Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, fasudil, through podocyte protection and prevention of leukocyte migration

American Journal of Pathology

Volumn 172, Issue 3, 2008, Pages 603-614

  Hidaka, Teruo ^a   Suzuki, Yusuke ^a   Yamashita, Michifumi ^a   Shibata, Terumi ^a   Tanaka, Yuichi ^a   Horikoshi, Satoshi ^a   Tomino, Yasuhiko ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; FASUDIL; LIPOPOLYSACCHARIDE; NEPHRIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE INHIBITOR; WT1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; FEMALE; GLOMERULONEPHRITIS; HEMATURIA; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LEUKOCYTE; LEUKOCYTE MIGRATION; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE;

EID: 40449099586     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2008.070196     Document Type: Article

References (63)

1. PG Tipping SR Holdsworth T cells in crescentic glomerulonephritis J Am Soc Nephrol 17 2006 1253 1263
2. CD Pusey Anti-glomerular basement membrane disease Kidney Int 64 2003 1535 1550
3. JJ Weening VD D'Agati MM Schwartz SV Seshan CE Alpers GB Appel JE Balow JA Bruijn T Cook F Ferrario AB Fogo EM Ginzler L Hebert G Hill P Hill JC Jennette NC Kong P Lesavre M Lockshin LM Looi H Makino LA Moura M Nagata The classification of glomerulonephritis in systemic lupus erythematosus revisited J Am Soc Nephrol 15 2004 241 250
4. T Morita Y Suzuki J Churg Structure and development of the glomerular crescent Am J Pathol 72 1973 349 368
5. KW Min F Gyorkey P Gyorkey JJ Yium G Eknoyan The morphogenesis of glomerular crescents in rapidly progressive glomerulonephritis Kidney Int 5 1974 47 56
6. JC Jennette CG Hipp The epithelial antigen phenotype of glomerular crescent cells Am J Clin Pathol 86 1986 274 280
7. A Boucher D Droz E Adafer LH Noel Relationship between the integrity of Bowman's capsule and the composition of cellular crescents in human crescentic glomerulonephritis Lab Invest 56 1987 526 533
8. M Nagata S Horita Y Shu S Shibata M Hattori K Ito T Watanabe Phenotypic characteristics and cyclin-dependent kinase inhibitors repression in hyperplastic epithelial pathology in idiopathic focal segmental glomerulosclerosis Lab Invest 80 2000 869 880
9. HY Lan DJ Nikolic-Paterson W Mu RC Atkins Local macrophage proliferation in the pathogenesis of glomerular crescent formation in rat anti-glomerular basement membrane (GBM) glomerulonephritis Clin Exp Immunol 110 1997 233 240
10. M Le Hir C Keller V Eschmann B Hahnel H Hosser W Kriz Podocyte bridges between the tuft and Bowman's capsule: an early event in experimental crescentic glomerulonephritis J Am Soc Nephrol 12 2001 2060 2071
11. MJ Moeller A Soofi I Hartmann M Le Hir R Wiggins W Kriz LB Holzman Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis J Am Soc Nephrol 15 2004 61 67
12. M Arakawa J Tokunaga A scanning electron microscope study of the glomerulus. Further consideration of the mechanism of the fusion of podocyte terminal processes in nephrotic rats Lab Invest 27 1972 366 371
13. R Rodewald MJ Karnovsky Porous substructure of the glomerular slit diaphragm in the rat and mouse J Cell Biol 60 1974 423 433
14. E Yamada The fine structure of the renal glomerulus of the mouse J Biophys Biochem Cytol 1 1955 551 566
15. J Reiser W Kriz M Kretzler P Mundel The glomerular slit diaphragm is a modified adherens junction J Am Soc Nephrol 11 2000 1 8
16. M Morigi S Buelli S Angioletti C Zanchi L Longaretti C Zoja M Galbusera S Gastoldi P Mundel G Remuzzi A Benigni In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies Am J Pathol 166 2005 1309 1320
17. L Van Aelst C D'Souza-Schorey Rho GTPases and signaling networks Genes Dev 11 1997 2295 2322
18. A Hall Rho GTPases and the actin cytoskeleton Science 279 1998 509 514
19. K Katoh Y Kano M Amano H Onishi K Kaibuchi K Fujiwara Rho-kinase-mediated contraction of isolated stress fibers J Cell Biol 153 2001 569 584
20. TM Seasholtz M Majumdar JH Brown Rho as a mediator of G protein-coupled receptor signaling Mol Pharmacol 55 1999 949 956
