메뉴 건너뛰기




Volumn 349, Issue 1, 2012, Pages 79-85

Stimulating axonal regeneration of mature retinal ganglion cells and overcoming inhibitory signaling

Author keywords

Ciliary neurotrophic factor; Inflammatory stimulation; Leukemia inhibitory factor; Optic nerve regeneration; Taxol

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; CYTOKINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MYELIN; NEUROTROPHIC FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING 3;

EID: 84862762933     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-011-1302-7     Document Type: Review
Times cited : (24)

References (84)
  • 2
    • 0021674552 scopus 로고
    • A quantitative comparison of the reactions of retinal ganglion cells to optic nerve crush in neonatal and adult mice
    • DOI 10.1016/0165-3806(84)90027-0
    • Allcutt D, Berry M, Sievers J (1984) A quantitative comparison of the reactions of retinal ganglion cells to optic nerve crush in neonatal and adult mice. Brain Res 318:219-230 (Pubitemid 15200282)
    • (1984) Developmental Brain Research , vol.16 , Issue.2 , pp. 219-230
    • Allcutt, D.1    Berry, M.2    Sievers, J.3
  • 3
    • 0028310855 scopus 로고
    • Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats
    • Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ (1994) Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci 14:4368-4374 (Pubitemid 24200558)
    • (1994) Journal of Neuroscience , vol.14 , Issue.7 , pp. 4368-4374
    • Berkelaar, M.1    Clarke, D.B.2    Wang, Y.-C.3    Bray, G.M.4    Aguayo, A.J.5
  • 4
    • 0029986963 scopus 로고    scopus 로고
    • Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve
    • Berry M, Carlile J, Hunter A (1996) Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve. J Neurocytol 25:147-170 (Pubitemid 26098922)
    • (1996) Journal of Neurocytology , vol.25 , Issue.2 , pp. 147-170
    • Berry, M.1    Carlile, J.2    Hunter, A.3
  • 6
    • 13944274451 scopus 로고    scopus 로고
    • Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats
    • DOI 10.1523/JNEUROSCI.3931-04.2005
    • Bertrand J, Winton MJ, Rodriguez-Hernandez N, Campenot RB, McKerracher L (2005) Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats. J Neurosci 25:1113-1121 (Pubitemid 40268952)
    • (2005) Journal of Neuroscience , vol.25 , Issue.5 , pp. 1113-1121
    • Bertrand, J.1    Winton, M.J.2    Rodriguez-Hernandez, N.3    Campenot, R.B.4    McKerracher, L.5
  • 7
    • 79959221589 scopus 로고    scopus 로고
    • Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1delta and CK1epsilon
    • Bischof J, Muller A, Fander M, Knippschild U, Fischer D (2011) Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1delta and CK1epsilon. PLoS One 6: e20857
    • (2011) PLoS One , vol.6
    • Bischof, J.1    Muller, A.2    Fander, M.3    Knippschild, U.4    Fischer, D.5
  • 8
    • 68849086666 scopus 로고    scopus 로고
    • Overcoming macrophage-mediated axonal dieback following CNS injury
    • Busch SA, Horn KP, Silver DJ, Silver J (2009) Overcoming macrophage-mediated axonal dieback following CNS injury. J Neurosci 29:9967-9976
    • (2009) J Neurosci , vol.29 , pp. 9967-9976
    • Busch, S.A.1    Horn, K.P.2    Silver, D.J.3    Silver, J.4
  • 9
    • 0034719513 scopus 로고    scopus 로고
    • Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
    • DOI 10.1038/35000219
    • Chen MS, Huber AB, Haar ME van der, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403:434-439 (Pubitemid 30073093)
    • (2000) Nature , vol.403 , Issue.6768 , pp. 434-439
    • Chen, M.S.1    Huber, A.B.2    Van Der, H.M.E.D.3    Frank, M.4    Schnell, L.5    Spillmann, A.A.6    Christ, F.7    Schwab, M.E.8
  • 10
    • 68949201797 scopus 로고    scopus 로고
    • NgR RNA interference, combined with zymosan intravitreal injection, enhances optic nerve regeneration
