique toxicities and resistance mechanisms associated with monoclonal antibody therapy
    • Friedberg, J.W. 2005. Unique toxicities and resistance mechanisms associated with monoclonal antibody therapy. Hematology Am. Soc. Hematol. Educ. Program. 2005:329-334.
    • (2005) Hematology Am. Soc. Hematol. Educ. Program , vol.2005 , pp. 329-334
    • Friedberg, J.W.1
  • 5
    • 0035836720 scopus 로고    scopus 로고
    • Toward rules for 1:1 polyamide:DNA recognition
    • Urbach, A.R., and Dervan, P.B. 2001. Toward rules for 1:1 polyamide:DNA recognition. Proc. Natl. Acad. Sci. U. S. A. 98:4343-4348.
    • (2001) Proc. Natl. Acad. Sci. U. S. A , vol.98 , pp. 4343-4348
    • Urbach, A.R.1    Dervan, P.B.2
  • 6
    • 27744530147 scopus 로고    scopus 로고
    • Zinc finger nucleases: Custom-designed molecular scissors for genome engineering of plant and mammalian cells
    • Durai, S., et al. 2005. Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells. Nucleic Acids Res. 33:5978-5990.
    • (2005) Nucleic Acids Res , vol.33 , pp. 5978-5990
    • Durai, S.1
  • 7
    • 0032147234 scopus 로고    scopus 로고
    • Nucleic acid therapeutics: State of the art and future prospects
    • Gewirtz, A.M., Sokol, D.L., and Ratajczak, M.Z. 1998. Nucleic acid therapeutics: state of the art and future prospects. Blood. 92:712-736.
    • (1998) Blood , vol.92 , pp. 712-736
    • Gewirtz, A.M.1    Sokol, D.L.2    Ratajczak, M.Z.3
  • 8
    • 0036636074 scopus 로고    scopus 로고
    • Nucleic-acid therapeutics: Basic principles and recent applications
    • Opalinska, J.B., and Gewirtz, A.M. 2002. Nucleic-acid therapeutics: basic principles and recent applications. Nat. Rev. Drug Discov. 1:503-514.
    • (2002) Nat. Rev. Drug Discov , vol.1 , pp. 503-514
    • Opalinska, J.B.1    Gewirtz, A.M.2
  • 9
    • 0344641913 scopus 로고    scopus 로고
    • Sequence-specific DNA recognition by polyamides
    • Dervan, P.B., and Burli, R.W. 1999. Sequence-specific DNA recognition by polyamides. Curr. Opin. Chem. Biol. 3:688-693.
    • (1999) Curr. Opin. Chem. Biol , vol.3 , pp. 688-693
    • Dervan, P.B.1    Burli, R.W.2
  • 10
    • 1542465051 scopus 로고    scopus 로고
    • Opalinska, J.B., and Gewirtz, A.M. 2003. Therapeutic potential of antisense nucleic acid molecules. Sci. STKE. 2003:pe47.
    • Opalinska, J.B., and Gewirtz, A.M. 2003. Therapeutic potential of antisense nucleic acid molecules. Sci. STKE. 2003:pe47.
  • 11
    • 33645108129 scopus 로고    scopus 로고
    • RNAi therapeutics: SNALPing siRNAs in vivo
    • Rossi, J.J. 2006. RNAi therapeutics: SNALPing siRNAs in vivo. Gene Ther. 13:583-584.
    • (2006) Gene Ther , vol.13 , pp. 583-584
    • Rossi, J.J.1
  • 12
    • 0034945672 scopus 로고    scopus 로고
    • Antisense effects in the cell nucleus: Modification of splicing
    • Kole, R., and Sazani, P. 2001. Antisense effects in the cell nucleus: modification of splicing. Curr. Opin. Mol. Ther. 3:229-234.
    • (2001) Curr. Opin. Mol. Ther , vol.3 , pp. 229-234
    • Kole, R.1    Sazani, P.2
  • 13
    • 0027988108 scopus 로고
    • Identification and characterization by antisense oligonucleotides of exon and intron sequences required for splicing
    • Dominski, Z., and Kole, R. 1994. Identification and characterization by antisense oligonucleotides of exon and intron sequences required for splicing. Mol. Cell. Biol. 14:7445-7454.
    • (1994) Mol. Cell. Biol , vol.14 , pp. 7445-7454
    • Dominski, Z.1    Kole, R.2
  • 14
    • 0030969949 scopus 로고    scopus 로고
    • Morpholino and phosphorothioate antisense oligomers compared in cell-free and in-cell systems
    • Summerton, J., et al. 1997. Morpholino and phosphorothioate antisense oligomers compared in cell-free and in-cell systems. Antisense Nucleic Acid Drug Dev. 7:63-70.
