Bone Proteinases

Principles of Bone Biology: Volume 1-2, Third Edition

Volumn , Issue , 2008, Pages 367-384

  Lee, Minnkyoung ^a   Shimizu, Emi ^a   Krane, Stephen M ^b   Partridge, Nicola C ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84862931391     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-373884-4.00038-0     Document Type: Chapter

References (239)

1. R.T. Aimes and J.P. Quigley (1995) Matrix metalloproteinase-2 is an interstitial collagenase: Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length cleavage fragments. J. Biol. Chem. 270 5872-5876.
2. A.I. Al-Aqeel (2005) Al-Aqeel Sewairi syndrome, a new autosomal recessive disorder with multicentric osteolysis, nodulosis, and arthropathy. The first genetic defect of matrix metalloproteinase-2 gene. Saudi Med. J. 26 24-30.
3. E.H. Allan, D.J. Hilton, M.A. Brown, R.S. Evely, S. Yumita, D. Medcalf, N.M. Gough, K.W. Ng, N.A. Nicola and T.J. Martin (1990) Osteoblasts display receptors for and responses to leukemia-inhibitory factor. J. Cell. Physiol. 145 110-119.
4. E.H. Allan, R. Zeheb, T.D. Gelehrter, J.H. Heaton, S. Fukumoto, J.A. Yee and T.J. Martin (1991) Transforming growth factor beta inhibits plasminogen activator (PA) activity and stimulates production of urokinase-type PA, PA inhibitor-1 mRNA, and protein in rat osteoblast-like cells. J. Cell. Physiol. 149 34-43.
5. P.A. Andreasen, L.S. Nielsen, P. Kristensen, J. Grondahl-Hansen, L. Skriver and K. Dano (1986) Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme. J. Biol. Chem. 261 7644-7651.
6. P.A. Andreasen, L. Sottrup-Jensen, L. Kjoller, A. Nykjaer, S.K. Moestrup, C.M. Petersen and J. Gliemann (1994) Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes. FEBS Lett. 338 239-245.
7. P. Angel and M. Karin (1991) The role of jun, fos, and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072 129-157.
8. S.S. Apte, N. Fukai, D.R. Beier and B.R. Olsen (1997) The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis. J. Biol. Chem. 272 25511-25517.
9. M. Balbín, A. Fueyo, V. Knauper, J.M. Lopez, J. Alvarez, L.M. Sanchez, V. Quesada, J. Bordallo, G. Murphy and C. Lopez-Otín (2001) Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J. Biol. Chem. 276 10253-10262.
10. M. Balbín, A. Fueyo, V. Knauper, A.M. Pendas, J.M. Lopez, M.G. Jimenez, G. Murphy and C. Lopez-Otín (1998) Collagenase 2(MMP-8) expression in murine tissue-remodeling processes: Analysis of its potential role in postpartum involution of the uterus. J. Biol. Chem. 273 23959-23968.
11. M. Balbin, A. Fueyo, A.M. Tester, A.M. Pendas, A.S. Pitiot, A. Astudillo, C.M. Overall, S.D. Shapiro and C. López-Otín (2003) Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat. Genet. 35 252-257.
12. C. Banerjee, L.R. McCabe, J.Y. Choi, S.W. Hiebert, J.L. Stein, G.S. Stein and J.B. Lian (1997) An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene. J. Cell. Biochem. 66 1-8.
13. L. Banyai, A. Varadi and L. Patthy (1983) Common evolutionary origin of the fibrin-binding structures of fibronectin and tissue-type plasminogen activator. FEBS Lett. 163 37-41.
14. O.Y. Barmina, H.W. Walling, G.J. Fiacco, J.M. Freije, C. López-Otín, J.J. Jeffrey and N.C. Partridge (1999) Collagenase-3 binds to a specific receptor and requires the low-density lipoprotein receptor-related protein for internalization. J. Biol. Chem. 274 30087-30093.
15. E.S. Barnathan, A. Kuo, H. Van der Keyl, K.R. McCrae, G.R. Larsen and D.B. Cines (1988) Tissue-type plasminogen activator binding to human endothelial cells. J. Biol. Chem. 263 7792-7799.
16. A.J. Barrett (1986) Physiological inhibitors of the human lysosomal cysteine proteinases. H. Ogawa, G.S. Lazarus, V.K. Hopsu-Havu (Eds) The Biological Role of Proteinases and Their Inhibitors in Skin New York: Elsevier 13-26.
17. M. Bartkiewicz, N. Hernando, S.V. Reddy, G.D. Roodman and R. Baron (1995) Characterization of the osteoclast vacuolar H(+)-ATPase B-subunit. Gene. 160 157-164.
18. F. Blasi (1988) Surface receptors for urokinase plasminogen activator. Fibrinolysis 2 73-84.
19. H.D. Blair, S.L. Teitelbaum, L.E. Grosso, D.L. Lacey, H.-L. Tan, D.W. McCourt and J.J. Jeffrey (1993) Extracellular-matrix degradation at acid pH: Avian osteoclast acid collagenase isolation and characterization. Biochem. J. 29 873-874.
20. A.B. Blom, P.L. van Lent, S. Libregts, A.E. Holthuysen, P.M. van der Kraan, N. van Rooijen and W.B. van den Berg (2007) Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: Involvement of matrix metalloproteinase 3. Arthritis Rheum. 56 147-157.
21. J.S. Bond and P.E. Butler (1987) Intracellular proteases. Annu. Rev. Biochem. 56 333-364.
22. M.J. Bossard, T.A. Tomaszek, S.K. Thompson, B.Y. Amegadzie, C.R. Hanning, C. Jones, J.T. Kurdyla, D.E. McNulty, F.H. Drake, M. Gowen and M.A. Levey (1996) Proteolytic activity of human osteoclast cathepsin K: Expression, purification, activation, and substrate identification. J. Biol. Chem. 271 12517-12524.
23. J.J. Breckon, S. Papaioannou, L.W. Kon, A. Tumber, R.M. Hembry, G. Murphy, J.J. Reynolds and M.C. Meikle (1999) Stromelysin (MMP-3) synthesis is up-regulated in estrogen-deficient mouse osteoblasts in vivo and in vitro. J. Bone Miner. Res. 14 1880-1890.
24. C.E. Brinckerhoff (1992) Regulation of metalloproteinase gene expression: Implications for osteoarthritis. Crit. Rev. Eukaryotic Gene Expression 2 145-164.
25. C.E. Brinckerhoff and E.D. Harris Jr. (1981) Modulation by retinoic acid and corticosteroids of collagenase production by rabbit synovial fibroblasts treated with phorbol myristate acetate or poly(ethylene glycol). Biochim. Biophys. Acta. 677 424-432.
26. T.H. Bugge, M.T. Flick, C.C. Daugherty and J.L. Degen (1995) Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev. 9 794-807.
27. P.G. Campbell, K. Wines, T.B. Yanosick and J.F. Novak (1994) Binding and activation of plasminogen on the surface of osteosarcoma cells. J. Cell. Physiol. 159 1-10.
28. E. Canalis, S. Rydziel, A.M. Delany, S. Varghese and J.J. Jeffrey (1995) Insulin-like growth factors inhibit interstitial collagenase synthesis in bone cultures. Endocrinology 136 1348-1354.
