-
1
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
DOI 10.1038/35001622
-
Imai, S., Armstrong, C. M., Kaeberlein, M., and Guarente, L. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800 (Pubitemid 30111843)
-
(2000)
Nature
, vol.403
, Issue.6771
, pp. 795-800
-
-
Imai, S.-I.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
2
-
-
0034705129
-
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
-
DOI 10.1073/pnas.110148297
-
Landry, J., Sutton, A., Tafrov, S. T., Heller, R. C., Stebbins, J., Pillus, L., and Sternglanz, R. (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. U. S. A. 97, 5807-5811 (Pubitemid 30367480)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.11
, pp. 5807-5811
-
-
Landry, J.1
Sutton, A.2
Tafrov, S.T.3
Heller, R.C.4
Stebbins, J.5
Pillus, L.6
Sternglanz, R.7
-
3
-
-
12944283150
-
+-dependent protein deacetylase activity in the Sir2 protein family
-
DOI 10.1073/pnas.97.12.6658
-
Smith, J. S., Brachmann, C. B., Celic, I., Kenna, M. A., Muhammad, S., Starai, V. J., Avalos, J. L., Escalante-Semerena, J. C., Grubmeyer, C., Wolberger, C., and Boeke, J. D. (2000) A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. U. S. A. 97, 6658-6663 (Pubitemid 30412770)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.12
, pp. 6658-6663
-
-
Smith, J.S.1
Brachmann, C.B.2
Celic, I.3
Kenna, M.A.4
Muhammad, S.5
Starai, V.J.6
Avalos, J.L.7
Escalante-Semerena, J.C.8
Grubmeyer, C.9
Wolberger, C.10
Boeke, J.D.11
-
4
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye, R. A. (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273, 793-798
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
5
-
-
77949887506
-
Mammalian sirtuins: Biological insights and disease relevance
-
Haigis, M. C., and Sinclair, D. A. (2010) Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 5, 253-295
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
6
-
-
79953898189
-
Sirtuin 1 in lipid metabolism and obesity
-
Schug, T. T., and Li, X. (2011) Sirtuin 1 in lipid metabolism and obesity. Annals Med. 43, 198-211
-
(2011)
Annals Med.
, vol.43
, pp. 198-211
-
-
Schug, T.T.1
Li, X.2
-
7
-
-
79960141848
-
Mammalian sirtuins and energy metabolism
-
Li, X., and Kazgan, N. (2011) Mammalian sirtuins and energy metabolism. Int. J. Biol. Sci. 7, 575-587
-
(2011)
Int. J. Biol. Sci.
, vol.7
, pp. 575-587
-
-
Li, X.1
Kazgan, N.2
-
8
-
-
56249100986
-
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
-
Liu, Y., Dentin, R., Chen, D., Hedrick, S., Ravnskjaer, K., Schenk, S., Milne, J., Meyers, D. J., Cole, P., Iii, J. Y., Olefsky, J., Guarente, L., and Montminy, M. (2008) A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456, 269-273
-
(2008)
Nature
, vol.456
, pp. 269-273
-
-
Liu, Y.1
Dentin, R.2
Chen, D.3
Hedrick, S.4
Ravnskjaer, K.5
Schenk, S.6
Milne, J.7
Meyers, D.J.8
Cole, P.9
Iii, J.Y.10
Olefsky, J.11
Guarente, L.12
Montminy, M.13
-
9
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
DOI 10.1038/nature03354
-
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., and Puigserver, P. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434, 113-118 (Pubitemid 40349395)
-
(2005)
Nature
, vol.434
, Issue.7029
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
10
-
-
63449112017
-
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
-
Purushotham, A., Schug, T. T., Xu, Q., Surapureddi, S., Guo, X., and Li, X. (2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 9, 327-338
-
(2009)
Cell Metab.
, vol.9
, pp. 327-338
-
-
Purushotham, A.1
Schug, T.T.2
Xu, Q.3
Surapureddi, S.4
Guo, X.5
Li, X.6
-
12
-
-
34948883324
-
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
-
DOI 10.1016/j.molcel.2007.07.032, PII S109727650700620X
-
Li, X., Zhang, S., Blander, G., Tse, J. G., Krieger, M., and Guarente, L. (2007) SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol. Cell 28, 91-106 (Pubitemid 47531974)
-
(2007)
Molecular Cell
, vol.28
, Issue.1
, pp. 91-106
-
-
Li, X.1
Zhang, S.2
Blander, G.3
Tse, J.G.4
Krieger, M.5
Guarente, L.6
-
13
-
-
70350606061
-
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
-
Kemper, J. K., Xiao, Z., Ponugoti, B., Miao, J., Fang, S., Kanamaluru, D., Tsang, S., Wu, S. Y., Chiang, C. M., and Veenstra, T. D. (2009) FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab. 10, 392-404
-
(2009)
Cell Metab.