    • (1997) Antisense Nucleic Acid Drug Dev , vol.7 , pp. 63-70
    • Summerton, J.1
  • 15
    • 0034939942 scopus 로고    scopus 로고
    • Phosphorodiamidate morpholino oligomers: Favorable properties for sequence-specific gene inactivation
    • Iversen, P.L. 2001. Phosphorodiamidate morpholino oligomers: favorable properties for sequence-specific gene inactivation. Curr. Opin. Mol. Ther. 3:235-238.
    • (2001) Curr. Opin. Mol. Ther , vol.3 , pp. 235-238
    • Iversen, P.L.1
  • 16
    • 0035962892 scopus 로고    scopus 로고
    • A critical survey of the structurefunction of the antisense oligo/RNA heteroduplex as substrate for RNase H
    • Zamaratski, E., Pradeepkumar, P.I., and Chattopadhyaya, J. 2001. A critical survey of the structurefunction of the antisense oligo/RNA heteroduplex as substrate for RNase H. J. Biochem. Biophys. Methods. 48:189-208.
    • (2001) J. Biochem. Biophys. Methods , vol.48 , pp. 189-208
    • Zamaratski, E.1    Pradeepkumar, P.I.2    Chattopadhyaya, J.3
  • 17
    • 0031922256 scopus 로고    scopus 로고
    • Molecular mechanisms of antisense drugs: RNase H
    • Crooke, S.T. 1998. Molecular mechanisms of antisense drugs: RNase H. Antisense Nucleic Acid Drug Dev. 8:133-134.
    • (1998) Antisense Nucleic Acid Drug Dev , vol.8 , pp. 133-134
    • Crooke, S.T.1
  • 18
    • 0033991459 scopus 로고    scopus 로고
    • Intracellular expression and function of antisense catalytic RNAs
    • Castanotto, D., Scherr, M., and Rossi, J.J. 2000. Intracellular expression and function of antisense catalytic RNAs. Methods Enzymol. 313:401-420.
    • (2000) Methods Enzymol , vol.313 , pp. 401-420
    • Castanotto, D.1    Scherr, M.2    Rossi, J.J.3
  • 19
    • 0345411390 scopus 로고    scopus 로고
    • Ribozymes in the nucleolus
    • Rossi, J.J. 1999. Ribozymes in the nucleolus. Science. 285:1685.
    • (1999) Science , vol.285 , pp. 1685
    • Rossi, J.J.1
  • 21
    • 0033589752 scopus 로고    scopus 로고
    • Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes)
    • Wu, Y., et al. 1999. Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes). Hum. Gene Ther. 10:2847-2857.
    • (1999) Hum. Gene Ther , vol.10 , pp. 2847-2857
    • Wu, Y.1
  • 22
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon, G.J. 2002. RNA interference. Nature. 418:244-251.
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 23
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez, J., et al. 2002. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell. 110:563-574.
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1
  • 24
    • 28844486728 scopus 로고    scopus 로고
    • RNA interference for treating haematological malignancies
    • Hexner, E.O., and Gewirtz, A.M. 2005. RNA interference for treating haematological malignancies. Expert Opin. Biol. Ther. 5:1585-1592.
    • (2005) Expert Opin. Biol. Ther , vol.5 , pp. 1585-1592
    • Hexner, E.O.1    Gewirtz, A.M.2
  • 25
    • 28644432079 scopus 로고    scopus 로고
    • RNA interference as a gene-specific approach for molecular medicine
    • Grunweller, A., and Hartmann, R.K. 2005. RNA interference as a gene-specific approach for molecular medicine. Curr. Med. Chem. 12:3143-3161.
    • (2005) Curr. Med. Chem , vol.12 , pp. 3143-3161
    • Grunweller, A.1    Hartmann, R.K.2
  • 26
    • 34848857313 scopus 로고    scopus 로고
    • Gene silencing by double-stranded RNA (Nobel lecture)
    • Fire, A.Z. 2007. Gene silencing by double-stranded RNA (Nobel lecture). Angew Chem. Int. Ed. Engl. 46:6966-6984.
    • (2007) Angew Chem. Int. Ed. Engl , vol.46 , pp. 6966-6984
    • Fire, A.Z.1
  • 27
    • 33750094787 scopus 로고    scopus 로고
    • Nobel Prize in Physiology or Medicine. Method to silence genes earns loud praise
    • Couzin, J. 2006. Nobel Prize in Physiology or Medicine. Method to silence genes earns loud praise. Science. 314:34.
