Stromelysin (MMP-3) synthesis is up-regulated in estrogen-deficient mouse osteoblasts in vivo and in vitro

Journal of Bone and Mineral Research

Volumn 14, Issue 11, 1999, Pages 1880-1890

  Breckon, Jeremy J W ^a   Papaioannou, Stelios ^a   Kon, Luke W M ^a   Tumber, Anthony ^a   Hembry, Rosalind M ^b   Murphy, Gillian ^b   Reynolds, John J ^a   Meikle, Murray C ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; ESTRADIOL; ESTROGEN; GELATINASE A; GELATINASE B; INTERLEUKIN 1; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; MESSENGER RNA; SEX HORMONE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; CELL ADHESION; CONTROLLED STUDY; ESTROGEN DEFICIENCY; FEMUR HEAD; LUMBAR VERTEBRA; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOID; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VERTEBRA BODY;

ANIMALS; BLOTTING, NORTHERN; CELLS, CULTURED; COLLAGENASES; ESTROGENS; FEMUR HEAD; LUMBAR VERTEBRAE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; MICE; OSTEOBLASTS; OVARIECTOMY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; UP-REGULATION;

EID: 0032759871     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1999.14.11.1880     Document Type: Article

References (60)

1. Raisz LG 1988 Local and systemic factors in the pathogenesis of osteoporosis. N Engl J Med 318:818-828.
2. Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson JB, Clarke AC 1976 Long-term prevention of postmenopausal osteoporosis by estrogen: Evidence for an increased bone mass after delayed onset of estrogen treatment. Lancet 1:1038-1041.
3. Ettinger B, Genant HK, Cann CE 1985 Long-term estrogen replacement therapy prevents bone loss and fractures. Ann Intern Med 102:319-324.
4. Komm BS, Terpening CM, Benz DJ, Graeme KA, Gallegos A, Korc M, Greene GL, O'Malley BW, Haussler MR 1988 Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science 214:81-84.
5. Eriksen EF, Colvard DS, Berg NG, Graham ML, Mann KG, Spelsberg TC, Riggs BL 1988 Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241:84-86.
6. Oursler MJ, Osdoby P, Pyfferoen J, Riggs BL, Spelsberg TC 1991 Avian osteoclasts as estrogen target cells. Proc Natl Acad Sci USA 88:6613-6617.
7. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC 1992 Increased osteoclast development after estrogen loss: Mediation by interleukin-6. Science 257:88-91.
8. Kameda T, Mano H, Yuasa T, Mori Y, Miyazawa K, Shiokawa M, Nakamaru Y, Horoi E, Hiura K, Kameda A, Yang NN, Hakeda Y, Kumegawa M 1997 Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med 186:489-495.
9. Horowitz MC 1993 Cytokines and estrogen in bone: Antiosteoporotic effects. Science 260:626-627.
10. Pacifici R, Rifas L, Teitelbaum S, Slatopolsky E, McCracken R, Bergfeld M, Lee W, Avioli LV, Peck WA 1987 Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis. Proc Natl Acad Sci USA 84:4616-4620.
11. Pacifici R, Rifas L, McCracken R, Vered I, McMurty C, Avioli LV, Peck WA 1989 Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release. Proc Natl Acad Sci USA 86:2398-2402.
12. Wong GG, Witek-Giannotti JS, Temple PA, Kriz R, Ferenz C, Herwick RM, Clark SC, Ikebuchi K, Ogawa M 1988 Stimulation of murine hemopoietic colony formation by human IL-6. J Immunol 140:3040-3044.
13. Kurihara N, Civin C, Roodman GD 1991 Osteotropic factor responsiveness of highly purified populations of early and late precursors for human multinucleated cells expressing the osteoclast phenotype. J Bone Miner Res 6:257-261.
14. Poli V, Balena R, Fattori E, Markatos A, Yamamoto M, Tanaka H, Ciliberto G, Roden GA, Costantini F 1994 Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J 13:1189-1196.
15. Heath JK, Saklatvala J, Meikle MC, Atkinson SJ, Reynolds JJ 1985 Pig interleukin 1 (catabolin) is a potent stimulator of bone resorption in vitro. Calcif Tissue Int 37:95-97.
16. 3 and inhibited by human recombinant TIMP (tissue inhibitor of metalloproteinases). Biochem Biophys Res Commun 148:596-602.
17. 3: Evidence for a plasminogen-plasmin-metalloproteinase activation cascade. Biochim Biophys Acta 1014: 125-132.
