-
1
-
-
0034708832
-
Te c-jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of ser(307)
-
Aguirre V, Uchida T, Yenush L, Davis R, White MF. (2000). Te c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275:9047-54.
-
(2000)
J Biol Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
2
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
Araki E, Lipes MA, Patti ME, Bruning JC, Haag 3rd B, Johnson RS, Kahn CR. (1994). Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372:186-90.
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.E.3
Bruning, J.C.4
Haag III, B.5
Johnson, R.S.6
Kahn, C.R.7
-
3
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. (2005). IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191-8.
-
(2005)
Nat Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.W.5
Long, J.M.6
Wynshaw-Boris, A.7
Poli, G.8
Olefsky, J.9
Karin, M.10
-
4
-
-
0031919552
-
Insulin signal transduction through protein kinase cascades
-
Avruch J. (1998). Insulin signal transduction through protein kinase cascades. Mol Cell Biochem 182:31-48.
-
(1998)
Mol Cell Biochem
, vol.182
, pp. 31-48
-
-
Avruch, J.1
-
5
-
-
0033695810
-
Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes
-
Bandyopadhyay G, Kanoh Y, Sajan MP, Standaert ML, Farese RV. (2000). Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes. Endocrinology 141:4120-27.
-
(2000)
Endocrinology
, vol.141
, pp. 4120-4127
-
-
Bandyopadhyay, G.1
Kanoh, Y.2
Sajan, M.P.3
Standaert, M.L.4
Farese, R.V.5
-
6
-
-
0036173994
-
PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes
-
Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Lea-Currie R, Sen A, Farese RV. (2002). PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes. J Clin Endocrinol Metab 87:716-23.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 716-723
-
-
Bandyopadhyay, G.1
Sajan, M.P.2
Kanoh, Y.3
Standaert, M.L.4
Quon, M.J.5
Lea-Currie, R.6
Sen, A.7
Farese, R.V.8
-
7
-
-
0033555859
-
Emergent properties of networks of biological signaling pathways
-
Bhalla US, Iyengar R. (1999). Emergent properties of networks of biological signaling pathways. Science 283:381-7.
-
(1999)
Science
, vol.283
, pp. 381-387
-
-
Bhalla, U.S.1
Iyengar, R.2
-
8
-
-
0038515285
-
Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells
-
Borge Jr PD, Wolf BA. (2003). Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells. J Biol Chem 278:11359-68.
-
(2003)
J Biol Chem
, vol.278
, pp. 11359-11368
-
-
Borge Jr., P.D.1
Wolf, B.A.2
-
9
-
-
65649098029
-
Phosphorylation of IRS proteins, insulin action, and insulin resistance
-
Boura-Halfon S, Zick Y. (2009). Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab 296:E581-91.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
Boura-Halfon, S.1
Zick, Y.2
-
10
-
-
33745668478
-
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
-
Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR. (2006). siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab 4:89-96.
-
(2006)
Cell Metab
, vol.4
, pp. 89-96
-
-
Bouzakri, K.1
Zachrisson, A.2
Al-Khalili, L.3
Zhang, B.B.4
Koistinen, H.A.5
Krook, A.6
Zierath, J.R.7
-
11
-
-
79960711294
-
Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
-
Chiu TT, Jensen TE, Sylow L, Richter EA, Klip A. (2011). Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle. Cell Signal 23:1546-54.
-
(2011)
Cell Signal
, vol.23
, pp. 1546-1554
-
-
Chiu, T.T.1
Jensen, T.E.2
Sylow, L.3
Richter, E.A.4
Klip, A.5
-
13
-
-
72649098413
-
Irs1 serine 307 promotes insulin sensitivity in mice
-
Copps KD, Hancer NJ, Opare-Ado L, Qiu W, Walsh C, White MF. (2010). Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab 11:84-92.
-
(2010)
Cell Metab
, vol.11
, pp. 84-92
-
-
Copps, K.D.1
Hancer, N.J.2
Opare-Ado, L.3
Qiu, W.4
Walsh, C.5
White, M.F.6
-
14
-
-
0033846889
-
Insulin induces epidermal growth factor (EGF) receptor clustering and potentiates EGF-stimulated DNA synthesis in swiss 3T3 cells: A mechanism for costimulation in mitogenic synergy
-
Crouch MF, Davy DA, Willard FS, Berven LA. (2000). Insulin induces epidermal growth factor (EGF) receptor clustering and potentiates EGF-stimulated DNA synthesis in Swiss 3T3 cells: a mechanism for costimulation in mitogenic synergy. Immunol Cell Biol 78:408-14.
