Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: Regulation by peroxisome proliferator-activated receptor γ

Molecular and Cellular Biology

Volumn 16, Issue 7, 1996, Pages 3410-3419

  Sears, Irina B ^a   MacGinnitie, Marissa A ^a   Kovacs, Laszlo G ^a   Graves, Reed A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; UNCOUPLING PROTEIN;

ARTICLE; BROWN ADIPOSE TISSUE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; GENE EXPRESSION; PEROXISOME; PRIORITY JOURNAL; PROTEIN BINDING; THERMOGENESIS; TRANSGENIC MOUSE;

EID: 0029941669     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.16.7.3410     Document Type: Article

References (54)

1. Aihaud, G., P. Grimaldi, and R. Negrel. 1992. Cellular and molecular aspects of adipose tissue development. Annu. Rev. Nutr. 12:207-233.
2. Aihaud, G., P. Grimaldi, and R. Negrel. 1994. Hormonal regulation of adipose differentiation. Trends Endocrinol. Metab. 5:132-136.
3. Alvarez, R., J. Andres, P. Yubero, O. Vinas, T. Mampel, R. Iglesias, M. Giralt, and F. Villarroya. 1995. A novel regulatory pathway of brown fat thermogenesis. J. Biol. Chem. 270:5666-5673.
4. Boyer, B., and L. Kozak. 1991. The mitochondrial uncoupling protein gene in brown fat: correlation between DNase hypersensitivity and expression of transgenic mice. Mol. Cell. Biol. 11:4147-4156.
5. Cassard-Doulcier, A., C. Gely, N. Fox, J. Schrementi, S. Raimbault, S. Klaus, C. Forest, F. Bouillaud, and D. Ricquier. 1993. Tissue-specific and β-adrenergic regulation of the mitochondrial uncoupling protein gene: control by cis-acting elements in the 5′-flanking region. Mol. Endocrinol. 7:497-506.
6. Cassard-Doulcier, A., M. Larose, J. Matamala, O. Champigny, F. Bouillaud, and D. Ricquier. 1994. In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1. retinoid X receptor, thyroid hormone receptor, and a CACCC box-binding protein. J. Biol. Chem. 269:24335-24342.
7. Chawla, A., and M. Lazar. 1994. Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. Proc. Natl. Acad. Sci. USA 91:1786-1790.
8. Cornelius, P., O. MacDougal, and M. Lane. 1994. Regulation of adipocyte development. Annu. Rev. Nutr. 14:99-129.
9. Fineberg, A. P., and B. Vogelstein. 1984. A technique for radiolabeling DNA restriction fragments to high specific activity. Anal. Biochem. 137:266-267.
10. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803-812.
11. Freytag, S. O., D. L. Paielli, and J. D. Gilbert. 1994. Ectopic expression of the CCAAT/enhancer-binding protein α promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev. 8:1654-1663.
12. Girardier, L., and J. Seydoux. 1986. Neural control of brown adipose tissue, p. 122-151. In P. Trayhum and D. Nichols (ed.), Brown adipose tissue. Arnold, London.
13. Gorman, C., L. Moffat, and B. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
14. Graham, F., and A. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
15. Graves, R. A., P. Tontonoz, S. R. Ross, and B. M. Spiegelman. 1991. Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor. Genes Dev. 5:428-437.
16. Graves, R. A., P. Tontonoz, and B. M. Spiegelman. 1992. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol. Cell. Biol. 12:1202-1208.
17. Green, H., and O. Kehinde. 1974. Sublines of mouse 3T3 cells that accumulate lipid. Cell 3:113-116.
18. Green, H., and O. Kehinde. 1975. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5:19-27.
19. Himms-Hagen, J. 1989. Brown adipose tissue thermogenesis and obesity. Prog. Lipid Res. 28:67-115.
20. Himms-Hagen, J. 1990. Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J. 4:2890-2898.
21. Keller, H., A. Mahfoudi, C. Dreyer, A. Hidi, J. Medin, K. Ozato, and W. Wahli. 1993. Peroxisome proliferator-activated receptors and lipid metabolism. Ann. N. Y. Acad. Sci. 684:157-173.
22. Klaus, S., L. Choy, O. Champigny, A. Cassard-Doulcier, S. Ross, B. Spiegelman, and D. Ricquier. 1994. Characterization of the novel brown adipocyte cell line H1B-1B: adrenergic pathways involved in regulation of uncoupling protein gene expression. J. Cell Sci. 107:313-319.
23. Kletzien, R., S. Clarke, and R. Ulrich. 1992. Enhancement of adipocyte differentiation by an insulin-sensitizing agent. Mol. Pharmacol. 41:393-398.
24. 2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83:813-819.
25. Kliewer, S., K. Umesono, D. Mangelsdorf, and R. Evans. 1992. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature (London) 355:446-449.
26. Kliewer, S., K. Umesono, D. Noonan, R. Heyman, and R. Evans. 1992. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (London) 358:771-774.
27. Kopecky, J., M. Baudysova, F. Zanotti, D. Janikova, S. Pavelka, and J. Houstek. 1990. Synthesis of mitochondrial uncoupling protein in brown adipocytes differentiated in cell culture. J. Biol. Chem. 265:22204-22209.
28. Kozak, U., J. Kopecky, J. Teisinger, S. Enerback, B. Boyer, and L. Kozak. 1994. An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol. Cell. Biol. 14:59-67.
