Chemocentric informatics approach to drug discovery: Identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers

Journal of Medicinal Chemistry

Volumn 55, Issue 12, 2012, Pages 5704-5719

  Hajjo, Rima ^a   Setola, Vincent ^b   Roth, Bryan L ^a,b   Tropsha, Alexander ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACEPROMAZINE; ALIMEMAZINE; ASTEMIZOLE; BEPRIDIL; BROMPERIDOL; CETIRIZINE; CHLORPROTHIXENE; CINCHOCAINE; CINNARIZINE; CITALOPRAM; CLOMIFENE; CLOMIPRAMINE; CLOZAPINE; DILTIAZEM; DOXEPIN; FENDILINE; FLAVOXATE; FLUSPIRILENE; IMIPRAMINE; NOOTROPIC AGENT; NORTRIPTYLINE; PRESTWICK 559; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SEROTONIN 6 ANTAGONIST; TAMOXIFEN; TOREMIFENE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZUCLOPENTHIXOL;

ALZHEIMER DISEASE; ANALYTIC METHOD; ARTICLE; CHEMOCENTRIC INFORMATICS METHODOLOGY; COMPUTER PROGRAM; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG TARGETING; GENE EXPRESSION PROFILING; GENE MAPPING; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; CELL LINE, TUMOR; CLONING, MOLECULAR; COGNITION; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; GENOMICS; HUMANS; INFORMATICS; LIGANDS; NOOTROPIC AGENTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RALOXIFENE; RECEPTORS, SEROTONIN; REPRODUCIBILITY OF RESULTS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SEROTONIN ANTAGONISTS; USER-COMPUTER INTERFACE;

EID: 84863092274     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2011657     Document Type: Article

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