    • (2006) Science , vol.314 , pp. 34
    • Couzin, J.1
  • 28
    • 33750482616 scopus 로고    scopus 로고
    • RNAi Nobel ignores vital groundwork on plants
    • Bots, M., Maughan, S., and Nieuwland, J. 2006. RNAi Nobel ignores vital groundwork on plants. Nature. 443:906.
    • (2006) Nature , vol.443 , pp. 906
    • Bots, M.1    Maughan, S.2    Nieuwland, J.3
  • 29
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvagner, G., et al. 2001. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 293:834-838.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvagner, G.1
  • 30
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
    • Ketting, R.F., et al. 2001. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15:2654-2659.
    • (2001) Genes Dev , vol.15 , pp. 2654-2659
    • Ketting, R.F.1
  • 31
    • 0036147007 scopus 로고    scopus 로고
    • Molecular characterization of a mouse cDNA encoding Dicer, a ribonuclease III ortholog involved in RNA interference
    • Nicholson, R.H., and Nicholson, A.W. 2002. Molecular characterization of a mouse cDNA encoding Dicer, a ribonuclease III ortholog involved in RNA interference. Mamm. Genome. 13:67-73.
    • (2002) Mamm. Genome , vol.13 , pp. 67-73
    • Nicholson, R.H.1    Nicholson, A.W.2
  • 32
    • 22144489833 scopus 로고    scopus 로고
    • RNAi: The nuts and bolts of the RISC machine
    • Filipowicz, W. 2005. RNAi: the nuts and bolts of the RISC machine. Cell. 122:17-20.
    • (2005) Cell , vol.122 , pp. 17-20
    • Filipowicz, W.1
  • 33
    • 0035261255 scopus 로고    scopus 로고
    • Post-transcriptional gene silencing by double-stranded RNA
    • Hammond, S.M., Caudy, A.A., and Hannon, G.J. 2001. Post-transcriptional gene silencing by double-stranded RNA. Nat. Rev. Genet. 2:110-119.
    • (2001) Nat. Rev. Genet , vol.2 , pp. 110-119
    • Hammond, S.M.1    Caudy, A.A.2    Hannon, G.J.3
  • 34
    • 11244279683 scopus 로고    scopus 로고
    • Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity
    • Parker, J.S., Roe, S.M., and Barford, D. 2004. Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J. 23:4727-4737.
    • (2004) EMBO J , vol.23 , pp. 4727-4737
    • Parker, J.S.1    Roe, S.M.2    Barford, D.3
  • 35
    • 18744407284 scopus 로고    scopus 로고
    • Purified Argonaute2 and an siRNA form recombinant human RISC
    • Rivas, F.V., et al. 2005. Purified Argonaute2 and an siRNA form recombinant human RISC. Nat. Struct. Mol. Biol. 12:340-349.
    • (2005) Nat. Struct. Mol. Biol , vol.12 , pp. 340-349
    • Rivas, F.V.1
  • 36
    • 10644234841 scopus 로고    scopus 로고
    • The Drosha-DGCR8 complex in primary microRNA processing
    • Han, J., et al. 2004. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 18:3016-3027.
    • (2004) Genes Dev , vol.18 , pp. 3016-3027
    • Han, J.1
  • 37
    • 1442360415 scopus 로고    scopus 로고
    • RNase III enzymes and the initiation of gene silencing
    • Carmell, M.A., and Hannon, G.J. 2004. RNase III enzymes and the initiation of gene silencing. Nat. Struct. Mol. Biol. 11:214-218.
    • (2004) Nat. Struct. Mol. Biol , vol.11 , pp. 214-218
    • Carmell, M.A.1    Hannon, G.J.2
  • 38
    • 0036534284 scopus 로고    scopus 로고
    • MicroRNAs: Deviants no longer
    • Pasquinelli, A.E. 2002. MicroRNAs: deviants no longer. Trends Genet. 18:171-173.
    • (2002) Trends Genet , vol.18 , pp. 171-173
    • Pasquinelli, A.E.1
  • 39
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen, C.Z., et al. 2004. MicroRNAs modulate hematopoietic lineage differentiation. Science. 303:83-86.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1
  • 40
    • 33645960451 scopus 로고    scopus 로고
    • Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance
    • Calin, G.A., and Croce, C.M. 2006. Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance. Semin. Oncol. 33:167-173.