    • Chen C, Chen X, Yin X, Yuan R, Wang B, Ye J (2009) NgR RNA interference, combined with zymosan intravitreal injection, enhances optic nerve regeneration. J Neurochem 110:1628-1634
    • (2009) J Neurochem , vol.110 , pp. 1628-1634
    • Chen, C.1    Chen, X.2    Yin, X.3    Yuan, R.4    Wang, B.5    Ye, J.6
  • 12
    • 0033216121 scopus 로고    scopus 로고
    • Optic nerve crush: Axonal responses in wild-type and bcl-2 transgenic mice
    • Chierzi S, Strettoi E, Cenni MC, Maffei L (1999) Optic nerve crush: axonal responses in wild-type and bcl-2 transgenic mice. J Neurosci 19:8367-8376 (Pubitemid 30226756)
    • (1999) Journal of Neuroscience , vol.19 , Issue.19 , pp. 8367-8376
    • Chierzi, S.1    Strettoi, E.2    Cenni, M.C.3    Maffei, L.4
  • 13
    • 0034521533 scopus 로고    scopus 로고
    • CNTF promotes the regrowth of retinal ganglion cell axons into murine peripheral nerve grafts
    • Cui Q, Harvey AR (2000) CNTF promotes the regrowth of retinal ganglion cell axons into murine peripheral nerve grafts. Neuroreport 11:3999-4002 (Pubitemid 32038792)
    • (2000) NeuroReport , vol.11 , Issue.18 , pp. 3999-4002
    • Cui, Q.1    Harvey, A.R.2
  • 14
    • 0006535184 scopus 로고    scopus 로고
    • CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters
    • Cui Q, Lu Q, So KF, Yip HK (1999) CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters. Invest Ophthalmol Vis Sci 40:760-766 (Pubitemid 29109456)
    • (1999) Investigative Ophthalmology and Visual Science , vol.40 , Issue.3 , pp. 760-766
    • Cui, Q.1    Lu, Q.2    So, K.-F.3    Yip, H.K.4
  • 15
    • 0036271504 scopus 로고    scopus 로고
    • Expression of trkA, trkB, and trkC in injured and regenerating retinal ganglion cells of adult rats
    • Cui Q, Tang LS, Hu B, So KF, Yip HK (2002) Expression of trkA, trkB, and trkC in injured and regenerating retinal ganglion cells of adult rats. Invest Ophthalmol Vis Sci 43:1954-1964 (Pubitemid 34587047)
    • (2002) Investigative Ophthalmology and Visual Science , vol.43 , Issue.6 , pp. 1954-1964
    • Cui, Q.1    Tang, L.S.2    Hu, B.3    So, K.-F.4    Yip, H.K.5
  • 16
    • 0037285301 scopus 로고    scopus 로고
    • Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons
    • DOI 10.1016/S1044-7431(02)00037-4
    • Cui Q, Yip HK, Zhao RC, So KF, Harvey AR (2003) Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factorinduced regeneration of adult rat retinal ganglion cell axons. Mol Cell Neurosci 22:49-61 (Pubitemid 36269115)
    • (2003) Molecular and Cellular Neuroscience , vol.22 , Issue.1 , pp. 49-61
    • Cui, Q.1    Yip, H.K.2    Zhao, R.C.H.3    So, K.-F.4    Harvey, A.R.5
  • 18
    • 34548165095 scopus 로고    scopus 로고
    • Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration
    • DOI 10.1523/JNEUROSCI.0612-07.2007
    • Erturk A, Hellal F, Enes J, Bradke F (2007) Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration. J Neurosci 27:9169-9180 (Pubitemid 47312058)
    • (2007) Journal of Neuroscience , vol.27 , Issue.34 , pp. 9169-9180
    • Erturk, A.1    Hellal, F.2    Enes, J.3    Bradke, F.4
  • 19
    • 0141499228 scopus 로고    scopus 로고
    • Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
    • Filbin MT (2003) Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat Rev Neurosci 4:703-713
    • (2003) Nat Rev Neurosci , vol.4 , pp. 703-713
    • Filbin, M.T.1
  • 20
    • 44949240448 scopus 로고    scopus 로고
    • CNTF, a key factor mediating the beneficial effects of inflammatory reactions in the eye
    • Fischer D (2008) CNTF, a key factor mediating the beneficial effects of inflammatory reactions in the eye. Brain 131:e97
    • (2008) Brain , vol.131
    • Fischer, D.1
  • 21
    • 75749083357 scopus 로고    scopus 로고
    • What are the principal mediators of optic nerve regeneration after inflammatory stimulation in the eye?
