메뉴 건너뛰기




Volumn 17, Issue 9-10, 2012, Pages 435-442

Targeting cancer-initiating cell drug-resistance: A Sroadmap to a new-generation of cancer therapies?

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; AUROTHIOMALATE; BANOXANTRONE; BMS 833923; CATUMAXOMAB; CYANAMIDE; CYCLOPHOSPHAMIDE; DISULFIRAM; DOCETAXEL; DOFEQUIDAR; DOXORUBICIN; ERISMODEGIB; GEMCITABINE; GIRENTUXIMAB; GLUCONATE COPPER; INDISULAM; METFORMIN; MK 0752; N (6,7 DIHYDRO 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL) 2,2 DIMETHYL N' (2,2,3,3,3 PENTAFLUOROPROPYL)PROPANEDIAMIDE; PR 104; RAPAMYCIN; RESVERATROL; SARIDEGIB; TARIQUIDAR; TEMOZOLOMIDE; TH 302; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE; VISMODEGIB; XL 139;

EID: 84857144607     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2011.02.005     Document Type: Review
Times cited : (31)

References (94)
  • 1
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • T. Lapidot A cell initiating human acute myeloid leukaemia after transplantation into SCID mice Nature 367 1994 645 648
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1
  • 2
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • M. Al-Hajj Prospective identification of tumorigenic breast cancer cells Proc. Natl. Acad. Sci. U. S. A. 100 2003 3983 3988
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 3983-3988
    • Al-Hajj, M.1
  • 3
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • S.K. Singh Identification of human brain tumour initiating cells Nature 432 2004 396 401
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1
  • 4
    • 34547193404 scopus 로고    scopus 로고
    • Phenotypic characterization of human colorectal cancer stem cells
    • P. Dalerba Phenotypic characterization of human colorectal cancer stem cells Proc. Natl. Acad. Sci. U. S. A. 104 2007 10158 10163
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 10158-10163
    • Dalerba, P.1
  • 5
    • 33846512398 scopus 로고    scopus 로고
    • Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    • M.E. Prince Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma Proc. Natl. Acad. Sci. U. S. A. 104 2007 973 978
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 973-978
    • Prince, M.E.1
  • 6
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • S. Zhang Identification and characterization of ovarian cancer-initiating cells from primary human tumors Cancer Res. 68 2008 4311 4320
    • (2008) Cancer Res. , vol.68 , pp. 4311-4320
    • Zhang, S.1
  • 7
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • P.C. Hermann Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer Stem Cells 1 2007 313 323
    • (2007) Stem Cells , vol.1 , pp. 313-323
    • Hermann, P.C.1
  • 8
    • 38349165576 scopus 로고    scopus 로고
    • Identification of cells initiating human melanomas
    • T. Schatton Identification of cells initiating human melanomas Nature 451 2008 345 349
    • (2008) Nature , vol.451 , pp. 345-349
    • Schatton, T.1
  • 9
    • 44049091352 scopus 로고    scopus 로고
    • Cancer stem cells - Old concepts, new insights
    • Review
    • L. Vermeulen Cancer stem cells - old concepts, new insights Cell Death Differ. 15 2008 947 958 Review
    • (2008) Cell Death Differ. , vol.15 , pp. 947-958
    • Vermeulen, L.1
  • 10
    • 57349143739 scopus 로고    scopus 로고
    • Efficient tumour formation by single human melanoma cells
    • E. Quintana Efficient tumour formation by single human melanoma cells Nature 456 2008 593 598
    • (2008) Nature , vol.456 , pp. 593-598
    • Quintana, E.1
  • 11
    • 34547113747 scopus 로고    scopus 로고
    • Tumor growth need not be driven by rare cancer stem cells
    • P.N. Kelly Tumor growth need not be driven by rare cancer stem cells Science 317 2007 337
    • (2007) Science , vol.317 , pp. 337
    • Kelly, P.N.1
  • 12
    • 70349123829 scopus 로고    scopus 로고
    • The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
    • A. Cicalese The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells Cell 138 2009 1083 1095