, vol.10
, pp. 392-404
-
-
Kemper, J.K.1
Xiao, Z.2
Ponugoti, B.3
Miao, J.4
Fang, S.5
Kanamaluru, D.6
Tsang, S.7
Wu, S.Y.8
Chiang, C.M.9
Veenstra, T.D.10
-
14
-
-
77954488637
-
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
-
Walker, A. K., Yang, F., Jiang, K., Ji, J. Y., Watts, J. L., Purushotham, A., Boss, O., Hirsch, M. L., Ribich, S., Smith, J. J., Israelian, K., Westphal, C. H., Rodgers, J. T., Shioda, T., Elson, S. L., Mulligan, P., Najafi-Shoushtari, H., Black, J. C., Thakur, J. K., Kadyk, L. C., Whetstine, J. R., Mostoslavsky, R., Puigserver, P., Li, X., Dyson, N. J., Hart, A. C., and Naar, A. M. (2010) Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 24, 1403-1417
-
(2010)
Genes Dev.
, vol.24
, pp. 1403-1417
-
-
Walker, A.K.1
Yang, F.2
Jiang, K.3
Ji, J.Y.4
Watts, J.L.5
Purushotham, A.6
Boss, O.7
Hirsch, M.L.8
Ribich, S.9
Smith, J.J.10
Israelian, K.11
Westphal, C.H.12
Rodgers, J.T.13
Shioda, T.14
Elson, S.L.15
Mulligan, P.16
Najafi-Shoushtari, H.17
Black, J.C.18
Thakur, J.K.19
Kadyk, L.C.20
Whetstine, J.R.21
Mostoslavsky, R.22
Puigserver, P.23
Li, X.24
Dyson, N.J.25
Hart, A.C.26
Naar, A.M.27
more..
-
15
-
-
77958595135
-
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
-
Ponugoti, B., Kim, D. H., Xiao, Z., Smith, Z., Miao, J., Zang, M., Wu, S. Y., Chiang, C. M., Veenstra, T. D., and Kemper, J. K. (2010) SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J. Biol. Chem. 285, 33959-33970
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 33959-33970
-
-
Ponugoti, B.1
Kim, D.H.2
Xiao, Z.3
Smith, Z.4
Miao, J.5
Zang, M.6
Wu, S.Y.7
Chiang, C.M.8
Veenstra, T.D.9
Kemper, J.K.10
-
16
-
-
25144454432
-
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
-
Moynihan, K. A., Grimm, A. A., Plueger, M. M., Bernal-Mizrachi, E., Ford, E., Cras-Meneur, C., Permutt, M. A., and Imai, S. (2005) Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab. 2, 105-117
-
(2005)
Cell Metab.
, vol.2
, pp. 105-117
-
-
Moynihan, K.A.1
Grimm, A.A.2
Plueger, M.M.3
Bernal-Mizrachi, E.4
Ford, E.5
Cras-Meneur, C.6
Permutt, M.A.7
Imai, S.8
-
17
-
-
33244486764
-
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
-
Bordone, L., Motta, M. C., Picard, F., Robinson, A., Jhala, U. S., Apfeld, J., McDonagh, T., Lemieux, M., McBurney, M., Szilvasi, A., Easlon, E. J., Lin, S. J., and Guarente, L. (2006) Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 4, e31
-
(2006)
PLoS Biol.
, vol.4
-
-
Bordone, L.1
Motta, M.C.2
Picard, F.3
Robinson, A.4
Jhala, U.S.5
Apfeld, J.6
McDonagh, T.7
Lemieux, M.8
McBurney, M.9
Szilvasi, A.10
Easlon, E.J.11
Lin, S.J.12
Guarente, L.13
-
18
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
-
DOI 10.1038/nature02583
-
Picard, F., Kurtev, M., Chung, N., Topark-Ngarm, A., Senawong, T., Machado De Oliveira, R., Leid, M., McBurney, M. W., and Guarente, L. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429, 771-776 (Pubitemid 38833129)
-
(2004)
Nature
, vol.429
, Issue.6993
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
De Oliveira, R.M.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
19
-
-
72849130743
-
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
-
Cohen, D. E., Supinski, A. M., Bonkowski, M. S., Donmez, G., and Guarente, L. P. (2009) Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev. 23, 2812-2817
-
(2009)
Genes Dev.