29. P. Carmeliet, L. Kieckens, L. Schoonjans, B. Ream, A. van Nuffelen, G. Prendergast, M. Cole, R. Bronson, D. Collen and R.C. Mulligan (1993) Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. J. Clin. Invest. 92 2746-2755.
30. P. Carmeliet, L. Schoonjans, L. Kieckens, B. Ream, J. Degen, R. Bronson, R. De Vos, J.J. van den Oord, D. Collen and R.C. Mulligan (1994) Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368 419-424.
31. M. Chakraborty, D. Chatterjee, F.S. Gorelick and R. Baron (1994) Cell cycle-dependent and kinase-specific regulation of the apical Na/H exchanger and the Na, K-ATPase in the kidney cell line LLC-PK1 by calcitonin. Proc. Natl. Acad. Sci. USA 91 2115-2119.
32. S.-L. Cheng, V. Shen and W.A. Peck (1991) Regulation of plasminogen activator and plasminogen activator inhibitor production by growth factors and cytokines in rat calvarial cells. Calcif. Tissue Int. 49 321-327.
33. J.R. Chin, G. Murphy and Z. Werb (1985) Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. J. Biol. Chem. 260 12367-12376.
34. R. Chiu, W.J. Boyle, J. Meek, T. Smeal, T. Hunter and M. Karin (1988) The c-fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54 541-542.
35. R. Civitelli, K.A. Hruska, J.J. Jeffrey, A.J. Kahn, L.V. Avioli and N.C. Partridge (1989) Second messenger signaling in the regulation of collagenase production by osteogenic sarcoma cells. Endocrinology 124 2928-2934.
36. J.C. Clohisy, D.K. Scott, K.D. Brakenhoff, C.O. Quinn and N.C. Partridge (1992) Parathyroid hormone induces c-fos and c-jun messenger RNA in rat osteoblastic cells. Mol. Endocrinol. 6 1834-1842.
37. A. Collen, R. Hanemaaijer, F. Lupu, P.H. Quax, N. van Lent, J. Grimbergen, E. Peters, P. Koolwijk and V.W.M. van Hinsbergh (2003) Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix. Blood 101 1810-1817.
38. I.E. Collier, S.M. Wilhelm, A.Z. Eisen, B.L. Marmer, G.A. Grant, J.L. Seltzer, A. Kronberger, C. He, E.A. Bauer and G.I. Goldberg (1988) H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. J. Biol. Chem. 263 6579-6587.
39. T.J. Connolly, J.C. Clohisy, K.D. Bergman, N.C. Partridge and C.O. Quinn (1994) Retinoic acid stimulates interstitial collagenase mRNA in osteosarcoma cells. Endocrinology 135 2542-2548.
40. C.A. Conover, S.K. Durham, J. Zopf, F.R. Masiarz and M.C. Kiefer (1995) Cleavage analysis of insulin-like growth factor (IGF)-dependent IGF-binding protein-4 proteolysis and expression of protease-resistant IGF-binding protein-4 mutants. J. Biol. Chem. 270 4395-4400.
41. H.C. Crawford and L.M. Matrisian (1996) Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells. Enzyme Protein 49 20-37.
42. M.V. Cubellis, P. Andreasen, P. Ragno, M. Mayer, K. Dano and F. Blasi (1989) Accessibility of receptor-bound urokinase to type-1plasminogen activator inhibitor. Proc. Natl. Acad. Sci. USA 86 4828-4832.
43. M.V. Cubellis, T.-C. Wun and F. Blasi (1990) Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1. EMBO J. 9 1079-1085.
44. E. Daci, N. Udagawa, T.J. Martin, R. Bouillon and G. Carmeliet (1999) The role of the plasminogen system in bone resorption in vitro. J. Bone Miner. Res. 14 946-952.
45. E. Daci, V. Everts, S. Torrekens, E. van Herck, W. Tigchelaar-Gutterr, R. Bouillon and G. Carmeliet (2003) Increased bone formation in mice lacking plasminogen activators. J. Bone Miner. Res. 18 1167-1176.
46. R.C. D’Alonzo, N. Selvamurugan, G. Karsenty and N.C. Partridge (2002) Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase promoter activation. J. Biol. Chem. 277 816-822.
47. B.A. Davis, B. Sipe, L.A. Gershan, G.J. Fiacco, T.C. Lorenz, J.J. Jeffrey and N.C. Partridge (1998) Collagenase and tissue plasminogen activator production in developing rat calvariae: Normal progression despite fetal exposure to microgravity. Calcif. Tiss. Int. 63 416-422.
48. A.C.W. De Bart, P.H.A. Quax, C.W.G.M. Lowik and J.H. Verheijen (1995) Regulation of plasminogen activation, matrix metalloproteinases, and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. J. Bone Miner. Res. 10 1374-1384.
49. J.-M. Delaissé, Y. Eeckhout and G. Vaes (1984) In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption. Biochem. Biophys. Res. Commun. 125 441-447.
50. J.-M. Delaissé, Y. Eeckhout and G. Vaes (1988) Bone-resorbing agents affect the production and distribution of procollagenase as well as the activity of collagenase in bone tissue. Endocrinology 123 264-276.
51. J.-M. Delaissé, P. Ledent and G. Vaes (1991) Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro) cathepsin L and a cathepsin-L like 70 kDa proteinase. Biochem. J. 279 167-174.
52. J.-M. Delaissé, Y. Eeckhout, L. Neff, C.H. Francois-Gillet, P. Henriet, Y. Su, G. Vaes and R. Baron (1993) (Pro) collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment. J. Cell. Sci. 106 1071-1082.
53. J.-M. Delaissé, M.T. Engsig, V. Everts, M. del Carmen Ovejero, M. Ferreras, L. Lund, T.H. Vu, Z. Werb, B. Winding, A. Lochter, M.A. Karsdal, T. Kirkegaard, T. Lenhard, A.M. Heegaard, L. Neff, R. Baron and N.T. Foged (2000) Proteinases in bone resorption: Obvious and less obvious roles. Clin. Chim. Acta. 291 223-234.
54. F.H. Drake, R.A. Dodds, I.E. James, J.R. Connor, S. Debouck, E. Richardson, L. Lee-Rykaczewski, D. Coleman, R. Rieman, G. Barthlow and M. Gowen (1996) Cathepsin K, but not cathepsin B, L, or S, is abundantly expressed in human osteoclasts. J. Biol. Chem. 271 12511-12516.
55. P. Ducy, R. Zhang, V. Geoffroy, A.L. Ridall and G. Karsenty (1997) Osf2/Cbfal: A transcriptional activator of osteoblast differentiation. Cell 89 747-754.
56. Y. Eeckhout and G. Vaes (1977) Further studies on the activation of procollagenase, the latent precursor of bone collagenase: Effects of lysosomal cathepsin B, plasmin and kallikrein and spontaneous activation. Biochem. J. 166 21-31.
57. W.R. English, X.S. Puente, J.M. Freije, V. Knauper, A. Amour, A. Merryweather, C. López-Otín and G. Murphy (2000) Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2. J. Biol. Chem. 275 14046-14055.
58. V. Everts, W. Korper, K.A. Hoeben, I.D. Jansen, D. Bromme, K.B. Cleutiens, S. Heeneman, C. Peters, T. Reinheckel, P. Saftig and W. Beertsen (2006) Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: Differences between calvaria and long bone. J. Bone Miner. Res. 21 1399-1408.
