ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients outcome

Laboratory Investigation

Volumn 90, Issue 2, 2010, Pages 234-244

  Li, Ting ^a   Su, Yun ^b   Mei, Yuping ^a   Leng, Qixin ^a   Leng, Bingjie ^a   Liu, Zhenqiu ^a   Stass, Sanford A ^a   Jiang, Feng ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

ALDH1A1; Biomarkers; Cancer stem cell; Prognosis; Prostate cancer

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 1A1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER SURVIVAL; CARCINOGENESIS; CELL HETEROGENEITY; CELL ISOLATION; CELL POPULATION; CLONOGENESIS; CONTROLLED STUDY; GLEASON SCORE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MALIGNANT PROSTATE STEM CELL; NEUROSECRETORY CELL; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROSTATE; PROSTATE CANCER; PROTEIN EXPRESSION; STEM CELL;

EID: 75949101677     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.127     Document Type: Article

References (32)

1. Cookson MS, Aus G, Burnett AL, et al. Variation in the definition of biochemical recurrence in patients treated for localized prostate cancer: the American Urological Association Prostate Guidelines for Localized Prostate Cancer Update Panel report and recommendations for a standard in the reporting of surgical outcomes. J Urol 2007;177:540-545.
2. Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-111.
3. Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med 2006;355:1253-1261.
4. Horst D, Kriegl L, Engel J, et al. CD133 expression is an independent prognostic marker for low survival in colorectal cancer. Br J Cancer 2008;99:1285-1289.
5. Lang SH, Frame FM, Collins AT. Prostate cancer stem cells. J Pathol 2009;217:299-306.
6. Kelly K, Yin JJ. Prostate cancer and metastasis initiating stem cells. Cell Res 2008;18:528-537.
7. Collins AT, Habib FK, Maitland NJ, et al. Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expression. J Cell Sci 2001;114:3865-3872.
8. Richardson GD, Robson CN, Lang SH, et al. CD133, a novel marker for human prostatic epithelial stem cells. J Cell Sci 2004;117: 3539-3545.
9. Patrawala L, Calhoun-Davis T, Schneider-Broussard R, et al. Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cells. Cancer Res 2007;67:6796-6805.
10. Tang DG, Patrawala L, Calhoun T, et al. Prostate cancer stem/ progenitor cells: identification, characterization, and implications. Mol Carcinog 2007;46:1-14.
11. Yoshida A, Hsu LC, Davé V. Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase. Enzyme 1992;46:239-244.
12. Armstrong L, Stojkovic M, Dimmick I, et al. Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity. Stem Cells 2004;22: 1142-1151.
13. Chute JP, Muramoto GG, Whitesides J, et al. Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc Natl Acad Sci USA 2006;103:11707-11712.
14. Hess DA, Craft TP, Wirthlin L, et al. Widespread non-hematopoietic tissue distribution by transplanted human progenitor cells with high aldehyde dehydrogenase activity. Stem Cells 2006;26: 611-620.
15. Hess DA, Wirthlin L, Craft TP, et al. Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells. Blood 2006;107:2162-2169.
16. Pearce DJ, Taussig D, Simpson C, et al. Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples. Stem Cells 2005;6:752-760.
17. Ginestier C, Hur MH, Charafe-Jauffret E, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007;15: 555-567.
18. Jiang F, Qiu Q, Khanna A, et al. Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer. Mol Cancer Res 2009;7:330-338.
19. Burger PE, Gupta R, Xiong X, et al. High ALDH activity: a novel functional marker of murine prostate stem/progenitor cells. Stem Cells 2009;27:2220-2228.
20. Palapattu GS, Wu C, Silvers CR, et al. Selective expression of CD44, a putative prostate cancer stem cell marker, in neuroendocrine tumor cells of human prostate cancer. Prostate 2009;69:787-798.
21. Sotomayor P, Godoy A, Smith GJ, et al. Oct4A is expressed by a subpopulation of prostate neuroendocrine cells. Prostate 2009;69:401-410.
22. Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006;66:9339-9344.
23. Pfeiffer MJ, Schalken JA. Stem cell characteristics in prostate cancer cell lines. Eur Urol 2009;19; e-pub ahead of print.
24. Croker AK, Allan AL. Cancer stem cells: implications for the progression and treatment of metastatic disease. J Cell Mol Med 2008;12:374-390.
25. Balicki D. Moving forward in human mammary stem cell biology and breast cancer prognostication using ALDH1. Cell Stem Cell 2007;15:485-487.
26. Sreerama L, Sladek NE. Class 1 and class 3 aldehyde dehydrogenase levels in the human tumor cell lines currently used by the National Cancer Institute to screen for potentially useful antitumor agents. Adv Exp Med Biol 1997;414:81-94.
27. Bhatia B, Tang S, Yang P, et al. Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells. Oncogene 2005;24:3583-3595.
28. Hudson DL, O'Hare M, Watt FM, et al. Proliferative heterogeneity in the human prostate: evidence for epithelial stem cells. Lab Invest 2000;80:1243-1250.
29. Raff M. Adult stem cell plasticity: fact or artifact? Annu Rev Cell Dev Biol 2003;19:1-22.
30. Liu AY, True LD, LaTray L, et al. Cell-cell interaction in prostate gene regulation and cytodifferentiation. Proc Natl Acad Sci USA 1997;94:10705-10710.
31. Gu G, Yuan J, Wills M, et al. Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo. Cancer Res 2007;67:4807-4815.
32. Cohen BL, Gomez P, Omori Y, et al. Cyclooxygenase-2 (COX-2) expression is an independent predictor of prostate cancer recurrence. Int J Cancer 2006;119:1082-1087.