메뉴 건너뛰기




Volumn 46, Issue 8, 2010, Pages 1323-1332

Mechanisms of resistance to antiangiogenesis therapy

Author keywords

Angiogenesis

Indexed keywords

AFLIBERCEPT; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; CYCLOPHOSPHAMIDE; FIBROBLAST GROWTH FACTOR 2; GLYCOPROTEIN P; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; IRINOTECAN; MONOCLONAL ANTIBODY DC101; NOTCH RECEPTOR; PACLITAXEL; PAZOPANIB; PLACENTAL GROWTH FACTOR; PROTEIN P53; SEMAXANIB; SORAFENIB; STROMAL CELL DERIVED FACTOR 1; SUNITINIB; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN ANTIBODY; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; VATALANIB; GH2 PROTEIN, HUMAN; GROWTH HORMONE; PLACENTAL PEPTIDE HORMONE;

EID: 77951667987     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.02.020     Document Type: Article
Times cited : (159)

References (120)
  • 1
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 3
    • 38949178835 scopus 로고    scopus 로고
    • Angiogenesis is regulated by a novel mechanism: pro- and anti-angiogenic proteins are organized into separate platelet alpha granules and differentially released
    • Italiano Jr. J.E., Richardson J.L., Patel-Hett S., et al. Angiogenesis is regulated by a novel mechanism: pro- and anti-angiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 111 (2008) 1227-1233
    • (2008) Blood , vol.111 , pp. 1227-1233
    • Italiano Jr., J.E.1    Richardson, J.L.2    Patel-Hett, S.3
  • 4
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 20 (2002) 4368-4380
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 5
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D., and Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86 (1996) 353-364
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 6
    • 77951666760 scopus 로고    scopus 로고
    • Why do tumors become resistant to antiangiogenesis drugs?
    • Schmidt C. Why do tumors become resistant to antiangiogenesis drugs?. J Natl Cancer Inst (2009)
    • (2009) J Natl Cancer Inst
    • Schmidt, C.1
  • 7
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumour activity
    • Ellis L.M., and Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 8 (2008) 579-591
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 8
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • Jain R.K., Duda D.G., Clark J.W., and Loeffler J.S. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 3 (2006) 24-40
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 9
    • 43549094700 scopus 로고    scopus 로고
    • New therapeutic directions for advanced pancreatic cancer: targeting the epidermal growth factor and vascular endothelial growth factor pathways
    • Burris III H., and Rocha-Lima C. New therapeutic directions for advanced pancreatic cancer: targeting the epidermal growth factor and vascular endothelial growth factor pathways. Oncologist 13 (2008) 289-298
    • (2008) Oncologist , vol.13 , pp. 289-298
    • Burris III, H.1    Rocha-Lima, C.2
  • 10
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G., and Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8 (2008) 592-603
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 11
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel R.S. Tumor angiogenesis. N Engl J Med 358 (2008) 2039-2049
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 12
    • 55949096784 scopus 로고    scopus 로고
    • Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies
    • Shojaei F., and Ferrara N. Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies. Drug Resist Updat 11 (2008) 219-230
    • (2008) Drug Resist Updat , vol.11 , pp. 219-230
    • Shojaei, F.1    Ferrara, N.2
  • 13
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer R.J., Michaelson M.D., Redman B.G., et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24 (2006) 16-24
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 14
    • 77951665717 scopus 로고    scopus 로고
    • Randomized phase III trial of Raf kinase and VEGFR inhibitor in patients with advanced renal cell cancer
    • Escudier B.S.C., Eisen T., et al. Randomized phase III trial of Raf kinase and VEGFR inhibitor in patients with advanced renal cell cancer. J Clin Oncol 23 (2005) 15-16
    • (2005) J Clin Oncol , vol.23 , pp. 15-16
    • Escudier, B.S.C.1    Eisen, T.2