    • Fischer D (2010) What are the principal mediators of optic nerve regeneration after inflammatory stimulation in the eye? Proc Natl Acad Sci USA 107:E8
    • (2010) Proc Natl Acad Sci USA , vol.107
    • Fischer, D.1
  • 22
    • 0033753722 scopus 로고    scopus 로고
    • Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture
    • Fischer D, Pavlidis M, Thanos S (2000) Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture. Invest Ophthalmol Vis Sci 41:3943-3954
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3943-3954
    • Fischer, D.1    Pavlidis, M.2    Thanos, S.3
  • 23
    • 0035690364 scopus 로고    scopus 로고
    • Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats
    • DOI 10.1006/exnr.2001.7822
    • Fischer D, Heiduschka P, Thanos S (2001) Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats. Exp Neurol 172:257-272 (Pubitemid 34075076)
    • (2001) Experimental Neurology , vol.172 , Issue.2 , pp. 257-272
    • Fischer, D.1    Heiduschka, P.2    Thanos, S.3
  • 24
    • 1242341969 scopus 로고    scopus 로고
    • Counteracting the Nogo Receptor Enhances Optic Nerve Regeneration if Retinal Ganglion Cells Are in an Active Growth State
    • DOI 10.1523/JNEUROSCI.5119-03.2004
    • Fischer D, He Z, Benowitz LI (2004a) Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state. J Neurosci 24:1646-1651 (Pubitemid 38240960)
    • (2004) Journal of Neuroscience , vol.24 , Issue.7 , pp. 1646-1651
    • Fischer, D.1    He, Z.2    Benowitz, L.I.3
  • 25
    • 5444270047 scopus 로고    scopus 로고
    • Switching mature retinal ganglion cells to a robust growth state in vivo: Gene expression and synergy with RhoA inactivation
    • DOI 10.1523/JNEUROSCI.2774-04.2004
    • Fischer D, Petkova V, Thanos S, Benowitz LI (2004b) Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation. J Neurosci 24:8726-8740 (Pubitemid 39362968)
    • (2004) Journal of Neuroscience , vol.24 , Issue.40 , pp. 8726-8740
    • Fischer, D.1    Petkova, V.2    Thanos, S.3    Benowitz, L.I.4
  • 26
    • 39649101076 scopus 로고    scopus 로고
    • Crystallins of the beta/gamma-superfamily mimic the effects of lens injury and promote axon regeneration
    • Fischer D, Hauk TG, Muller A, Thanos S (2008) Crystallins of the beta/gamma-superfamily mimic the effects of lens injury and promote axon regeneration. Mol Cell Neurosci 37:471-479
    • (2008) Mol Cell Neurosci , vol.37 , pp. 471-479
    • Fischer, D.1    Hauk, T.G.2    Muller, A.3    Thanos, S.4
  • 27
    • 5344265069 scopus 로고    scopus 로고
    • Intrinsic neuronal regulation of axon and dendrite growth
    • Goldberg JL (2004) Intrinsic neuronal regulation of axon and dendrite growth. Curr Opin Neurobiol 14:551-557
    • (2004) Curr Opin Neurobiol , vol.14 , pp. 551-557
    • Goldberg, J.L.1
  • 28
    • 0037186139 scopus 로고    scopus 로고
    • Retinal ganglion cells do not extend axons by default: Promotion by neurotrophic signaling and electrical activity
    • DOI 10.1016/S0896-6273(02)00602-5
    • Goldberg JL, Espinosa JS, Xu Y, Davidson N, Kovacs GT, Barres BA (2002) Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity. Neuron 33:689-702 (Pubitemid 34219241)
    • (2002) Neuron , vol.33 , Issue.5 , pp. 689-702
    • Goldberg, J.L.1    Espinosa, J.S.2    Xu, Y.3    Davidson, N.4    Kovacs, G.T.A.5    Barres, B.A.6
  • 29
    • 0043127450 scopus 로고    scopus 로고
    • A broad role for melanopsin in nonvisual photoreception
    • Gooley JJ, Lu J, Fischer D, Saper CB (2003) A broad role for melanopsin in nonvisual photoreception. J Neurosci 23:7093-7106 (Pubitemid 36975874)
    • (2003) Journal of Neuroscience , vol.23 , Issue.18 , pp. 7093-7106
    • Gooley, J.J.1    Lu, J.2    Fischer, D.3    Saper, C.B.4
  • 30
    • 0030792971 scopus 로고    scopus 로고
    • Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor
    • Gutman CR, Strittmatter WJ, Weisgraber KH, Matthew WD (1997) Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor. J Neurosci 17:6114-6121 (Pubitemid 27329887)
    • (1997) Journal of Neuroscience , vol.17 , Issue.16 , pp. 6114-6121
    • Gutman, C.R.1    Strittmatter, W.J.2    Weisgraber, K.H.3    Matthew, W.D.4
  • 31
    • 38649110471 scopus 로고    scopus 로고
    • Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages
    • DOI 10.1016/j.expneurol.2007.09.020, PII S0014488607003640