    • (2009) Cell , vol.138 , pp. 1083-1095
    • Cicalese, A.1
  • 13
    • 44049100934 scopus 로고    scopus 로고
    • Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
    • X. Li Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy J. Natl. Cancer Inst. 100 2008 672 679
    • (2008) J. Natl. Cancer Inst. , vol.100 , pp. 672-679
    • Li, X.1
  • 14
    • 33750695509 scopus 로고    scopus 로고
    • Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: The need for a multivariate approach in biomarker studies
    • A. Yaromina Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies Radiother. Oncol. 81 2006 122 129
    • (2006) Radiother. Oncol. , vol.81 , pp. 122-129
    • Yaromina, A.1
  • 15
    • 67651031415 scopus 로고    scopus 로고
    • Cancer stem cells: A new paradigm for understanding tumor growth and progression and drug resistance
    • Review
    • R. Gangemi Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance Curr. Med. Chem. 16 2009 1688 1703 Review
    • (2009) Curr. Med. Chem. , vol.16 , pp. 1688-1703
    • Gangemi, R.1
  • 17
    • 77950853025 scopus 로고    scopus 로고
    • New promising drug targets in cancer- and metastasis-initiating cells
    • Review
    • M. Mimeault, and S.K. Batra New promising drug targets in cancer- and metastasis-initiating cells Drug Discov. Today 15 2010 354 364 Review
    • (2010) Drug Discov. Today , vol.15 , pp. 354-364
    • Mimeault, M.1    Batra, S.K.2
  • 18
    • 33746871832 scopus 로고    scopus 로고
    • Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy
    • Review
    • C.A. Rabik Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy Cancer Treat. Rev. 32 2006 261 276 Review
    • (2006) Cancer Treat. Rev. , vol.32 , pp. 261-276
    • Rabik, C.A.1
  • 19
    • 62449096923 scopus 로고    scopus 로고
    • Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma
    • J.A. Quinn Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma J. Clin. Oncol. 27 2009 1262 1267
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1262-1267
    • Quinn, J.A.1
  • 20
    • 77956302698 scopus 로고    scopus 로고
    • Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers
    • S. Deng Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers PLoS One 5 2010 e10277
    • (2010) PLoS One , vol.5 , pp. 10277
    • Deng, S.1
  • 21
    • 33746846201 scopus 로고    scopus 로고
    • Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells
    • J.P. Chute Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells Proc. Natl. Acad. Sci. U. S. A. 103 2006 11707 11712
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 11707-11712
    • Chute, J.P.1
  • 22
    • 33751285781 scopus 로고    scopus 로고
    • Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity
    • D. Chen Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity Cancer Res. 66 2006 10425 10433
    • (2006) Cancer Res. , vol.66 , pp. 10425-10433
    • Chen, D.1
  • 23
    • 37649004412 scopus 로고    scopus 로고
    • Flexibility in the ABC transporter MsbA: Alternating access with a twist
    • A. Ward Flexibility in the ABC transporter MsbA: alternating access with a twist Proc. Natl. Acad. Sci. U. S. A. 104 2007 19005 19010
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 19005-19010
    • Ward, A.1
  • 24
    • 34250306257 scopus 로고    scopus 로고
    • Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    • M.M. Ho Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells Cancer Res. 67 2007 4827 4833
    • (2007) Cancer Res. , vol.67 , pp. 4827-4833
    • Ho, M.M.1
  • 25
    • 34248205311 scopus 로고    scopus 로고
    • ABCA3 as a lipid transporter in pulmonary surfactant biogenesis
    • N. Ban ABCA3 as a lipid transporter in pulmonary surfactant biogenesis J. Biol. Chem. 282 2007 9628 9634
    • (2007) J. Biol. Chem. , vol.282 , pp. 9628-9634
    • Ban, N.1
  • 26
    • 33645747683 scopus 로고    scopus 로고
    • Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma
    • M. Haber Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma J. Clin. Oncol. 24 2006 1546 1553
