A polymorphism in the 5′ untranslated region and a Met229→ Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to Type II diabetes mellitus

Diabetologia

Volumn 44, Issue 3, 2001, Pages 373-376

  Mori, H ^a   Okazawa, H ^a   Iwamoto, K ^a   Maeda, E ^a   Hashiramoto, M ^a   Kasuga, M ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Linkage disequilibrium; PCR RFLP; PCR SSCP; Polymorphism; SNPs; Thrifty factor; Type II diabetes mellitus; UCP1

Indexed keywords

LEUCINE; METHIONINE; CARRIER PROTEIN; ION CHANNEL; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

ADULT; AGED; ALLELE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; EXON; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE STRAND CONFORMATION POLYMORPHISM; UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINO ACID SUBSTITUTION; ASIAN; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; GENOTYPE; JAPAN; MIDDLE AGED; MITOCHONDRION; REFERENCE VALUE;

5' UNTRANSLATED REGIONS; AGED; ALLELES; AMINO ACID SUBSTITUTION; ASIAN CONTINENTAL ANCESTRY GROUP; CARRIER PROTEINS; DIABETES MELLITUS, TYPE 2; EXONS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; ION CHANNELS; JAPAN; LEUCINE; MALE; MEMBRANE PROTEINS; METHIONINE; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; REFERENCE VALUES; VARIATION (GENETICS);

EID: 0034745057     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051629     Document Type: Article

References (9)

1. 3-adrenergic-receptor gene
2. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of Type II diabetes
3. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians
4. Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes
5. Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity
6. Analysis of the uncoupling protein-1 (UCP1) gene in obese and lean subjects: Identification of four amino acid variants
7. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
8. Regulation of gene expression by insulin
9. Inhibition of PI 3-kinase and ras blocks IGF-1 and insulin-induced uncoupling protein 1 gene expression in brown adipocytes