    • Hauk TG, Muller A, Lee J, Schwendener R, Fischer D (2008) Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence oflarge numbers of activated macrophages. Exp Neurol 209:469-482 (Pubitemid 351174139)
    • (2008) Experimental Neurology , vol.209 , Issue.2 , pp. 469-482
    • Hauk, T.G.1    Muller, A.2    Lee, J.3    Schwendener, R.4    Fischer, D.5
  • 32
    • 75749128695 scopus 로고    scopus 로고
    • Intravitreal application of the Toll-like receptor 2 agonist Pam3Cys stimulates axon regeneration in the mature optic nerve
    • Hauk TG, Leibinger M, Müller A, Andreadaki A, Knippschild U, Fischer D (2010) Intravitreal application of the Toll-like receptor 2 agonist Pam3Cys stimulates axon regeneration in the mature optic nerve. Invest Ophthalmol Vis Sci 51: 459-464
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 459-464
    • Hauk, T.G.1    Leibinger, M.2    Müller, A.3    Andreadaki, A.4    Knippschild, U.5    Fischer, D.6
  • 34
    • 83455213993 scopus 로고    scopus 로고
    • Post-injury delivery of rAAV2-CNTF combined with short-term pharmacotherapy is neuroprotective and promotes extensive axonal regeneration after optic nerve trauma
    • in press
    • Hellstrom M, Pollett MA, Harvey AR (2011) Post-injury delivery of rAAV2-CNTF combined with short-term pharmacotherapy is neuroprotective and promotes extensive axonal regeneration after optic nerve trauma. J Neurotrauma (in press)
    • (2011) J Neurotrauma
    • Hellstrom, M.1    Pollett, M.A.2    Harvey, A.R.3
  • 35
    • 56949089831 scopus 로고    scopus 로고
    • Another barrier to regeneration in the CNS: Activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions
    • Horn KP, Busch SA, Hawthorne AL, Rooijen N van, Silver J (2008) Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. J Neurosci 28:9330-9341
    • (2008) J Neurosci , vol.28 , pp. 9330-9341
    • Horn, K.P.1    Busch, S.A.2    Hawthorne, A.L.3    Rooijen, N.4    Van Silver, J.5
  • 36
    • 0036616874 scopus 로고    scopus 로고
    • Bcl-2 Overexpression Does Not Enhance In Vivo Axonal Regeneration of Retinal Ganglion Cells after Peripheral Nerve Transplantation in Adult Mice
    • Inoue T, Hosokawa M, Morigiwa K, Ohashi Y, Fukuda Y (2002) Bcl-2 overexpression does not enhance in vivo axonal regeneration of retinal ganglion cells after peripheral nerve transplantation in adult mice. J Neurosci 22:4468-4477 (Pubitemid 37465663)
    • (2002) Journal of Neuroscience , vol.22 , Issue.11 , pp. 4468-4477
    • Inoue, T.1    Hosokawa, M.2    Morigiwa, K.3    Ohashi, Y.4    Fukuda, Y.5
  • 37
    • 33749410628 scopus 로고    scopus 로고
    • Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons
    • DOI 10.1074/jbc.M602740200
    • Jiang Q, Yan Z, Feng J (2006) Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons. J Biol Chem 281:29391-29400 (Pubitemid 44507082)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.39 , pp. 29391-29400
    • Jiang, Q.1    Yan, Z.2    Feng, J.3
  • 38
    • 0033103498 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells
    • DOI 10.1016/S0306-4522(98)00546-6, PII S0306452298005466
    • Jo SA, Wang E, Benowitz LI (1999) Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells. Neuroscience 89:579-591 (Pubitemid 29044338)
    • (1999) Neuroscience , vol.89 , Issue.2 , pp. 579-591
    • Jo, S.A.1    Wang, E.2    Benowitz, L.I.3
  • 39
    • 0024341956 scopus 로고
    • Electrophysiologic responses in hamster superior colliculus evoked by regenerating retinal axons
    • Keirstead SA, Rasminsky M, Fukuda Y, Carter DA, Aguayo AJ, Vidal-Sanz M (1989) Electrophysiologic responses in hamster superior colliculus evoked by regenerating retinal axons. Science 246:255-257 (Pubitemid 19264640)
    • (1989) Science , vol.246 , Issue.4927 , pp. 255-257
    • Keirstead, S.A.1    Rasminsky, M.2    Fukuda, Y.3    Carter, D.A.4    Aguayo, A.J.5    Vidal-Sanz, M.6
  • 40
    • 0344333441 scopus 로고    scopus 로고
    • Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo
    • Kermer P, Klocker N, Labes M, Bahr M (1998) Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. J Neurosci 18:4656-4662 (Pubitemid 28280174)
    • (1998) Journal of Neuroscience , vol.18 , Issue.12 , pp. 4656-4662
    • Kermer, P.1    Klocker, N.2    Labes, M.3    Bahr, M.4
