The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen α1(I), TIMP-1 and MMP-2

Digestive and Liver Disease

Volumn 36, Issue 11, 2004, Pages 744-751

  Di Sario, A ^a   Bendia, E ^a   Macarri, G ^a   Candelaresi, C ^a   Taffetani, S ^a   Marzioni, M ^a   Omenetti, A ^a   De Minicis, S ^a   Trozzi, L ^a   Benedetti, A ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Liver fibrosis; Pirfenidone

Indexed keywords

ALANINE AMINOTRANSFERASE; DIMETHYLNITROSAMINE; GELATINASE A; MESSENGER RNA; PIRFENIDONE; PROCOLLAGEN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; COLLAGEN TYPE 1; PYRIDONE DERIVATIVE;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL STRUCTURE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIETARY INTAKE; DOWN REGULATION; DRUG EFFECT; EXTRACELLULAR MATRIX; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; MALE; NONHUMAN; NORTHERN BLOTTING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; RNA EXTRACTION; SCORING SYSTEM; STELLATE CELL; WESTERN BLOTTING; ANIMAL; LIVER CIRRHOSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; COLLAGEN TYPE I; DOWN-REGULATION; LIVER CIRRHOSIS; MALE; MATRIX METALLOPROTEINASE 2; PYRIDONES; RATS; RATS, SPRAGUE-DAWLEY; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 21644453426     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2004.05.012     Document Type: Article

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