  • 15
    • 1442305186 scopus 로고    scopus 로고
    • Emerging roles of targeted small molecule protein-tyrosine kinase inhibitors in cancer therapy
    • Smith J.K., Mamoon N.M., and Duhe R.J. Emerging roles of targeted small molecule protein-tyrosine kinase inhibitors in cancer therapy. Oncol Res 14 (2004) 175-225
    • (2004) Oncol Res , vol.14 , pp. 175-225
    • Smith, J.K.1    Mamoon, N.M.2    Duhe, R.J.3
  • 16
    • 20544455330 scopus 로고    scopus 로고
    • Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy
    • Ferrara N., Hillan K.J., and Novotny W. Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 333 (2005) 328-335
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 328-335
    • Ferrara, N.1    Hillan, K.J.2    Novotny, W.3
  • 17
    • 58149190795 scopus 로고    scopus 로고
    • Pathways mediating resistance to vascular endothelial growth factor-targeted therapy
    • Ellis L.M., and Hicklin D.J. Pathways mediating resistance to vascular endothelial growth factor-targeted therapy. Clin Cancer Res 14 (2008) 6371-6375
    • (2008) Clin Cancer Res , vol.14 , pp. 6371-6375
    • Ellis, L.M.1    Hicklin, D.J.2
  • 18
    • 39749166386 scopus 로고    scopus 로고
    • Antiangiogenic therapy for cancer: an update
    • Shojaei F., and Ferrara N. Antiangiogenic therapy for cancer: an update. Cancer J 13 (2007) 345-348
    • (2007) Cancer J , vol.13 , pp. 345-348
    • Shojaei, F.1    Ferrara, N.2
  • 19
    • 0037303885 scopus 로고    scopus 로고
    • E2100: a phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer
    • Miller K.D. E2100: a phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer. Clin Breast Cancer 3 (2003) 421-422
    • (2003) Clin Breast Cancer , vol.3 , pp. 421-422
    • Miller, K.D.1
  • 20
    • 30344437303 scopus 로고    scopus 로고
    • VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells
    • Grunewald M., Avraham I., Dor Y., et al. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124 (2006) 175-189
    • (2006) Cell , vol.124 , pp. 175-189
    • Grunewald, M.1    Avraham, I.2    Dor, Y.3
  • 21
    • 35748957169 scopus 로고    scopus 로고
    • Potential therapeutic strategies for lymphatic metastasis
    • Zwaans B.M., and Bielenberg D.R. Potential therapeutic strategies for lymphatic metastasis. Microvasc Res 74 (2007) 145-158
    • (2007) Microvasc Res , vol.74 , pp. 145-158
    • Zwaans, B.M.1    Bielenberg, D.R.2
  • 22
    • 56749174211 scopus 로고    scopus 로고
    • FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
    • Fischer C., Mazzone M., Jonckx B., and Carmeliet P. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?. Nat Rev Cancer 8 (2008) 942-956
    • (2008) Nat Rev Cancer , vol.8 , pp. 942-956
    • Fischer, C.1    Mazzone, M.2    Jonckx, B.3    Carmeliet, P.4
  • 23
    • 0036941610 scopus 로고    scopus 로고
    • The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF
    • Neufeld G., Kessler O., and Herzog Y. The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF. Adv Exp Med Biol 515 (2002) 81-90
    • (2002) Adv Exp Med Biol , vol.515 , pp. 81-90
    • Neufeld, G.1    Kessler, O.2    Herzog, Y.3
  • 24
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin D.J., and Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23 (2005) 1011-1027
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 25
    • 34447310236 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): A dual regulator for angiogenesis
    • discussion 31
    • Shibuya M. Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis. Angiogenesis 2006;9:225-30 [discussion 31].
    • (2006) Angiogenesis , vol.9 , pp. 225-230
    • Shibuya, M.1
  • 26
    • 36749052895 scopus 로고    scopus 로고
    • Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
    • Ebos J.M., Lee C.R., Christensen J.G., Mutsaers A.J., and Kerbel R.S. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc Natl Acad Sci USA 104 (2007) 17069-17074
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17069-17074
    • Ebos, J.M.1    Lee, C.R.2    Christensen, J.G.3    Mutsaers, A.J.4    Kerbel, R.S.5
  • 27
    • 77951497977 scopus 로고    scopus 로고
    • Pathways mediating VEGF-independent tumor angiogenesis
    • Ferrara N. Pathways mediating VEGF-independent tumor angiogenesis. Cytokine Growth Factor Rev 2009.
