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Volumn 3, Issue 2, 2012, Pages 117-136

Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies

Author keywords

Epithelial mesenchymal transition; Metastasis; Prevention; Therapy; Tumor microenvironment

Indexed keywords

FRIZZLED PROTEIN; MICRORNA; NOTCH RECEPTOR; SECRETED FRIZZLED RELATED PROTEIN 5; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD7 PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; TRANSCRIPTION FACTOR ZEB2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN; WNT PROTEIN;

EID: 84862495767     PISSN: None     EISSN: 21524114     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (164)

References (107)
  • 1
    • 67649528138 scopus 로고    scopus 로고
    • Collective cell migration in morphogenesis, regeneration and cancer
    • Friedl P and Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 2009; 10: 445-457.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 445-457
    • Friedl, P.1    Gilmour, D.2
  • 2
    • 0019999977 scopus 로고
    • Interaction of embryonic surface and cytoskeleton with extracellular matrix
    • Hay ED. Interaction of embryonic surface and cytoskeleton with extracellular matrix. Am J Anat 1982; 165: 1-12.
    • (1982) Am J Anat , vol.165 , pp. 1-12
    • Hay, E.D.1
  • 3
    • 77954860342 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression
    • Micalizzi DS, Farabaugh SM and Ford HL. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 2010; 15: 117-134.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 117-134
    • Micalizzi, D.S.1    Farabaugh, S.M.2    Ford, H.L.3
  • 4
    • 42149114501 scopus 로고    scopus 로고
    • Crosstalk between tumor cells and microenvironment via Wnt pathway in colorectal cancer dissemination
    • Huang D and Du X. Crosstalk between tumor cells and microenvironment via Wnt pathway in colorectal cancer dissemination. World J Gastroenterol 2008; 14: 1823-1827.
    • (2008) World J Gastroenterol , vol.14 , pp. 1823-1827
    • Huang, D.1    Du, X.2
  • 5
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human disease
    • Blobe GC, Schiemann WP and Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000; 342: 1350-1358.
    • (2000) N Engl J Med , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 6
    • 78649982907 scopus 로고    scopus 로고
    • The dynamic roles of TGF-beta in cancer
    • Meulmeester E and Ten Dijke P. The dynamic roles of TGF-beta in cancer. J Pathol 2011; 223: 205-218.
    • (2011) J Pathol , vol.223 , pp. 205-218
    • Meulmeester, E.1    Ten Dijke, P.2
  • 7
    • 84857119664 scopus 로고    scopus 로고
    • Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer progression
    • Wendt MK, Tian M and Schiemann WP. Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer progression. Cell Tissue Res 2012; 347: 85-101.
    • (2012) Cell Tissue Res , vol.347 , pp. 85-101
    • Wendt, M.K.1    Tian, M.2    Schiemann, W.P.3
  • 9
    • 79952706985 scopus 로고    scopus 로고
    • Transforming growth factor-beta and the hallmarks of cancer
    • Tian M, Neil JR and Schiemann WP. Transforming growth factor-beta and the hallmarks of cancer. Cell Signal 2011; 23: 951-962.
    • (2011) Cell Signal , vol.23 , pp. 951-962
    • Tian, M.1    Neil, J.R.2    Schiemann, W.P.3
  • 10
    • 30944444113 scopus 로고    scopus 로고
    • Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
    • Levy L and Hill CS. Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev 2006; 17: 41-58.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 41-58
    • Levy, L.1    Hill, C.S.2
  • 12
    • 0038324070 scopus 로고    scopus 로고
    • Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
    • Postigo AA, Depp JL, Taylor JJ and Kroll KL. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J 2003; 22: 2453-2462.
    • (2003) EMBO J , vol.22 , pp. 2453-2462
    • Postigo, A.A.1    Depp, J.L.2    Taylor, J.J.3    Kroll, K.L.4
  • 13
    • 0028603343 scopus 로고
    • TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
    • Miettinen PJ, Ebner R, Lopez AR and Derynck R. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 1994; 127: 2021-2036.
    • (1994) J Cell Biol , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3    Derynck, R.4
  • 14
    • 59449090107 scopus 로고    scopus 로고
    • TGF-betainduced epithelial to mesenchymal transition
    • Xu J, Lamouille S and Derynck R. TGF-betainduced epithelial to mesenchymal transition. Cell Res 2009; 19: 156-172.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 15
    • 0026009094 scopus 로고
    • Twist and snail as positive and negative regulators during Drosophila mesoderm development
    • Leptin M. twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev 1991; 5: 1568-1576.