18. Meikle MC, McGarrity AM, Thomson BM, Reynolds JJ 1991 Bone-derived growth factors modulate collagenase and TIMP (tissue inhibitor of melalloproteinases) activity and type I collagen degradation by mouse calvarial osteoblasts. Bone Miner 12:41-55.
19. Hill PA, Reynolds JJ, Meikle MC 1993 Inhibition of stimulated bone resorption in vitro by TIMP-1 and TIMP-2. Biochim Biophys Acta 1177:71-74.
20. Meikle MC, Bord S, Hembry RM, Compston J, Croucher PI, Reynolds JJ 1992 Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines. J Cell Sci 103:1093-1099.
21. Murphy G, Reynolds JJ 1993 Connective tissue degradation. In: Royce PM, Steinmann B (eds.) Connective Tissue and Its Heritable Disorders. Wiley-Liss, Inc., New York, NY, U.S.A., pp. 287-316.
22. Docherty AJP, Lyons A, Smith BJ, Wright EM, Stephens PE, Harris TJ, Murphy G, Reynolds JJ 1985 Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature 318:66-69.
23. Stetler-Stevenson WG, Krutzsch HC, Liotta LA 1989 Tissue inhibitor of metalloproteinases (TIMP-2): A new member of the metalloproteinase inhibitor family. J Biol Chem 264:17374-17378.
24. Leco KJ, Khokha R, Pavloff N, Hawkes SP, Edwards DR 1994 Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extra-cellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J Biol Chem 269:9352-9360.
25. Apte SS, Mattei M-G, Olsen BR 1994 Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP-3 gene to chromosome 22. Genomics 19:86-90.
26. Greene J, Wang M, Liu YE, Raymond LA, Rosen C, Shi YE 1996 Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. J Biol Chem 271:30375-30380.
27. Leco KJ, Apte SS, Taniguchi GT, Hawkes SP, Khokha R, Schultz GA, Edwards DR 1997 Murine tissue inhibitor of metalloproteinases-4 (TIMP-4): cDNA isolation and expression in adult mouse tissues. FEBS Lett 401:213-217.
28. Hill PA, Murphy G, Docherty AJP, Hembry RM, Millican TA, Reynolds JJ, Meikle MC 1994 The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts. J Cell Sci 107:3055-3064.
29. Delaissé JM, Eeckhout Y, Neff L, Francois-Gillet C, Henriet P, Su Y, Vaes G, Baron R 1993 (Pro) collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment. J Cell Sci 106:1071-1082.
30. Hill PA, Docherty AJP, Bottomley KMK, O'Connell JP, Morphy JR, Reynolds JJ, Meikle MC 1995 Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase. Biochem J 308:167-175.
31. Hembry RM, Murphy G, Reynolds JJ 1985 Immunolocalization of tissue inhibitor of metalloproteinases (TIMP) in human cells: Characterization and use of a specific antiserum. J Cell Sci 73:105-119.
32. Bancroft JD, Stevens A 1996 Theory and Practice of Histological Techniques, 4th Ed. Churchill Livingstone, London, U.K.
33. Parfitt AM, Drezner MK, Gloieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: Standardization of nomenclature, symbols, and units. J Bone Miner Res 2:595-610.
34. Heath JK, Atkinson SJ, Meikle MC, Reynolds JJ 1984 Mouse osteoblasts synthesize collagenase in response to bone resorbing agents. Biochim Biophys Acta 802:151-154.
35. Dew G, Murphy G, Stanton H, Vallon R, Angel P, Hembry RM 1998 Demonstration of matrix metalloproteinases and TIMP-2 in bone resorption (submitted).
36. Hipps DS, Hembry RM, Docherty AJP, Reynolds JJ, Murphy G 1991 Purification and characterization of human 72-kDa gelatinase (type IV collagenase): Use of immunolocalization to demonstrate the non-coordinate regulation of the 72-kDa and 95-kDa gelatinases by human fibroblasts. Biol Chem 372:287-296.
37. Breckon JJW, Hembry RM, Reynolds JJ, Meikle MC 1994 Regional and temporal changes in the synthesis of matrix metalloproteinases and TIMP-1 during development of the rabbit mandibular condyle. J Anat 184:99-110.
38. Breckon JJW, Hembry RM, Reynolds JJ, Meikle MC 1995 Matrix metalloproteinases and TIMP-1 localization at sites of osteogenesis in the craniofacial region of the rabbit embryo. Anat Rec 242:177-187.