    • (2009) Cytokine Growth Factor Rev
    • Ferrara, N.1
  • 28
    • 7944220649 scopus 로고    scopus 로고
    • Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
    • Oliner J., Min H., Leal J., et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 6 (2004) 507-516
    • (2004) Cancer Cell , vol.6 , pp. 507-516
    • Oliner, J.1    Min, H.2    Leal, J.3
  • 29
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • Noguera-Troise I., Daly C., Papadopoulos N.J., et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444 (2006) 1032-1037
    • (2006) Nature , vol.444 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.J.3
  • 30
    • 31544448010 scopus 로고    scopus 로고
    • Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function
    • Williams C.K., Li J.L., Murga M., Harris A.L., and Tosato G. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 107 (2006) 931-939
    • (2006) Blood , vol.107 , pp. 931-939
    • Williams, C.K.1    Li, J.L.2    Murga, M.3    Harris, A.L.4    Tosato, G.5
  • 31
    • 36048978608 scopus 로고    scopus 로고
    • Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
    • Shawber C.J., Funahashi Y., Francisco E., et al. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest 117 (2007) 3369-3382
    • (2007) J Clin Invest , vol.117 , pp. 3369-3382
    • Shawber, C.J.1    Funahashi, Y.2    Francisco, E.3
  • 32
    • 1642523576 scopus 로고    scopus 로고
    • Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways
    • MacKenzie F., Duriez P., Wong F., Noseda M., and Karsan A. Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways. J Biol Chem 279 (2004) 11657-11663
    • (2004) J Biol Chem , vol.279 , pp. 11657-11663
    • MacKenzie, F.1    Duriez, P.2    Wong, F.3    Noseda, M.4    Karsan, A.5
  • 33
    • 5044238876 scopus 로고    scopus 로고
    • Integrin signalling during tumour progression
    • Guo W., and Giancotti F.G. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5 (2004) 816-826
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 816-826
    • Guo, W.1    Giancotti, F.G.2
  • 34
    • 0033636606 scopus 로고    scopus 로고
    • A mechanism for modulation of cellular responses to VEGF: activation of the integrins
    • Byzova T.V., Goldman C.K., Pampori N., et al. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol Cell 6 (2000) 851-860
    • (2000) Mol Cell , vol.6 , pp. 851-860
    • Byzova, T.V.1    Goldman, C.K.2    Pampori, N.3
  • 35
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669-676
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 36
    • 0037093078 scopus 로고    scopus 로고
    • Placental growth factor is a survival factor for tumor endothelial cells and macrophages
    • Adini A., Kornaga T., Firoozbakht F., and Benjamin L.E. Placental growth factor is a survival factor for tumor endothelial cells and macrophages. Cancer Res 62 (2002) 2749-2752
    • (2002) Cancer Res , vol.62 , pp. 2749-2752
    • Adini, A.1    Kornaga, T.2    Firoozbakht, F.3    Benjamin, L.E.4
  • 37
    • 0037703184 scopus 로고    scopus 로고
    • Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    • Autiero M., Waltenberger J., Communi D., et al. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med 9 (2003) 936-943
    • (2003) Nat Med , vol.9 , pp. 936-943
    • Autiero, M.1    Waltenberger, J.2    Communi, D.3
  • 38
    • 33746602209 scopus 로고    scopus 로고
    • Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor
    • Marcellini M., De Luca N., Riccioni T., et al. Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor. Am J Pathol 169 (2006) 643-654
    • (2006) Am J Pathol , vol.169 , pp. 643-654
    • Marcellini, M.1    De Luca, N.2    Riccioni, T.3
  • 39
    • 33847407090 scopus 로고    scopus 로고
    • Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts
    • Taylor A.P., and Goldenberg D.M. Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts. Mol Cancer Ther 6 (2007) 524-531
    • (2007) Mol Cancer Ther , vol.6 , pp. 524-531
    • Taylor, A.P.1    Goldenberg, D.M.2
  • 40
    • 35548982639 scopus 로고    scopus 로고
    • Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    • Fischer C., Jonckx B., Mazzone M., et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 131 (2007) 463-475
    • (2007) Cell , vol.131 , pp. 463-475
    • Fischer, C.1    Jonckx, B.2    Mazzone, M.3
  • 41
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: a VEGF blocker with potent antitumor effects
    • Holash J., Davis S., Papadopoulos N., et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 99 (2002) 11393-11398
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 42
    • 70350757650 scopus 로고    scopus 로고
    • A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration
    • e1
    • Nguyen Q.D., Shah S.M., Browning D.J., et al. A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. Ophthalmology 116 (2009) 2141-2148 e1
    • (2009) Ophthalmology , vol.116 , pp. 2141-2148