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1546-1553
    • Haber, M.1
  • 27
    • 75149143363 scopus 로고    scopus 로고
    • ABC transporters in cancer: More than just drug efflux pumps
    • Review
    • J.I. Fletcher ABC transporters in cancer: more than just drug efflux pumps Nat. Rev. Cancer 10 2010 147 156 Review
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 147-156
    • Fletcher, J.I.1
  • 28
    • 0027274736 scopus 로고
    • Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia
    • A.F. List Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia J. Clin. Oncol. 11 1993 1652 1660
    • (1993) J. Clin. Oncol. , vol.11 , pp. 1652-1660
    • List, A.F.1
  • 29
    • 20844440529 scopus 로고    scopus 로고
    • Addition of cyclosporin A to the combination of mitoxantrone and etoposide to overcome resistance to chemotherapy in refractory or relapsing acute myeloid leukaemia: A randomised phase II trial from HOVON, the Dutch-Belgian Haemato-Oncology Working Group for adults
    • S. Daenen Addition of cyclosporin A to the combination of mitoxantrone and etoposide to overcome resistance to chemotherapy in refractory or relapsing acute myeloid leukaemia: a randomised phase II trial from HOVON, the Dutch-Belgian Haemato-Oncology Working Group for adults Leuk. Res. 28 2004 1057 1067
    • (2004) Leuk. Res. , vol.28 , pp. 1057-1067
    • Daenen, S.1
  • 30
    • 45749089027 scopus 로고    scopus 로고
    • Phase III study of valspodar (PSC 833) combined with paclitaxel and carboplatin compared with paclitaxel and carboplatin alone in patients with stage IV or suboptimally debulked stage III epithelial ovarian cancer or primary peritoneal cancer
    • C. Lhommé Phase III study of valspodar (PSC 833) combined with paclitaxel and carboplatin compared with paclitaxel and carboplatin alone in patients with stage IV or suboptimally debulked stage III epithelial ovarian cancer or primary peritoneal cancer J. Clin. Oncol. 26 2008 2674 2682
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2674-2682
    • Lhommé, C.1
  • 31
    • 66149192405 scopus 로고    scopus 로고
    • A phase i study of the P-glycoprotein antagonist tariquidar in combination with vinorelbine
    • J. Abraham A phase I study of the P-glycoprotein antagonist tariquidar in combination with vinorelbine Clin. Cancer Res. 15 2009 3574 3582
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3574-3582
    • Abraham, J.1
  • 32
    • 23644452472 scopus 로고    scopus 로고
    • Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma
    • L. Pusztai Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma Cancer 104 2005 682 691
    • (2005) Cancer , vol.104 , pp. 682-691
    • Pusztai, L.1
  • 33
    • 71049189661 scopus 로고    scopus 로고
    • Dofequidar fumarate sensitizes cancer stem-like side population cells chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export
    • R. Katayama Dofequidar fumarate sensitizes cancer stem-like side population cells chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export Cancer Sci. 100 2009 2060 2068
    • (2009) Cancer Sci. , vol.100 , pp. 2060-2068
    • Katayama, R.1
  • 34
    • 33846999327 scopus 로고    scopus 로고
    • Dofequidar fumarate (MS-209) in combination with cyclophosphamide, doxorubicin, and fluorouracil for patients with advanced or recurrent breast cancer
    • T. Saeki Dofequidar fumarate (MS-209) in combination with cyclophosphamide, doxorubicin, and fluorouracil for patients with advanced or recurrent breast cancer J. Clin. Oncol. 25 2007 411 417
    • (2007) J. Clin. Oncol. , vol.25 , pp. 411-417
    • Saeki, T.1
  • 35
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • P.B. Gupta Identification of selective inhibitors of cancer stem cells by high-throughput screening Cell 138 2009 645 659
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1
  • 36
    • 77953126613 scopus 로고    scopus 로고
    • The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor
    • R. Riccioni The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor Blood Cells Mol. Dis. 45 2010 86 92