    • (1991) Genes Dev , vol.5 , pp. 1568-1576
    • Leptin, M.1
  • 18
    • 77954167982 scopus 로고    scopus 로고
    • Transcriptional crosstalk between TGF-beta and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes
    • Fuxe J, Vincent T and Garcia de Herreros A. Transcriptional crosstalk between TGF-beta and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes. Cell Cycle 2010; 9: 2363-2374.
    • (2010) Cell Cycle , vol.9 , pp. 2363-2374
    • Fuxe, J.1    Vincent, T.2    de Herreros, A.G.3
  • 19
    • 84855999650 scopus 로고    scopus 로고
    • E/N-cadherin switch mediates cancer progression via TGF-beta-induced epithelial-tomesenchymal transition in extrahepatic cholangiocarcinoma
    • Araki K, Shimura T, Suzuki H, Tsutsumi S, Wada W, Yajima T, Kobayahi T, Kubo N and Kuwano H. E/N-cadherin switch mediates cancer progression via TGF-beta-induced epithelial-tomesenchymal transition in extrahepatic cholangiocarcinoma. Br J Cancer 2011; 105: 1885-1893.
    • (2011) Br J Cancer , vol.105 , pp. 1885-1893
    • Araki, K.1    Shimura, T.2    Suzuki, H.3    Tsutsumi, S.4    Wada, W.5    Yajima, T.6    Kobayahi, T.7    Kubo, N.8    Kuwano, H.9
  • 20
    • 34248185926 scopus 로고    scopus 로고
    • Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression
    • Biswas S, Guix M, Rinehart C, Dugger TC, Chytil A, Moses HL, Freeman ML and Arteaga CL. Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J Clin Invest 2007; 117: 1305-1313.
    • (2007) J Clin Invest , vol.117 , pp. 1305-1313
    • Biswas, S.1    Guix, M.2    Rinehart, C.3    Dugger, T.C.4    Chytil, A.5    Moses, H.L.6    Freeman, M.L.7    Arteaga, C.L.8
  • 22
    • 33751073938 scopus 로고    scopus 로고
    • Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades
    • Katoh M. Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. Cancer Biol Ther 2006; 5: 1059-1064.
    • (2006) Cancer Biol Ther , vol.5 , pp. 1059-1064
    • Katoh, M.1
  • 23
    • 42549096546 scopus 로고    scopus 로고
    • Beyond Wnt inhibition: New functions of secreted Frizzled-related proteins in development and disease
    • Bovolenta P, Esteve P, Ruiz JM, Cisneros E and Lopez-Rios J. Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci 2008; 121: 737-746.
    • (2008) J Cell Sci , vol.121 , pp. 737-746
    • Bovolenta, P.1    Esteve, P.2    Ruiz, J.M.3    Cisneros, E.4    Lopez-Rios, J.5
  • 25
    • 79551681371 scopus 로고    scopus 로고
    • SFRP1 reduction results in an increased sensitivity to TGF-beta signaling
    • Gauger KJ, Chenausky KL, Murray ME and Schneider SS. SFRP1 reduction results in an increased sensitivity to TGF-beta signaling. BMC Cancer 2011; 11: 59.
    • (2011) BMC Cancer , vol.11 , pp. 59
    • Gauger, K.J.1    Chenausky, K.L.2    Murray, M.E.3    Schneider, S.S.4
  • 26
    • 66749092153 scopus 로고    scopus 로고
    • Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis
    • Gauger KJ, Hugh JM, Troester MA and Schneider SS. Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis. Cancer Cell Int 2009; 9: 11.
    • (2009) Cancer Cell Int , vol.9 , pp. 11
    • Gauger, K.J.1    Hugh, J.M.2    Troester, M.A.3    Schneider, S.S.4
  • 28
    • 79960554597 scopus 로고    scopus 로고
    • Rad6B acts downstream of Wnt signaling to stabilize beta-catenin: Implications for a novel Wnt/beta-catenin target
    • Gerard B, Tait L, Nangia-Makker P and Shekhar MP. Rad6B acts downstream of Wnt signaling to stabilize beta-catenin: Implications for a novel Wnt/beta-catenin target. J Mol Signal 2011; 6: 6.