59. M.A.J. Ferguson and A.F. Williams (1988) Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures. Annu. Rev. Biochem. 57 285-320.
60. V. Firlej, B. Bocquet, X. Desbiens, Y. de Launoit and A. Chotteau-Lelievre (2005) Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site. J. Biol. Chem. 280 887-898.
61. K. Forbes, M.A. Webb and I. Sehgal (2003) Growth factor regulation of secreted matrix metalloproteinase and plasminogen activators in prostate cancer cells, normal prostate fibroblasts, and normal osteoblasts. Prostate Cancer Prostatic Dis. 6 148-153.
62. J.L. Fowlkes, J.J. Enghild, K. Suzuki and H. Nagase (1994) Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures. J. Biol. Chem. 269 25742-25746.
63. J.L. Fowlkes, K. Suzuki, H. Nagase and K.M. Thraikill (1994) Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: A role for matrix metalloproteinases. Endocrinology 135 2810-2813.
64. A. Frattini, P.J. Orchard, C. Sobacchi, S. Giliani, M. Abinun, J.P. Matsson, D.J. Kieling, A.K. Andersson, P. Wallbrandt, L. Zecca, L.D. Notarangelo, P. Vezzoni and A. Villa (2000) Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nature Genet. 25 343-346.
65. J.M.P. Freije, I. Diez-Itza, M. Balbín, L.M. Sanchez, R. Blasco, J. Tolivia and C. López-Otín (1994) Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J. Biol. Chem. 269 16766-16773.
66. K. Fuller and T.J. Chambers (1995) Localisation of mRNA for collagenase in osteocytic, bone surface, and chondrocytic cells but not osteoclasts. J. Cell. Sci. 108 2221-2230.
67. B.G. Galvez, S. Matias-Roman, J.P. Alber, F. Sanchez-Madrid and A.G. Arroyo (2001) Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling. J. Biol. Chem. 276 37491-37500.
68. B.D. Gelb, G.P. Shi, H.A. Chapman and R.J. Desnick (1996) Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 273 1236-1238.
69. V. Geoffroy, P. Ducy and G. Karsenty (1995) A PEBP2a/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element. J. Biol. Chem. 270 30973-30979.
70. H.P. Gerber, T.H. Vu, A.M. Ryan, J. Kowalski, Z. Werb and N. Ferrara (2000) VEGF couples hypertrophic cartilage remodeling, ossification, and angiogenesis during endochondral bone formation. Nature Med. 5 623-628.
71. M.J. Glimcher (1998) The nature of the mineral component of bone: Biological and clinical implications. L.V. Avioli, S.M. Krane (Eds) Metabolic Bone Disease and Clinically Related Disorders San Diego: Academic Press 23-50.
72. G.I. Goldberg, S.M. Wilhelm, A. Kronberger, E.A. Bauer, G.A. Grant and A.Z. Eisen (1986) Human fibroblast collagenase: Complete primary structure and homology to an oncogene transformation-induced rat protein. J. Biol. Chem. 261 6600-6605.
73. W. Gotz, F. Quondamatteo, S. Ragotzki, J. Affeldt and A. Jager (2000) Localization of cathepsin D in human odontoclasts. A light and electron microscopical immunocytochemical study. Connect. Tissue Res. 41 185-194.
74. A.E. Grigoriadis, Z.-Q. Wang, M.G. Cecchini, W. Hofstetter, R. Felix, H.A. Fleisch and E.F. Wagner (1994) c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266 443-448.
75. M. Gowen, R. Lazner, R. Dodds, R. Kapadia, J. Field and M. Tavaria (1999) Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization. J. Bone Miner. Res. 14 1654-1663.
76. K.A. Hajjar (1991) The endothelial cell tissue plasminogen activator receptor. J. Biol. Chem. 266 21962-21970.
77. J.A. Hamilton, S.R. Lingelbach, N.C. Partridge and T.J. Martin (1984) Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones. Biochem. Biophys. Res. Commun. 122 230-236.
78. J.A. Hamilton, S. Lingelbach, N.C. Partridge and T.J. Martin (1985) Regulation of plasminogen activator production by bone-resorbing hormones in normal and malignant osteoblasts. Endocrinology 116 2186-2191.
79. J.K. Heath, J.J. Reynolds and M.C. Meikle (1990) Osteopetrotic (grey-lethal) bone produces collagenase and TIMP in organ culture: Regulation by vitamin A. Biochem. Biophys. Res. Commun. 168 1171-1176.
80. J. Herz and H.H. Bock (2002) Lipoprotein receptors in the nervous system. Annu Rev Biochem. 71 405-434.
81. N. Hiraoka, E. Allen, I.J. Apel, M.R. Gyetko and S.J. Weiss (1998) Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell 95 365-377.
82. K. Holmbeck, P. Bianco, J. Caterina, S. Yamada, M. Kromer, S.A. Kuznetsov, M. Mankani, P.G. Robey, A.R. Poole, I. Pidoux, J.M. Ward and H. Birkedal-Hansen (1999) MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell 99 81-92.
83. K. Hotary, E. Allen, A. Punturieri, I. Yana and S.J. Weiss (2000) Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases., 1, 2, and 3. J. Cell Biol. 149 1309-1323.
84. Y.S. Hsieh, S.C. Chu, S.F. Yang, P.N. Chen, Y.C. Liu and K.H. Lu (2007) Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2, Carcinogenesis 28 977-987.
85. P. Huhtala, L.T. Chow and K. Tryggvason (1990) Structure of the human type IV collagenase gene. J. Biol. Chem. 265 11077-11082.
86. P. Huhtala, A. Tuuttila, L.T. Chow, J. Lohi, J. Keski-Oja and K. Tryggvason (1991) Complete structure of the human gene for 92-kDa type IV collagenase, Divergent regulation of expression for the 92- and 72-kiloDalton enzyme genes in HT-1080 cells. J. Biol. Chem. 266 16485-16490.
87. M. Inada, Y. Wang, M.H. Byrne, M.U. Rahman, C. Miyaura, C. Lopez-Otin and S.M. Krane (2004) Critical roles for collagenase-3 (Mmp-13) in development of growth plate cartilage and in endochondral ossification. Proc. Natl. Acad. Sci.USA. 101 17192-17197.
88. K. Inoue, Y. Mikuni-Takagaki, K. Oikawa, T. Itoh, M. Inada, T. Noguchi, J.S. Park, T. Onodera, S.M. Krane, M. Noda and S. Itohara (2006) A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. J. Biol. Chem. 281 33814-33824.
89. T. Itoh, T. Ikeda, H. Gomi, S. Nakao, T. Suzuki and S. Itohara (1997) Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. J. Biol Chem. 272 22389-22392.
90. R. Janknecht and A. Nordheim (1993) Gene regulation by Ets proteins. Biochim. Biophys. Acta. 1155 346-356.
91. R.L. Jilka and D.V. Cohn (1983) A collagenolytic response to parathormone, 1, 25-dihydroxycholecalciferol D3, and prostaglandin E2 in bone of osteopetrotic (mi/mi) mice. Endocrinology. 112 945-950.