, vol.23
, pp. 2812-2817
-
-
Cohen, D.E.1
Supinski, A.M.2
Bonkowski, M.S.3
Donmez, G.4
Guarente, L.P.5
-
20
-
-
77955344258
-
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus
-
Satoh, A., Brace, C. S., Ben-Josef, G., West, T., Wozniak, D. F., Holtzman, D. M., Herzog, E. D., and Imai, S. (2010) SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J. Neurosci. 30, 10220-10232
-
(2010)
J. Neurosci.
, vol.30
, pp. 10220-10232
-
-
Satoh, A.1
Brace, C.S.2
Ben-Josef, G.3
West, T.4
Wozniak, D.F.5
Holtzman, D.M.6
Herzog, E.D.7
Imai, S.8
-
21
-
-
77949506721
-
Hypothalamic Sirt1 regulates food intake in a rodent model system
-
Cakir, I., Perello, M., Lansari, O., Messier, N. J., Vaslet, C. A., and Nillni, E. A. (2009) Hypothalamic Sirt1 regulates food intake in a rodent model system. PLoS One 4, e8322
-
(2009)
PLoS One
, vol.4
-
-
Cakir, I.1
Perello, M.2
Lansari, O.3
Messier, N.J.4
Vaslet, C.A.5
Nillni, E.A.6
-
22
-
-
77956241193
-
Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: Roles for Sirt1 in neuronal firing and synaptic plasticity
-
Dietrich, M. O., Antunes, C., Geliang, G., Liu, Z. W., Borok, E., Nie, Y., Xu, A. W., Souza, D. O., Gao, Q., Diano, S., Gao, X. B., and Horvath, T. L. (2010) Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J. Neurosci. 30, 11815-11825
-
(2010)
J. Neurosci.
, vol.30
, pp. 11815-11825
-
-
Dietrich, M.O.1
Antunes, C.2
Geliang, G.3
Liu, Z.W.4
Borok, E.5
Nie, Y.6
Xu, A.W.7
Souza, D.O.8
Gao, Q.9
Diano, S.10
Gao, X.B.11
Horvath, T.L.12
-
23
-
-
77956644726
-
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
-
Ramadori, G., Fujikawa, T., Fukuda, M., Anderson, J., Morgan, D. A., Mostoslavsky, R., Stuart, R. C., Perello, M., Vianna, C. R., Nillni, E. A., Rahmouni, K., and Coppari, R. (2010) SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 12, 78-87
-
(2010)
Cell Metab.
, vol.12
, pp. 78-87
-
-
Ramadori, G.1
Fujikawa, T.2
Fukuda, M.3
Anderson, J.4
Morgan, D.A.5
Mostoslavsky, R.6
Stuart, R.C.7
Perello, M.8
Vianna, C.R.9
Nillni, E.A.10
Rahmouni, K.11
Coppari, R.12
-
24
-
-
47749140333
-
SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
-
DOI 10.1016/j.cell.2008.06.050, PII S0092867408008374
-
Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., and Schibler, U. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134, 317-328 (Pubitemid 352024391)
-
(2008)
Cell
, vol.134
, Issue.2
, pp. 317-328
-
-
Asher, G.1
Gatfield, D.2
Stratmann, M.3
Reinke, H.4
Dibner, C.5
Kreppel, F.6
Mostoslavsky, R.7
Alt, F.W.8
Schibler, U.9
-
25
-
-
47549088250
-
+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
-
DOI 10.1016/j.cell.2008.07.002, PII S0092867408008799
-
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., and Sassone-Corsi, P. (2008) The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329-340 (Pubitemid 352010336)
-
(2008)
Cell
, vol.134
, Issue.2
, pp. 329-340
-
-
Nakahata, Y.1
Kaluzova, M.2
Grimaldi, B.3
Sahar, S.4
Hirayama, J.5
Chen, D.6
Guarente, L.P.7
Sassone-Corsi, P.8
-
26
-
-
65549118773
-
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
-
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., and Sassone-Corsi, P. (2009) Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 324, 654-657