    • (2011) J Mol Signal , vol.6 , pp. 6
    • Gerard, B.1    Tait, L.2    Nangia-Makker, P.3    Shekhar, M.P.4
  • 29
    • 77957862980 scopus 로고    scopus 로고
    • Involvement of the Wnt-beta-catenin pathway in invasion and migration of oral squamous carcinoma cells
    • Iwai S, Yonekawa A, Harada C, Hamada M, Katagiri W, Nakazawa M and Yura Y. Involvement of the Wnt-beta-catenin pathway in invasion and migration of oral squamous carcinoma cells. Int J Oncol 2010; 37: 1095-1103.
    • (2010) Int J Oncol , vol.37 , pp. 1095-1103
    • Iwai, S.1    Yonekawa, A.2    Harada, C.3    Hamada, M.4    Katagiri, W.5    Nakazawa, M.6    Yura, Y.7
  • 30
    • 77955457024 scopus 로고    scopus 로고
    • Stromelysin-1 (MMP- 3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT)
    • Blavier L, Lazaryev A, Shi XH, Dorey FJ, Shackleford GM and DeClerck YA. Stromelysin-1 (MMP- 3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Can cer Biol Ther 2010; 10: 198-208.
    • (2010) Can Cer Biol Ther , vol.10 , pp. 198-208
    • Blavier, L.1    Lazaryev, A.2    Shi, X.H.3    Dorey, F.J.4    Shackleford, G.M.5    Declerck, Y.A.6
  • 31
    • 85027953706 scopus 로고    scopus 로고
    • MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma
    • Zhai Y, Iura A, Yeasmin S, Wiese AB, Wu R, Feng Y, Fearon ER and Cho KR. MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma. Oncogene 2011; 30: 4152-4162.
    • (2011) Oncogene , vol.30 , pp. 4152-4162
    • Zhai, Y.1    Iura, A.2    Yeasmin, S.3    Wiese, A.B.4    Wu, R.5    Feng, Y.6    Fearon, E.R.7    Cho, K.R.8
  • 32
    • 70349784071 scopus 로고    scopus 로고
    • Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast
    • Prasad CP, Rath G, Mathur S, Bhatnagar D, Parshad R and Ralhan R. Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast. BMC Cancer 2009; 9: 325.
    • (2009) BMC Cancer , vol.9 , pp. 325
    • Prasad, C.P.1    Rath, G.2    Mathur, S.3    Bhatnagar, D.4    Parshad, R.5    Ralhan, R.6
  • 34
    • 77953695990 scopus 로고    scopus 로고
    • The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
    • Yee DS, Tang Y, Li X, Liu Z, Guo Y, Ghaffar S, McQueen P, Atreya D, Xie J, Simoneau AR, Hoang BH and Zi X. The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol Cancer 2010; 9: 162.
    • (2010) Mol Cancer , vol.9 , pp. 162
    • Yee, D.S.1    Tang, Y.2    Li, X.3    Liu, Z.4    Guo, Y.5    Ghaffar, S.6    McQueen, P.7    Atreya, D.8    Xie, J.9    Simoneau, A.R.10    Hoang, B.H.11    Zi, X.12
  • 35
    • 79958201891 scopus 로고    scopus 로고
    • Knockdown of beta-Catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1alpha
    • Zhao JH, Luo Y, Jiang YG, He DL and Wu CT. Knockdown of beta-Catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1alpha. Cancer Invest 2011; 29: 377-382.
    • (2011) Cancer Invest , vol.29 , pp. 377-382
    • Zhao, J.H.1    Luo, Y.2    Jiang, Y.G.3    He, D.L.4    Wu, C.T.5
  • 36
    • 35448976966 scopus 로고    scopus 로고
    • Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1alpha
    • Jiang YG, Luo Y, He DL, Li X, Zhang LL, Peng T, Li MC and Lin YH. Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1alpha. Int J Urol 2007; 14: 1034-1039.
    • (2007) Int J Urol , vol.14 , pp. 1034-1039
    • Jiang, Y.G.1    Luo, Y.2    He, D.L.3    Li, X.4    Zhang, L.L.5    Peng, T.6    Li, M.C.7    Lin, Y.H.8
  • 37
    • 79952679115 scopus 로고    scopus 로고
    • Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelialmesenchymal transition
    • M110. 001131
    • Chen YS, Mathias RA, Mathivanan S, Kapp EA, Moritz RL, Zhu HJ and Simpson RJ. Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelialmesenchymal transition. Mol Cell Proteomics 2011; 10: M110. 001131.