92. M.J.G. Jimenez, M. Balbín, J.M. Lopez, J. Alvarez, T. Komori and C. López-Otín (1999) Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol. Cell. Biol. 19 4431-4442.
93. N. Johansson, U. Saarialho-Kere, K. Airola, R. Herva, L. Nissinen, J. Westermarck, E. Vuorio, J. Heino and V.M. Kahari (1997) Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development. Dev. Dyn. 208 387-397.
94. J.I. Jones and D.R. Clemmons (1995) Insulin-like growth factors and their binding proteins: Biological actions. Endocrine Rev. 16 3-34.
95. L. Kaczmarek, J. Lapinska-Dzwonek and S. Szymczak (2002) Matrix Metalloproteinases in the adult brain physiology: A link between c-Fos, AP-1, and remodeling of neuronal connections? EMBO J. 21 6643-6648.
96. H. Kagoshima, M. Satake, H. Miyoshi, M. Ohki, M. Pepling, J.P. Gergen, K. Shigesada and Y. Ito (1993) The runt domain identifies a new family of heteromeric transcriptional regulators. Trends Genet. 9 338-341.
97. T. Kanno, Y. Kanno, L.F. Chen, E. Ogawa, W.Y. Kim and Y. Ito (1998) Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit. Mol. Cell. Biol. 18 2444-2454.
98. T. Katono, T. Kawato, N. Tanabe, N. Suzuki, K. Yamanaka, H. Oka, M. Motohashi and M. Maeno (2006) Nicotine treatment induces expression of matrix metalloproteinases in human osteoblastic Saos-2 cells. Acta. Biochim. Biophys. Sin (Shanghai) 38 874-882.
99. A.M. Kennedy, M. Inada, S.M. Krane, P.T. Christie, B. Harding, C. Lopez-Otin, L.M. Sanchez, A.A. Pannett, A. Dearlove, C. Hartley, M.H. Byrne, A.A. Reed, M.A. Nesbit, M.P. Whyte and R.V. Thakker (2005) MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMDMO). J. Clin. Invest. 115 2832-2842.
100. L.D. Kerr, J.T. Holt and L.M. Matrisian (1988) Growth factors regulate transin gene expression by c-fos-dependent and c-fos-independent pathways. Science 242 1424-1427.
101. L.D. Kerr, N.E. Olashaw and L.M. Matrisian (1988) Transforming growth factor β1 and and cAMP inhibit transcription of the ­epidermal growth factor and oncogene-induced transin RNA. J. Biol. Chem. 263 16999-17005.
102. L.D. Kerr, D.B. Miller and L.M. Matrisian (1990) TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos-binding sequence. Cell 61 267-278.
103. H. Kinoh, H. Sato, Y. Tsunezuka, T. Takino, A. Kawashima, Y. Okada and M. Seiki (1996) MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis. J. Cell Sci. 109 953-959.
104. R. Kiviranta, J. Morko, S.L. Alartalo, R. NicAmhlaoibh, J. Risteli, T. Laitala-Leinonen and E. Vuorio (2005) Impared bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio. Bone 36 159-172.
105. V. Knauper, S.M. Wilhelm, P.K. Seperack, Y.A. DeClerck, A. Osthues and H. Tschesche (1993) Direct activation of human neutrophil procollagenase by recombinant stromelysin. Biochem. J. 295 581-586.
106. T. Komori, H. Yagi, S. Nomura, A. Yamaguchi, K. Sasaki, K. Deguchi, Y. Shimizu, R.T. Bronson, Y-H. Gao, M. Inada, M. Sato, R. Okamoto, Y. Kitamura, S. Yoshiki and T. Kishimoto (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89 755-764.
107. Y.T. Konttinen, M. Ainola, H. Valleala, J. Ma, H. Ida, J. Mandelin, R.W. Kinne, S. Santavirta, T. Sorsa, C. Lopez-Otin and M. Takagi (1999) Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: Different profiles in trauma and rheumatoid arthritis. Ann. Rheum. Dis. 58 691-697.
108. U. Kornak, A. Schulz, W. Friedrich, S. Uhlhaas, B. Kremens, T. Voit, C. Hasan, U. Bole, T.J. Jentsch and C. Kubisch (2000) Mutations in the a3 subunit of the vacuolar H+-ATPase cause infantile malignant osteopetrosis. Hum. Mol. Genet. 9 2059-2063.
109. U. Kornak, D. Kasper, M.R. Bösl, E. Kaiser, M. Schweizer, A. Schulz, W. Friedrich, G. Delling and T.J. Jentsch (2001) Loss of the C1C-7 chloride channel leads to osteopetrosis in mice and man. Cell 104 205-215.
110. N. Kosaki, H. Takaishi, S. Kamekura, T. Kimura, Y. Okada, L. Minqi, N. Amizuka, U.I. Chung, K. Nakamura, H. Kawaguchi, Y. Toyama and J. D’Armiento (2007) Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem. Biophys. Res. Commun. 354 846-851.
111. K. Kusano, C. Miyaura, M. Inada, T. Tamura, A. Ito, H. Nagase, K. Kamoi and T. Suda (1998) Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: Association of MMP induction with bone resorption. Endocrinology 139 1338-1345.
112. C. Lalou, C. Silve, R. Rosato, B. Segovia and M. Binoux (1994) Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells. Endocrinology 135 2318-2326.
113. B. Lanske, P. Divieti, C.S. Kovacs, A. Pirro, W.J. Landis, S.M. Krane, F.R. Bringhurst and H.M. Kronenberg (1998) The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology 139 5194-5204.
114. B. Lanske, C.A.C. Karaplis, K. Lee, A. Luz, A. Vortkamp, A. Pirro, M. Karperien, L.H.K. Defize, C. Ho, R.C. Mulligan, A.B. Abou-Samra, H. Jüppner, G.V. Segre and H.M. Kronenberg (1996) PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273 663-666.
115. N.D. Lawson, A. Khanna-Gupta and N. Berliner (1998) Isolation and characterization of the cDNA for mouse neutrophil collagenase: Demonstration of shared negative regulatory pathway neutrophil secondary granule protein gene expression. Blood 91 2517-2524.
116. W. Lee, P. Mitchell and R. Tjian (1987) Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell 49 741-752.
117. G. Leloup, J.-M. Delaissé and G. Vaes (1994) Relationship of the plasminogen activator/plasmin cascade to osteoclast invasion and mineral resorption in explanted fetal metatarsal bones. J. Bone Miner. Res. 9 891-902.
118. G. Leloup, C. Peeters-Joris, J.-M. Delaissé, G. Opdenakker and G. Vaes (1991) Tissue and urokinase plasminogen activators in bone tissue and their regulation by parathyroid hormone. J. Bone Miner. Res. 6 1081-1090.
119. C.L. Le Maitre, A.J. Freemont and J.A. Hoyland (2005) The role of interleukin-1 in the pathogenesis of human intervertebral disc degradation. Arthritis Res. Ther. 7 R732-R745.
120. Y.P. Li, W. Chen, Y. Liang, E. Li and P. Stashenko (1999) Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nature Genet. 23 447-451.
121. A. Littlewood-Evans, T. Kokubo, O. Ishibashi, T. Inaoka, B. Wlodarski, J.A. Gallagher and G. Bilbe (1997) Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry. Bone 20 81-86.