    • (2010) Blood Cells Mol. Dis. , vol.45 , pp. 86-92
    • Riccioni, R.1
  • 37
    • 70449724577 scopus 로고    scopus 로고
    • Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells
    • D. Fuchs Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells Biochem. Biophys. Res. Commun. 390 2009 743 749
    • (2009) Biochem. Biophys. Res. Commun. , vol.390 , pp. 743-749
    • Fuchs, D.1
  • 38
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • Z. Li Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells Cancer Cell 15 2009 501 513
    • (2009) Cancer Cell , vol.15 , pp. 501-513
    • Li, Z.1
  • 39
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • S.A. Mani The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 2009 704 715
    • (2009) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1
  • 40
    • 70449687092 scopus 로고    scopus 로고
    • Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha
    • A. Soeda Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha Oncogene 28 2009 3949 3959
    • (2009) Oncogene , vol.28 , pp. 3949-3959
    • Soeda, A.1
  • 41
    • 34548599785 scopus 로고    scopus 로고
    • Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung
    • Y. Chen Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung Cancer Res. 67 2007 7954 7959
    • (2007) Cancer Res. , vol.67 , pp. 7954-7959
    • Chen, Y.1
  • 42
    • 84965808588 scopus 로고
    • Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin
    • D.M. Brown Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin Cancer Res. 53 1993 4633 4636
    • (1993) Cancer Res. , vol.53 , pp. 4633-4636
    • Brown, D.M.1
  • 43
    • 77954600498 scopus 로고    scopus 로고
    • Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): A phase III trial of the Trans-Tasman Radiation Oncology Group
    • D. Rischin Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group J. Clin. Oncol. 28 2010 2989 2995
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2989-2995
    • Rischin, D.1
  • 44
    • 34447122556 scopus 로고    scopus 로고
    • Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA crosslinking agent PR-104
    • A.V. Patterson Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA crosslinking agent PR-104 Clin. Cancer Res. 13 2007 3922 3932
    • (2007) Clin. Cancer Res. , vol.13 , pp. 3922-3932
    • Patterson, A.V.1
  • 45
    • 0036041236 scopus 로고    scopus 로고
    • Bioreductively activated antitumor n-oxides: The case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy
    • Review
    • L.H. Patterson Bioreductively activated antitumor n-oxides: the case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy Drug Metab. Rev. 34 2002 581 592 Review
    • (2002) Drug Metab. Rev. , vol.34 , pp. 581-592
    • Patterson, L.H.1
  • 46
    • 34447312859 scopus 로고    scopus 로고
    • The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase i study
    • W.P. Steward The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study Ann. Oncol. 18 2007 1099 1103
    • (2007) Ann. Oncol. , vol.18 , pp. 1099-1103
    • Steward, W.P.1
  • 47
    • 34347263760 scopus 로고    scopus 로고
    • Bioreductive drugs: From concept to clinic
    • S.R. McKeown Bioreductive drugs: from concept to clinic Clin. Oncol. 19 2007 427 442
    • (2007) Clin. Oncol. , vol.19 , pp. 427-442
    • McKeown, S.R.1
  • 48
    • 33847637262 scopus 로고    scopus 로고
    • P66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres
    • P. Sansone p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres Stem Cells 25 2007 807 815
    • (2007) Stem Cells , vol.25 , pp. 807-815
    • Sansone, P.1
  • 49
    • 77953521863 scopus 로고    scopus 로고
    • Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII
    • Review
    • O.O. Guler Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII Curr. Med. Chem. 2010 1516 1526 Review
    • (2010) Curr. Med. Chem. , pp. 1516-1526
    • Guler, O.O.1
  • 50
    • 77950949729 scopus 로고    scopus 로고
    • Are cancer stem cells concentrated in more alkaline hypoxic regions of tumors?