    • (2011) Mol Cell Proteomics , pp. 10
    • Chen, Y.S.1    Mathias, R.A.2    Mathivanan, S.3    Kapp, E.A.4    Moritz, R.L.5    Zhu, H.J.6    Simpson, R.J.7
  • 38
    • 67650496215 scopus 로고    scopus 로고
    • A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelialmesenchymal transition in basal-like breast cancer
    • DiMeo TA, Anderson K, Phadke P, Fan C, Perou CM, Naber S and Kuperwasser C. A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelialmesenchymal transition in basal-like breast cancer. Cancer Res 2009; 69: 5364-5373.
    • (2009) Cancer Res , vol.69 , pp. 5364-5373
    • Dimeo, T.A.1    Anderson, K.2    Phadke, P.3    Fan, C.4    Perou, C.M.5    Naber, S.6    Kuperwasser, C.7
  • 40
    • 77950683362 scopus 로고    scopus 로고
    • Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling
    • Heuberger J and Birchmeier W. Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb Perspect Biol 2010; 2: a002915.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Heuberger, J.1    Birchmeier, W.2
  • 41
    • 34250744600 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in cell fate and epithelialmesenchymal transitions
    • Doble BW and Woodgett JR. Role of glycogen synthase kinase-3 in cell fate and epithelialmesenchymal transitions. Cells Tissues Organs 2007; 185: 73-84.
    • (2007) Cells Tissues Organs , vol.185 , pp. 73-84
    • Doble, B.W.1    Woodgett, J.R.2
  • 42
    • 33745197598 scopus 로고    scopus 로고
    • Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia
    • Weerkamp F, van Dongen JJ and Staal FJ. Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia. Leukemia 2006; 20: 1197-1205.
    • (2006) Leukemia , vol.20 , pp. 1197-1205
    • Weerkamp, F.1    van Dongen, J.J.2    Staal, F.J.3
  • 47
    • 84863393099 scopus 로고    scopus 로고
    • A Monoclonal Antibody against Human Notch1 Ligand Binding Domain Depletes Subpopulation of Breast Cancer Stem-like Cells
    • Sharma A, Paranjape AN, Rangarajan A and Dighe RR. A Monoclonal Antibody against Human Notch1 Ligand Binding Domain Depletes Subpopulation of Breast Cancer Stem-like Cells. Mol Cancer Ther 2012; 11: 77-86.
    • (2012) Mol Cancer Ther , vol.11 , pp. 77-86
    • Sharma, A.1    Paranjape, A.N.2    Rangarajan, A.3    Dighe, R.R.4
  • 49
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • Bao B, Wang Z, Ali S, Kong D, Li Y, Ahmad A, Banerjee S, Azmi AS, Miele L and Sarkar FH. Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett 2011; 307: 26-36.
    • (2011) Cancer Lett , vol.307 , pp. 26-36
    • Bao, B.1    Wang, Z.2    Ali, S.3    Kong, D.4    Li, Y.5    Ahmad, A.6    Banerjee, S.7    Azmi, A.S.8    Miele, L.9    Sarkar, F.H.10
  • 52
    • 35148825636 scopus 로고    scopus 로고
    • Chemoresistance to paclitaxel induces epithelialmesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
    • Kajiyama H, Shibata K, Terauchi M, Yamashita M, Ino K, Nawa A and Kikkawa F. Chemoresistance to paclitaxel induces epithelialmesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. Int J Oncol 2007; 31: 277-283.
    • (2007) Int J Oncol , vol.31 , pp. 277-283
    • Kajiyama, H.1    Shibata, K.2    Terauchi, M.3    Yamashita, M.4    Ino, K.5    Nawa, A.6    Kikkawa, F.7
  • 54
    • 79951681780 scopus 로고    scopus 로고
    • Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern
    • Iseri OD, Kars MD, Arpaci F, Atalay C, Pak I and Gunduz U. Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern. Biomed Pharmacother 2011; 65: 40-45.
    • (2011) Biomed Pharmacother , vol.65 , pp. 40-45
    • Iseri, O.D.1    Kars, M.D.2    Arpaci, F.3    Atalay, C.4    Pak, I.5    Gunduz, U.6
  • 55
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelialmesenchymal transition phenotype of gemcitabine- resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • Wang Z, Li Y, Kong D, Banerjee S, Ahmad A, Azmi AS, Ali S, Abbruzzese JL, Gallick GE and Sarkar FH. Acquisition of epithelialmesenchymal transition phenotype of gemcitabine- resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res 2009; 69: 2400-2407.
