Benzyl isothiocyanate (BITC) induces G 2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 2, 2012, Pages 665-675

  Huang, Su Hua ^a   Wu, Liu Wei ^a   Huang, An Cheng ^b   Yu, Chien Chih ^c   Lien, Jin Cherng ^c   Huang, Yi Ping ^c   Yang, Jai Sing ^c   Yang, Jen Hung ^d   Hsiao, Yu Ping ^e,f   Wood, W Gibson ^g   Yu, Chun Shu ^c   Chung, Jing Gung ^a,c  

^a ASIA UNIVERSITY   (Taiwan)

^b St Mary's Medicine Nursing and Management College   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d TZU CHI UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^f CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^g UNIVERSITY OF MINNESOTA   (United States)

Author keywords

A375.S2 melanoma cells; apoptosis; BITC; G2 M phase arrest; mitochondria; ROS

Indexed keywords

ANNEXINS; BENZYL ISOTHIOCYANATE; BITC; CASPASE-3; CELL COUNTING; CELL CYCLE; CELL NUMBER; CELL-CYCLE PROGRESSION; CONFOCAL LASER MICROSCOPES; CYCLIN A; DOSE-DEPENDENT MANNER; DOWN-REGULATION; ER STRESS; HUMAN CANCER CELLS; INDUCED APOPTOSIS; INTRACELLULAR CA; ISOTHIOCYANATES; MELANOMA CANCER; MELANOMA CELLS; MITOCHONDRIAL MEMBRANE POTENTIAL; MORPHOLOGICAL CHANGES; N-ACETYL L-CYSTEINE; PHASE ARREST; PRE-TREATMENT; PROPIDIUM IODIDE; REACTIVE OXYGEN SPECIES; ROS; SIGNALING PATHWAYS; UP-REGULATION; WESTERN BLOTTING;

AMINO ACIDS; CELL CULTURE; CELL MEMBRANES; DERMATOLOGY; DISEASES; DRUG PRODUCTS; MICROSCOPIC EXAMINATION; MITOCHONDRIA; MORPHOLOGY; ONCOLOGY; OXYGEN;

CELL DEATH;

BAX PROTEIN, HUMAN; BENZYL ISOTHIOCYANATE; CALCIUM; CARDIOLIPIN; CASPASE 3; CDC25C PROTEIN, HUMAN; CYCLIN A; CYCLIN DEPENDENT KINASE 1; ISOTHIOCYANIC ACID DERIVATIVE; PROTEIN BAX; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CHROMATIN; DNA DAMAGE; DRUG EFFECT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; M PHASE CELL CYCLE CHECKPOINT; MELANOMA; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PATHOLOGY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CARDIOLIPINS; CASPASE 3; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CHROMATIN; CYCLIN A; DNA DAMAGE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; ISOTHIOCYANATES; M PHASE CELL CYCLE CHECKPOINTS; MELANOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84862916212     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf204193v     Document Type: Article

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