122. X. Liu, H. Wu, M. Byrne, J. Jeffrey, S. Krane and R. Jaenisch (1995) A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J. Cell Biol. 130 227-237.
123. E. Llano, A.M. Pendas, J.P. Freije, A. Nakano, V. Knauper, G. Murphy and C. López-Otín (1999) Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase A overexpressed in brain tumors. Cancer Res. 59 2570-2576.
124. E. Lutgens, S.P. Lutgens, B.C. Faber, S. Heeneman, M.M. Gijbels, M.P. de Winther, P. Frederik, I. van der Made, A. Daugherty, A.M. Sijbergs, A. Fisher, C.J. Long, P. Saftig, D. Black, M.J. Daemen and K.B. Cleutjens (2006) Disruption of cathpsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation. Circulation 113 98-107.
125. S.P. Lutgens, N. Kisters, E. Lutgens, R.I. van Haaften, C.T. Evelo, M.P. de Winther, P. Saftig, M.J. Daemen, S. Heenaman and K.B. Cleutjens (2006) Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic. J. Pathol. 210 334-343.
126. C.C. Lynch, A. Hikosaka, H.B. Acuff, M.D. Martin, N. Kawai, R.K. Singh, T.C. Vargo-Gogola, J.L. Begtrup, T.E. Peterson, B. Fingleton, T. Shirai, L.M. Matrisian and M. Futakuchi (2005) MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell 5 485-496.
127. J.A. Martignetti, A.A. Aqeel, W.A. Sewairi, C.E. Boumah, M. Kambouris, S.A. Mayouf, K.V. Sheth, W.A. Eid, O. Dowling, J. Harris, M.J. Glucksman, S. Bahabri, B.F. Meyer and R.J. Desnick (2001) Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. Nat. Genet. 28 261-265.
128. E. Mathieu, L. Meheus, J. Raymackers and J. Merregaert (1994) Characterization of the osteogenic stromal cell line MN7: Identification of secreted MN7 proteins using two-dimensional polyacrylamide gel electrophoresis, Western blotting, and microsequencing. J. Bone Miner. Res. 9 903-913.
129. L.M. Matrisian (1992) The matrix-degrading metalloproteinases. Bio-Essays 14 455-463.
130. L.M. Matrisian, N. Glaichenhaus, M.C. Gesnel and R. Breathnach (1985) Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. EMBO J. 4 1440-1445.
131. L.M. Matrisian, P. Leroy, C. Ruhlmann, M.C. Gesnel and R. Breathnach (1986) Isolation of the oncogene and epidermal growth factor-induced transin gene: Complex control in rat fibroblasts. Mol. Cell. Biol. 6 1679-1686.
132. V. Mattot, M.B. Raes, P. Henriet, Y. Eeckhout, D. Stehelin, B. Vandenbunder and X. Desbiens (1995) Expression of interstitial collagenase is restricted to skeletal tissue during mouse embryogenesis. J. Cell. Sci. 108 529-535.
133. T.L. McCarthy, M. Centrella and E. Canalis (1990) Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures. J. Biol. Chem. 265 15353-15356.
134. T.L. McCarthy, M. Centrella, L.G. Raisz and E. Canalis (1991) Prostaglandin E2 stimulates insulin-like growth factor I synthesis in osteoblast-enriched cultures from fetal rat bone. Endocrinology 128 2895-2900.
135. S.E. McDonnell, L.D. Kerr and L.M. Matrisian (1990) Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C. J. Biol. Chem. 10 4284-4293.
136. M.C. Meikle, S. Bond, R.M. Hembry, J. Compston, P.I. Croucher and J.J. Reynolds (1992) Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotrophic hormones and cytokines. J. Cell. Sci. 103 1093-1099.
137. H.L. Merriman, A.J. van Wijnen, S. Hiebert, J.P. Bidwell, E. Fey, J. Lian, J. Stein and G.S. Stein (1995) The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: Interactions with the osteocalcin gene promoter. Biochemistry 34 13125-13132.
138. A. Mitra, J. Charkrabarti, A. Banerji and A. Chatterjee (2006) Cell membrane-associated MT1-MMP dependent activation of MMP-2 in SiHa (human cervical cancer) cells. J. Environ. Pathol. Toxicol. Oncol. 25 655-666.
139. P.G. Mitchell, H.A. Magna, L.M. Reeves, L.L. Lopresti-Morrow, S.A. Yocum, P.J. Rosner, K.F. Geoghegan and J.E. Hambor (1996) Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J. Clin. Invest. 97 761-768.
140. J.P. Montenez, J.-M. Delaissé, P.M. Tulkens and B.K. Kishore (1994) Increased activities of cathepsin B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of cysteine proteinases inhibitors. Life Sci. 55 1199-1209.
141. R.A. Mosig, O. Dowling, A. Difeo, M.C. Ramirez, I.C. Parker, E. Abe, J. Diouri, A.A. Ageel, J.D. Wylie, S.A. Oblander, J. Madri, P. Bianco, S.S. Apte, M. Zaidi, S.B. Doty, R.J. Majeska, M.B. Schaffler and J.A. Martignetti (2007) Loss of MMP-2 disrupts skeletal and craniofacial development, and results in decreased bone mineralization, joint erosion, and defects in osteoblast and osteoclast growth. Hum. Mol. Genet. 41 1113-1123.
142. J.S. Mudgett, N.I. Hutchinson, N.A. Chartrain, A.J. Forsyth, J. McDonnell, I.I. Singer, E.K. Bayne, J. Flanagan, D. Kawka, C.F. Shen, K. Stevens, H. Chen, M. Trumbauer and D.M. Visco (1998) Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. Arthritis Rheum. 41 110-121.
143. S. Mundlos, F. Otto, C. Mundlos, J.B. Mulliken, A.S. Aylsworth, S. Albright, D. Lindhout, W.G. Cole, W. Henn, J.H. Knoll, M.J. Owen, R. Mertelsmann, B.U. Zabel and B.R. Olsen (1997) Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89 773-779.
144. G. Murphy, M.I. Cockett, P.E. Stephens, B.J. Smith and A.J.P. Docherty (1987) Stromelysin is an activator of procollagenase. Biochem. J. 248 265-268.
145. G. Murphy, R.M. Hembry, A.M. McGarrity and J.J. Reynolds (1989) Gelatinase (type IV collagenase) immunolocalization in cells and tissues: Use of an antiserum to rabbit bone gelatinase that identifies high and low Mr forms. J. Cell. Sci. 92 487-495.
146. L.S. Nielsen, G.M. Kellerman, N. Behrendt, R. Picone, K. Dano and F. Blasi (1988) A 55, 000–60, 000 Mr receptor protein for urokinase-type plasminogen activator. J. Biol. Chem. 263 2358-2363.
147. Y. Ohsawa, T. Nitatori, S. Higuchi, E. Kominami and Y. Uchiyama (1993) Lysosomal cysteine and aspartic proteinases, acid phosphatase, and endogenous cysteine proteinase inhibitor, cystatin-β, in rat osteoclasts. J. Histochem. Cytochem. 41 1075-1083.
148. E. Ohuchi, K. Imai, Y. Fuji, H. Sato, M. Seiki and Y. Okada (1997) Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J. Biol. Chem. 272 2446-2451.
