Recent progress in the study of brown adipose tissue

Cell and Bioscience

Volumn 1, Issue 1, 2011, Pages

  Yao, Xuan ^a,b   Shan, Shifang ^a,b   Zhang, Ying ^a,b   Ying, Hao ^a,b  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Brown adipose; Differentiation; Obesity control; Thermogenesis

Indexed keywords

MAMMALIA;

EID: 84862854999     PISSN: None     EISSN: 20453701     Source Type: Journal    
DOI: 10.1186/2045-3701-1-35     Document Type: Review

References (63)

1. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004, 84:277-359. 10.1152/physrev.00015.2003, 14715917.
2. Nedergaard J, Bengtsson T, Cannon B. New powers of brown fat: fighting the metabolic syndrome. Cell Metab 2011, 13:238-240. 10.1016/j.cmet.2011.02.009, 21356513.
3. Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med 2011, 17:200-205. 10.1038/nm.2297, 21258337.
4. Rothwell NJ, Stock MJ. Luxuskonsumption, diet-induced thermogenesis and brown fat: the case in favour. Clin Sci (Lond) 1983, 64:19-23.
5. Collins S, Cao W, Robidoux J. Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. Mol Endocrinol 2004, 18:2123-2131. 10.1210/me.2004-0193, 15243132.
6. Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional control of brown fat determination by PRDM16. Cell Metab 2007, 6:38-54. 10.1016/j.cmet.2007.06.001, 2564846, 17618855.
7. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scime A, Devarakonda S, Conroe HM, Erdjument-Bromage H, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008, 454:961-967. 10.1038/nature07182, 2583329, 18719582.
8. Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Penicaud L, Casteilla L. Occurrence of Brown Adipocytes in Rat White Adipose-Tissue - Molecular and Morphological Characterization. Journal of Cell Science 1992, 103:931-942.
9. Vegiopoulos A, Muller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, Berriel Diaz M, Rozman J, Hrabe de Angelis M, Nusing RM, et al. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 2010, 328:1158-1161. 10.1126/science.1186034, 20448152.
10. Houstek J, Vizek K, Pavelka S, Kopecky J, Krejcova E, Hermanska J, Cermakova M. Type II iodothyronine 5'-deiodinase and uncoupling protein in brown adipose tissue of human newborns. J Clin Endocrinol Metab 1993, 77:382-387. 10.1210/jc.77.2.382, 8393883.
11. Frontini A, Cinti S. Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab 2010, 11:253-256. 10.1016/j.cmet.2010.03.004, 20374956.
12. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009, 360:1509-1517. 10.1056/NEJMoa0810780, 2859951, 19357406.
13. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009, 360:1500-1508. 10.1056/NEJMoa0808718, 19357405.
14. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerback S, Nuutila P. Functional brown adipose tissue in healthy adults. N Engl J Med 2009, 360:1518-1525. 10.1056/NEJMoa0808949, 19357407.
15. Jia JJ, Tian YB, Cao ZH, Tao LL, Zhang X, Gao SZ, Ge CR, Lin QY, Jois M. The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes. Mol Biol Rep 2010, 37:1513-1522. 10.1007/s11033-009-9550-2, 19444646.
16. Mori H, Okazawa H, Iwamoto K, Maeda E, Hashiramoto M, Kasuga M. A polymorphism in the 5' untranslated region and a Met229--> Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus. Diabetologia 2001, 44:373-376. 10.1007/s001250051629, 11317671.
17. Oppert JM, Vohl MC, Chagnon M, Dionne FT, Cassard-Doulcier AM, Ricquier D, Perusse L, Bouchard C. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. Int J Obes Relat Metab Disord 1994, 18:526-531.
18. Sears IB, MacGinnitie MA, Kovacs LG, Graves RA. Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: Regulation by peroxisome proliferator-activated receptor gamma. Molecular and Cellular Biology 1996, 16:3410-3419. 231335, 8668156.
19. Rabelo R, Schifman A, Rubio A, Sheng XY, Silva JE. Delineation of Thyroid Hormone-Responsive Sequences within a Critical Enhancer in the Rat Uncoupling Protein Gene. Endocrinology 1995, 136:1003-1013. 10.1210/en.136.3.1003, 7867554.