    • (2006) Semin. Oncol , vol.33 , pp. 167-173
    • Calin, G.A.1    Croce, C.M.2
  • 41
    • 33846945735 scopus 로고    scopus 로고
    • Processing of intronic microRNAs
    • Kim, Y.K., and Kim, V.N. 2007. Processing of intronic microRNAs. EMBO J. 26:775-783.
    • (2007) EMBO J , vol.26 , pp. 775-783
    • Kim, Y.K.1    Kim, V.N.2
  • 42
    • 30344454402 scopus 로고    scopus 로고
    • Short interfering RNA (siRNA): Tool or therapeutic?
    • Cejka, D., Losert, D., and Wacheck, V. 2006. Short interfering RNA (siRNA): tool or therapeutic? Clin. Sci. (Lond.) 110:47-58.
    • (2006) Clin. Sci. (Lond.) , vol.110 , pp. 47-58
    • Cejka, D.1    Losert, D.2    Wacheck, V.3
  • 43
    • 25844481481 scopus 로고    scopus 로고
    • Biomembrane-permeable and Ribonuclease-resistant siRNA with enhanced activity
    • Liao, H., and Wang, J.H. 2005. Biomembrane-permeable and Ribonuclease-resistant siRNA with enhanced activity. Oligonucleotides. 15:196-205.
    • (2005) Oligonucleotides , vol.15 , pp. 196-205
    • Liao, H.1    Wang, J.H.2
  • 44
    • 20444455464 scopus 로고    scopus 로고
    • Target accessibility dictates the potency of human RISC
    • Brown, K.M., Chu, C.Y., and Rana, T.M. 2005. Target accessibility dictates the potency of human RISC. Nat. Struct. Mol. Biol. 12:469-470.
    • (2005) Nat. Struct. Mol. Biol , vol.12 , pp. 469-470
    • Brown, K.M.1    Chu, C.Y.2    Rana, T.M.3
  • 45
    • 27944473306 scopus 로고    scopus 로고
    • Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency
    • Patzel, V., et al. 2005. Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency. Nat. Biotechnol. 23:1440-1444.
    • (2005) Nat. Biotechnol , vol.23 , pp. 1440-1444
    • Patzel, V.1
  • 46
    • 6344291687 scopus 로고    scopus 로고
    • Lipidic carriers of siRNA: Differences in the formulation, cellular uptake, and delivery with plasmid DNA
    • Spagnou, S., Miller, A.D., and Keller, M. 2004. Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA. Biochemistry. 43:13348-13356.
    • (2004) Biochemistry , vol.43 , pp. 13348-13356
    • Spagnou, S.1    Miller, A.D.2    Keller, M.3
  • 47
    • 25144511023 scopus 로고    scopus 로고
    • siRNA delivery in vivo
    • Sioud, M. 2005. siRNA delivery in vivo. Methods Mol. Biol. 309:237-249.
    • (2005) Methods Mol. Biol , vol.309 , pp. 237-249
    • Sioud, M.1
  • 48
    • 4243754537 scopus 로고    scopus 로고
    • Confirming specificity of RNAi in mammalian cells
    • Lassus, P., Rodriguez, J., and Lazebnik, Y. 2002. Confirming specificity of RNAi in mammalian cells. Sci. STKE. 2002:PL13.
    • (2002) Sci. STKE , vol.2002
    • Lassus, P.1    Rodriguez, J.2    Lazebnik, Y.3
  • 49
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
    • Hornung, V., et al. 2005. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11:263-270.
    • (2005) Nat. Med , vol.11 , pp. 263-270
    • Hornung, V.1
  • 50
    • 33645698822 scopus 로고    scopus 로고
    • siRNA binding proteins of microglial cells: PKR is an unanticipated ligand
    • Zhang, Z., et al. 2006. siRNA binding proteins of microglial cells: PKR is an unanticipated ligand. J. Cell. Biochem. 97:1217-1229.
    • (2006) J. Cell. Biochem , vol.97 , pp. 1217-1229
    • Zhang, Z.1
  • 51
    • 16544382507 scopus 로고    scopus 로고
    • Antisense inhibition: Oligonucleotides, ribozymes, and siRNAs
    • Zhang, Y.C., et al. 2005. Antisense inhibition: oligonucleotides, ribozymes, and siRNAs. Methods Mol. Med. 106:11-34.
    • (2005) Methods Mol. Med , vol.106 , pp. 11-34
    • Zhang, Y.C.1
  • 52
    • 13444262170 scopus 로고    scopus 로고
    • Inhibition of respiratory viruses by nasally administered siRNA
    • Bitko, V., et al. 2005. Inhibition of respiratory viruses by nasally administered siRNA. Nat. Med. 11:50-55.
