Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-λ on insulin-stimulated glucose transport in L6 myotubes

Endocrinology

Volumn 141, Issue 11, 2000, Pages 4120-4127

  Bandyopadhyay, G ^a   Kanoh, Y ^a   Sajan, M P ^a   Standaert, M L ^a   Farese, R V ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGLUCOSE; GLUCOSE TRANSPORTER; INSULIN; PROTEIN KINASE C;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; GENE TRANSFER; GLUCOSE TRANSPORT; HORMONAL REGULATION; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0033695810     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.11.7766     Document Type: Article

References (18)

1. Activation of protein kinase C (α, β, and ζ) by insulin m 3T3/L1 cells. Transfection studies suggest a role for PKC-ζ in glucose transport
2. Evidence for involvement of protein kinase C (PKC)-ζ and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes
3. Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport
4. Effects of transiently expressed atypical (ζ, λ), conventional (α, β) and novel (δ, ε) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: Specific interchangeable effects of protein kinases C-ζ and C-λ
5. Expression of a constitutively active Akt Ser/Thr kinase in 3T3/L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
6. Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes
7. Physiologic role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells
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12. Insulin activates protein kinases C-ζ and C-λ by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes
13. A new member of the third class in the protein kinase C family, PKCλ, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells
14. Dependence of insulin-stimulated glucose transporter 4 translocation on 3-phosphoinositide-dependent protein kinase-1 and its target threonine-410 in the activation loop of protein kinase C-ζ
15. Protein kinase Cζ is a negative regulator of protein kinase B activity
16. An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes
17. Identification of wortmannin-sensitive targets in 3T3-L1 adipocytes. Dissociation of insulin-stimulated glucose uptake and GLUT4 translocation
18. In vivo adenoviral delivery of recombinant human protein kinase C-ζ stimulates glucose transport activity in rat skeletal muscle