Fluorofenidone suppresses epithelial-mesenchymal transition and the expression of connective tissue growth factor via inhibiting TGF-β/Smads signaling in human proximal tubular epithelial cells

Pharmazie

Volumn 66, Issue 12, 2011, Pages 961-967

  Yuan, Qiongjing ^a   Wang, Linghao ^a   Zhang, Fangfang ^a   Wang, Rui ^a   Fu, Xiao ^a   Peng, Zhangzhe ^a   Ning, Wangbin ^a   Hu, Gaoyun ^b   Wang, Zhaohe ^c   Tao, Lijian ^a,b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c Sunshine Lake Pharma Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; FLUOROFENIDONE; LOSARTAN; PIRFENIDONE; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MORPHOLOGY; PREMEDICATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BLOTTING, WESTERN; CELL LINE; CONNECTIVE TISSUE GROWTH FACTOR; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INDICATORS AND REAGENTS; KIDNEY TUBULES, PROXIMAL; LOSARTAN; PYRIDONES; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84862916774     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2011.1535     Document Type: Article

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