-
(2009)
Science
, vol.324
, pp. 654-657
-
-
Nakahata, Y.1
Sahar, S.2
Astarita, G.3
Kaluzova, M.4
Sassone-Corsi, P.5
-
27
-
-
65549103855
-
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
-
Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H. K., Chong, J. L., Buhr, E. D., Lee, C., Takahashi, J. S., Imai, S., and Bass, J. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324, 651-654
-
(2009)
Science
, vol.324
, pp. 651-654
-
-
Ramsey, K.M.1
Yoshino, J.2
Brace, C.S.3
Abrassart, D.4
Kobayashi, Y.5
Marcheva, B.6
Hong, H.K.7
Chong, J.L.8
Buhr, E.D.9
Lee, C.10
Takahashi, J.S.11
Imai, S.12
Bass, J.13
-
28
-
-
0037207475
-
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
-
DOI 10.1128/MCB.23.1.38-54.2003
-
McBurney, M. W., Yang, X., Jardine, K., Hixon, M., Boekelheide, K., Webb, J. R., Lansdorp, P. M., and Lemieux, M. (2003) The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol. Cell. Biol. 23, 38-54 (Pubitemid 36008499)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.1
, pp. 38-54
-
-
McBurney, M.W.1
Yang, X.2
Jardine, K.3
Hixon, M.4
Boekelheide, K.5
Webb, J.R.6
Lansdorp, P.M.7
Lemieux, M.8
-
29
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng, H. L., Mostoslavsky, R., Saito, S., Manis, J. P., Gu, Y., Patel, P., Bronson, R., Appella, E., Alt, F. W., and Chua, K. F. (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. U. S. A.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
Bronson, R.7
Appella, E.8
Alt, F.W.9
Chua, K.F.10
-
30
-
-
0026934722
-
A simple enzymatic quantitative analysis of triglycerides in tissues
-
Danno, H., Jincho, Y., Budiyanto, S., Furukawa, Y., and Kimura, S. (1992) A simple enzymatic quantitative analysis of triglycerides in tissues. J. Nutr. Sci. Vitaminol. (Tokyo) 38, 517-521
-
(1992)
J. Nutr. Sci. Vitaminol. (Tokyo)
, vol.38
, pp. 517-521
-
-
Danno, H.1
Jincho, Y.2
Budiyanto, S.3
Furukawa, Y.4
Kimura, S.5
-
31
-
-
68649113524
-
Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats
-
Ohta, T., Masutomi, N., Tsutsui, N., Sakairi, T., Mitchell, M., Milburn, M. V., Ryals, J. A., Beebe, K. D., and Guo, L. (2009) Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats. Toxicol. Pathol. 37, 521-535
-
(2009)
Toxicol. Pathol.
, vol.37
, pp. 521-535
-
-
Ohta, T.1
Masutomi, N.2
Tsutsui, N.3
Sakairi, T.4
Mitchell, M.5
Milburn, M.V.6
Ryals, J.A.7
Beebe, K.D.8
Guo, L.9
-
32
-
-
68849083050
-
Integrated, nontargeted ultrahigh performance liquid chromatography/ electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems
-
Evans, A. M., DeHaven, C. D., Barrett, T., Mitchell, M., and Milgram, E. (2009) Integrated, nontargeted ultrahigh performance liquid chromatography/ electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal. Chem. 81, 6656-6667
-
(2009)
Anal. Chem.
, vol.81
, pp. 6656-6667
-
-
Evans, A.M.1
DeHaven, C.D.2
Barrett, T.3
Mitchell, M.4
Milgram, E.5
-
33
-
-
78649702566
-
Organization of GC/MS and LC/MS metabolomics data into chemical libraries
-
Dehaven, C. D., Evans, A. M., Dai, H., and Lawton, K. A. (2010) Organization of GC/MS and LC/MS metabolomics data into chemical libraries. J. Cheminform. 2, 9
-
(2010)