    • K.M. Anderson Are cancer stem cells concentrated in more alkaline hypoxic regions of tumors? Med. Hypotheses 74 2010 868 870
    • (2010) Med. Hypotheses , vol.74 , pp. 868-870
    • Anderson, K.M.1
  • 51
    • 0024379967 scopus 로고
    • Acid pH in tumors and its potential for therapeutic exploitation
    • I.F. Tannock, and D. Rotin Acid pH in tumors and its potential for therapeutic exploitation Cancer Res. 49 1989 4373 4384
    • (1989) Cancer Res. , vol.49 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2
  • 52
    • 0030017852 scopus 로고    scopus 로고
    • Anti-renal-cell carcinoma chimeric antibody G250 facilitates antibody-dependent cellular cytotoxicity with in vitro and in vivo interleukin-2-activated effectors
    • J.E. Surfus Anti-renal-cell carcinoma chimeric antibody G250 facilitates antibody-dependent cellular cytotoxicity with in vitro and in vivo interleukin-2-activated effectors J. Immunother. Emphasis Tumor Immunol. 19 1996 184 191
    • (1996) J. Immunother. Emphasis Tumor Immunol. , vol.19 , pp. 184-191
    • Surfus, J.E.1
  • 53
    • 53549092273 scopus 로고    scopus 로고
    • Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1
    • T.N. Milovanova Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1 Mol. Cell Biol. 28 2008 6248 6261
    • (2008) Mol. Cell Biol. , vol.28 , pp. 6248-6261
    • Milovanova, T.N.1
  • 54
    • 51949087589 scopus 로고    scopus 로고
    • The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants
    • J. Ceccarelli The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants Int. J. Cancer 123 2008 1770 2177
    • (2008) Int. J. Cancer , vol.123 , pp. 1770-2177
    • Ceccarelli, J.1
  • 55
    • 0033796101 scopus 로고    scopus 로고
    • The role of the redox protein thioredoxin in cell growth and cancer
    • G. Powis The role of the redox protein thioredoxin in cell growth and cancer Free Radical Biol. Med. 29 2000 312 322
    • (2000) Free Radical Biol. Med. , vol.29 , pp. 312-322
    • Powis, G.1
  • 56
    • 77955551373 scopus 로고    scopus 로고
    • Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302
    • S. Li Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302 Biol. Trace Elem. Res. 136 2010 294 301
    • (2010) Biol. Trace Elem. Res. , vol.136 , pp. 294-301
    • Li, S.1
  • 57
    • 43049083694 scopus 로고    scopus 로고
    • Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs
    • J. Duan Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs J. Med. Chem. 51 2008 2412 2420
    • (2008) J. Med. Chem. , vol.51 , pp. 2412-2420
    • Duan, J.1
  • 58
    • 70349552398 scopus 로고    scopus 로고
    • Antitumor immunity and cancer stem cells
    • T. Schatton, and M.H. Frank Antitumor immunity and cancer stem cells Ann. N. Y. Acad. Sci. 1176 2009 154 169
    • (2009) Ann. N. Y. Acad. Sci. , vol.1176 , pp. 154-169
    • Schatton, T.1    Frank, M.H.2
  • 59
    • 78049270536 scopus 로고    scopus 로고
    • Glioma cancer stem cells induce immunosuppressive macrophages/microglia
    • A. Wu Glioma cancer stem cells induce immunosuppressive macrophages/microglia Neuro. Oncol. 12 2010 1113 1125
    • (2010) Neuro. Oncol. , vol.12 , pp. 1113-1125