    • (2005) Nat. Med , vol.11 , pp. 50-55
    • Bitko, V.1
  • 53
    • 36849094017 scopus 로고    scopus 로고
    • Chemical modification: The key to clinical application of RNA interference?
    • Corey, D.R. 2007. Chemical modification: the key to clinical application of RNA interference? J. Clin. Invest. 117:3615-3622.
    • (2007) J. Clin. Invest , vol.117 , pp. 3615-3622
    • Corey, D.R.1
  • 54
    • 0028956615 scopus 로고
    • Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides
    • Beltinger, C., et al. 1995. Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides. J. Clin. Invest. 95:1814-1823.
    • (1995) J. Clin. Invest , vol.95 , pp. 1814-1823
    • Beltinger, C.1
  • 55
    • 34250646692 scopus 로고    scopus 로고
    • Systemic RNAi in Caenorhabditis elegans
    • Hunter, C.P., et al. 2006. Systemic RNAi in Caenorhabditis elegans. Cold Spring Harb. Symp. Quant. Biol. 71:95-100.
    • (2006) Cold Spring Harb. Symp. Quant. Biol , vol.71 , pp. 95-100
    • Hunter, C.P.1
  • 56
    • 35148815670 scopus 로고    scopus 로고
    • Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
    • Wolfrum, C., et al. 2007. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat. Biotechnol. 25:1149-1157.
    • (2007) Nat. Biotechnol , vol.25 , pp. 1149-1157
    • Wolfrum, C.1
  • 57
    • 36849044732 scopus 로고    scopus 로고
    • Nonviral delivery of synthetic siRNAs in vivo
    • Akhtar, S., and Benter, I.F. 2007. Nonviral delivery of synthetic siRNAs in vivo. J. Clin. Invest. 117:3623-3632.
    • (2007) J. Clin. Invest , vol.117 , pp. 3623-3632
    • Akhtar, S.1    Benter, I.F.2
  • 58
    • 36849087968 scopus 로고    scopus 로고
    • Therapeutic application of RNAi: Is mRNA targeting finally ready for prime time?
    • Grimm, D., and Kay, M.A. 2007. Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? J. Clin. Invest. 117:3633-3641.
    • (2007) J. Clin. Invest , vol.117 , pp. 3633-3641
    • Grimm, D.1    Kay, M.A.2
  • 59
    • 33751172532 scopus 로고    scopus 로고
    • Ocular delivery of nucleic acids: Antisense oligonucleotides, aptamers and siRNA
    • Fattal, E., and Bochot, A. 2006. Ocular delivery of nucleic acids: antisense oligonucleotides, aptamers and siRNA. Adv. Drug Deliv. Rev. 58:1203-1223.
    • (2006) Adv. Drug Deliv. Rev , vol.58 , pp. 1203-1223
    • Fattal, E.1    Bochot, A.2
  • 60
    • 34848851014 scopus 로고    scopus 로고
    • Short interfering RNA (siRNA), a novel therapeutic tool acting on angiogenesis
    • Hadj-Slimane, R., et al. 2007. Short interfering RNA (siRNA), a novel therapeutic tool acting on angiogenesis. Biochimie. 89:1234-1244.
    • (2007) Biochimie , vol.89 , pp. 1234-1244
    • Hadj-Slimane, R.1
  • 61
    • 34447559636 scopus 로고    scopus 로고
    • Interfering with disease: A progress report on siRNA-based therapeutics
    • de Fougerolles, A., et al. 2007. Interfering with disease: a progress report on siRNA-based therapeutics. Nat. Rev. Drug Discov. 6:443-453.
    • (2007) Nat. Rev. Drug Discov , vol.6 , pp. 443-453
    • de Fougerolles, A.1
  • 62
    • 33745641278 scopus 로고    scopus 로고
    • Safety concerns raised over RNA interference
    • Frantz, S. 2006. Safety concerns raised over RNA interference. Nat. Rev. Drug Discov. 5:528-529.
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 528-529
    • Frantz, S.1
  • 63
    • 33745299723 scopus 로고    scopus 로고
    • Fatality in mice due to over-saturation of cellular microRNA/short hairpin RNA pathways
    • Grimm, D., et al. 2006. Fatality in mice due to over-saturation of cellular microRNA/short hairpin RNA pathways. Nature. 441:537-541.
    • (2006) Nature , vol.441 , pp. 537-541
    • Grimm, D.1


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