21. A Gohla G Schultz S Offermanns Role for G(12)/G(13) in agonist-induced vascular smooth muscle cell contraction Circ Res 87 2000 221 227
22. Y Suzuki M Ruiz-Ortega O Lorenzo M Ruperez V Esteban J Egido Inflammation and angiotensin II Int J Biochem Cell Biol 35 2003 881 900
23. KA Nahmod ME Vermeulen S Raiden G Salamone R Gamberale P Fernandez-Calotti A Alvarez V Nahmod M Giordano JR Geffner Control of dendritic cell differentiation by angiotensin II FASEB J 17 2003 491 493
24. B Rodríguez-Iturbe H Pons J Herrera-Acosta RJ Johnson Role of immunocompetent cells in nonimmune renal diseases Kidney Int 59 2001 1626 1640
25. Y Suzuki C Gomez-Guerrero I Shirato O Lopez-Franco P Hernandez-Vargas G Sanjuan M Ruiz-Ortega T Sugaya K Okumura Y Tomino C Ra J Egido Susceptibility to T cell-mediated injury in immune complex disease is linked to local activation of renin-angiotensin system: the role of NF-AT pathway J Immunol 169 2002 4136 4146
26. Y Suzuki I Shirato K Okumura JV Ravetch T Takai Y Tomino C Ra Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis Kidney Int 54 1998 1166 1174
27. C Gómez-Guerrero O Lopez-Franco Y Suzuki G Sanjuan P Hernandez-Vargas J Blanco J Egido Nitric oxide production in renal cells by immune complexes: role of kinases and nuclear factor-kappaB Kidney Int 62 2002 2022 2034
28. A Poole JM Gibbins M Turner MJ van Vugt JG van de Winkel T Saito VL Tybulewicz SP Watson The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen EMBO J 16 1997 2333 2341
29. S Satoh T Utsunomiya K Tsurui T Kobayashi I Ikegaki Y Sasaki T Asano Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage Life Sci 69 2001 1441 1453
30. M Higashi H Shimokawa T Hattori J Hiroki Y Mukai K Morikawa T Ichiki S Takahashi A Takeshita Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system Circ Res 93 2003 767 775
31. O López-Franco Y Suzuki G Sanjuan J Blanco P Hernandez-Vargas Y Yo J Kopp J Egido C Gomez-Guerrero Nuclear factor-kappa B inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritis Am J Pathol 161 2002 1497 1505
32. MA Saleem L Ni I Witherden K Tryggvason V Ruotsalainen P Mundel PW Mathieson Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation Am J Pathol 161 2002 1459 1466
33. W Falk RH Goodwin Jr EJ Leonard A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration J Immunol Methods 33 1980 239 247
34. K Asanuma E Yanagida-Asanuma C Faul Y Tomino K Kim P Mundel Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling Nat Cell Biol 8 2006 485 491
35. E Yanagida-Asanuma K Asanuma K Kim M Donnelly H Young Choi J Hyung Chang S Suetsugu Y Tomino T Takenawa C Faul P Mundel Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes Am J Pathol 171 2007 415 427
36. CC Tisher BM Brenner Renal Pathology with Clinical and Functional Correlations 1994 J.B. Lippincott Company Philadelphia 355
37. NY Shih J Li V Karpitskii A Nguyen ML Dustin O Kanagawa JH Miner AS Shaw Congenital nephrotic syndrome in mice lacking CD2-associated protein Science 286 1999 312 315
38. J Reiser G von Gersdorff M Loos J Oh K Asanuma L Giardino MP Rastaldi N Calvaresi H Watanabe K Schwarz C Faul M Kretzler A Davidson H Sugimoto R Kalluri AH Sharpe JA Kreidberg P Mundel Induction of B7-1 in podocytes is associated with nephrotic syndrome J Clin Invest 113 2004 1390 1397
39. RV Durvasula AT Petermann K Hiromura M Blonski J Pippin P Mundel R Pichler S Griffin WG Couser SJ Shankland Activation of a local tissue angiotensin system in podocytes by mechanical strain Kidney Int 65 2004 30 39
40. P Hernández-Vargas O Lopez-Franco G Sanjuan M Ruperez G Ortiz-Munoz Y Suzuki P Aguado-Roncero G Perez-Tejerizo J Blanco J Egido M Ruiz-Ortega C Gomez-Guerrero Suppressors of cytokine signaling regulate angiotensin II-activated Janus kinase-signal transducers and activators of transcription pathway in renal cells J Am Soc Nephrol 16 2005 1673 1683
41. T Yamakawa S Tanaka K Numaguchi Y Yamakawa ED Motley S Ichihara T Inagami Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells Hypertension 35 2000 313 318