    • Nguyen, Q.D.1    Shah, S.M.2    Browning, D.J.3
  • 43
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
    • Shojaei F., Wu X., Malik A.K., et al. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat Biotechnol 25 (2007) 911-920
    • (2007) Nat Biotechnol , vol.25 , pp. 911-920
    • Shojaei, F.1    Wu, X.2    Malik, A.K.3
  • 44
    • 49649088463 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity
    • Kawamura H., Li X., Harper S.J., Bates D.O., and Claesson-Welsh L. Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity. Cancer Res 68 (2008) 4683-4692
    • (2008) Cancer Res , vol.68 , pp. 4683-4692
    • Kawamura, H.1    Li, X.2    Harper, S.J.3    Bates, D.O.4    Claesson-Welsh, L.5
  • 46
    • 42149152015 scopus 로고    scopus 로고
    • VEGF 165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and anti-angiogenic VEGF-A isoforms has implications for therapy
    • Varey A.H., Rennel E.S., Qiu Y., et al. VEGF 165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and anti-angiogenic VEGF-A isoforms has implications for therapy. Br J Cancer 98 (2008) 1366-1379
    • (2008) Br J Cancer , vol.98 , pp. 1366-1379
    • Varey, A.H.1    Rennel, E.S.2    Qiu, Y.3
  • 47
    • 41649101428 scopus 로고    scopus 로고
    • The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice
    • Rennel E., Waine E., Guan H., et al. The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice. Br J Cancer 98 (2008) 1250-1257
    • (2008) Br J Cancer , vol.98 , pp. 1250-1257
    • Rennel, E.1    Waine, E.2    Guan, H.3
  • 48
    • 0037098860 scopus 로고    scopus 로고
    • VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma
    • Bates D.O., Cui T.G., Doughty J.M., et al. VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. Cancer Res 62 (2002) 4123-4131
    • (2002) Cancer Res , vol.62 , pp. 4123-4131
    • Bates, D.O.1    Cui, T.G.2    Doughty, J.M.3
  • 49
    • 33748479489 scopus 로고    scopus 로고
    • A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2
    • Cebe Suarez S., Pieren M., Cariolato L., et al. A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2. Cell Mol Life Sci 63 (2006) 2067-2077
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2067-2077
    • Cebe Suarez, S.1    Pieren, M.2    Cariolato, L.3
  • 50
    • 67650380136 scopus 로고    scopus 로고
    • Biomarkers of response and resistance to antiangiogenic therapy
    • Jain R.K., Duda D.G., Willett C.G., et al. Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol 6 (2009) 327-338
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 327-338
    • Jain, R.K.1    Duda, D.G.2    Willett, C.G.3
  • 51
    • 70349585443 scopus 로고    scopus 로고
    • Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer
    • Masago K., Fujita S., Kim Y.H., et al. Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer. Cancer Sci 100 (2009) 1917-1922
    • (2009) Cancer Sci , vol.100 , pp. 1917-1922
    • Masago, K.1    Fujita, S.2    Kim, Y.H.3
  • 52
    • 70549107877 scopus 로고    scopus 로고
    • The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer
    • Guan X., Zhao H., Niu J., Tang D., Ajani J.A., and Wei Q. The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. BMC Gastroenterol 9 (2009) 77
    • (2009) BMC Gastroenterol , vol.9 , pp. 77
    • Guan, X.1    Zhao, H.2    Niu, J.3    Tang, D.4    Ajani, J.A.5    Wei, Q.6
  • 53
    • 67651055473 scopus 로고    scopus 로고
    • Prognostic importance of vascular endothelial growth factor-A expression and vascular endothelial growth factor polymorphisms in epithelial ovarian cancer
    • Smerdel M.P., Waldstrom M., Brandslund I., Steffensen K.D., Andersen R.F., and Jakobsen A. Prognostic importance of vascular endothelial growth factor-A expression and vascular endothelial growth factor polymorphisms in epithelial ovarian cancer. Int J Gynecol Cancer 19 (2009) 578-584
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 578-584
    • Smerdel, M.P.1    Waldstrom, M.2    Brandslund, I.3    Steffensen, K.D.4    Andersen, R.F.5    Jakobsen, A.6
  • 54
    • 47549084805 scopus 로고    scopus 로고
    • Association of polymorphisms of angiogenesis genes with breast cancer
    • Schneider B.P., Radovich M., Sledge G.W., et al. Association of polymorphisms of angiogenesis genes with breast cancer. Breast Cancer Res Treat 111 (2008) 157-163
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 157-163
    • Schneider, B.P.1    Radovich, M.2    Sledge, G.W.3
  • 56
    • 33745683838 scopus 로고    scopus 로고
    • Population-based case-control study of VEGF gene polymorphisms and breast cancer risk among Chinese women
    • Kataoka N., Cai Q., Wen W., et al. Population-based case-control study of VEGF gene polymorphisms and breast cancer risk among Chinese women. Cancer Epidemiol Biomarkers Prev 15 (2006) 1148-1152
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1148-1152
    • Kataoka, N.1    Cai, Q.2    Wen, W.3
  • 57