-
(2000)
Immunol Cell Biol
, vol.78
, pp. 408-414
-
-
Crouch, M.F.1
Davy, D.A.2
Willard, F.S.3
Berven, L.A.4
-
15
-
-
2342428466
-
Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner
-
de Alvaro C, Teruel T, Hernandez R, Lorenzo M. (2004). Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem 279:17070-78.
-
(2004)
J Biol Chem
, vol.279
, pp. 17070-17078
-
-
De Alvaro, C.1
Teruel, T.2
Hernandez, R.3
Lorenzo, M.4
-
16
-
-
3242880193
-
Inhibitor kappaB kinase is involved in the paracrine crosstalk between human fat and muscle cells
-
Dietze D, Ramrath S, Ritzeler O, Tennagels N, Hauner H, Eckel J. (2004). Inhibitor kappaB kinase is involved in the paracrine crosstalk between human fat and muscle cells. Int J Obes Relat Metab Disord 28:985-92.
-
(2004)
Int J Obes Relat Metab Disord
, vol.28
, pp. 985-992
-
-
Dietze, D.1
Ramrath, S.2
Ritzeler, O.3
Tennagels, N.4
Hauner, H.5
Eckel, J.6
-
17
-
-
0033838960
-
Synergistic stimulation of airway smooth muscle cell mitogenesis
-
Ediger TL, Toews ML. (2000). Synergistic stimulation of airway smooth muscle cell mitogenesis. J Pharmacol Exp Ter 294:1076-82.
-
(2000)
J Pharmacol Exp Ter
, vol.294
, pp. 1076-1082
-
-
Ediger, T.L.1
Toews, M.L.2
-
18
-
-
0033956283
-
Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis
-
Fantin VR, Wang Q, Lienhard GE, Keller SR. (2000). Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am J Physiol Endocrinol Metab 278:E127-33.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.278
-
-
Fantin, V.R.1
Wang, Q.2
Lienhard, G.E.3
Keller, S.R.4
-
19
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
-
Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J. (2002). Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem 277:48115-21.
-
(2002)
J Biol Chem
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
Hwang, D.2
Bataille, F.3
Lefevre, M.4
York, D.5
Quon, M.J.6
Ye, J.7
-
20
-
-
0037183974
-
Epidermal growth factor and transforming growth factor alpha mimic the effects of insulin in human fat cells and augment downstream signaling in insulin resistance
-
Gogg S, Smith U. (2002). Epidermal growth factor and transforming growth factor alpha mimic the effects of insulin in human fat cells and augment downstream signaling in insulin resistance. J Biol Chem 277:36045-51.
-
(2002)
J Biol Chem
, vol.277
, pp. 36045-36051
-
-
Gogg, S.1
Smith, U.2
-
21
-
-
63049091804
-
Te phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2
-
Hanke S, Mann M. (2009). Te phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2. Mol Cell Proteomics 8:519-34.
-
(2009)
Mol Cell Proteomics
, vol.8
, pp. 519-534
-
-
Hanke, S.1
Mann, M.2
-
22
-
-
34547102518
-
Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance
-
Herschkovitz A, Liu Y F, Ilan E, Ronen D, Boura-Halfon S, Zick Y. (2007). Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance. J Biol Chem 282:18018-27.
-
(2007)
J Biol Chem
, vol.282
, pp. 18018-18027
-
-
Herschkovitz, A.1
Liu, Y.F.2
Ilan, E.3
Ronen, D.4
Boura-Halfon, S.5
Zick, Y.6
-
23
-
-
42649127400
-
IRS1-independent defects define major nodes of insulin resistance
-
Hoehn KL, Hohnen-Behrens C, Cederberg A, Wu LE, Turner N, Yuasa T, Ebina Y, James DE. (2008). IRS1-independent defects define major nodes of insulin resistance. Cell Metab 7:421-33.
-
(2008)
Cell Metab
, vol.7
, pp. 421-433
-
-
Hoehn, K.L.1
Hohnen-Behrens, C.2
Cederberg, A.3
Wu, L.E.4
Turner, N.5
Yuasa, T.6
Ebina, Y.7
James, D.E.8
-
24
-
-
0028931724
-
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
-
Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. (1995). Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95:2409-15.