149. T. Okamura, H. Shimokawa, Y. Takagi, H. Ono and S. Sasaki (1993) Detection of collagenase mRNA in odontoclasts of bovine root-resorbing tissue by in situ hybridization. Calcif. Tissue Int. 52 325-330.
150. T.H. Omura, A. Noguchi, C.A. Johanns, J.J. Jeffrey and N.C. Partridge (1994) Identification of a specific receptor for interstitial collagenase on osteoblastic cells. J. Biol. Chem. 269 24994-24998.
151. N. Ortega, D.J. Behonick, C. Colnot, D.N. Cooper and Z. Werb (2005) Galectin-3 is a downstream regulator of matrix metalloproteinase-9function during endochondral bone formation. Mol. Biol. Cell 16 3028-3039.
152. F. Otto, A.P. Thornell, T. Crompton, A. Denzel, K.C. Gilmour, I.R. Rosewell, G.W.H. Stamp, R.S.P. Beddington, S. Mundlos, B.R. Olsen, P.B. Selby and M.J. Owen (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89 765-771.
153. T.C. Otto, R.R. Bowers and M.D. Lane (2007) BMP-4 treatment of C3H10T1/2 stem cells blocks expression of MMP-3 and MMP-13. Biochem. Biophys. Res. Commun. 353 1097-1104.
154. M.J. Oursler, B.L. Riggs and T.C. Spelsberg (1993) Glucocorticoid-induced activation of latent transforming growth factor-β by normal human osteoblast-like cells. Endocrinology 133 2187-2196.
155. C.M. Overall, J.F. Wrana and J. Sodek (1989) Transforming growth factor-β regulation of collagenase, 72 kDa-progelatinase, TIMP and PAI-1 expression in rat bone cell populations and human fibroblasts. Connect. Tissue Res 20 289-294.
156. T. Pap, Y. Shigeyama, S. Kuchen, J.K. Fernihough, B. Simmen, R.E. Gay, M. Billingham and S. Gay (2000) Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis. Arthritis Rheum. 43 1226-1232.
157. N.C. Partridge, R.J. Frampton, J.A. Eisman, V.P. Michelangeli, E. Elms, T.R. Bradley and T.J. Martin (1980) Receptors for 1, 25(OH)2-vitamin D3 enriched in cloned osteoblast-like rat osteogenic sarcoma cells. FEBS Lett. 115 139-142.
158. N.C. Partridge, D. Alcorn, V.P. Michelangeli, G. Ryan and T.J. Martin (1983) Morphological and biochemical characterization of four clonal osteogenic sarcoma cell lines of rat origin. Cancer Res. 43 4308-4314.
159. N.C. Partridge, J.J. Jeffrey, L.S. Ehlich, S.L. Teitelbaum, C. Fliszar, H.G. Welgus and A.J. Kahn (1987) Hormonal regulation of the production of collagenase and a collagenase inhibitor activity by rat osteogenic sarcoma cells. Endocrinology 120 1956-1962.
160. N.C. Partridge, D.K. Scott, L.A. Gershan, T.H. Omura, J.S. Burke, J.J. Jeffrey, M.E. Bolander and C.O. Quinn (1993) Collagenase production by normal and malignant osteoblastic cells. J.F. Novak, J.H. McMaster (Eds) Frontiers of Osteosarcoma Research Seattle: Hogrefe and Huber Publishers 269-276.
161. A.T. Pearman, W.Y. Chou, K.D. Bergman, M.R. Pulumati and N.C. Partridge (1996) Parathyroid hormone induces c-fos promoter activity in osteoblastic cells through phosphorylated cAMP response element (CRE)-binding protein binding to the major CRE. J. Biol. Chem. 271 25715-25721.
162. D. Pei (1999) Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP. J. Biol. Chem. 274 8925-8932.
163. D. Pei and S.J. Weiss (1996) Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity. J. Biol. Chem. 271 9135-9140.
164. D. Pennica, W.E. Holmes, W.T. Kohr, R.N. Harkins, G.A. Vehar, C.A. Ward, W.F. Bennett, E. Yelverton, P.H. Seeburg, H.L. Heyneker, D.V. Goeddel and D. Collen (1983) Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature. 301 214-221.
165. M.S. Pepper (1997) Manipulating angiogenesis: From basic science to the bedside. Arterioscler. Thromb. Vasc. Biol. 17 605-619.
166. J. Pfeilschifter, J. Erdmann, W. Schmidt, A. Naumann, H.W. Minne and R. Ziegler (1990) Differential regulation of plasminogen activator and plasminogen activator inhibitor by osteotropic factors in primary cultures of mature osteoblasts and osteoblast precursors. Endocrinology. 126 703-711.
167. M.D. Posthumus, P.C. Limburg, J. Westra, M.A. van Leeuwen and M.H. van Rijswijk (2000) Serum matrix metalloproteinase 3 in early rheumatoid arthritis is correlated with disease activity and radiological progression. J. Rheumatol. 27 2761-2768.
168. J. Potempa, E. Korzos and J. Travis (1994) The serpin superfamily of proteinase inhibitors: Structure, function, and regulation. J. Biol. Chem. 269 15957-15960.
169. C. Prontera, G. Crescenzi and D. Rotilio (1996) Inhibition by interleukin-4 of stromelysin expression in human skin fibroblasts: Role of PKC. Exp. Cell Res. 224 183-188.
170. X.S. Puente, A.M. Pendás, E. Llano, G. Velasco and C. López-Otín (1996) Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res. 56 944-949.
171. C.O. Quinn, D.K. Scott, C.E. Brinckerhoff, L.M. Matrisian, J.J. Jeffrey and N.C. Partridge (1990) Rat collagenase: Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells. J. Biol. Chem. 265 22342-22347.
172. S.A. Rabbani, J. Desjardins, A.W. Bell, D. Banville, A. Mazar, J. Henkin and D. Goltzman (1990) An amino terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells. Biochem. Biophys. Res. Commun. 173 1058-1064.
173. L.J. Raggatt, S.C. Jefcoat Jr., I. Choudhury, S. Williams, M. Tiku and N.C. Partridge (2006) Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes. Osteoarthritis Cartilage 14 680-689.
174. R.A. Rajakumar, N.C. Partridge and C.O. Quinn (1993) Transcriptional induction of collagenase in rat osteosarcoma cells is mediated by sequence 5 prime of the gene. J. Bone Miner. Res. 8(Suppl. 1), S294.
175. P. Reboul, J.P. Pelletier, G. Tardif, J.M. Cloutier and J. Martel-Pelletier (1996) The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes: A role in osteoarthritis. J. Clin. Invest. 97 2011-2019.
176. L. Rifas, L.R. Halstead, W.A. Peck, L.V. Avioli and H.G. Welgus (1989) Human osteoblasts in vitro secrete tissue inhibitor of metalloproteinases and gelatinase but not interstitial collagenase as major cellular products. J. Clin. Invest. 84 686-694.
177. L. Rifas, A. Fausto, M.J. Scott, L.V. Avioli and H.G. Welgus (1994) Expression of metalloproteinases and tissue inhibitors of metallopro-teinases in human osteoblast-like cells: Differentiation is associated with repression of metalloproteinase biosynthesis. Endocrinology 134 213-221.
178. W.T. Roswit, J. Halme and J.J. Jeffrey (1983) Purification and properties of rat uterine procollagenase. Arch. Biochem. Biophys. 225 285-295.