    • 56649123321 scopus 로고    scopus 로고
    • Combined effects of the angiogenic genes polymorphisms on prostate cancer susceptibility and aggressiveness
    • Sfar S., Saad H., Mosbah F., and Chouchane L. Combined effects of the angiogenic genes polymorphisms on prostate cancer susceptibility and aggressiveness. Mol Biol Rep 36 (2009) 37-45
    • (2009) Mol Biol Rep , vol.36 , pp. 37-45
    • Sfar, S.1    Saad, H.2    Mosbah, F.3    Chouchane, L.4
  • 58
    • 53749093040 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
    • Schneider B.P., Wang M., Radovich M., et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 26 (2008) 4672-4678
    • (2008) J Clin Oncol , vol.26 , pp. 4672-4678
    • Schneider, B.P.1    Wang, M.2    Radovich, M.3
  • 59
    • 58149346076 scopus 로고    scopus 로고
    • Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab
    • Schultheis A.M., Lurje G., Rhodes K.E., et al. Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab. Clin Cancer Res 14 (2008) 7554-7563
    • (2008) Clin Cancer Res , vol.14 , pp. 7554-7563
    • Schultheis, A.M.1    Lurje, G.2    Rhodes, K.E.3
  • 60
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - a key regulatory factor in tumour growth
    • Harris A.L. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2 (2002) 38-47
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 62
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur J., Dayan F., and Mazure N.M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441 (2006) 437-443
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 63
    • 33644849887 scopus 로고    scopus 로고
    • Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
    • Koukourakis M.I., Bentzen S.M., Giatromanolaki A., et al. Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J Clin Oncol 24 (2006) 727-735
    • (2006) J Clin Oncol , vol.24 , pp. 727-735
    • Koukourakis, M.I.1    Bentzen, S.M.2    Giatromanolaki, A.3
  • 64
    • 0037443587 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma
    • Bos R., van der Groep P., Greijer A.E., et al. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 97 (2003) 1573-1581
    • (2003) Cancer , vol.97 , pp. 1573-1581
    • Bos, R.1    van der Groep, P.2    Greijer, A.E.3
  • 65
    • 38349155463 scopus 로고    scopus 로고
    • Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
    • Sathornsumetee S., Cao Y., Marcello J.E., et al. Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol 26 (2008) 271-278
    • (2008) J Clin Oncol , vol.26 , pp. 271-278
    • Sathornsumetee, S.1    Cao, Y.2    Marcello, J.E.3
  • 66
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos J.M., Lee C.R., Cruz-Munoz W., Bjarnason G.A., Christensen J.G., and Kerbel R.S. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15 (2009) 232-239
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 67
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M., Allen E., Hudock J., et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15 (2009) 220-231
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 68
    • 33749441325 scopus 로고    scopus 로고
    • Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    • Mancuso M.R., Davis R., Norberg S.M., et al. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest 116 (2006) 2610-2621
    • (2006) J Clin Invest , vol.116 , pp. 2610-2621
    • Mancuso, M.R.1    Davis, R.2    Norberg, S.M.3
  • 69
    • 33644863498 scopus 로고    scopus 로고
    • Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF
    • Liang W.C., Wu X., Peale F.V., et al. Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J Biol Chem 281 (2006) 951-961
    • (2006) J Biol Chem , vol.281 , pp. 951-961
    • Liang, W.C.1    Wu, X.2    Peale, F.V.3
  • 70
    • 33749005405 scopus 로고    scopus 로고
    • Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
    • Shaked Y., Ciarrocchi A., Franco M., et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313 (2006) 1785-1787
    • (2006) Science , vol.313 , pp. 1785-1787
    • Shaked, Y.1    Ciarrocchi, A.2    Franco, M.3
  • 71
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J., and Pollard J.W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124 (2006) 263-266
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 72
    • 33747602354 scopus 로고    scopus 로고
    • Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis
    • Nozawa H., Chiu C., and Hanahan D. Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci USA 103 (2006) 12493-12498
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12493-12498
    • Nozawa, H.1    Chiu, C.2    Hanahan, D.3
  • 73
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce J.A., and Pollard J.W. Microenvironmental regulation of metastasis. Nat Rev Cancer 9 (2009) 239-252
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 74
    • 24944587964 scopus 로고    scopus 로고
    • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    • De Palma M., Venneri M.A., Galli R., et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8 (2005) 211-226
    • (2005) Cancer Cell , vol.8 , pp. 211-226
    • De Palma, M.1    Venneri, M.A.2    Galli, R.3
  • 75
    • 0036344496 scopus 로고    scopus 로고
    • Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    • Hattori K., Heissig B., Wu Y., et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med 8 (2002) 841-849
    • (2002) Nat Med , vol.8 , pp. 841-849
    • Hattori, K.1    Heissig, B.2    Wu, Y.3
  • 76
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan R.N., Riba R.D., Zacharoulis S., et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438 (2005) 820-827
    • (2005) Nature , vol.438 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3
  • 77
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R., Lu K.V., Petritsch C., et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13 (2008) 206-220
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3
  • 78
    • 54449094358 scopus 로고    scopus 로고
    • Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity
    • Eikesdal H.P., Sugimoto H., Birrane G., et al. Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity. Proc Natl Acad Sci USA 105 (2008) 15040-15045
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15040-15045
    • Eikesdal, H.P.1    Sugimoto, H.2    Birrane, G.3
  • 79
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: building a framework
    • Gupta G.P., and Massague J. Cancer metastasis: building a framework. Cell 127 (2006) 679-695
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 80
    • 40649104348 scopus 로고    scopus 로고
    • Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
    • Shojaei F., Singh M., Thompson J.D., and Ferrara N. Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression. Proc Natl Acad Sci USA 105 (2008) 2640-2645
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2640-2645
    • Shojaei, F.1    Singh, M.2    Thompson, J.D.3    Ferrara, N.4
  • 81
    • 41149119143 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells
    • Marigo I., Dolcetti L., Serafini P., Zanovello P., and Bronte V. Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol Rev 222 (2008) 162-179
    • (2008) Immunol Rev , vol.222 , pp. 162-179
    • Marigo, I.1    Dolcetti, L.2    Serafini, P.3    Zanovello, P.4    Bronte, V.5
  • 82
    • 66149092730 scopus 로고    scopus 로고
    • G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
    • Shojaei F., Wu X., Qu X., et al. G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc Natl Acad Sci USA 106 (2009) 6742-6747
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6742-6747
    • Shojaei, F.1    Wu, X.2    Qu, X.3
  • 83
    • 41449091030 scopus 로고    scopus 로고
    • Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis
    • Pham N.A., Schwock J., Iakovlev V., Pond G., Hedley D.W., and Tsao M.S. Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis. BMC Cancer 8 (2008) 43
    • (2008) BMC Cancer , vol.8 , pp. 43
    • Pham, N.A.1    Schwock, J.2    Iakovlev, V.3    Pond, G.4    Hedley, D.W.5    Tsao, M.S.6
  • 84
    • 33746544343 scopus 로고    scopus 로고
    • New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors
    • Faivre S., Djelloul S., and Raymond E. New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors. Semin Oncol 33 (2006) 407-420
    • (2006) Semin Oncol , vol.33 , pp. 407-420
    • Faivre, S.1    Djelloul, S.2    Raymond, E.3
  • 85
    • 0038363443 scopus 로고    scopus 로고
    • Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
    • Cao R., Brakenhielm E., Pawliuk R., et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med 9 (2003) 604-613
    • (2003) Nat Med , vol.9 , pp. 604-613
    • Cao, R.1    Brakenhielm, E.2    Pawliuk, R.3
  • 86
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O., Hicklin D.J., Bergers G., and Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8 (2005) 299-309
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 87
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor T.T., Sorensen A.G., di Tomaso E., et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11 (2007) 83-95
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 88
    • 41049085948 scopus 로고    scopus 로고
    • Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies
    • Sainson R.C., and Harris A.L. Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies. Angiogenesis 11 (2008) 41-51
    • (2008) Angiogenesis , vol.11 , pp. 41-51
    • Sainson, R.C.1    Harris, A.L.2
  • 89
    • 34247539127 scopus 로고    scopus 로고
    • The delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
    • Thurston G., Noguera-Troise I., and Yancopoulos G.D. The delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat Rev Cancer 7 (2007) 327-331
    • (2007) Nat Rev Cancer , vol.7 , pp. 327-331
    • Thurston, G.1    Noguera-Troise, I.2    Yancopoulos, G.D.3
  • 90