    • Wu, A.1
  • 60
    • 76549126237 scopus 로고    scopus 로고
    • Modulation of T-cell activation by malignant melanoma initiating cells
    • T. Schatton Modulation of T-cell activation by malignant melanoma initiating cells Cancer Res. 70 2010 697 708
    • (2010) Cancer Res. , vol.70 , pp. 697-708
    • Schatton, T.1
  • 61
    • 74549187948 scopus 로고    scopus 로고
    • Glioma-associated cancer-initiating cells induce immunosuppression
    • J. Wei Glioma-associated cancer-initiating cells induce immunosuppression Clin. Cancer Res. 16 2010 461 473
    • (2010) Clin. Cancer Res. , vol.16 , pp. 461-473
    • Wei, J.1
  • 62
    • 30644472381 scopus 로고    scopus 로고
    • Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers
    • P. Went Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers Br. J. Cancer 94 2006 128 135
    • (2006) Br. J. Cancer , vol.94 , pp. 128-135
    • Went, P.1
  • 63
    • 77956574908 scopus 로고    scopus 로고
    • More than markers: Biological significance of cancer stem cell-defining molecules
    • S.B. Keysar, and A. Jimeno More than markers: biological significance of cancer stem cell-defining molecules Mol. Cancer Ther. 9 2010 2450 2457
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 2450-2457
    • Keysar, S.B.1    Jimeno, A.2
  • 64
    • 46349107401 scopus 로고    scopus 로고
    • CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers
    • L.M. Smith CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers Br. J. Cancer 99 2008 100 109
    • (2008) Br. J. Cancer , vol.99 , pp. 100-109
    • Smith, L.M.1
  • 65
    • 77449145878 scopus 로고    scopus 로고
    • Targeting of cancer stem cell marker EpCAM by bispecific antibody EpCAMxCD3 inhibits pancreatic carcinoma
    • A. Salnikov Targeting of cancer stem cell marker EpCAM by bispecific antibody EpCAMxCD3 inhibits pancreatic carcinoma J. Cell. Mol. Med. 13 2009 4023 4033
    • (2009) J. Cell. Mol. Med. , vol.13 , pp. 4023-4033
    • Salnikov, A.1
  • 66
    • 44849130717 scopus 로고    scopus 로고
    • Catumaxomab, a rat/murine hybrid trifunctional bispecific monoclonal antibody for the treatment of cancer
    • J. Shen, and Z. Zhu Catumaxomab, a rat/murine hybrid trifunctional bispecific monoclonal antibody for the treatment of cancer Curr. Opin. Mol. Ther. 10 2008 273 284
    • (2008) Curr. Opin. Mol. Ther. , vol.10 , pp. 273-284
    • Shen, J.1    Zhu, Z.2
  • 67
    • 60649122009 scopus 로고    scopus 로고
    • Induction of anti-tumor immunity by trifunctional antibodies in patients with peritoneal carcinomatosis
    • M.A. Ströhlein Induction of anti-tumor immunity by trifunctional antibodies in patients with peritoneal carcinomatosis J. Exp. Clin. Cancer Res. 28 2009 18 28
    • (2009) J. Exp. Clin. Cancer Res. , vol.28 , pp. 18-28
    • Ströhlein, M.A.1
  • 68
    • 84860686612 scopus 로고    scopus 로고
    • University Health Network Patent US2007237761
    • Dick, J. et al. University Health Network. (2007) Patent US2007237761.
    • (2007)
    • Dick, J.1
  • 69
    • 84860693151 scopus 로고    scopus 로고
    • Arius Research Inc. Patent WO2007098571
    • Young, D. et al. Arius Research Inc. (2007) Patent WO2007098571.