J. Cheminform.
, vol.2
, pp. 9
-
-
Dehaven, C.D.1
Evans, A.M.2
Dai, H.3
Lawton, K.A.4
-
35
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
DOI 10.1126/science.1061620
-
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z. W., Karin, M., and Shoelson, S. E. (2001) Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293, 1673-1677 (Pubitemid 32807849)
-
(2001)
Science
, vol.293
, Issue.5535
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.-W.5
Karin, M.6
Shoelson, S.E.7
-
36
-
-
0037153158
-
A central, role for JNK in obesity and insulin resistance
-
DOI 10.1038/nature01137
-
Hirosumi, J., Tuncman, G., Chang, L., Gorgun, C. Z., Uysal, K. T., Maeda, K., Karin, M., and Hotamisligil, G. S. (2002) A central role for JNK in obesity and insulin resistance. Nature 420, 333-336 (Pubitemid 35398190)
-
(2002)
Nature
, vol.420
, Issue.6913
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
37
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
DOI 10.1126/science.1103160
-
Ozcan, U., Cao, Q., Yilmaz, E., Lee, A. H., Iwakoshi, N. N., Ozdelen, E., Tuncman, G., Gorgun, C., Glimcher, L. H., and Hotamisligil, G. S. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457-461 (Pubitemid 39372439)
-
(2004)
Science
, vol.306
, Issue.5695
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.-H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
38
-
-
0025768055
-
The role of the liver in metabolic homeostasis: Implications for inborn errors of metabolism
-
Van den Berghe, G. (1991) The role of the liver in metabolic homeostasis: implications for inborn errors of metabolism. J. Inherit. Metab. Dis. 14, 407-420
-
(1991)
J. Inherit. Metab. Dis.
, vol.14
, pp. 407-420
-
-
Van Den Berghe, G.1
-
39
-
-
0042991264
-
Glyceroneogenesis and the triglyceride/fatty acid cycle
-
DOI 10.1074/jbc.R300017200
-
Reshef, L., Olswang, Y., Cassuto, H., Blum, B., Croniger, C. M., Kalhan, S. C., Tilghman, S. M., and Hanson, R. W. (2003) Glyceroneogenesis and the triglyceride/fatty acid cycle. J. Biol. Chem. 278, 30413-30416 (Pubitemid 36994541)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.33
, pp. 30413-30416
-
-
Reshef, L.1
Olswang, Y.2
Cassuto, H.3
Blum, B.4
Croniger, C.M.5
Kalhan, S.C.6
Tilghman, S.M.7
Hanson, R.W.8
-
40
-
-
53049094467
-
Glycerolipid metabolism and signaling in health and disease
-
Prentki, M., and Madiraju, S. R. (2008) Glycerolipid metabolism and signaling in health and disease. Endocr. Rev. 29, 647-676
-
(2008)
Endocr. Rev.
, vol.29
, pp. 647-676
-
-
Prentki, M.1
Madiraju, S.R.2
-
41
-
-
37449020075
-
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
-
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R., Newgard, C. B., Lopaschuk, G. D., and Muoio, D. M. (2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7, 45-56
-
(2008)
Cell Metab.
, vol.7
, pp. 45-56
-
-
Koves, T.R.1
Ussher, J.R.2
Noland, R.C.3
Slentz, D.4
Mosedale, M.5
Ilkayeva, O.6
Bain, J.7
Stevens, R.8
Dyck, J.R.9
Newgard, C.B.10
Lopaschuk, G.D.11
Muoio, D.M.12
-
42
-
-
56749096610
-
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
-
Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., and Hobbs, H. H. (2008) Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 40, 1461-1465
-
(2008)
Nat. Genet.
, vol.40
, pp. 1461-1465
-
-
Romeo, S.1
Kozlitina, J.2
Xing, C.3
Pertsemlidis, A.4
Cox, D.5
Pennacchio, L.A.6
Boerwinkle, E.7
Cohen, J.C.8
Hobbs, H.H.9
-
43
-
-
79960729651
-
Mouse patatin-like phospholipase domaincontaining 3 influences systemic lipid and glucose homeostasis
-
Qiao, A., Liang, J., Ke, Y., Li, C., Cui, Y., Shen, L., Zhang, H., Cui, A., Liu, X., Liu, C., Chen, Y., Zhu, Y., Guan, Y., Fang, F., and Chang, Y. (2011) Mouse patatin-like phospholipase domaincontaining 3 influences systemic lipid and glucose homeostasis. Hepatology 54, 509-521
-
(2011)
Hepatology
, vol.54
, pp. 509-521
-
-
Qiao, A.1
Liang, J.2
Ke, Y.3
Li, C.4
Cui, Y.5
Shen, L.6
Zhang, H.7
Cui, A.8
Liu, X.9
Liu, C.10
Chen, Y.11
Zhu, Y.12
Guan, Y.13
Fang, F.14
Chang, Y.15
-
44
-
-
78650435043
-
Testosterone-induced permanent changes of hepatic gene expression in female mice sustained during Plasmodium chabaudi malaria infection
-
Delic, D., Gailus, N., Vohr, H. W., Dkhil, M., Al-Quraishy, S., and Wunderlich, F. (2010) Testosterone-induced permanent changes of hepatic gene expression in female mice sustained during Plasmodium chabaudi malaria infection. J. Mol. Endocrinol. 45, 379-390
-
(2010)