42. ME Pagtalunan PL Miller S Jumping-Eagle RG Nelson BD Myers HG Rennke NS Coplon L Sun TW Meyer Podocyte loss and progressive glomerular injury in type II diabetes J Clin Invest 99 1997 342 348
43. KV Lemley RA Lafayette M Safai G Derby K Blouch A Squarer BD Myers Podocytopenia and disease severity in IgA nephropathy Kidney Int 61 2002 1475 1485
44. TW Meyer PH Bennett RG Nelson Podocyte number predicts long-term urinary albumin excretion in Pima Indians with type II diabetes and microalbuminuria Diabetologia 42 1999 1341 1344
45. S Hoffmann D Podlich B Hahnel W Kriz N Gretz Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats J Am Soc Nephrol 15 2004 1475 1487
46. YH Kim M Goyal D Kurnit B Wharram J Wiggins L Holzman D Kershaw R Wiggins Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat Kidney Int 60 2001 957 968
47. V Ruotsalainen P Ljungberg J Wartiovaara U Lenkkeri M Kestila H Jalanko C Holmberg K Tryggvason Nephrin is specifically located at the slit diaphragm of glomerular podocytes Proc Natl Acad Sci USA 96 1999 7962 7967
48. LB Holzman PL St John IA Kovari R Verma H Holthofer DR Abrahamson Nephrin localizes to the slit pore of the glomerular epithelial cell Kidney Int 56 1999 1481 1491
49. K Tryggvason J Wartiovaara Molecular basis of glomerular permselectivity Curr Opin Nephrol Hypertens 10 2001 543 549
50. D Macconi M Abbate M Morigi S Angioletti M Mister S Buelli M Bonomelli P Mundel K Endlich A Remuzzi G Remuzzi Permselective dysfunction of podocyte-podocyte contact upon angiotensin II unravels the molecular target for renoprotective intervention Am J Pathol 168 2006 1073 1085
51. K Schwarz M Simons J Reiser MA Saleem C Faul W Kriz AS Shaw LB Holzman P Mundel Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin J Clin Invest 108 2001 1621 1629
52. K Asanuma K Kim J Oh L Giardino S Chabanis C Faul J Reiser P Mundel Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner J Clin Invest 115 2005 1188 1198
53. MM Monick LS Powers NS Butler GW Hunninghake Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure J Immunol 171 2003 2625 2630
54. JS Duffield PG Tipping T Kipari JF Cailhier S Clay R Lang JV Bonventre J Hughes Conditional ablation of macrophages halts progression of crescentic glomerulonephritis Am J Pathol 167 2005 1207 1219
55. H Honing TK van den Berg SM van der Pol CD Dijkstra RA van der Kammen JG Collard HE de Vries RhoA activation promotes transendothelial migration of monocytes via ROCK J Leukoc Biol 75 2004 523 528
56. L Liu BR Schwartz N Lin RK Winn JM Harlan Requirement for RhoA kinase activation in leukocyte de-adhesion J Immunol 169 2002 2330 2336
57. M Kohno K Yasunari M Minami H Kano K Maeda AK Mandal K Inoki M Haneda J Yoshikawa Regulation of rat mesangial cell migration by platelet-derived growth factor, angiotensin II, and adrenomedullin J Am Soc Nephrol 10 1999 2495 2502
58. M Kohno K Shinomiya S Abe T Noma I Kondo A Oshita H Takeuchi Y Takagi K Yukiiri K Mizushige K Ohmori Inhibition of migration and proliferation of rat vascular smooth muscle cells by a new HMG-CoA reductase inhibitor, pitavastatin Hypertens Res 25 2002 279 285
59. LM Blanco-Colio J Tunon JL Martin-Ventura J Egido Anti-inflammatory and immunomodulatory effects of statins Kidney Int 63 2003 12 23
60. PL Tharaux RC Bukoski PN Rocha SD Crowley P Ruiz C Nataraj DN Howell K Kaibuchi RF Spurney TM Coffman Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells J Immunol 171 2003 96 105
61. CE Turner KM Pietras DS Taylor CJ Molloy Angiotensin II stimulation of rapid paxillin tyrosine phosphorylation correlates with the formation of focal adhesions in rat aortic smooth muscle cells J Cell Sci 108 1995 333 342
62. K Fernstrom P Farmer MS Ali Cytoskeletal remodeling in vascular smooth muscle cells in response to angiotensin II-induced activation of the SHP-2 tyrosine phosphatase J Cell Physiol 205 2005 402 413
63. MA Barber HC Welch PI3K and RAC signalling in leukocyte and cancer cell migration Bull Cancer 93 2006 E44 E52