-
(1995)
J Clin Invest
, vol.95
, pp. 2409-2415
-
-
Hotamisligil, G.S.1
Arner, P.2
Caro, J.F.3
Atkinson, R.L.4
Spiegelman, B.M.5
-
25
-
-
0028587742
-
Tumor necrosis factor alpha: A key component of the obesity-diabetes link
-
Hotamisligil GS, Spiegelman BM. (1994). Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 43: 1271-8.
-
(1994)
Diabetes
, vol.43
, pp. 1271-1278
-
-
Hotamisligil, G.S.1
Spiegelman, B.M.2
-
26
-
-
21444460644
-
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes
-
Huang C, Tirone AC, Huang X, Klip A. (2005). Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes. J Biol Chem 280:19426-35.
-
(2005)
J Biol Chem
, vol.280
, pp. 19426-19435
-
-
Huang, C.1
Tirone, A.C.2
Huang, X.3
Klip, A.4
-
27
-
-
0030851268
-
Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor
-
Ish-Shalom D, Christoffersen CT, Vorwerk P, Sacerdoti-Sierra N, Shymko RM, Naor D, De Meyts P. (1997). Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor. Diabetologia 40 Suppl 2:S25-31.
-
(1997)
Diabetologia
, vol.40
, Issue.SUPPL. 2
-
-
Ish-Shalom, D.1
Christoffersen, C.T.2
Vorwerk, P.3
Sacerdoti-Sierra, N.4
Shymko, R.M.5
Naor, D.6
De Meyts, P.7
-
28
-
-
0028114186
-
Epidermal growth factor triggers the translocation of insulin-responsive glucose transporter (GLUT4)
-
Ishii K, Kamohara S, Hayashi H, Todaka M, Kanai F, Imanaka T, Ebina Y. (1994). Epidermal growth factor triggers the translocation of insulin-responsive glucose transporter (GLUT4). Biochem Biophys Res Commun 205:857-63.
-
(1994)
Biochem Biophys Res Commun
, vol.205
, pp. 857-863
-
-
Ishii, K.1
Kamohara, S.2
Hayashi, H.3
Todaka, M.4
Kanai, F.5
Imanaka, T.6
Ebina, Y.7
-
29
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
Kahn SE, Hull RL, Utzschneider KM. (2006). Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840-46.
-
(2006)
Nature
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
30
-
-
72449170135
-
O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs
-
Klein AL, Berkaw MN, Buse MG, Ball LE. (2009). O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs. Mol Cell Proteomics 8:2733-45.
-
(2009)
Mol Cell Proteomics
, vol.8
, pp. 2733-2745
-
-
Klein, A.L.1
Berkaw, M.N.2
Buse, M.G.3
Ball, L.E.4
-
31
-
-
2542418816
-
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo
-
Kotzka J, Lehr S, Roth G, Avci H, Knebel B, Muller-Wieland D. (2004). Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding Protein-2 at serine residues 432 and 455 in vivo. J Biol Chem 279: 22404-11.
-
(2004)
J Biol Chem
, vol.279
, pp. 22404-22411
-
-
Kotzka, J.1
Lehr, S.2
Roth, G.3
Avci, H.4
Knebel, B.5
Muller-Wieland, D.6
-
32
-
-
79953178205
-
Te giant protein titin: A regulatory node that integrates myocyte signaling pathways
-
Kruger M, Linke WA. (2011). Te giant protein titin: a regulatory node that integrates myocyte signaling pathways. J Biol Chem 286:9905-12.
-
(2011)
J Biol Chem
, vol.286
, pp. 9905-9912
-
-
Kruger, M.1
Linke, W.A.2
-
33
-
-
0033755408
-
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
-
Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H et al. (2000). Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 49:1880-89.
-
(2000)
Diabetes
, vol.49
, pp. 1880-1889
-
-
Kubota, N.1
Tobe, K.2
Terauchi, Y.3
Eto, K.4
Yamauchi, T.5
Suzuki, R.6
Tsubamoto, Y.7
Komeda, K.8
Nakano, R.9
Miki, H.10
-
34
-
-
84856071074
-
Identification and validation of novel adipokines released from primary human adipocytes
-
Lehr S, Hartwig S, Lamers D, Famulla S, Muller S, Hanisch FG, Cuvelier C, Ruige J, Eckardt K, Ouwens DM et al. (2012). Identification and validation of novel adipokines released from primary human adipocytes. Mol Cell Proteomics 11:1-13.