  • 41
    • 0344759190 scopus 로고    scopus 로고
    • Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo
    • DOI 10.1016/S0014-5793(99)00747-4, PII S0014579399007474
    • Kermer P, Klocker N, Labes M, Thomsen S, Srinivasan A, Bahr M (1999) Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo. FEBS Lett 453:361-364 (Pubitemid 29326679)
    • (1999) FEBS Letters , vol.453 , Issue.3 , pp. 361-364
    • Kermer, P.1    Klocker, N.2    Labes, M.3    Thomsen, S.4    Srinivasan, A.5    Bahr, M.6
  • 42
    • 0032078286 scopus 로고    scopus 로고
    • Effects of GDNF on retinal ganglion cell survival following axotomy
    • DOI 10.1016/S0042-6989(97)00364-7, PII S0042698997003647
    • Koeberle PD, Ball AK (1998) Effects of GDNF on retinal ganglion cell survival following axotomy. Vis Res 38:1505-1515 (Pubitemid 28239269)
    • (1998) Vision Research , vol.38 , Issue.10 , pp. 1505-1515
    • Koeberle, P.D.1    Ball, A.K.2
  • 43
    • 0037139305 scopus 로고    scopus 로고
    • Neurturin enhances the survival of axotomized retinal ganglion cells in vivo: Combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor
    • DOI 10.1016/S0306-4522(01)00557-7, PII S0306452201005577
    • Koeberle PD, Ball AK (2002) Neurturin enhances the survival of axotomized retinal ganglion cells in vivo: combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor. Neuroscience 110:555-567 (Pubitemid 34242782)
    • (2002) Neuroscience , vol.110 , Issue.3 , pp. 555-567
    • Koeberle, P.D.1    Ball, A.K.2
  • 44
    • 78449235139 scopus 로고    scopus 로고
    • Long-distance axon regeneration in the mature optic nerve: Contributions of oncomodulin, cAMP, and PTEN gene deletion
    • Kurimoto T, Yin Y, Omura K, Gilbert HY, Kim D, Cen LP, Moko L, Kugler S, Benowitz LI (2010) Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and PTEN gene deletion. J Neurosci 30:15654-15663
    • (2010) J Neurosci , vol.30 , pp. 15654-15663
    • Kurimoto, T.1    Yin, Y.2    Omura, K.3    Gilbert, H.Y.4    Kim, D.5    Cen, L.P.6    Moko, L.7    Kugler, S.8    Benowitz, L.I.9
  • 45
    • 33845641404 scopus 로고    scopus 로고
    • Cooperative effects of bcl-2 and AAV-mediated expression of CNTF on retinal ganglion cell survival and axonal regeneration in adult transgenic mice
    • DOI 10.1111/j.1460-9568.2006.05230.x
    • Leaver SG, Cui Q, Bernard O, Harvey AR (2006a) Cooperative effects of bcl-2 and AAV-mediated expression of CNTF on retinal ganglion cell survival and axonal regeneration in adult transgenic mice. Eur J Neurosci 24:3323-3332 (Pubitemid 44952599)
    • (2006) European Journal of Neuroscience , vol.24 , Issue.12 , pp. 3323-3332
    • Leaver, S.G.1    Cui, Q.2    Bernard, O.3    Harvey, A.R.4
  • 46
    • 33748299407 scopus 로고    scopus 로고
    • AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells
    • DOI 10.1038/sj.gt.3302791, PII 3302791
    • Leaver SG, Cui Q, Plant GW, Arulpragasam A, Hisheh S, Verhaagen J, Harvey AR (2006b) AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells. Gene Ther 13:1328-1341 (Pubitemid 44323689)
    • (2006) Gene Therapy , vol.13 , Issue.18 , pp. 1328-1341
    • Leaver, S.G.1    Cui, Q.2    Plant, G.W.3    Arulpragasam, A.4    Hisheh, S.5    Verhaagen, J.6    Harvey, A.R.7
  • 47
    • 70449640540 scopus 로고    scopus 로고
    • Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor
    • Leibinger M, Muller A, Andreadaki A, Hauk TG, Kirsch M, Fischer D (2009) Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor. J Neurosci 29:14334-14341
    • (2009) J Neurosci , vol.29 , pp. 14334-14341
    • Leibinger, M.1    Muller, A.2    Andreadaki, A.3    Hauk, T.G.4    Kirsch, M.5    Fischer, D.6
  • 48
    • 84859494283 scopus 로고    scopus 로고
    • MTOR-signaling in neuroprotection and axon regeneration in the mature CNS after inflammatory stimulation
    • doi:10.1016/j.nbd.2012.01.004
    • Leibinger M, Andreadaki A, Fischer D (2012) mTOR-signaling in neuroprotection and axon regeneration in the mature CNS after inflammatory stimulation. Neurobiology of Disease. doi:10.1016/j.nbd.2012.01.004
    • (2012) Neurobiology of Disease
    • Leibinger, M.1    Andreadaki, A.2    Fischer, D.3
  • 49
    • 0034659957 scopus 로고    scopus 로고
    • Lens injury stimulates axon regeneration in the mature rat optic nerve
