Chemical genomics: A systematic approach in biological research and drug discovery

Current Issues in Molecular Biology

Volumn 4, Issue 2, 2002, Pages 33-43

  Steven Zheng, X F S ^a   Chan, Ting Fung ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTIMITOTIC AGENT; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; LACTACYSTIN; LIGAND; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME INHIBITOR; RAPAMYCIN; TACROLIMUS; TUNICAMYCIN; WORTMANNIN;

ARTICLE; BIOTECHNOLOGY; CELL MEMBRANE PERMEABILITY; CHEMICAL GENETICS; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TARGETING; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE SEQUENCE; GENE STRUCTURE; MEDICAL RESEARCH; MOLECULAR BIOLOGY; PROTEIN FUNCTION;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG INDUSTRY; GENOMICS; HUMANS; LIGANDS; MODELS, BIOLOGICAL; PHARMACOGENETICS;

EID: 0036194512     PISSN: 14673037     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (90)

1. Chemical genetic approaches for the elucidation of signaling pathways
2. Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent
3. A versatile synthetic dimerizer for the regulation of protein-protein interactions
4. Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons
5. High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans
6. GASP: A computer program to generate automatically polycyclic structures
7. The TOR signaling pathway controls nuclear localization of nutrient-regulated transcriptional factors
8. Immunophenotyping of leukemias using a cluster of differentiation antibody microarray
9. Controlling Programmed Cell Death with a Cyclophilin-Cyclosporin-Based Chemical Inducer of dimerization
10. Genomewide studies of histone deacetylase function in yeast
11. Tripartite regulation of Gln3p by TOR, Ure2p and phosphatases
12. Unnatural ligands for engineered proteins: New tools for chemical genetics
13. Design of allele-specific inhibitors to probe protein kinase signaling
14. Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations
15. Target selection for structural genomics
16. A mammalian protein targeted by G1-arresting rapamycin-receptor complex
17. Search and discovery strategies for biotechnology: The paradigm shift
18. An overview of structural genomics
19. Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity
20. The TOR signaling cascade regulates gene expression in response to nutrients
21. A chemical genomics approach toward understanding the global functions of TOR
22. Differential screening and mass mapping of proteins from premalignant and cancer cell lines using nonporous reversed-phase HPLC coupled with mass spectrometric analysis
23. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
24. Genome-wide mutant collections: Toolboxes for functional genomics
25. Chemical genetics: Exploring and controlling cellular processes with chemical probes
26. Natural products in anticancer therapy
27. Allosteric drugs: Thinking outside the active-site box
28. Lactacystin, proteasome function, and cell fate
29. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
30. Pharmacological rescue of mutant p53 conformation and function
31. A new general approach for the simultaneous chemical synthesis of large numbers of oligonucleotides: Segmental solid supports
32. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
33. The complexity of p53 modulation: Emerging patterns from divergent signals
34. Genomic profiling of drug sensitivities via induced haploinsufficiency
35. Combinatorial libraries and biological discovery
36. Mass spectrometry and proteomics
37. Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions
38. The Rb/E2F pathway: Expanding roles and emerging paradigms
39. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
40. THE UBIQUITIN SYSTEM
41. Evolution and function of ubiquitin-like protein-conjugation systems
42. Detection of multiple proteins in an antibody-based protein microarray system
43. Functional discovery via a compendium of expression profiles
44. Signalling-2000 and beyond
45. Drug chirality: A consideration of the significance of the stereochemistry of antimicrobial agents
46. Simulated molecular evolution in a full combinatorial library
47. Recent developments in structure-based drug design
48. Intracellular targets of cyclin-dependent kinase inhibitors: Identification by affinity chromatography using immobilised inhibitors
49. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
50. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
51. Genes are mutable units (Chapter 3)
52. High-throughput isolation of Caenorhabditis elegans deletion mutants
53. Genomics, gene expression and DNA arrays
54. Protein microarrays for gene expression and antibody screening
55. Printing small molecules as microarrays and detecting protein-ligand interactions en masse
56. Printing proteins as microarrays for high-throughput function determination
57. Inhibition of the immune response by rapamycin, a new antifungal antibiotic
58. The meteoric rise of regulated intracellular proteolysis
59. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
60. Two-dimensional gel electrophoresis: A powerful method to elucidate cellular responses to toxic compounds
61. Regulation of protein kinase C
62. The promise of comparative genomics in mammals
63. Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome
64. Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells
65. Histone methylation versus histone acetylation: New insights into epigenetic regulation
66. Comparative genomics of the eukaryotes
67. New roles for structure in biology and drug discovery
68. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
69. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
70. Target-oriented and diversity-oriented organic synthesis in drug discovery
71. Chemistry and biology of the immunophilins and their immunosuppressive ligands
72. Chemical genetics resulting from a passion for synthetic organic chemistry
73. Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates
74. Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae
75. Application of genetic algorithms to combinatorial synthesis: A computational approach to lead identification and lead optimization
76. Controlling signal transduction with synthetic ligands
77. The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
78. Acetylation of histones and transcription-related factors
79. High-throughput protein crystallization
80. Global efforts in structural genomics
81. Chemical genetics: Ligand-based discovery of gene function
82. High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications
83. A genomic perspective on protein families
84. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
85. The sequence of the human genome
86. Prospects for drug screening using the reverse two-hybrid system
87. Fundamentals of chirality
88. Isoelectric focusing nonporous RP HPLC: A two-dimensional liquid-phase separation method for mapping of cellular proteins with identification using MALDI-TOF mass spectrometry
89. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
90. Analysis of yeast protein kinases using protein chips