Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 12, 2000, Pages 3943-3954

  Fischer, D ^a   Pavlidis, M ^a   Thanos, S ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN;

ANIMAL EXPERIMENT; ARTICLE; CATARACTOGENESIS; CELL DEATH; CONTROLLED STUDY; EYE INJURY; FEMALE; LENS DISEASE; MALE; NERVE FIBER REGENERATION; NEURITE; NEUROPROTECTION; NONHUMAN; OPTIC NERVE LESION; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL;

ANIMALS; AXONS; AXOTOMY; BLOTTING, WESTERN; CATARACT; CELL SURVIVAL; EYE INJURIES, PENETRATING; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; LENS, CRYSTALLINE; MALE; NERVE GROWTH FACTORS; NERVE REGENERATION; NEURITES; NEUROPROTECTIVE AGENTS; OPTIC NERVE; RATS; RATS, SPRAGUE-DAWLEY; RETINAL GANGLION CELLS;

EID: 0033753722     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in adult rat
2. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats
3. Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats
4. In vitro regeneration of adult rat ganglion cell axons from retinal explants
5. Survival and axonal elongation of adult rat retinal ganglion cells: In vitro effects of lesioned sciatic nerve and brain derived neurotrophic factor (BDNF)
6. Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells
7. Neurotrophin-4/5 (NT-4/5) increases adult rat retinal ganglion cell survival and neurite outgrowth in vitro
8. Brain-derived neurotrophic factor and neurotrophin-4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells
9. Effect of NGF on the survival of rat retinal ganglion cells following optic nerve section
10. Fibroblast growth factors promotes survival of adult rat ganglion cells after transection of the optic nerve
11. Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo
12. Effects of ocular injury and the administration of brain-derived neurotrophic factor (BDNF) on the survival and regrowth of axotomized retinal ganglion cells
13. Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro
14. CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters
15. In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells
16. Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo
17. Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells
18. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor
19. Multiple growth factors, cytokines and neurotrophins rescue photoreceptors from the damaging effects of constant light
20. Macrophages can modify the non-permissive nature of the adult mammalian central nervous system
21. Injury-induced upregulation of bFGF, CNTF mRNAs in the rat retina
22. The bcl-2 family of proteins, and the regulation of neuronal survival
23. The protooncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
24. bcl-2 Promotes regeneration of severed axons in mammalian CNS
25. Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice
26. The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing bcl-2
27. Optic nerve crush: Axonal responses in wild-type and bcl-2 transgenic mice
28. Inhibition of cell death by lens-specific over-expression of bcl-2 in transgenic mice
29. Patterned expression of BDNF and NT-3 in the retina and anterior segment of the developing mammalian eye
30. Nerve growth factors in chick tissues
31. Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB
32. Brain-derived neurotrophic factor modulates GAP 43 but not T alphal expression in injured retinal ganglion cells in adult rats
33. Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve
34. Two-dimensional gel electrophoresis of human lens epithelium: A study of spatial protein patterns and aging
35. Lens crystallins: Gene recruitment and evolutionary dynamism
36. Transglutaminase involvement in UV-A damage to the eye lens
37. The role of the lens epithelium in development of UV cataract
38. UV-mediated cataractogenesis: A radical perspective
39. Lensectomy and vitrectomy decrease the rate of photoreceptor loss in Rhodopsin P347L transgenic pigs