J. Mol. Endocrinol.
, vol.45
, pp. 379-390
-
-
Delic, D.1
Gailus, N.2
Vohr, H.W.3
Dkhil, M.4
Al-Quraishy, S.5
Wunderlich, F.6
-
45
-
-
66349126363
-
Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver
-
Guillen, N., Navarro, M. A., Arnal, C., Noone, E., Arbones-Mainar, J. M., Acin, S., Surra, J. C., Muniesa, P., Roche, H. M., and Osada, J. (2009) Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. Physiol. Genomics 37, 187-198
-
(2009)
Physiol. Genomics
, vol.37
, pp. 187-198
-
-
Guillen, N.1
Navarro, M.A.2
Arnal, C.3
Noone, E.4
Arbones-Mainar, J.M.5
Acin, S.6
Surra, J.C.7
Muniesa, P.8
Roche, H.M.9
Osada, J.10
-
46
-
-
0028980484
-
The mouse 3 beta-hydroxysteroid dehydrogenase multigene family includes two functionally distinct groups of proteins
-
Abbaszade, I. G., Clarke, T. R., Park, C. H., and Payne, A. H. (1995) The mouse 3 beta-hydroxysteroid dehydrogenase multigene family includes two functionally distinct groups of proteins. Mol. Endocrinol. 9, 1214-1222
-
(1995)
Mol. Endocrinol.
, vol.9
, pp. 1214-1222
-
-
Abbaszade, I.G.1
Clarke, T.R.2
Park, C.H.3
Payne, A.H.4
-
47
-
-
0030061508
-
Expression of multiple forms of 3beta-hydroxysteroid dehydrogenase in the mouse liver during fetal and postnatal development
-
DOI 10.1016/0303-7207(95)03707-1
-
Park, C. H., Abbaszade, I. G., and Payne, A. H. (1996) Expression of multiple forms of 3 beta-hydroxysteroid dehydrogenase in the mouse liver during fetal and postnatal development. Mol. Cell. Endocrinol. 116, 157-164 (Pubitemid 26052791)
-
(1996)
Molecular and Cellular Endocrinology
, vol.116
, Issue.2
, pp. 157-164
-
-
Parka, C.-H.J.1
Abbaszade, I.G.2
Payne, A.H.3
-
48
-
-
77956677458
-
Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
-
Schug, T. T., Xu, Q., Gao, H., Peres-da-Silva, A., Draper, D. W., Fessler, M. B., Purushotham, A., and Li, X. (2010) Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol. Cell. Biol. 30, 4712-4721
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 4712-4721
-
-
Schug, T.T.1
Xu, Q.2
Gao, H.3
Peres-da-Silva, A.4
Draper, D.W.5
Fessler, M.B.6
Purushotham, A.7
Li, X.8
-
49
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
DOI 10.1038/nature05354, PII NATURE05354
-
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., Pistell, P. J., Poosala, S., Becker, K. G., Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, K. W., Spencer, R. G., Lakatta, E. G., Le Couteur, D., Shaw, R. J., Navas, P., Puigserver, P., Ingram, D. K., de Cabo, R., and Sinclair, D. A. (2006) Resveratrol improves health and survival of mice on a highcalorie diet. Nature 444, 337-342 (Pubitemid 44764104)
-
(2006)
Nature
, vol.444
, Issue.7117
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
Pistell, P.J.11
Poosala, S.12
Becker, K.G.13
Boss, O.14
Gwinn, D.15
Wang, M.16
Ramaswamy, S.17
Fishbein, K.W.18
Spencer, R.G.19
Lakatta, E.G.20
Le, C.D.21
Shaw, R.J.22
Navas, P.23
Puigserver, P.24
Ingram, D.K.25
De Cabo, R.26
Sinclair, D.A.27
more..