    • (2009) Cancer Res , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6    Ali, S.7    Abbruzzese, J.L.8    Gallick, G.E.9    Sarkar, F.H.10
  • 56
    • 79960385475 scopus 로고    scopus 로고
    • Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer
    • Gungor C, Zander H, Effenberger KE, Vashist YK, Kalinina T, Izbicki JR, Yekebas E and Bockhorn M. Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer. Cancer Res 2011; 71: 5009-5019.
    • (2011) Cancer Res , vol.71 , pp. 5009-5019
    • Gungor, C.1    Zander, H.2    Effenberger, K.E.3    Vashist, Y.K.4    Kalinina, T.5    Izbicki, J.R.6    Yekebas, E.7    Bockhorn, M.8
  • 57
    • 84859095585 scopus 로고    scopus 로고
    • Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells
    • Xie M, Zhang L, He CS, Xu F, Liu JL, Hu ZH, Zhao LP and Tian Y. Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells. J Cell Biochem 2012; 113: 1501-1513.
    • (2012) J Cell Biochem , vol.113 , pp. 1501-1513
    • Xie, M.1    Zhang, L.2    He, C.S.3    Xu, F.4    Liu, J.L.5    Hu, Z.H.6    Zhao, L.P.7    Tian, Y.8
  • 58
    • 78650223132 scopus 로고    scopus 로고
    • Molecular signature of epithelial-mesenchymal transition (EMT) in human prostate cancer bone metastasis
    • Sethi S, Macoska J, Chen W and Sarkar FH. Molecular signature of epithelial-mesenchymal transition (EMT) in human prostate cancer bone metastasis. Am J Transl Res 2010; 3: 90-99.
    • (2010) Am J Transl Res , vol.3 , pp. 90-99
    • Sethi, S.1    Macoska, J.2    Chen, W.3    Sarkar, F.H.4
  • 59
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, Lockwood G and Egan SE. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 2005; 65: 8530-8537.
    • (2005) Cancer Res , vol.65 , pp. 8530-8537
    • Reedijk, M.1    Odorcic, S.2    Chang, L.3    Zhang, H.4    Miller, N.5    McCready, D.R.6    Lockwood, G.7    Egan, S.E.8
  • 60
    • 77956814604 scopus 로고    scopus 로고
    • Interactions between Hedgehog proteins and their binding partners come into view
    • Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ and Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev 2010; 24: 2001-2012.
    • (2010) Genes Dev , vol.24 , pp. 2001-2012
    • Beachy, P.A.1    Hymowitz, S.G.2    Lazarus, R.A.3    Leahy, D.J.4    Siebold, C.5
  • 61
    • 77957571588 scopus 로고    scopus 로고
    • The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer
    • Sarkar FH, Li Y, Wang Z and Kong D. The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer. Cancer Metastasis Rev 2010; 29: 383-394.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 383-394
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4
  • 63
    • 79251547708 scopus 로고    scopus 로고
    • Up-regulation of sonic hedgehog contributes to TGF-beta1-induced epithelial to mesenchymal transition in NSCLC cells
    • Maitah MY, Ali S, Ahmad A, Gadgeel S and Sarkar FH. Up-regulation of sonic hedgehog contributes to TGF-beta1-induced epithelial to mesenchymal transition in NSCLC cells. PLoS One 2011; 6: e16068.
    • (2011) PLoS One , vol.6
    • Maitah, M.Y.1    Ali, S.2    Ahmad, A.3    Gadgeel, S.4    Sarkar, F.H.5
  • 64
    • 80052947064 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations
    • Chen X, Lingala S, Khoobyari S, Nolta J, Zern MA and Wu J. Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations. J Hepatol 2011; 55: 838-845.
    • (2011) J Hepatol , vol.55 , pp. 838-845
    • Chen, X.1    Lingala, S.2    Khoobyari, S.3    Nolta, J.4    Zern, M.A.5    Wu, J.6
  • 65
    • 73649145223 scopus 로고    scopus 로고
    • Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
    • Varnat F, Duquet A, Malerba M, Zbinden M, Mas C, Gervaz P and Ruiz i Altaba A. Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Mol Med 2009; 1: 338-351.
