The murine nephrin gene is specifically expressed in kidney, brain and pancreas: Inactivation of the gene leads to massive proteinuria and neonatal death

Human Molecular Genetics

Volumn 10, Issue 1, 2001, Pages 1-8

  Putaala, Heli ^a   Soininen, Raija ^a,c   Kilpeläinen, Pekka ^a   Wartiovaara, Jorma ^b   Tryggvason, Karl ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

NEPHRIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH; BRAIN; BRAIN FOURTH VENTRICLE; CEREBELLUM; CONGENITAL NEPHROTIC SYNDROME; CONTROLLED STUDY; DEATH; EDEMA; ESCHERICHIA COLI; GENE CONSTRUCT; GENE EXPRESSION; GENE FREQUENCY; GENE INACTIVATION; GENE LOCATION; GENE TARGETING; GENETIC RECOMBINATION; GLIA CELL; GLOMERULUS; HIPPOCAMPUS; HOMOZYGOSITY; KIDNEY; KIDNEY TUBULE; MOUSE; NEWBORN; NEWBORN DEATH; NONHUMAN; OLFACTORY BULB; PANCREAS; PODOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEINURIA; REPORTER GENE; SPINAL CORD; STEM CELL;

ANIMALIA; ESCHERICHIA COLI; GLOMERULUS; MURINAE;

EID: 0035164681     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.1.1     Document Type: Article

References (34)

1. Positionally cloned gene for a novel glomerular protein-nephrin is mutated in congenital nephrotic syndrome
2. Nephrin is specifically located at the slit diaphragm of glomerular podocytes
3. Structure of the gene for congenital nephrotic syndrome of the Finnish type (NPHS1) and characterization of mutations
4. Congenital nephrotic syndrome
5. Unravelling the mechanisms of glomerular ultrafiltration: Nephrin, a key component of the slit diaphragm
6. Congenital nephrotic syndrome in mice lacking CD2-associated protein
7. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome
8. The glomerular slit diaphragm is a modified adherens junction
9. Precocious mammary gland development in P-cadherin-deficient mice
10. High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination
11. Mice with an aspartyglucosaminuria mutation similar to humans replicate the pathophysiology in patients
12. Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene
13. Nephrin localizes to the slit pore of the glomerular epithelial cell
14. Differentiation of epithelial foot processes and filtration slits
15. Number of nephrons in normal human kidneys and kidneys of patients with the congenital nephrotic syndrome. A study using a sieving method for counting of glomeruli
16. Renal pathology in congenital nephrotic syndrome of Finnish type: A quantitative light microscopic study on 50 patients
17. Renal pathology of fetuses with congenital nephrotic syndrome of the Finnish type. A qualitative and quantitative light microscopic study
18. Immunofluorescent and morphological studies in congenital nephrotic syndrome
19. The altered glomerular filtration slits seen in puromycin aminonucleoside nephrosis and protamine sulfate-treated rats contain the tight junction protein ZO-1
20. Pathology of fetal congenital nephrosis: Immunohistochemical and ultrastructural studies
21. Prenatal diagnosis of congenital nephrosis in 23 highrisk families
22. Vimentin, the 57 000 molecular weight protein of fibroblast filaments, is the major cytoskeletal component in immature glia
23. Localization of vimentin, the nonspecific intermediate filament protein, in embryonal glia and in early differentiating neurons
24. Nephrin in human nephrogenesis
25. Radial glial cells: Scaffolding for brain construction
26. Central nervous system neuronal migration
27. Mechanisms of neural patterning and specification in the developing cerebellum
28. Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A golgi and electronmicroscopic study in Macacus Rhesus
29. Graft function 5-7 years after renal transplantation in early childhood
30. Glycoproteins that regulate the growth and guidance of vertebrate axons: Domains and dynamics of the immunoglobulin/fibronectin type III subfamily
31. Axonin-1 and NgCAM as 'recognition' components of the pathway sensor apparatus of growth cones: A synopsis
32. The cell adhesion molecule L1: Species- and cell-type-dependent multiple binding mechanisms
33. Gene and enhancer trap screens in ES cell chimeras
34. A beta-1 integrin receptor for fibronectin in human kidney glomeruli