179. N. Ruangpanit, D. Chan, K. Holmbeck, H. Birkedal-Hansen, J. Polarek, C. Yang, J.F. Bateman and E.W. Thompson (2001) Gelatinase A (MMP-2) activation by skin fibroblasts: Dependence on MT-1MMP expression and fibrillar collagen form. Matrix Biol. 20 193-203.
180. S. Rydziel, D. Durant and E. Canalis (2000) Platelet-derived growth factor induces collagenase 3 transcription in osteoblasts through the activator protein 1 complex. J. Cell. Physiol. 184 326-333.
181. F. Sabeh, I. Ota, K. Holmbeck, H. Birkedal-Hansen, P. Soloway, M. Balbin, C. Lopez-Otin, S. Shapiro, M. Inada, S. Krane, E. Allen, D. Chung and S.J. Weiss (2004) Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J. Cell Biol. 167 769-781.
182. P. Saftig, E. Hunziker, O. Wehmeyer, S. Jones, A. Boyde, W. Rommerskirch, J.D. Moritz, P. Schu and K. von Figura (1998) Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc. Nat. Acad. Sci. USA 95 13453-13458.
183. P. Saftig, E. Hunziker, V. Everts, S. Jones, A. Boyde, O. Wehmeyer, A. Suter and K. Figura (2000) Functions of cathepsin K in bone resorption: Lessons from cathepsin K – deficient mice. Adv. Exp. Biol. Med. 477 293-303.
184. T. Sahara, K. Itoh, K. Debari and T. Sasaki (2003) Specific biological functions of vacuolar-type H(+)-ATPase and lysosomal cystein proteinase, cathepsin K, in osteoclasts. Anat Rec A Discov Mol. Cell Evol. Biol. 270 152-161.
185. H. Sato, T. Takino, Y. Okada, J. Cao, A. Shinagawa, E. Yamamoto and M. Seiki (1994) A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 370 61-65.
186. H. Sato, T. Kinoshita, T. Takino, K. Nakayama and M. Seiki (1996) Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2. FEBS Lett. 393 101-104.
187. H. Sato, Y. Okada and M. Seiki (1997) Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion. Thromb. Haemos. 78 497-500.
188. D.J. Schroen and C.E. Brinckerhoff (1996) Nuclear hormone receptors inhibit matrix metalloproteinase (MMP) gene expression through diverse mechanisms. Gene Expr. 6 197-207.
189. D.K. Scott, K.D. Brakenhoff, J.C. Clohisy, C.O. Quinn and N.C. Partridge (1992) Parathyroid hormone induces transcription of collagenase in rat osteoblastic cells by a mechanism using cyclic adenosine 3′, 5′-monophosphate and requiring protein synthesis. Mol. Endocrinol. 6 2153-2159.
190. M. Seandel, K. Noack-Kunnmann, D. Zhu, R.T. Aimes and J.P. Quigley (2001) Growth factor-induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen. Blood 97 2323-2332.
191. N. Selvamurugan, W.Y. Chou, A.T. Pearman, M.R. Pulumati and N.C. Partridge (1998) Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the runt domain binding sequence. J. Biol. Chem. 273 10647-10657.
192. N. Selvamurugan, R.J. Brown and N.C. Partridge (2000) Constitutive expression and regulation of collagenase-3 in human breast cancer cells. J. Cell. Biochem. 79 182-190.
193. N. Selvamurugan, M.R. Pulumati, D.R. Tyson and N.C. Partridge (2000) Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor A1. J. Biol. Chem. 275 5037-5042.
194. N. Selvamurugan, S. Kwok, T. Alliston, M. Reiss and N.C. Partridge (2004) Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2. J. Biol.Chem. 279 19327-19334.
195. N. Selvamurugan, S.C. Jefcoat, S. Kwok, R. Kowalewski, J.A. Tamasi and N.C. Partridge (2006) Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx2/RD/Cbfa sites alters bone remodeling in vivo. J. Cell Biochem. 99 545-557.
196. R. Shah, M. Alvarez, D.R. Joes, K. Torrungruang, A.J. Wat, N. Selvamurugan, N.C. Partridge, C.O. Quinn, F.M. Pavalko, S.J. Rhodes and J.P. Bidwell (2004) Nmp4/CIZ regulation of matrix metalloproteinase 13 (MMP-13) response to parathyroid hormone in osteoblasts. Am. J. Physiol. Endocrinol. Metab. 287 E289-E296.
197. V. Shalhoub, D. Conlon, M. Tassinari, C. Quinn, N. Partridge, G.S. Stein and J.B. Lian (1992) Glucocorticoids promote development of the osteoblast phenotype by selectively modulating expression of cell growth and differentiation associated genes. J. Cell. Biochem. 50 425-440.
198. K.I. Shofuda, D. Hasenstab, R. Kenagy, T. Shofuda, Z.Y. Li, A. Lieber and A.W. Clowes (2001) Membrane-type matrix metalloproteinase-1 and -3 activity in primate smooth muscle cells. FASEB J. 15 2010-2012.
199. G.S. Stein and J.B. Lian (1993) Molecular mechanisms mediating proliferation/differentiation of the osteoblast phenotype. Endocrine Rev. 14 424-442.
200. G.S. Stein, J.B. Lian and T.A. Owen (1990) Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J. 4 3111-3123.
201. W.G. Stetler-Stevenson, H.C. Krutzsch and L.A. Liotta (1989) Tissue inhibitor of metalloproteinase (TIMP-2): A new member of the metalloproteinase family. J. Biol. Chem. 264 17374-17378.
202. D. Stewart, M. Javadi, M. Chambers, C. Gunsolly, G. Gorski and R.C. Borghaei (2007) Interleukin-4 inhibition of interleukin-1-induced expression of matrix metalloproteinase-3 (MMP-3) is independent of lipoxygenase and PPARgamma activation in human gingival fibroblasts. BMC Mol. Bio. 8 12. 1–13.
203. D. Stickens, D.J. Behonick, N. Ortega, B. Heyer, B. Hartenstein, Y. Yu, A.J. Fosang, M. Schorpp-Kistner, P. Angel and Z. Werb (2004) Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development 131 5883-5895.
204. M.A. Stolow, D.D. Bauzon, J. Li, T. Sedgwick, V.C. Liang, Q.A. Sang and Y.B. Shi (1996) Identification and characterization of a novel collagenase in Xenopus laevis: Possible roles during frog development. Mol. Biol. Cell. 7 1471-1483.
205. G. Tardif, P. Reboul, J.P. Pelletier and J. Martel-Pelletier (2004) Ten years in the life of an enzyme: The story of the human MMP-13 (collagenase-3). Mod. Rheumatol. 14 197-204.
206. S.L. Teitelbaum (2000) Bone resorption by osteoclasts. Science 289 1504-1508.
207. K.-I. Tezuka, K. Nemoto, Y. Tezuka, T. Sato, Y. Ikeda, M. Kobori, H. Kawashima, H. Eguchi, Y. Hakeda and M. Kumegawa (1994) Identification of matrix metalloproteinase 9 in rabbit osteoclasts. J. Biol. Chem. 269 15006-15009.
208. K.-I. Tezuka, Y. Tezuka, A. Maejima, T. Sato, K. Nemoto, H. Kamioka, Y. Hakeda and M. Kumegawa (1994) Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts. J. Biol. Chem. 269 1106-1109.