39. Meikle MC, Bord S, Hembry RM, Reynolds JJ 1994 Rabbit calvarial osteoblasts in culture constitutively synthesize progelatinase-A, and TIMP-1 and TIMP-2. Biochim Biophys Acta 1224:99-102.
40. Henriet P, Rousseau GG, Eekhout Y 1992 Cloning and sequencing of mouse collagenase cDNA: Divergence of mouse and rat collagenase from the other mammalian collagenases. FEBS Lett 310:175-178.
41. Reponen P, Sahlberg C, Huhtala P, Hurskainen T, Thesleff I, Tryggvason K 1992 Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development. J Biol Chem 267:7856-7862.
42. Reponen P, Shalberg C, Munaut C, Thesleff I, Trygvason K 1994 High expression of 92-kDa type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development. J Cell Biol 124:1091-1102.
43. Hammani K, Henriet P, Eeckhout Y 1992 Cloning and sequencing of a cDNA encoding mouse stromelysin-1. Gene 120:321-322.
44. Edwards DR, Rocheleau H, Sharma RR, Wills AJ, Cowie A, Hassell JA, Heath JK 1992 Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription. Biochim Biophys Acta 1174:41-55.
45. Shimizu S, Malik K, Sejima H, Kishi J, Hayakawa T, Koiwai O 1992 Cloning and sequencing of the cDNA encoding a mouse tissue inhibitor of metalloproteinase-2. Gene 114:291-292.
46. Tokunaga K, Taniguchi H, Yoda K, Shimizu M, Sakiyama S 1986 Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA. Nucleic Acids Res 14:2829.
47. Wang ZQ, Grigoriadis AE, Möhle-Steinlein U, Wagner EF 1991 A novel target cell for c-fos induced oncogenesis: Development of chondrogenic tumours in embryonic stem cell chimeras. EMBO J 10:2437-2450.
48. Witty EP, Wright JH, Matrisian LM 1995 Matrix metalloproteinases are expressed during ductal and alveolar morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development. Mol Biol Cell 6:1287-1303.
49. Sun Y, Pommier Y, Colbum NH 1992 Acquisition of a growth inhibitory response to phorbol esters involves DNA damage. Cancer Res 52:1907-1915.
50. Hembry RM, Murphy G, Cawston TE, Dingle JT, Reynolds JJ 1986 Characterization of a specific antiserum for mammalian collagenase from several species: Immunolocalization of collagenase in rabbit chondrocytes and uterus. J Cell Sci 81:105-123.
51. Ward RV, Hembry RM, Reynolds JJ, Murphy G 1991 The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Biochem J 278:179-187.
52. Bord S, Horner A, Hembry RM, Reynolds JJ, Compston JE 1997 Distribution of matrix metalloproteinases and their inhibitor, TIMP-1, in developing human osteophytic bone. J Anat 191:39-48.
53. Murphy G, Cawston TE, Galloway WA, Barnes MJ, Bunning RAD, Mercer E, Reynolds JJ, Brugeson RE 1981 Metalloproteinases from rabbit bone culture medium degrade types IV and V collagens, laminin and fibronectin. Biochem J 199:807-811.
54. Hughes C, Murphy G, Hardingham TE 1991 Metalloproteinase digestion of cartilage proteoglycan: Pattern of cleavage by stromelysin and susceptibility to collagenase. Biochem J 279:733-739.
55. Wu JJ, Lark MW, Chun LE, Eyre DR 1991 Sites of stromelysin cleavage in collagen types II, IX, X and XI of cartilage. J Biol Chem 266:5625-5628.
56. Hembry RM, Bagga MR, Reynolds JJ, Hamblen DL 1995 Immunolocalization studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis. Ann Rheum Dis 54:25-32.
57. Gowen M, Mundy GR 1986 Actions of recombinant interleukin-1, interleukin-2, and interferon-gamma on bone resorption in vitro. J Immunol 136:2478-2482.
58. Pacifici R, Carano A, Santoro SA, Rifas LJ, Malone JD, McCracken R, Avioli LV 1991 Bone matrix constituents stimulate interleukin-1 release from human blood mononuclear cells. J Clin Invest 87:221-228.
59. Linkhart TA, Linkhart SG, MacCharles DC, Long DL, Strong DD 1991 Interleukin-6 messenger RNA expression and interleukin-6 protein secretion in cells isolated from normal human bone: Regulation by interleukin-1. J Bone Miner Res 6:1285-1294.
60. Kusano K, Miyaura C, Inada M, Tamura T, Ito A, Nagese H, Kamoi K, Suda T 1998 Regulation of matrix metalloproteinases (MMP-2-3-9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: Association of MMP induction with bone resorption. Endocrinology 139:1338-1345.