29. Laborda, J. 1991. 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res. 19:3998.
30. Lehmann, J., L. Moore, T. Smith-Oliver, W. Wilkison, T. Willson, and S. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270:12953-12956.
31. Lowell, B., V. S. Susulic, A. Hamann, J. Lawitts, J. Himms-Hagen, B. Boyer, L. Kozak, and J. Filer. 1993. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature (London) 366:740-742.
32. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
33. McGrane, M. M., J. S. Yun, A. F. Moorman, W. H. Lamers, G. K. Hendrick, B. M. Arafah, E. A. Park, T. E. Wagner, and R. W. Hanson. 1990. Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice. J. Biol. Chem. 265:22371-22379.
34. Mercer, S., and P. Trayhurn. 1986. Effects of ciglitazone on insulin resistance and thermogenic responsiveness to acute cold in brown adipose tissue of genetically obese (ob/ob) mice. FEBS Lett. 195:12-16.
35. Nicholls, D., and R. Locke. 1984. Thermogenic mechanisms in brown fat. Physiol. Rev. 64:1-64.
36. Rabelo, R., A. Schifman, A. Rubio, X. Sheng, and J. Suva. 1995. Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene. Endocrinology 136:1003-1013.
37. Rehnmark, S., J. Kopecky, J. Jacobsson, M. Nechad, D. Herron, B. Neldon, M. Obregon, J. Nedergaard, and B. Cannon. 1989. Brown adipocytes differentiated in culture in vitro can express the gene for the uncoupling protein thermogenin: effects of hypothyroidism and norepinephrine. Exp. Cell Res. 182:75-83.
38. Rehnmark, S., M. Nechad, D. Herren, B. Cannon, and J. Nedergaard. 1990. α- and β-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture. J. Biol. Chem. 265:16464-16471.
39. Ricquirer, D., F. Bouillaud, G. Toumelin, G. Mory, R. Bazin, J. Arch, and L. Penicaud. 1986. Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue: evidence for a rapid β-adrenoreceptor-mediated and transcriptionally regulated step during activation or thermogenesis. J. Biol. Chem. 261:13905-13910.
40. Ross, S., L. Choy, R. Graves, N. Fox, V. Solevjeva, S. Klaus, D. Ricquier, and B. Spiegelman. 1992. Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene. Proc. Natl. Acad. Sci. USA 89:7561-7565.
41. Ross, S., R. Graves, A. Greenstein, K. Platt, H.-L. Shyu, B. Mellovitz, and B. Spielgelman. 1990. A fat-specific enhancer is the primary determinant of adipocyte P2 (aP2) gene expression in vivo. Proc. Natl. Acad. Sci. USA 87:9590-9594.
42. Rothwell, N., M. Stock, and A. Tedstone. 1987. Effects of ciglitazone on energy balance, thermogenesis and brown fat activity in the rat. Mol. Cell. Endocrinol. 57:253-257.
43. Shapiro, D., P. Sharp, W. Wahli, and M. Keller. 1988. A high-efficiency HeLa cell nuclear transcription extract. Gene 7:47-55.
44. Short, M. K., D. E. Clouthier, M. Schaefer, R. E. Hammer, M. A. Magnuson, and E. G. Beale. 1992. Tissue-specific, developmental, hormonal and dietary regulation of a rat phosphoenolpyruvate carboxykinase-human growth hormone fusion gene in transgenic mice. Mol. Cell. Biol. 12:1007-1020.
45. Siebenlist, U., and W. Gilbert. 1980. Contacts between Escherichia coli RNA polymerase and an early promoter of phage TV. Proc. Natl. Acad. Sci. USA 77:122-126.
46. Spiegelman, B., and H. Green. 1980. Control of specific protein biosynthesis during the adipose conversion of 3T3 cells. J. Biol. Chem. 255:8811-8818.
47. Tontonoz, P., R. Graves, and B. Spiegelman. Unpublished data.
48. Tontonoz, P., R. A. Graves, A. I. Budavari, H. Erdjument-Bromage, M. Lui, E. Hu, P. Tempst, and B. M. Spiegelman. 1994. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPARγ and RXRα. Nucleic Acids Res. 22:5628-5634.
49. Tontonoz, P., E. Hu, J. Devine, E. G. Beale, and B. M. Spiegelman. 1995. PPARγ2 regulates adipocyte expression of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 15:351-357.
50. Tontonoz, P., E. Hu, R. Graves, A. Budavari, and B. Spiegelman. 1994. mPPAR2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8:1224-1234.
51. Tontonoz, P., E. Hu, and B. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid activated transcription factor. Cell 79:1147-1156.
52. Umesono, K., K. Murakami, C. C. Thompson, and R. Evans. 1991. Direct repeats as selective response elements for the thyroid hormone, retinoic acid and vitamin D3 receptors. Cell 65:1255-1266.
53. Yubero, P., C. Manchado, A. Cassard-Doulcier, T. Mampel, O. Vinas, R. Iglesias, M. Giralt, and F. Villarroya. 1994. CCAAT/enhancer binding proteins alpha and beta are transcriptional activators of the brown fat uncoupling protein gene promoter. Biochem. Biophys. Res. Commun. 198:653-659.
54. Yubero, P., O. Vinas, R. Iglesias, T. Mampel, F. Villarroya, and M. Giralt. 1994. Identification of tissue-specific protein binding domains in the 5′-proximal regulatory region of the rat mitochondrial brown fat uncoupling protein gene. Biochem. Biophys. Res. Commun. 204:867-873.