    • Leon S, Yin Y, Nguyen J, Irwin N, Benowitz LI (2000) Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci 20:4615-4626 (Pubitemid 30396627)
    • (2000) Journal of Neuroscience , vol.20 , Issue.12 , pp. 4615-4626
    • Leon, S.1    Yin, Y.2    Nguyen, J.3    Irwin, N.4    Benowitz, L.I.5
  • 50
    • 0036808209 scopus 로고    scopus 로고
    • Single cell RT-PCR analysis of tyrosine kinase receptor expression in adult rat retinal ganglion cells isolated by retinal sandwiching
    • DOI 10.1016/S1385-299X(02)00184-8, PII S1385299X02001848
    • Lindqvist N, Vidal-Sanz M, Hallbook F (2002) Single cell RT-PCR analysis of tyrosine kinase receptor expression in adult rat retinal ganglion cells isolated by retinal sandwiching. Brain Res Brain Res Protoc 10:75-83 (Pubitemid 35335973)
    • (2002) Brain Research Protocols , vol.10 , Issue.2 , pp. 75-83
    • Lindqvist, N.1    Vidal-Sanz, M.2    Hallbook, F.3
  • 51
    • 2342549194 scopus 로고    scopus 로고
    • GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection
    • DOI 10.1016/j.expneurol.2004.02.002, PII S001448860400055X
    • Lindqvist N, Peinado-Ramonn P, Vidal-Sanz M, Hallbook F (2004) GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection. Exp Neurol 187:487-499 (Pubitemid 38610295)
    • (2004) Experimental Neurology , vol.187 , Issue.2 , pp. 487-499
    • Lindqvist, N.1    Peinado-Ramon, P.2    Vidal-Sanz, M.3    Hallbook, F.4
  • 52
    • 37549015155 scopus 로고    scopus 로고
    • ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells
    • Lingor P, Tonges L, Pieper N, Bermel C, Barski E, Planchamp V, Bahr M (2008) ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells. Brain 131:250-263
    • (2008) Brain , vol.131 , pp. 250-263
    • Lingor, P.1    Tonges, L.2    Pieper, N.3    Bermel, C.4    Barski, E.5    Planchamp, V.6    Bahr, M.7
  • 53
    • 40549095400 scopus 로고    scopus 로고
    • Different factors promote axonal regeneration of adult rat retinal ganglion cells after lens injury and intravitreal peripheral nerve grafting
    • DOI 10.1002/jnr.21545
    • Lorber B, Berry M, Logan A (2008) Different factors promote axonal regeneration of adult rat retinal ganglion cells after lens injury and intravitreal peripheral nerve grafting. J Neurosci Res 86:894-903 (Pubitemid 351357769)
    • (2008) Journal of Neuroscience Research , vol.86 , Issue.4 , pp. 894-903
    • Lorber, B.1    Berry, M.2    Logan, A.3
  • 54
    • 70350640206 scopus 로고    scopus 로고
    • Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein e
    • Lorber B, Berry M, Douglas MR, Nakazawa T, Logan A (2009) Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein E. J Neurosci Res 87:2645-2652
    • (2009) J Neurosci Res , vol.87 , pp. 2645-2652
    • Lorber, B.1    Berry, M.2    Douglas, M.R.3    Nakazawa, T.4    Logan, A.5
  • 55
    • 14044260099 scopus 로고    scopus 로고
    • L gene transfer
    • DOI 10.1016/j.ymthe.2004.11.014, PII S1525001604015631
    • Malik JM, Shevtsova Z, Bahr M, Kugler S (2005) Long-term in vivo inhibition of CNS neurodegeneration by Bcl-XL gene transfer. Mol Ther 11:373-381 (Pubitemid 40277313)
    • (2005) Molecular Therapy , vol.11 , Issue.3 , pp. 373-381
    • Malik, J.M.I.1    Shevtsova, Z.2    Bahr, M.3    Kugler, S.4
  • 56
    • 0028075680 scopus 로고
    • Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth
    • McKerracher L, David S, Jackson DL, Kottis V, Dunn RJ, Braun PE (1994) Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron 13:805-811
    • (1994) Neuron , vol.13 , pp. 805-811
    • McKerracher, L.1    David, S.2    Jackson, D.L.3    Kottis, V.4    Dunn, R.J.5    Braun, P.E.6
  • 57
    • 0027522462 scopus 로고
    • Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo
    • DOI 10.1016/0006-8993(93)90695-J
    • Mey J, Thanos S (1993) Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res 602:304-317 (Pubitemid 23053202)
    • (1993) Brain Research , vol.602 , Issue.2 , pp. 304-317
    • Mey, J.1    Thanos, S.2
  • 58
    • 33845572631 scopus 로고    scopus 로고
    • Immunohistochemical localization of CNTFRalpha in adult mouse retina and optic nerve following intraorbital nerve crush: Evidence for the axonal loss of a trophic factor receptor after injury
    • DOI 10.1002/cne.21174
