Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 13, 1997, Pages 6700-6705

  Cameron, Craig E ^a   Ghosh, Madhumita ^b   Le Grice, Stuart F J ^b   Benkovic, Stephen J ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; PROTEIN P51; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS RNA;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DNA RNA HYBRIDIZATION; DNA STRAND; DNA SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; EQUINE INFECTIOUS ANEMIA VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; VIRUS NUCLEOCAPSID;

BASE SEQUENCE; CAPSID; GENE DELETION; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MOLECULAR SEQUENCE DATA; RIBONUCLEASE H, CALF THYMUS;

DNA VIRUSES; EQUIDAE; EQUINE INFECTIOUS ANEMIA VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; MIRIDAE;

EID: 0030962706     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.13.6700     Document Type: Article

References (25)

1. Barre-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Chamaret, S., Gruest, J., Dauget, C., Axler-Blin, C., Vezinet-Brun, F., Rouzious, C., Rozenbaum, W. & Montagnier, L. (1983) Science 220, 868-871.
2. Popovic, M., Sarngadharan, M. G., Read, E. & Gallo, R. C. (1984) Science 224, 497-500.
3. Coffin, J. M. (1990) in Virology, ed. Fields, B. N. (Raven, New York), pp. 1437-1500.
4. Larder, B. A. (1993) in Reverse Transcriptase, eds. Skalka, A. M. & Goff, S. P. (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 205-222.
5. Telesnitsky, A. & Goff, S. P. (1993) in Reverse Transcriptase, eds. Skalka, A. M. & Goff, S. P. (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 49-83.
6. Peliska, J. A. & Benkovic, S. J. (1992) Science 258, 1112-1118.
7. Gopalakrishnan, V., Peliska, J. A. & Benkovic, S. J. (1992) Proc. Natl. Acad. Sci. USA 89, 10763-10767.
8. Peliska, J. A., Balasubramanian, S., Giedroc, D. P. & Benkovic S. J. (1994) Biochemistry 33, 13817-13823.
9. Rodgers, D. W., Gamblin, S. J., Harris, B. A., Ray, S., Culp, J. S., Hellmig, B., Woolf, D. J., Debouck, C. & Harrison, S. C. (1995) Proc. Natl. Acad. Sci. USA 92, 1222-1226.
10. Jacques, P. S., Woehrl, B. M., Howard, K. J. & Le Grice, S. F. J. (1994) J. Biol. Chem. 269, 1388-1393.
11. Arts, E. J., Ghosh, M., Jacques, P. S., Ehresmann, B. & Le Grice, S. F. J. (1996) J. Biol. Chem. 271, 9054-9061.
12. Kati, W. M., Johnson, K. A., Jerva, L. F. & Anderson, K. S. (1992) J. Biol. Chem. 267, 25988-25997.
13. Ghosh, M., Howard, K. J., Cameron, C. E., Benkovic, S. J., Hughes, S. H. & Le Grice, S. F. J. (1995) J. Biol. Chem. 270, 7068-7076.
14. Metzger, W., Hermann, T., Schatz, O., Le Grice, S. F. J. & Heumann, H. (1993) Proc. Natl. Acad. Sci. USA 90, 5909-5913.
15. Woehrl, B. M., Georgiadis, M., Telesnitsky, A., Hendrickson, W. & Le Grice, S. F. J. (1995) Science 267, 96-99.
16. Darlix, J.-L., Lapadat-Tapolsky, M., de Rocquigny, H. & Roques, B. P. (1995) J. Mol. Biol. 254, 523-537.
17. Khan, R. & Giedroc, D. P. (1994) J. Biol. Chem. 269, 22538-22546.
18. Gelfand, C. A., Wang, Q., Randall, S. & Jentoft, J. E. (1993) J. Biol. Chem. 268, 18450-18456.
19. Arts, E. J., Stetor, S. R., Li, X., Rausch, J. W., Howard, K. J., Ehresmann, B., North, T. W., Woehrl, B. M., Goody, R. S., Wainberg, M. A. & Le Grice, S. F. J. (1996) Proc. Natl. Acad. Sci. USA 93, 10063-10068.
20. Hermann, T., Meier, T., Goette, M. & Heumann, H. (1994) Nucleic Acids Res. 22, 4625-4633.
21. Kohlstaedt, L. A., Wang, J., Rice, P. A., Friedman, J. M. & Steitz, T. A. (1993) in Reverse Transcriptase, eds. Skalka, A. M. & Goff, S. P. (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 223-249.
22. Mishima, V. & Steitz, J. (1995) EMBO J. 14, 2679-2687.
23. Rausch, J. W., Arts, E. J., Woehrl, B. M. & Le Grice, S. F. J. (1996) J. Mol. Biol. 257, 500-511.
24. Allain, B., Lapadat-Tapolsky, M., Berlioz, C. & Darlix, J.-L. (1994) EMBO J. 13, 973-981.
25. You, J. C. & McHenry, C. S. (1994) J. Biol. Chem. 269, 31491-31495.