20. Larose M, CassardDoulcier AM, Fleury C, Serra F, Champigny O, Bouillaud F, Ricquier D. Essential cis-acting elements in rat uncoupling protein gene are in an enhancer containing a complex retinoic acid response domain. Journal of Biological Chemistry 1996, 271:31533-31542. 10.1074/jbc.271.49.31533, 8940169.
21. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998, 92:829-839. 10.1016/S0092-8674(00)81410-5, 9529258.
22. Nicholls DG. Hamster brown-adipose-tissue mitochondria. Purine nucleotide control of the ion conductance of the inner membrane, the nature of the nucleotide binding site. European Journal of Biochemistry 1976, 62:223-228. 10.1111/j.1432-1033.1976.tb10151.x, 1253787.
23. Rial E, Nicholls DG. A history of the first uncoupling protein, UCP1. Journal of Bioenergetics and Biomembranes 1999, 31:399-406. 10.1023/A:1005436121005, 10653469.
24. Locke RM, Rial E, Scott ID, Nicholls DG. Fatty-Acids as Acute Regulators of the Proton Conductance of Hamster Brown-Fat Mitochondria. European Journal of Biochemistry 1982, 129:373-380. 10.1111/j.1432-1033.1982.tb07060.x, 6295765.
25. Silva JE. Thermogenic mechanisms and their hormonal regulation. Physiological Reviews 2006, 86:435-464. 10.1152/physrev.00009.2005, 16601266.
26. Marrif H, Schifman A, Stepanyan Z, Gillis MA, Calderone A, Weiss RE, Samarut J, Silva JE. Temperature homeostasis in transgenic mice lacking thyroid hormone receptor-alpha gene products. Endocrinology 2005, 146:2872-2884. 10.1210/en.2004-1544, 15845618.
27. Bianco AC. Minireview: cracking the metabolic code for thyroid hormone signaling. Endocrinology 2011, 152:3306-3311. 10.1210/en.2011-1104, 21712363.
28. Castillo M, Hall JA, Correa-Medina M, Ueta C, Kang HW, Cohen DE, Bianco AC. Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes 2011, 60:1082-1089. 10.2337/db10-0758, 21335378.
29. Bianco AC, Silva JE. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest 1987, 79:295-300. 10.1172/JCI112798, 424048, 3793928.
30. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest 2001, 108:1379-1385. 209445, 11696583.
31. Thomas C, Auwerx J, Schoonjans K. Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism. Thyroid 2008, 18:167-174. 10.1089/thy.2007.0255, 18279017.
32. Houten SM, Watanabe M, Auwerx J. Endocrine functions of bile acids. EMBO J 2006, 25:1419-1425. 10.1038/sj.emboj.7601049, 1440314, 16541101.
33. Hansen JB, Kristiansen K. Regulatory circuits controlling white versus brown adipocyte differentiation. Biochem J 2006, 398:153-168. 10.1042/BJ20060402, 1550312, 16898874.
34. Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab 2006, 3:333-341. 10.1016/j.cmet.2006.04.002, 16679291.
35. Scarpulla RC. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiological Reviews 2008, 88:611-638. 10.1152/physrev.00025.2007, 18391175.
36. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, et al. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol 2005, 3:e101. 10.1371/journal.pbio.0030101, 1064854, 15760270.
37. Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jager S, Vianna CR, Reznick RM, et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 2004, 119:121-135. 10.1016/j.cell.2004.09.013, 15454086.
38. Treuter E, Albrektsen T, Johansson L, Leers J, Gustafsson JA. A regulatory role for RIP140 in nuclear receptor activation. Mol Endocrinol 1998, 12:864-881. 10.1210/me.12.6.864, 9626662.
39. Leonardsson G, Steel JH, Christian M, Pocock V, Milligan S, Bell J, So PW, Medina-Gomez G, Vidal-Puig A, White R, Parker MG. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci USA 2004, 101:8437-8442. 10.1073/pnas.0401013101, 420412, 15155905.
40. Steel JH, White R, Parker MG. Role of the RIP140 corepressor in ovulation and adipose biology. J Endocrinol 2005, 185:1-9. 10.1677/joe.1.05896, 15817822.