209. B.M. Thomson, S.J. Atkinson, A.M. McGarrity, R.M. Hembry, J.J. Reynolds and M.C. Meikle (1989) Type I collagen degradation by mouse calvarial osteoblasts stimulated with 1, 25-dihydroxyvitamin D-3: Evidence for a plasminogen-plasmin-metalloproteinase activation cascade. Biochim. Biophys. Acta. 1014 125-132.
210. A. Tumber, S. Papaioannou, J. Breckon, M.C. Meikle, J.J. Reynolds and P.A. Hill (2003) The effects of serine protease inhibitors on bone resorption in vitro. J. Endocrinol. 178 437-447.
211. V. Turk and W. Bode (1991) The cystatins: Protein inhibitors of cysteine proteinases. FEBS Lett. 285 213-219.
212. D.R. Tyson, J.T. Swarthout and N.C. Partridge (1999) Increased osteoblastic c-fos expression by parathyroid hormone requires protein kinase A phosphorylation of the cyclic adenosine 3', 5'-monophosphate response element-binding protein at serine 133. Endocrinology 140 1255-1261.
213. G. Vaes (1988) Cellular biology and biochemical mechanism of bone resorption, A review of recent developments on the formation, activation, and mode of action of osteoclasts. Clin. Orthop. Relat. Res. 231 239-271.
214. A.-J. van Zonneveld, H. Veerman and H. Pannekoek (1986) On the interaction of the finger and the kringle-2 domain of tissue-type plasminogen activator with fibrin. J. Biol. Chem. 261 14214-14218.
215. S. Varghese, S. Rydziel, J.J. Jeffrey and E. Canalis (1994) Regulation of interstitial collagenase expression and collagen degradation by retinoic acid in bone cells. Endocrinology 134 2438-2444.
216. S. Varghese, S. Rydziel and E. Canalis (2000) Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Endocrinology 141 2185-2191.
217. S. Varghese (2006) Matrix metalloproteinases and their inhibitors in bone: An overview of regulation and functions. Front Biosci. 11 2949-2966.
218. G. Velasco, S. Cal, A. Merlos-Suárez, A.A. Ferrando, S. Alvarez, A. Nakano, J. Arribas and C. López-Otín (2000) Human MT6-matrix metalloproteinase: Identification, progelatinase A activation, and expression in brain tumors. Cancer Res. 60 877-882.
219. T.H. Vu, J.M. Shipley, G. Bergers, J.E. Berger, J.A. Helms, D. Hanahan, S.D. Shapiro, R.M. Senior and Z. Werb (1998) MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93 411-422.
220. T.H. Vu and Z. Werb (2000) Matrix metalloproteinases: Effectors of development and normal physiology. Genes Dev. 14 2123-2133.
221. H.W. Walling, P.T. Chan, T.H. Omura, O.Y. Barmina, G.J. Fiacco, J.J. Jeffrey and N.C. Partridge (1998) Regulation of the collagenase-3 receptor and its role in intracellular ligand processing in rat osteoblastic cells. J. Cell. Physiol. 177 563-574.
222. B. Wasylyk, S.L. Hahn and A. Giovane (1993) The Ets family of transcription factors. Eur. J. Biochem. 211 7-18.
223. D. Wernicke, C. Seyfert, B. Hinzmann and E. Gromnica-Ihle (1996) Cloning of collagenase 3 from the synovial membrane and its expression in rheumatoid arthritis and osteoarthritis. J. Rheumatol 23 590-595.
224. B.D. Wilcox, J.A. Dumin and J.J. Jeffrey (1994) Serotonin regulation of interleukin-1 messenger RNA in rat uterine smooth muscle cells. J. Biol. Chem. 269 29658-29664.
225. C.L. Wilson, K.J. Heppner, P.A. Labosky, B.L.M. Hogan and L.M. Matrisian (1997) Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase, matrilysin. Proc. Natl. Acad. Sci. USA 94 1402-1407.
226. S.M. Wilhelm, I.E. Collier, B.L. Marmer, A.Z. Eisen, G.A. Grant and G.I. Goldberg (1989) SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J. Biol. Chem. 264 17213-17221.
227. H. Will, S.J. Atkinson, G.S. Butler, B. Smith and G. Murphy (1996) The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3. J. Biol. Chem. 271 17119-17123.
228. S.K. Winchester, S.R. Bloch, G.J. Fiacco and N.C. Partridge (1999) Regulation of expression of collagenase-3 in normal, differentiating rat osteoblasts. J. Cell. Physiol. 181 479-488.
229. S.K. Winchester, N. Selvamurugan, R.C. D’Alonzo and N.C. Partridge (2000) Developmental regulation of collagenase-3 mRNA in normal, differentiating osteoblasts through the activator protein-1 and the runt domain binding sites. J. Biol. Chem. 275 23310-23318.
230. J.P. Witter, M.H. Byrne, M. Aoun-Wathne, L-F. Suen, S.M. Krane and M.B. Goldring (1995) Human matrix metalloproteinase-13 (MMP-13 or collagenase-3), the homologue of murine interstitial collagenase is expressed in skeletal cells. J. Bone Miner. Res. 10(Suppl. 1), S439.
231. J.P. Witty, L. Matrisian, S. Foster and P.H. Stern (1992) Stromelysin in PTH-stimulated bones in vitro. J. Bone Miner. Res. 7(Suppl. 1), S103.
232. A.L. Wucherpfennig, Y.-P. Li, W.G. Stetler-Stevenson, A.E. Rosenberg and P. Stashenko (1994) Expression of 92 kD type IV collagenase/gelatinase B in human osteoclasts. J. Bone Miner. Res. 9 549-556.
233. T.-C. Wun, L. Ossowski and E. Reich (1982) A proenzyme form of human urokinase. J. Biol. Chem. 257 7262-7268.
234. L. Xia, J. Kilb, H. Wex, Z. Li, A. Lipyansky, V. Breuil, L. Stein, J.T. Palmer, D.W. Dempster and D. Bromme (1999) Localization of rat cathepsin K in osteoclasts and resorption pits: Inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones. Biol. Chem. 380 679-687.
235. A. Xiang, M. Kanematsu, S. Kumar, D. Yamashita, T. Kaise, H. Kikkawa, S. Asano and M. Kinoshita (2007) Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in ovariectomized mice. Bone 40 1231-1237.
236. J.N. Yang, E.H. Allan, G.I. Anderson, T.J. Martin and C. Minkin (1997) Plasminogen activator system in osteoclasts. J. Bone Miner. Res. 12 761-768.
237. W. Zhao, M.H. Byrne, B.F. Boyce and S.M. Krane (1999) Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mice. J. Clin. Invest. 103 517-524.
238. W. Zhao, M.H. Byrne, Y. Wang and S.M. Krane (2000) Inability of collagenase to cleave type I collagen in vivo is associated with osteocyte and osteoblast apoptosis and excessive bone deposition. J. Clin. Invest. 106 841-849.
239. Z. Zhou, S.S. Apte, R. Soininen, R. Cao, G.Y. Baaklini, R.W. Rauser, J. Wang, Y. Cao and K. Tryggvason (2000) Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc. Natl. Acad. Sci. USA 97 4052-4057.