-
(2012)
Mol Cell Proteomics
, vol.11
, pp. 1-13
-
-
Lehr, S.1
Hartwig, S.2
Lamers, D.3
Famulla, S.4
Muller, S.5
Hanisch, F.G.6
Cuvelier, C.7
Ruige, J.8
Eckardt, K.9
Ouwens, D.M.10
-
35
-
-
77953896432
-
Cell signaling by receptor tyrosine kinases
-
Lemmon MA, Schlessinger J. (2010). Cell signaling by receptor tyrosine kinases. Cell 141:1117-34.
-
(2010)
Cell
, vol.141
, pp. 1117-1134
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
36
-
-
0033581023
-
Insulin receptor substrate 3 is not essential for growth or glucose homeostasis
-
Liu SC, Wang Q, Lienhard GE, Keller SR. (1999). Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. J Biol Chem 274:18093-9.
-
(1999)
J Biol Chem
, vol.274
, pp. 18093-18099
-
-
Liu, S.C.1
Wang, Q.2
Lienhard, G.E.3
Keller, S.R.4
-
37
-
-
33646168160
-
Lipid droplets: A unified view of a dynamic organelle
-
Martin S, Parton RG. (2006). Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7:373-8.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 373-378
-
-
Martin, S.1
Parton, R.G.2
-
38
-
-
84858299087
-
Lowering physical activity impairs glycemic control in healthy volunteers
-
Mikus CR, Oberlin DJ, Libla JL, Taylor AM, Booth FW, Tyfault JP. (2011). Lowering Physical Activity Impairs Glycemic Control in Healthy Volunteers. Med Sci Sports Exerc 44:225-31.
-
(2011)
Med Sci Sports Exerc
, vol.44
, pp. 225-231
-
-
Mikus, C.R.1
Oberlin, D.J.2
Libla, J.L.3
Taylor, A.M.4
Booth, F.W.5
Tyfault, J.P.6
-
39
-
-
0142247618
-
Te muscle ankyrin repeat proteins: Carp, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules
-
Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K, Granzier H, McElhinny AS, Gregorio CC, Labeit S. (2003). Te muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol 333:951-64.
-
(2003)
J Mol Biol
, vol.333
, pp. 951-964
-
-
Miller, M.K.1
Bang, M.L.2
Witt, C.C.3
Labeit, D.4
Trombitas, C.5
Watanabe, K.6
Granzier, H.7
McElhinny, A.S.8
Gregorio, C.C.9
Labeit, S.10
-
40
-
-
9644268058
-
Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis
-
Mohanty S, Spinas GA, Maedler K, Zuellig RA, Lehmann R, Donath MY, Trub T, Niessen M. (2005). Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis. Exp Cell Res 303:68-78.
-
(2005)
Exp Cell Res
, vol.303
, pp. 68-78
-
-
Mohanty, S.1
Spinas, G.A.2
Maedler, K.3
Zuellig, R.A.4
Lehmann, R.5
Donath, M.Y.6
Trub, T.7
Niessen, M.8
-
41
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS. (2004). Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-61.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
43
-
-
0035145978
-
Insulin receptor - Structural and functional characteristics
-
Perz M, Torlinska T. (2001). Insulin receptor - structural and functional characteristics. Med Sci Monit 7:169-77.
-
(2001)
Med Sci Monit
, vol.7
, pp. 169-177
-
-
Perz, M.1
Torlinska, T.2
-
45
-
-
33646429745
-
Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors
-
Roberts CK, Won D, Pruthi S, Kurtovic S, Sindhu RK, Vaziri ND, Barnard RJ. (2006). Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors. J Appl Physiol 100:1657-65.
-
(2006)
J Appl Physiol
, vol.100
, pp. 1657-1665
-
-
Roberts, C.K.1
Won, D.2
Pruthi, S.3
Kurtovic, S.4
Sindhu, R.K.5
Vaziri, N.D.6
Barnard, R.J.7
-
46
-
-
0034721772
-
MAP kinases erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro
-
Roth G, Kotzka J, Kremer L, Lehr S, Lohaus C, Meyer HE, Krone W, Muller-Wieland D. (2000). MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro. J Biol Chem 275:33302-7.