41. Christian M, Kiskinis E, Debevec D, Leonardsson G, White R, Parker MG. RIP140-targeted repression of gene expression in adipocytes. Mol Cell Biol 2005, 25:9383-9391. 10.1128/MCB.25.21.9383-9391.2005, 1265803, 16227589.
42. Spiegelman BM, Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes & Development 2008, 22:1397-1409. 10.1101/gad.1666108, 22039609.
43. Spiegelman BM, Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature 2009, 460:1154-U1125. 10.1038/nature08262, 2754867, 19641492.
44. Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 2011, 121:96-105. 10.1172/JCI44271, 3007155, 21123942.
45. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004, 20:781-810. 10.1146/annurev.cellbio.20.010403.113126, 15473860.
46. Kang S, Bajnok L, Longo KA, Petersen RK, Hansen JB, Kristiansen K, MacDougald OA. Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha. Mol Cell Biol 2005, 25:1272-1282. 10.1128/MCB.25.4.1272-1282.2005, 548004, 15684380.
47. Longo KA, Wright WS, Kang S, Gerin I, Chiang SH, Lucas PC, Opp MR, MacDougald OA. Wnt10b inhibits development of white and brown adipose tissues. J Biol Chem 2004, 279:35503-35509. 10.1074/jbc.M402937200, 15190075.
48. Hatakeyama M, Weinberg RA. The role of RB in cell cycle control. Prog Cell Cycle Res 1995, 1:9-19.
49. Jacks T, Lipinski MM. The retinoblastoma gene family in differentiation and development. Oncogene 1999, 18:7873-7882.
50. Wells J, Boyd KE, Fry CJ, Bartley SM, Farnham PJ. Target gene specificity of E2F and pocket protein family members in living cells. Molecular and Cellular Biology 2000, 20:5797-5807. 10.1128/MCB.20.16.5797-5807.2000, 86057, 10913163.
51. Kristiansen K, Hansen JB, Jorgensen C, Petersen RK, Hallenborg P, De Matteis R, Boye HA, Petrovic N, Enerback S, Nedergaard J, et al. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:4112-4117. 10.1073/pnas.0301964101, 384703, 15024128.
52. Rudnicki MA, Scime A, Grenier G, Huh MS, Gillespie MA, Bevilacqua L, Harper ME. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1 alpha. Cell Metabolism 2005, 2:283-295. 10.1016/j.cmet.2005.10.002, 16271529.
53. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 2000, 69:145-182. 10.1146/annurev.biochem.69.1.145, 10966456.
54. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LBA, Lipsky PE. Cyclooxygenase in biology and disease. Faseb Journal 1998, 12:1063-1073.
55. Fitzpatrick FA. Cyclooxygenase enzymes: Regulation and function. Current Pharmaceutical Design 2004, 10:577-588. 10.2174/1381612043453144, 14965321.
56. Madsen L, Pedersen LM, Lillefosse HH, Fjaere E, Bronstad I, Hao Q, Petersen RK, Hallenborg P, Ma T, De Matteis R, et al. UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity. PLoS ONE 2010, 5.
57. Halpern A. Pharmacological Treatment of Obesity (Clinical Aspects). Proceedings of the 13th International Congress of Endocrinology 2008, 59-61.
58. Cypess AM, Kahn CR. Brown fat as a therapy for obesity and diabetes. Curr Opin Endocrinol Diabetes Obes 2010, 17:143-149. 10.1097/MED.0b013e328337a81f, 20160646.
59. Kahn CR, Cypess AM. Brown fat as a therapy for obesity and diabetes. Current Opinion in Endocrinology Diabetes and Obesity 2010, 17:143-149.
60. Bartlett J, Brunner M, Gough K. Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill. Emergency Medicine Journal 2010, 27:159-160. 10.1136/emj.2008.069401, 20156878.
61. Grundlingh J, Dargan PI, El-Zanfaly M, Wood DM. 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death. J Med Toxicol 2011, 7:205-212. 10.1007/s13181-011-0162-6, 21739343.
62. Kahn CR, Tran TT. Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nature Reviews Endocrinology 2010, 6:195-213. 10.1038/nrendo.2010.20, 20195269.
63. Van RL, Roncari DA. Complete differentiation in vivo of implanted cultured adipocyte precursors from adult rats. Cell Tissue Res 1982, 225:557-566.