Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions

Journal of Neuroscience

Volumn 28, Issue 16, 2008, Pages 4261-4270

  Pezet, Sophie ^a,c   Marchand, Fabien ^a   D'Mello, Richard ^b   Grist, John ^a   Clark, Anna K ^a   Malcangio, Marzia ^a   Dickenson, Anthony H ^b   Williams, Robert J ^a   McMahon, Stephen B ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CNRS   (France)

Author keywords

CaMKII; ERK; Formalin; GluR1; NMDA; Phosphorylation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AMPA RECEPTOR; GLUTAMATE RECEPTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; AUTACOID; CHROMONE DERIVATIVE; FORMALDEHYDE; MORPHOLINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MEDIATOR RELEASE; NERVE CELL; NONHUMAN; ONCOGENE C FOS; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SENSITIZATION; SPINAL CORD; SPRAGUE DAWLEY RAT; WISTAR RAT; ANIMAL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METHODOLOGY; PAIN ASSESSMENT; PATHOLOGY; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CHROMONES; FORMALDEHYDE; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MORPHOLINES; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SPINAL CORD;

EID: 42949128674     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5392-07.2008     Document Type: Article

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