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    • Ridgway J., Zhang G., Wu Y., et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444 (2006) 1083-1087
    • (2006) Nature , vol.444 , pp. 1083-1087
    • Ridgway, J.1    Zhang, G.2    Wu, Y.3
  • 91
    • 37549030522 scopus 로고    scopus 로고
    • Delta-like 4/Notch signaling and its therapeutic implications
    • Yan M., and Plowman G.D. Delta-like 4/Notch signaling and its therapeutic implications. Clin Cancer Res 13 (2007) 7243-7246
    • (2007) Clin Cancer Res , vol.13 , pp. 7243-7246
    • Yan, M.1    Plowman, G.D.2
  • 92
    • 33845642740 scopus 로고    scopus 로고
    • Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate
    • Diez H., Fischer A., Winkler A., et al. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res 313 (2007) 1-9
    • (2007) Exp Cell Res , vol.313 , pp. 1-9
    • Diez, H.1    Fischer, A.2    Winkler, A.3
  • 93
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307 (2005) 58-62
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 94
    • 38849202330 scopus 로고    scopus 로고
    • Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
    • Pietras K., Pahler J., Bergers G., and Hanahan D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med 5 (2008) e19
    • (2008) PLoS Med , vol.5
    • Pietras, K.1    Pahler, J.2    Bergers, G.3    Hanahan, D.4
  • 95
    • 33745192635 scopus 로고    scopus 로고
    • Autocrine PDGFR signaling promotes mammary cancer metastasis
    • Jechlinger M., Sommer A., Moriggl R., et al. Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest 116 (2006) 1561-1570
    • (2006) J Clin Invest , vol.116 , pp. 1561-1570
    • Jechlinger, M.1    Sommer, A.2    Moriggl, R.3
  • 96
    • 57649135172 scopus 로고    scopus 로고
    • A role for VEGF as a negative regulator of pericyte function and vessel maturation
    • Greenberg J.I., Shields D.J., Barillas S.G., et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 456 (2008) 809-813
    • (2008) Nature , vol.456 , pp. 809-813
    • Greenberg, J.I.1    Shields, D.J.2    Barillas, S.G.3
  • 97
    • 33644643376 scopus 로고    scopus 로고
    • Pericytes limit tumor cell metastasis
    • Xian X., Hakansson J., Stahlberg A., et al. Pericytes limit tumor cell metastasis. J Clin Invest 116 (2006) 642-651
    • (2006) J Clin Invest , vol.116 , pp. 642-651
    • Xian, X.1    Hakansson, J.2    Stahlberg, A.3
  • 98
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras K., and Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 23 (2005) 939-952
    • (2005) J Clin Oncol , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 99
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., Bergsland E., and Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 111 (2003) 1287-1295
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 100
    • 34548175694 scopus 로고    scopus 로고
    • Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors
    • Hariharan S., Gustafson D., Holden S., et al. Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors. Ann Oncol 18 (2007) 1400-1407
    • (2007) Ann Oncol , vol.18 , pp. 1400-1407
    • Hariharan, S.1    Gustafson, D.2    Holden, S.3
  • 101
    • 30744469267 scopus 로고    scopus 로고
    • Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses
    • Calabrese E.J. Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses. Crit Rev Toxicol 35 (2005) 463-582
    • (2005) Crit Rev Toxicol , vol.35 , pp. 463-582
    • Calabrese, E.J.1
  • 102
    • 64149106522 scopus 로고    scopus 로고
    • Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
    • Reynolds A.R., Hart I.R., Watson A.R., et al. Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med 15 (2009) 392-400
    • (2009) Nat Med , vol.15 , pp. 392-400
    • Reynolds, A.R.1    Hart, I.R.2    Watson, A.R.3
  • 103
    • 0036067866 scopus 로고    scopus 로고
    • Vascularization of cutaneous melanoma involves vessel co-option and has clinical significance
    • Dome B., Paku S., Somlai B., and Timar J. Vascularization of cutaneous melanoma involves vessel co-option and has clinical significance. J Pathol 197 (2002) 355-362
    • (2002) J Pathol , vol.197 , pp. 355-362
    • Dome, B.1    Paku, S.2    Somlai, B.3    Timar, J.4
  • 104
    • 0033822622 scopus 로고    scopus 로고
    • Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
    • Rubenstein J.L., Kim J., Ozawa T., et al. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2 (2000) 306-314
    • (2000) Neoplasia , vol.2 , pp. 306-314
    • Rubenstein, J.L.1    Kim, J.2    Ozawa, T.3
  • 105
    • 4644304024 scopus 로고    scopus 로고
    • Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option
    • Leenders W.P., Kusters B., Verrijp K., et al. Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option. Clin Cancer Res 10 (2004) 6222-6230
    • (2004) Clin Cancer Res , vol.10 , pp. 6222-6230
    • Leenders, W.P.1    Kusters, B.2    Verrijp, K.3
  • 106
    • 36148937125 scopus 로고    scopus 로고