    • Miotke JA, MacLennan AJ, Meyer RL (2007) Immunohistochemical localization of CNTFRalpha in adult mouse retina and optic nerve following intraorbital nerve crush: evidence for the axonal loss of a trophic factor receptor after injury. J Comp Neurol 500:384-400 (Pubitemid 44937130)
    • (2007) Journal of Comparative Neurology , vol.500 , Issue.2 , pp. 384-400
    • Miotke, J.A.1    MacLennan, A.J.2    Meyer, R.L.3
  • 59
    • 0028060651 scopus 로고
    • A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration
    • DOI 10.1016/0896-6273(94)90042-6
    • Mukhopadhyay G, Doherty P, Walsh FS, Crocker PR, Filbin MT (1994) A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13:757-767 (Pubitemid 24300179)
    • (1994) Neuron , vol.13 , Issue.3 , pp. 757-767
    • Mukhopadhyay, G.1    Doherty, P.2    Walsh, F.S.3    Crocker, P.R.4    Filbin, M.T.5
  • 60
    • 36749004288 scopus 로고    scopus 로고
    • Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation
    • DOI 10.1093/brain/awm257
    • Muller A, Hauk TG, Fischer D (2007) Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation. Brain 130:3308-3320 (Pubitemid 350209074)
    • (2007) Brain , vol.130 , Issue.12 , pp. 3308-3320
    • Muller, A.1    Hauk, T.G.2    Fischer, D.3
  • 61
    • 67349139928 scopus 로고    scopus 로고
    • Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF
    • Muller A, Hauk TG, Leibinger M, Marienfeld R, Fischer D (2009) Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF. Mol Cell Neurosci 41:233-246
    • (2009) Mol Cell Neurosci , vol.41 , pp. 233-246
    • Muller, A.1    Hauk, T.G.2    Leibinger, M.3    Marienfeld, R.4    Fischer, D.5
  • 62
    • 10044292873 scopus 로고    scopus 로고
    • Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells
    • DOI 10.1523/JNEUROSCI.3532-04.2004
    • Park K, Luo JM, Hisheh S, Harvey AR, Cui Q (2004) Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J Neurosci 24:10806-10815 (Pubitemid 39602392)
    • (2004) Journal of Neuroscience , vol.24 , Issue.48 , pp. 10806-10815
    • Park, K.1    Luo, J.-M.2    Hisheh, S.3    Harvey, A.R.4    Cui, Q.5
  • 65
    • 33645046628 scopus 로고    scopus 로고
    • Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo
    • Pernet V, Di Polo A (2006) Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo. Brain 129:1014-1026
    • (2006) Brain , vol.129 , pp. 1014-1026
    • Pernet, V.1    Di Polo, A.2
  • 66
    • 0034212562 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia
    • Peterson WM, Wang Q, Tzekova R, Wiegand SJ (2000) Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia. J Neurosci 20:4081-4090 (Pubitemid 30365678)
    • (2000) Journal of Neuroscience , vol.20 , Issue.11 , pp. 4081-4090
    • Peterson, W.M.1    Wang, Q.2    Tzekova, R.3    Wiegand, S.J.4
  • 68
    • 0344737616 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury
    • DOI 10.1016/S1044-7431(03)00228-8
    • Sapieha PS, Peltier M, Rendahl KG, Manning WC, Di Polo A (2003) Fibroblast growth factor-2 gene delivery stimulates axon growthby adult retinal ganglion cells after acute optic nerve injury. Mol Cell Neurosci 24:656-672 (Pubitemid 37506010)
    • (2003) Molecular and Cellular Neuroscience , vol.24 , Issue.3 , pp. 656-672
    • Sapieha, P.S.1    Peltier, M.2    Rendahl, K.G.3    Manning, W.C.4    Di, P.A.5
  • 69
    • 2942613689 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor and its receptors are differentially expressed in the optic nerve transected adult rat retina
    • DOI 10.1016/j.brainres.2004.03.030, PII S0006899304004615
    • Sarup V, Patil K, Sharma SC (2004) Ciliary neurotrophic factor and its receptors are differentially expressed in the optic nerve transected adult rat retina. Brain Res 1013:152-158 (Pubitemid 38757420)
    • (2004) Brain Research , vol.1013 , Issue.2 , pp. 152-158
    • Sarup, V.1    Patil, K.2    Sharma, S.C.3
  • 70
    • 70349469686 scopus 로고    scopus 로고
    • GM-CSF regulates the ERK1/2 pathways and protects injured retinal ganglion cells from induced death
    • Schallenberg M, Charalambous P, Thanos S (2009) GM-CSF regulates the ERK1/2 pathways and protects injured retinal ganglion cells from induced death. Exp Eye Res 89:665-677
    • (2009) Exp Eye Res , vol.89 , pp. 665-677
    • Schallenberg, M.1    Charalambous, P.2    Thanos, S.3