-
50
-
-
33845399894
-
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1alpha
-
DOI 10.1016/j.cell.2006.11.013, PII S0092867406014280
-
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Geny, B., Laakso, M., Puigserver, P., and Auwerx, J. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC- 1alpha. Cell 127, 1109-1122 (Pubitemid 44894520)
-
(2006)
Cell
, vol.127
, Issue.6
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
51
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
DOI 10.1038/nature06261, PII NATURE06261
-
Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P., Smith, J. J., Gagne, D. J., Jin, L., Boss, O., Perni, R. B., Vu, C. B., Bemis, J. E., Xie, R., Disch, J. S., Ng, P. Y., Nunes, J. J., Lynch, A. V., Yang, H., Galonek, H., Israelian, K., Choy, W., Iffland, A., Lavu, S., Medvedik, O., Sinclair, D. A., Olefsky, J. M., Jirousek, M. R., Elliott, P. J., and Westphal, C. H. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450, 712-716 (Pubitemid 350207685)
-
(2007)
Nature
, vol.450
, Issue.7170
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
Gagne, D.J.6
Jin, L.7
Boss, O.8
Perni, R.B.9
Vu, C.B.10
Bemis, J.E.11
Xie, R.12
Disch, J.S.13
Ng, P.Y.14
Nunes, J.J.15
Lynch, A.V.16
Yang, H.17
Galonek, H.18
Israelian, K.19
Choy, W.20
Iffland, A.21
Lavu, S.22
Medvedik, O.23
Sinclair, D.A.24
Olefsky, J.M.25
Jirousek, M.R.26
Elliott, P.J.27
Westphal, C.H.28
more..
-
52
-
-
47749128879
-
Sirt1 protects against high-fat diet-induced metabolic damage
-
DOI 10.1073/pnas.0802917105
-
Pfluger, P. T., Herranz, D., Velasco-Miguel, S., Serrano, M., and Tschop, M. H. (2008) Sirt1 protects against high-fat diet-induced metabolic damage. Proc. Natl. Acad. Sci. U. S. A. 105, 9793-9798 (Pubitemid 352031379)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.28
, pp. 9793-9798
-
-
Pfluger, P.T.1
Herranz, D.2
Velasco-Miguel, S.3
Serrano, M.4
Tschop, M.H.5
-
53
-
-
52749091816
-
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
-
Banks, A. S., Kon, N., Knight, C., Matsumoto, M., Gutierrez-Juarez, R., Rossetti, L., Gu, W., and Accili, D. (2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8, 333-341
-
(2008)
Cell Metab.
, vol.8
, pp. 333-341
-
-
Banks, A.S.1
Kon, N.2
Knight, C.3
Matsumoto, M.4
Gutierrez-Juarez, R.5
Rossetti, L.6
Gu, W.7
Accili, D.8
-
54
-
-
55249125750
-
Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects-a monozygotic twin study
-
Pietilainen, K. H., Sysi-Aho, M., Rissanen, A., Seppanen-Laakso, T., Yki-Jarvinen, H., Kaprio, J., and Oresic, M. (2007) Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects-a monozygotic twin study. PLoS One 2, e218
-
(2007)
PLoS One
, vol.2
-
-
Pietilainen, K.H.1
Sysi-Aho, M.2
Rissanen, A.3
Seppanen-Laakso, T.4
Yki-Jarvinen, H.5
Kaprio, J.6
Oresic, M.7
-
55
-
-
77954515012
-
Lack of SIRT1 (mammalian sirtuin 1) activity leads to liver steatosis in the SIRT1+/- Mice: A role of lipid mobilization and inflammation
-
Xu, F., Gao, Z., Zhang, J., Rivera, C. A., Yin, J., Weng, J., and Ye, J. (2010) Lack of SIRT1 (mammalian sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. Endocrinology 151, 2504-2514
-
(2010)
Endocrinology
, vol.151
, pp. 2504-2514
-
-
Xu, F.1
Gao, Z.2
Zhang, J.3
Rivera, C.A.4
Yin, J.5
Weng, J.6
Ye, J.7
-
56
-
-
77956490333
-
Insulin and hyperandrogenism in women with polycystic ovary syndrome
-
Baptiste, C. G., Battista, M. C., Trottier, A., and Baillargeon, J. P. (2010) Insulin and hyperandrogenism in women with polycystic ovary syndrome. J. Steroid Biochem. Mol. Biol. 122, 42-52
-
(2010)
J. Steroid Biochem. Mol. Biol.
, vol.122
, pp. 42-52
-
-
Baptiste, C.G.1
Battista, M.C.2
Trottier, A.3
Baillargeon, J.P.4
-
57
-
-
77949817711
-
AMPK and SIRT1: A long-standing partnership?