    • Tumour vascularization: sprouting angiogenesis and beyond
    • Hillen F., and Griffioen A.W. Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev 26 (2007) 489-502
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 489-502
    • Hillen, F.1    Griffioen, A.W.2
  • 107
    • 34548842816 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome
    • Teodoro J.G., Evans S.K., and Green M.R. Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome. J Mol Med 85 (2007) 1175-1186
    • (2007) J Mol Med , vol.85 , pp. 1175-1186
    • Teodoro, J.G.1    Evans, S.K.2    Green, M.R.3
  • 108
    • 63149084589 scopus 로고    scopus 로고
    • P53-mediated inhibition of angiogenesis in diffuse low-grade astrocytomas
    • Gaiser T., Becker M.R., Meyer J., Habel A., and Siegelin M.D. P53-mediated inhibition of angiogenesis in diffuse low-grade astrocytomas. Neurochem Int 54 (2009) 458-463
    • (2009) Neurochem Int , vol.54 , pp. 458-463
    • Gaiser, T.1    Becker, M.R.2    Meyer, J.3    Habel, A.4    Siegelin, M.D.5
  • 109
    • 33750800316 scopus 로고    scopus 로고
    • Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch
    • Giuriato S., Ryeom S., Fan A.C., et al. Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. Proc Natl Acad Sci USA 103 (2006) 16266-16271
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16266-16271
    • Giuriato, S.1    Ryeom, S.2    Fan, A.C.3
  • 110
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • Yu J.L., Rak J.W., Coomber B.L., Hicklin D.J., and Kerbel R.S. Effect of p53 status on tumor response to antiangiogenic therapy. Science 295 (2002) 1526-1528
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3    Hicklin, D.J.4    Kerbel, R.S.5
  • 111
    • 34249669336 scopus 로고    scopus 로고
    • Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells
    • Brendel C., Scharenberg C., Dohse M., et al. Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells. Leukemia 21 (2007) 1267-1275
    • (2007) Leukemia , vol.21 , pp. 1267-1275
    • Brendel, C.1    Scharenberg, C.2    Dohse, M.3
  • 112
    • 59649129538 scopus 로고    scopus 로고
    • Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2
    • Shukla S., Robey R.W., Bates S.E., and Ambudkar S.V. Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Dispos 37 (2009) 359-365
    • (2009) Drug Metab Dispos , vol.37 , pp. 359-365
    • Shukla, S.1    Robey, R.W.2    Bates, S.E.3    Ambudkar, S.V.4
  • 113
    • 8544249895 scopus 로고    scopus 로고
    • Tumor-associated endothelial cells with cytogenetic abnormalities
    • Hida K., Hida Y., Amin D.N., et al. Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res 64 (2004) 8249-8255
    • (2004) Cancer Res , vol.64 , pp. 8249-8255
    • Hida, K.1    Hida, Y.2    Amin, D.N.3
  • 114
    • 68049139572 scopus 로고    scopus 로고
    • Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells
    • Xiong Y.Q., Sun H.C., Zhang W., et al. Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells. Clin Cancer Res 15 (2009) 4838-4846
    • (2009) Clin Cancer Res , vol.15 , pp. 4838-4846
    • Xiong, Y.Q.1    Sun, H.C.2    Zhang, W.3
  • 115
    • 69349097400 scopus 로고    scopus 로고
    • Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy
    • Ebos J.M., Lee C.R., and Kerbel R.S. Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy. Clin Cancer Res 15 (2009) 5020-5025
    • (2009) Clin Cancer Res , vol.15 , pp. 5020-5025
    • Ebos, J.M.1    Lee, C.R.2    Kerbel, R.S.3
  • 116
    • 0041382820 scopus 로고    scopus 로고
    • The hypoxic response of tumors is dependent on their microenvironment
    • Blouw B., Song H., Tihan T., et al. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 4 (2003) 133-146
    • (2003) Cancer Cell , vol.4 , pp. 133-146
    • Blouw, B.1    Song, H.2    Tihan, T.3
  • 117
    • 41649112610 scopus 로고    scopus 로고
    • Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence
    • Norden A.D., Young G.S., Setayesh K., et al. Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence. Neurology 70 (2008) 779-787
    • (2008) Neurology , vol.70 , pp. 779-787
    • Norden, A.D.1    Young, G.S.2    Setayesh, K.3
  • 118
    • 60649116273 scopus 로고    scopus 로고
    • Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival
    • Narayana A., Kelly P., Golfinos J., et al. Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival. J Neurosurg 110 (2009) 173-180
    • (2009) J Neurosurg , vol.110 , pp. 173-180
    • Narayana, A.1    Kelly, P.2    Golfinos, J.3
  • 119
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K., Wang M., Gralow J., et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357 (2007) 2666-2676
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 120
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • Miller K.D., Chap L.I., Holmes F.A., et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 23 (2005) 792-799
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.