    • (2007)
    • Young, D.1
  • 70
    • 50049134725 scopus 로고    scopus 로고
    • Phase i trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma
    • H. Riechelmann Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma Oral Oncol. 44 2008 823 829
    • (2008) Oral Oncol. , vol.44 , pp. 823-829
    • Riechelmann, H.1
  • 71
    • 14044263594 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, immunogenicity and biodistribution of (186)Re-labeled humanized monoclonal antibody BIWA 4 (Bivatuzumab) in patients with early-stage breast cancer
    • M. Koppe Safety, pharmacokinetics, immunogenicity and biodistribution of (186)Re-labeled humanized monoclonal antibody BIWA 4 (Bivatuzumab) in patients with early-stage breast cancer Cancer Biother. Radiopharm. 19 2004 720 729
    • (2004) Cancer Biother. Radiopharm. , vol.19 , pp. 720-729
    • Koppe, M.1
  • 72
    • 33750685640 scopus 로고    scopus 로고
    • A phase i dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus
    • B.M. Tijink A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus Clin. Cancer Res. 12 2006 6064 6072
    • (2006) Clin. Cancer Res. , vol.12 , pp. 6064-6072
    • Tijink, B.M.1
  • 73
    • 78751702579 scopus 로고    scopus 로고
    • Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody
    • doi:10. 1016/j. nano. 2010. 06.010
    • C.H. Wang Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody Nanomedicine 2010 doi:10. 1016/j. nano. 2010. 06.010
    • (2010) Nanomedicine
    • Wang, C.H.1
  • 74
    • 49249106900 scopus 로고    scopus 로고
    • Crucial role of interleukin-4 in the survival of colon cancer stem cells
    • M.G. Francipane Crucial role of interleukin-4 in the survival of colon cancer stem cells Cancer Res. 68 2008 4022 4025
    • (2008) Cancer Res. , vol.68 , pp. 4022-4025
    • Francipane, M.G.1
  • 75
    • 34848866647 scopus 로고    scopus 로고
    • Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    • M. Todaro Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4 Cell Stem Cell. 1 2007 389 402
    • (2007) Cell Stem Cell. , vol.1 , pp. 389-402
    • Todaro, M.1
  • 76
    • 70350223977 scopus 로고    scopus 로고
    • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth
    • H. Wang Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth Stem Cells 27 2009 2393 2404
    • (2009) Stem Cells , vol.27 , pp. 2393-2404
    • Wang, H.1
  • 77
    • 77950832189 scopus 로고    scopus 로고
    • Lung cancer stem cells as a target for therapy
    • E. Gorelik Lung cancer stem cells as a target for therapy Anticancer Agents Med. Chem. 10 2010 164 171
    • (2010) Anticancer Agents Med. Chem. , vol.10 , pp. 164-171
    • Gorelik, E.1
  • 78
    • 76649113726 scopus 로고    scopus 로고
    • CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    • C. Ginestier CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts J. Clin. Invest. 120 2010 485-497
    • (2010) J. Clin. Invest. , vol.120 , pp. 485-485
    • Ginestier, C.1
  • 79
    • 78649987710 scopus 로고    scopus 로고
    • Transforming growth factor-beta-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression
    • doi: 10. 1038/onc. 2010.377
    • M.K. Wendt Transforming growth factor-beta-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression Oncogene 2010 doi: 10. 1038/onc. 2010.377
    • (2010) Oncogene
    • Wendt, M.K.1
  • 80
    • 77957705072 scopus 로고    scopus 로고
    • Differential susceptibility to epithelial-mesenchymal transition (EMT) of alveolar, bronchial and intestinal epithelial cells in vitro and the effect of angiotensin II receptor inhibition
    • S.T. Buckley Differential susceptibility to epithelial-mesenchymal transition (EMT) of alveolar, bronchial and intestinal epithelial cells in vitro and the effect of angiotensin II receptor inhibition Cell Tissue Res. 342 2010 39 51
    • (2010) Cell Tissue Res. , vol.342 , pp. 39-51
    • Buckley, S.T.1
  • 81
    • 77958153789 scopus 로고    scopus 로고
    • TGFβ and EGF synergistically induce a more invasive phenotype of epithelial ovarian cancer cells
    • Z. Xu TGFβ and EGF synergistically induce a more invasive phenotype of epithelial ovarian cancer cells Biochem. Biophys. Res. Commun. 401 2010 376 381
    • (2010) Biochem. Biophys. Res. Commun. , vol.401 , pp. 376-381
    • Xu, Z.1
  • 82
    • 77952830726 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors
    • S. Ohashi Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors Cancer Res. 70 2010 4174 4184
    • (2010) Cancer Res. , vol.70 , pp. 4174-4184
    • Ohashi, S.1
  • 83
    • 79951797048 scopus 로고    scopus 로고
    • The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells
    • doi: 10.1002/jcp.22439
    • L. Caja The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells J. Cell Physiol. 2010 doi: 10.1002/jcp.22439
    • (2010) J. Cell Physiol.
