Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy

Nephrology Dialysis Transplantation

Volumn 24, Issue 8, 2009, Pages 2378-2383

  Sakurai, Noriyuki ^a   Kuroiwa, Takashi ^a   Ikeuchi, Hidekazu ^a   Hiramatsu, Noriyuki ^a   Takeuchi, Shigeru ^a   Tomioka, Mai ^a   Shigehara, Tetsuya ^a   Maeshima, Akito ^a   Kaneko, Yoriaki ^a   Hiromura, Keiju ^a   Kopp, Jeffery B ^b   Nojima, Yoshihisa ^a  

^a GUNMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Fluvastatin; HIV associated nephropathy; Podocyte

Indexed keywords

ALBUMIN; ANGIOTENSIN II; CREATININE; CYCLINE; DOXYCYCLINE; FLUINDOSTATIN; NEPHRIN; SYNAPTOPODIN; VPR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOWN REGULATION; DRUG EFFECT; FOCAL GLOMERULOSCLEROSIS; HEMINEPHRECTOMY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KIDNEY DISEASE; KIDNEY FUNCTION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RENAL PROTECTION; TRANSGENIC MOUSE; UPREGULATION; URINARY EXCRETION;

AIDS-ASSOCIATED NEPHROPATHY; ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FATTY ACIDS, MONOUNSATURATED; FLUORESCENT ANTIBODY TECHNIQUE; GENES, WILMS TUMOR; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; IMMUNOENZYME TECHNIQUES; INDOLES; KIDNEY; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; NEPHRECTOMY; PHENOTYPE; PODOCYTES; PROTEINURIA;

EID: 67651089825     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp012     Document Type: Article

References (29)

1. Bourgoignie JJ, Pardo V. The nephropathology in human immunodeficiency virus (HIV-1) infection. Kidney Int Suppl 1991; 35: S19-S23
2. Lu TC, Ross M. HIV-associated nephropathy: a brief review. Mt Sinai J Med 2005; 72: 193-199
3. Bruggeman LA, Ross MD, Tanji N et al. Renal epithelium is a previously unrecognized site of HIV-1 infection. J Am Soc Nephrol 2000; 11: 2079-2087
4. Marras D, Bruggeman LA, Gao F et al. Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIVassociated nephropathy. Nat Med 2002; 8: 522-526
5. Zhong J, Zuo Y, Ma J et al. Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy. Kidney Int 2005; 68: 1048-1060
6. Shigehara T, Zaragoza C, Kitiyakara C et al. Inducible podocytespecific gene expression in transgenic mice. J Am Soc Nephrol 2003; 14: 1998-2003
7. Hiramatsu N, Hiromura K, Shigehara T et al. Angiotensin II type receptor blockade inhibits the development and progression of HIVassociated nephropathy in a mouse model. J Am Soc Nephrol 2007; 18: 515-527
8. Massy ZA, Keane WF, Kasiske BL. Inhibition of the mevalonate pathway: benefits beyond cholesterol reduction? Lancet 1996; 347: 102-103
9. Blum CB. Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Am J Cardiol 1994; 73: 3D-11D
10. Kobashigawa JA, Katznelson S, Laks H et al. Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med 1995; 333: 621-627
11. Gueler F, Rong S, Park JK et al. Postischemic acute renal failure is reduced by short-term statin treatment in a rat model. J Am Soc Nephrol 2002; 13: 2288-2298
12. Li C, Yang CW, Park JH et al. Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporineinduced nephropathy. Am J Physiol Renal Physiol 2004; 286: F46-F57
13. Moriyama T, Kawada N, Nagatoya K et al. Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction. Kidney Int 2001; 59: 2095-2103
14. Yoshimura A, Inui K, Nemoto T et al. Simvastatin suppresses glomerular cell proliferation and macrophage infiltration in rats with mesangial proliferative nephritis. J Am Soc Nephrol 1998; 9: 2027-2039
15. Zoja C, Corna D, Camozzi D et al. How to fully protect the kidney in a severe model of progressive nephropathy: a multidrug approach. J Am Soc Nephrol 2002; 13: 2898-2908
16. Ota T, Takamura T, Ando H et al. Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model. Diabetologia 2003; 46: 843-851
17. Christensen M, Su AW, Snyder RW et al. Simvastatin protection against acute immune-mediated glomerulonephritis in mice. Kidney Int 2006; 69: 457-463
18. Shibata S, Nagase M, Fujita T. Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling. J Am Soc Nephrol 2006; 17: 754-764
19. Whaley-Connell AT, Chowdhury NA, Hayden MR et al. Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat. Am J Physiol Renal Physiol 2006; 291: F1308-F1314
20. Ideura H, Hiromura K, Hiramatsu N et al. Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathy. Am J Physiol Renal Physiol 2007; 293: F1214-F1221
21. Logar CM, Brinkkoetter PT, Krofft RD et al. Darbepoetin alfa protects podocytes from apoptosis in vitro and in vivo. Kidney Int 2007; 72: 489-498
22. Mundel P, Shankland SJ. Podocyte biology and response to injury. J Am Soc Nephrol 2002; 13: 3005-3015
23. Tonolo G, Velussi M, Brocco E et al. Simvastatin maintains steady patterns of GFR and improves AER and expression of slit diaphragm proteins in type II diabetes. Kidney Int 2006; 70: 177-186
24. Nakamura T, Ushiyama C, Hirokawa K et al. Effect of cerivastatin on proteinuria and urinary podocytes in patients with chronic glomerulonephritis. Nephrol Dial Transplant 2002; 17: 798-802
25. Macconi D, Abbate M, Morigi M et al. Permselective dysfunction of podocyte-podocyte contact upon angiotensin II unravels themolecular target for renoprotective intervention. Am J Pathol 2006; 168: 1073-1085
26. Kourliouros A, De Souza A, Roberts N et al. Dose-related effect of statins on atrial fibrillation after cardiac surgery. Ann Thorac Surg 2008; 85: 1515-1520
27. Atta MG, Gallant JE, Rahman MH et al. Antiretroviral therapy in the treatment of HIV-associated nephropathy. Nephrol Dial Transplant 2006; 21: 2809-2813
28. Wei A, Burns GC, Williams BA et al. Long-term renal survival in HIV-associated nephropathy with angiotensin-converting enzyme inhibition. Kidney Int 2003; 64: 1462-1471
29. Eustace JA, Nuermberger E, Choi M et al. Cohort study of the treatment of severe HIV-associated nephropathy with corticosteroids. Kidney Int 2000; 58: 1253-1260