-
(2000)
J Biol Chem
, vol.275
, pp. 33302-33307
-
-
Roth, G.1
Kotzka, J.2
Kremer, L.3
Lehr, S.4
Lohaus, C.5
Meyer, H.E.6
Krone, W.7
Muller-Wieland, D.8
-
47
-
-
1942424955
-
Targets for TNF-alpha-induced lipolysis in human adipocytes
-
Ryden M, Arvidsson E, Blomqvist L, Perbeck L, Dicker A, Arner P. (2004). Targets for TNF-alpha-induced lipolysis in human adipocytes. Biochem Biophys Res Commun 318:168-75.
-
(2004)
Biochem Biophys Res Commun
, vol.318
, pp. 168-175
-
-
Ryden, M.1
Arvidsson, E.2
Blomqvist, L.3
Perbeck, L.4
Dicker, A.5
Arner, P.6
-
48
-
-
78751494530
-
Te portal theory supported by venous drainage-selective fat transplantation
-
Rytka JM, Wueest S, Schoenle EJ, Konrad D. (2011). Te portal theory supported by venous drainage-selective fat transplantation. Diabetes 60:56-63.
-
(2011)
Diabetes
, vol.60
, pp. 56-63
-
-
Rytka, J.M.1
Wueest, S.2
Schoenle, E.J.3
Konrad, D.4
-
49
-
-
73549091444
-
Role of muscle c-jun NH2-terminal kinase 1 in obesity-induced insulin resistance
-
Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ. (2010). Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol 30:106-15.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 106-115
-
-
Sabio, G.1
Kennedy, N.J.2
Cavanagh-Kyros, J.3
Jung, D.Y.4
Ko, H.J.5
Ong, H.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
50
-
-
33745198007
-
Repletion of atypical protein kinase C following RNA interference- mediated depletion restores insulin-stimulated glucose transport
-
Sajan MP, Rivas J, Li P, Standaert ML, Farese R V. (2006). Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport. J Biol Chem 281:17466-73.
-
(2006)
J Biol Chem
, vol.281
, pp. 17466-17473
-
-
Sajan, M.P.1
Rivas, J.2
Li, P.3
Standaert, M.L.4
Farese, R.V.5
-
51
-
-
77954348590
-
Adipose tissue inflammation: Novel insight into the role of macrophages and lymphocytes
-
Sell H, Eckel J. (2010). Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes. Curr Opin Clin Nutr Metab Care 13:366-70.
-
(2010)
Curr Opin Clin Nutr Metab Care
, vol.13
, pp. 366-370
-
-
Sell, H.1
Eckel, J.2
-
52
-
-
0346880505
-
Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance
-
Shoelson SE, Lee J, Yuan M. (2003). Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord 27 Suppl 3:S49-52.
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, Issue.SUPPL. 3
-
-
Shoelson, S.E.1
Lee, J.2
Yuan, M.3
-
53
-
-
79961004321
-
Signalling by insulin and IGF receptors: Supporting acts and new players
-
Siddle K. (2011). Signalling by insulin and IGF receptors: supporting acts and new players. J Mol Endocrinol 47:R1-10.
-
(2011)
J Mol Endocrinol
, vol.47
-
-
Siddle, K.1
-
54
-
-
0028032894
-
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
-
Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S et al. (1994). Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372:182-6.
-
(1994)
Nature
, vol.372
, pp. 182-186
-
-
Tamemoto, H.1
Kadowaki, T.2
Tobe, K.3
Yagi, T.4
Sakura, H.5
Hayakawa, T.6
Terauchi, Y.7
Ueki, K.8
Kaburagi, Y.9
Satoh, S.10
-
55
-
-
33244464562
-
Critical nodes in signalling pathways: Insights into insulin action
-
Taniguchi CM, Emanuelli B, Kahn CR. (2006). Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85-96.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 85-96
-
-
Taniguchi, C.M.1
Emanuelli, B.2
Kahn, C.R.3
-
56
-
-
14644426519
-
Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism
-
Taniguchi CM, Ueki K, Kahn R. (2005). Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. J Clin Invest 115:718-27.
-
(2005)
J Clin Invest
, vol.115
, pp. 718-727
-
-
Taniguchi, C.M.1
Ueki, K.2
Kahn, R.3
-
57
-
-
33644514920
-
Tissue-specific roles of IRS proteins in insulin signaling and glucose transport
-
Tirone AC, Huang C, Klip A. (2006). Tissue-specific roles of IRS proteins in insulin signaling and glucose transport. Trends Endocrinol Metab 17:72-8.