-
Ruderman, N. B., Xu, X. J., Nelson, L., Cacicedo, J. M., Saha, A. K., Lan, F., and Ido, Y. (2010) AMPK and SIRT1: a long-standing partnership? Am. J. Physiol. Endocrinol. Metab. 298, E751-E760
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
-
-
Ruderman, N.B.1
Xu, X.J.2
Nelson, L.3
Cacicedo, J.M.4
Saha, A.K.5
Lan, F.6
Ido, Y.7
-
58
-
-
77951872309
-
2+and AMPK/SIRT1
-
2+ and AMPK/SIRT1. Nature 464, 1313-1319
-
(2010)
Nature
, vol.464
, pp. 1313-1319
-
-
Iwabu, M.1
Yamauchi, T.2
Okada-Iwabu, M.3
Sato, K.4
Nakagawa, T.5
Funata, M.6
Yamaguchi, M.7
Namiki, S.8
Nakayama, R.9
Tabata, M.10
Ogata, H.11
Kubota, N.12
Takamoto, I.13
Hayashi, Y.K.14
Yamauchi, N.15
Waki, H.16
Fukayama, M.17
Nishino, I.18
Tokuyama, K.19
Ueki, K.20
Oike, Y.21
Ishii, S.22
Hirose, K.23
Shimizu, T.24
Touhara, K.25
Kadowaki, T.26
more..
-
59
-
-
50649112638
-
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
-
Hou, X., Xu, S., Maitland-Toolan, K. A., Sato, K., Jiang, B., Ido, Y., Lan, F., Walsh, K., Wierzbicki, M., Verbeuren, T. J., Cohen, R. A., and Zang, M. (2008) SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J. Biol. Chem. 283, 20015-20026
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 20015-20026
-
-
Hou, X.1
Xu, S.2
Maitland-Toolan, K.A.3
Sato, K.4
Jiang, B.5
Ido, Y.6
Lan, F.7
Walsh, K.8
Wierzbicki, M.9
Verbeuren, T.J.10
Cohen, R.A.11
Zang, M.12
-
60
-
-
55549096745
-
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
-
Lan, F., Cacicedo, J. M., Ruderman, N., and Ido, Y. (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J. Biol. Chem. 283, 27628 -27635
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 27628-27635
-
-
Lan, F.1
Cacicedo, J.M.2
Ruderman, N.3
Ido, Y.4
-
61
-
-
57349169258
-
Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
-
Fulco, M., and Sartorelli, V. (2008) Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. Cell Cycle 7, 3669-3679
-
(2008)
Cell Cycle
, vol.7
, pp. 3669-3679
-
-
Fulco, M.1
Sartorelli, V.2
-
62
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Canto, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., and Auwerx, J. (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458, 1056-1060
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
63
-
-
77249156847
-
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
-
Canto, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., Lagouge, M., Zierath, J. R., and Auwerx, J. (2010) Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 11, 213-219
-
(2010)
Cell Metab.
, vol.11
, pp. 213-219
-
-
Canto, C.1
Jiang, L.Q.2
Deshmukh, A.S.3
Mataki, C.4
Coste, A.5
Lagouge, M.6
Zierath, J.R.7
Auwerx, J.8
-
64
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
-
DOI 10.1038/nature02789
-
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., and Sinclair, D. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686-689 (Pubitemid 39061685)
-
(2004)
Nature
, vol.430
, Issue.7000
, pp. 686-689
-
-
Wood, J.G.1
Regina, B.2
Lavu, S.3
Hewitz, K.4
Helfand, S.L.5
Tatar, M.6
Sinclair, D.7
-
65
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
-
Kahn, B. B., Alquier, T., Carling, D., and Hardie, D. G. (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1, 15-25 (Pubitemid 43960587)
-
(2005)
Cell Metabolism
, vol.1
, Issue.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
|