    • Caja, L.1
  • 84
    • 31544463515 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells
    • A.D. Yang Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells Cancer Res. 66 2006 46 51
    • (2006) Cancer Res. , vol.66 , pp. 46-51
    • Yang, A.D.1
  • 85
    • 77956280130 scopus 로고    scopus 로고
    • Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness
    • E.J. Giannoni Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness Cancer Res. 70 2010 6945 6956
    • (2010) Cancer Res. , vol.70 , pp. 6945-6956
    • Giannoni, E.J.1
  • 86
    • 68449094056 scopus 로고    scopus 로고
    • Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells
    • G. Zheng Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells Am. J. Pathol. 175 2009 580 591
    • (2009) Am. J. Pathol. , vol.175 , pp. 580-591
    • Zheng, G.1
  • 87
    • 77449108417 scopus 로고    scopus 로고
    • VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop
    • O. Gonzalez-Moreno VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop Exp. Cell Res. 316 2010 554 567
    • (2010) Exp. Cell Res. , vol.316 , pp. 554-567
    • Gonzalez-Moreno, O.1
  • 88
    • 79952534509 scopus 로고    scopus 로고
    • Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions
    • doi: 10.1038/onc. 2010.498
    • K.S. Chae Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions Oncogene 2010 doi: 10.1038/onc. 2010.498
    • (2010) Oncogene
    • Chae, K.S.1
  • 89
    • 74549196076 scopus 로고    scopus 로고
    • HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors
    • N. Ahmed HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors Clin. Cancer Res. 16 2010 474 485
    • (2010) Clin. Cancer Res. , vol.16 , pp. 474-485
    • Ahmed, N.1
  • 90
    • 35949001624 scopus 로고    scopus 로고
    • Identification of human aldehyde dehydrogenase 1 family member A1 as a novel CD8 + T-cell-defined tumor antigen in squamous cell carcinoma of the head and neck
    • C. Visus Identification of human aldehyde dehydrogenase 1 family member A1 as a novel CD8 + T-cell-defined tumor antigen in squamous cell carcinoma of the head and neck Cancer Res. 67 2007 10538 10545
    • (2007) Cancer Res. , vol.67 , pp. 10538-10545
    • Visus, C.1
  • 91
    • 67449135832 scopus 로고    scopus 로고
    • Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes
    • M. Todaro Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes J. Immunol. 182 2009 7287 7296
    • (2009) J. Immunol. , vol.182 , pp. 7287-7296
    • Todaro, M.1
  • 92
    • 34547638252 scopus 로고    scopus 로고
    • Targeting human {gamma}{delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer
    • F. Dieli Targeting human {gamma}{delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer Cancer Res. 67 2007 7450 7457
    • (2007) Cancer Res. , vol.67 , pp. 7450-7457
    • Dieli, F.1
  • 93
    • 77958050592 scopus 로고    scopus 로고
    • Aminobisphosphonate-pretreated dendritic cells trigger successful Vgamma9Vdelta2 T cell amplification for immunotherapy in advanced cancer patients
    • F. Cabillic Aminobisphosphonate-pretreated dendritic cells trigger successful Vgamma9Vdelta2 T cell amplification for immunotherapy in advanced cancer patients Cancer Immunol. Immunother. 59 2010 1611 1619
    • (2010) Cancer Immunol. Immunother. , vol.59 , pp. 1611-1619
    • Cabillic, F.1
  • 94
    • 0041562407 scopus 로고    scopus 로고
    • The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors
    • P.E. Fecci The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors J. Neurooncol. 64 2003 161 176
    • (2003) J. Neurooncol. , vol.64 , pp. 161-176
    • Fecci, P.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.