-
(2006)
Trends Endocrinol Metab
, vol.17
, pp. 72-78
-
-
Tirone, A.C.1
Huang, C.2
Klip, A.3
-
58
-
-
79953684026
-
Secreted proteins from adipose tissue and skeletal muscle - Adipokines, myokines and adipose/muscle cross-talk
-
Trayhurn P, Drevon CA, Eckel J. (2011). Secreted proteins from adipose tissue and skeletal muscle - adipokines, myokines and adipose/muscle cross-talk. Arch Physiol Biochem 117:47-56.
-
(2011)
Arch Physiol Biochem
, vol.117
, pp. 47-56
-
-
Trayhurn, P.1
Drevon, C.A.2
Eckel, J.3
-
59
-
-
76149094848
-
Insulin receptor substrates-5 and -6 are poor substrates for the insulin receptor
-
Versteyhe S, Blanquart C, Hampe C, Mahmood S, Christeff N, De Meyts P, Gray SG, Issad T. (2010). Insulin receptor substrates-5 and -6 are poor substrates for the insulin receptor. Mol Med Report 3:189-93.
-
(2010)
Mol Med Report
, vol.3
, pp. 189-193
-
-
Versteyhe, S.1
Blanquart, C.2
Hampe, C.3
Mahmood, S.4
Christeff, N.5
De Meyts, P.6
Gray, S.G.7
Issad, T.8
-
60
-
-
77950642292
-
Networking with AKAPs: Context-dependent regulation of anchored enzymes
-
Welch EJ, Jones BW, Scott JD. (2010). Networking with AKAPs: context-dependent regulation of anchored enzymes. Mol Interv 10:86-97.
-
(2010)
Mol Interv
, vol.10
, pp. 86-97
-
-
Welch, E.J.1
Jones, B.W.2
Scott, J.D.3
-
61
-
-
0030748457
-
Te insulin signalling system and the IRS proteins
-
White MF. (1997). Te insulin signalling system and the IRS proteins. Diabetologia 40:S2-17.
-
(1997)
Diabetologia
, vol.40
-
-
White, M.F.1
-
63
-
-
0035958981
-
Te role of ca2+ in insulin-stimulated glucose transport in 3T3-L1 cells
-
Whitehead JP, Molero JC, Clark S, Martin S, Meneilly G, James DE. (2001). Te role of Ca2+ in insulin-stimulated glucose transport in 3T3-L1 cells. J Biol Chem 276:27816-24.
-
(2001)
J Biol Chem
, vol.276
, pp. 27816-27824
-
-
Whitehead, J.P.1
Molero, J.C.2
Clark, S.3
Martin, S.4
Meneilly, G.5
James, D.E.6
-
64
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI et al. (1998). Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391:900-904.
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.M.5
Previs, S.6
Zhang, Y.7
Bernal, D.8
Pons, S.9
Shulman, G.I.10
-
65
-
-
77955024822
-
ER stress in adipocytes inhibits insulin signaling, represses lipolysis, and alters the secretion of adipokines without inhibiting glucose transport
-
Xu L, Spinas GA, Niessen M. (2010). ER stress in adipocytes inhibits insulin signaling, represses lipolysis, and alters the secretion of adipokines without inhibiting glucose transport. Horm Metab Res 42:643-51.
-
(2010)
Horm Metab Res
, vol.42
, pp. 643-651
-
-
Xu, L.1
Spinas, G.A.2
Niessen, M.3
-
66
-
-
0031171216
-
Te IRS-signalling system during insulin and cytokine action
-
Yenush L, White MF. (1997). Te IRS-signalling system during insulin and cytokine action. Bioessays 19:491-500.
-
(1997)
Bioessays
, vol.19
, pp. 491-500
-
-
Yenush, L.1
White, M.F.2
-
67
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of ikkbeta
-
Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. (2001). Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293:1673-7.
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
Karin, M.6
Shoelson, S.E.7
-
68
-
-
75149145088
-
Filamins in cell signaling, transcription and organ development
-
Zhou AX, Hartwig JH, Akyurek LM. (2010). Filamins in cell signaling, transcription and organ development. Trends Cell Biol 20: 113-23.
-
(2010)
Trends Cell Biol
, vol.20
, pp. 113-123
-
-
Zhou, A.X.1
Hartwig, J.H.2
Akyurek, L.M.3
|