  • 71
    • 0036460130 scopus 로고    scopus 로고
    • Dose-dependent rescue of axotomized rat retinal ganglion cells by adenovirus-mediated expression of glial cell-line derived neurotrophic factor in vivo
    • DOI 10.1046/j.1460-9568.2002.01893.x
    • Schmeer C, Straten G, Kugler S, Gravel C, Bahr M, Isenmann S (2002) Dose-dependent rescue of axotomized rat retinal ganglion cells by adenovirus-mediated expression of glial cell-line derived neurotrophic factor in vivo. Eur J Neurosci 15:637-643 (Pubitemid 35471932)
    • (2002) European Journal of Neuroscience , vol.15 , Issue.4 , pp. 637-643
    • Schmeer, C.1    Straten, G.2    Kugler, S.3    Gravel, C.4    Bahr, M.5    Isenmann, S.6
  • 72
    • 1342328010 scopus 로고    scopus 로고
    • Nogo and axon regeneration
    • Schwab ME (2004) Nogo and axon regeneration. Curr Opin Neurobiol 14:118-124
    • (2004) Curr Opin Neurobiol , vol.14 , pp. 118-124
    • Schwab, M.E.1
  • 73
    • 79960091227 scopus 로고    scopus 로고
    • Facilitating axon regeneration in the injured CNS by microtubules stabilization
    • Sengottuvel V (2011) Facilitating axon regeneration in the injured CNS by microtubules stabilization. Commun Integr Biol 4:391-393
    • (2011) Commun Integr Biol , vol.4 , pp. 391-393
    • Sengottuvel, V.1
  • 75
  • 77
    • 77956649915 scopus 로고    scopus 로고
    • Neuronal intrinsic barriers for axon regeneration in the adult CNS
    • Sun F, He Z (2010) Neuronal intrinsic barriers for axon regeneration in the adult CNS. Curr Opin Neurobiol 20:510-518
    • (2010) Curr Opin Neurobiol , vol.20 , pp. 510-518
    • Sun, F.1    He, Z.2
  • 78
    • 79955668006 scopus 로고    scopus 로고
    • Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo
    • Tonges L, Ostendorf T, Lamballe F, Genestine M, Dono R, Koch JC, Bahr M, Maina F, Lingor P (2011) Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo. J Neurochem 117:892-903
    • (2011) J Neurochem , vol.117 , pp. 892-903
    • Tonges, L.1    Ostendorf, T.2    Lamballe, F.3    Genestine, M.4    Dono, R.5    Koch, J.C.6    Bahr, M.7    Maina, F.8    Lingor, P.9
  • 79
    • 0023410632 scopus 로고
    • Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat
    • Vidal-Sanz M, Bray GM, Villegas-Perez MP, Thanos S, Aguayo AJ (1987) Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat. J Neurosci 7:2894-2909
    • (1987) J Neurosci , vol.7 , pp. 2894-2909
    • Vidal-Sanz, M.1    Bray, G.M.2    Villegas-Perez, M.P.3    Thanos, S.4    Aguayo, A.J.5
  • 80
    • 0027463379 scopus 로고
    • Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats
    • DOI 10.1002/neu.480240103
    • Villegas-Perez MP, Vidal-Sanz M, Rasminsky M, Bray GM, Aguayo AJ (1993) Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats. J Neurobiol 24:23-36 (Pubitemid 23001493)
    • (1993) Journal of Neurobiology , vol.24 , Issue.1 , pp. 23-36
    • Villegas-Perez, M.-P.1    Vidal-Sanz, M.2    Rasminsky, M.3    Bray, G.M.4    Aguayo, A.J.5
  • 81
    • 0037182860 scopus 로고    scopus 로고
    • Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth
    • DOI 10.1038/nature00867
    • Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z (2002) Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417:941-944 (Pubitemid 34716869)
    • (2002) Nature , vol.417 , Issue.6892 , pp. 941-944
    • Wang, K.C.1    Koprivica, V.2    Kim, J.A.3    Sivasankaran, R.4    Guo, Y.5    Neve, R.L.6    He, Z.7
  • 82
    • 0037710752 scopus 로고    scopus 로고
    • Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo
    • DOI 10.1016/S0969-9961(03)00032-9
    • Weishaupt JH, Diem R, Kermer P, Krajewski S, Reed JC, Bahr M (2003) Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo. Neurobiol Dis 13:124-135 (Pubitemid 36793977)
    • (2003) Neurobiology of Disease , vol.13 , Issue.2 , pp. 124-135
    • Weishaupt, J.H.1    Diem, R.2    Kermer, P.3    Krajewski, S.4    Reed, J.C.5    Bahr, M.6
  • 84
    • 33746308062 scopus 로고    scopus 로고
    • Glial inhibition of CNS axon regeneration
    • DOI 10.1038/nrn1956, PII NRN1956
    • Yiu G, He Z (2006) Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 7:617-627 (Pubitemid 44106744)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.8 , pp. 617-627
    • Yiu, G.1    He, Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.