Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in ovariectomized mice

Bone

Volumn 40, Issue 5, 2007, Pages 1231-1237

  Xiang, Anbo ^a   Kanematsu, Masahiro ^a   Kumar, Sanjay ^b   Yamashita, Dennis ^b   Kaise, Toshihiko ^a   Kikkawa, Hideo ^a   Asano, Satoshi ^a   Kinoshita, Mine ^a  

^a Development and Medical Affairs Division   (Japan)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Bone formation; Bone resorption; Cathepsin K; Micro CT; Ovariectomized mice

Indexed keywords

CATHEPSIN K INHIBITOR; ROLIPRAM; SB 553484; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORTICAL BONE; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OVARIECTOMY; THREE DIMENSIONAL IMAGING;

ANIMALS; BONE DENSITY; BONE RESORPTION; CATHEPSINS; CELLS, CULTURED; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; OSTEOCLASTS; OSTEOGENESIS; OVARIECTOMY; PROTEASE INHIBITORS; PYRIDINES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 34047274288     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.01.010     Document Type: Article

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