    • (2009) EMBO Mol Med , vol.1 , pp. 338-351
    • Varnat, F.1    Duquet, A.2    Malerba, M.3    Zbinden, M.4    Mas, C.5    Gervaz, P.6    Ruiz, A.A.7
  • 66
    • 78649486807 scopus 로고    scopus 로고
    • Evaluation of glioma-associated oncogene 1 expression and its correlation with the expression of sonic hedgehog, E-cadherin and S100a4 in human hepatocellular carcinoma
    • Zheng X, Yao Y, Xu Q, Tu K and Liu Q. Evaluation of glioma-associated oncogene 1 expression and its correlation with the expression of sonic hedgehog, E-cadherin and S100a4 in human hepatocellular carcinoma. Mol Med Report 2010; 3: 965-970.
    • (2010) Mol Med Report , vol.3 , pp. 965-970
    • Zheng, X.1    Yao, Y.2    Xu, Q.3    Tu, K.4    Liu, Q.5
  • 67
    • 81155126047 scopus 로고    scopus 로고
    • Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer
    • Yoo YA, Kang MH, Lee HJ, Kim BH, Park JK, Kim HK, Kim JS and Oh SC. Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. Cancer Res 2011; 71: 7061-7070.
    • (2011) Cancer Res , vol.71 , pp. 7061-7070
    • Yoo, Y.A.1    Kang, M.H.2    Lee, H.J.3    Kim, B.H.4    Park, J.K.5    Kim, H.K.6    Kim, J.S.7    Oh, S.C.8
  • 70
    • 44449144396 scopus 로고    scopus 로고
    • Epithelialmesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J and Weinberg RA. Epithelialmesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008; 14: 818-829.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 71
    • 34249289041 scopus 로고    scopus 로고
    • Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado H, Olmeda D and Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007; 7: 415-428.
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Snail, C.A.3
  • 72
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY and Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 73
    • 15744374449 scopus 로고    scopus 로고
    • Wnt-dependent regulation of the E-cadherin repressor snail
    • Yook JI, Li XY, Ota I, Fearon ER and Weiss SJ. Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem 2005; 280: 11740-11748.
    • (2005) J Biol Chem , vol.280 , pp. 11740-11748
    • Yook, J.I.1    Li, X.Y.2    Ota, I.3    Fearon, E.R.4    Weiss, S.J.5
  • 75
    • 79951896236 scopus 로고    scopus 로고
    • Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snailmediated epithelial-mesenchymal transition
    • Ren D, Minami Y and Nishita M. Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snailmediated epithelial-mesenchymal transition. Genes Cells 2011; 16: 304-315.
    • (2011) Genes Cells , vol.16 , pp. 304-315
    • Ren, D.1    Minami, Y.2    Nishita, M.3
  • 77
    • 84055184850 scopus 로고    scopus 로고
    • MiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • Siemens H, Jackstadt R, Hunten S, Kaller M, Menssen A, Gotz U and Hermeking H. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 2011; 10: 4256-4271.
    • (2011) Cell Cycle , vol.10 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hunten, S.3    Kaller, M.4    Menssen, A.5    Gotz, U.6    Hermeking, H.7
  • 80
    • 79351468712 scopus 로고    scopus 로고
    • Activation of beta-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem celllike characters
    • Li J and Zhou BP. Activation of beta-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem celllike characters. BMC Cancer 2011; 11: 49.
    • (2011) BMC Cancer , vol.11 , pp. 49
    • Li, J.1    Zhou, B.P.2
  • 81
    • 0345166971 scopus 로고    scopus 로고
    • Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
    • Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U and Ibanez CF. Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol 2003; 163: 723-728.
    • (2003) J Cell Biol , vol.163 , pp. 723-728
    • Blokzijl, A.1    Dahlqvist, C.2    Reissmann, E.3    Falk, A.4    Moliner, A.5    Lendahl, U.6    Ibanez, C.F.7
  • 82
    • 34250727945 scopus 로고    scopus 로고
    • Chromatin structure regulation in transforming growth factorbeta- directed epithelial-mesenchymal transition
    • Blumenberg M, Gao S, Dickman K, Grollman AP, Bottinger EP and Zavadil J. Chromatin structure regulation in transforming growth factorbeta- directed epithelial-mesenchymal transition. Cells Tissues Organs 2007; 185: 162-174.
    • (2007) Cells Tissues Organs , vol.185 , pp. 162-174
    • Blumenberg, M.1    Gao, S.2    Dickman, K.3    Grollman, A.P.4    Bottinger, E.P.5    Zavadil, J.6
  • 83
    • 54049084380 scopus 로고    scopus 로고
    • A doublenegative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial- mesenchymal transition
    • Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF and Goodall GJ. A doublenegative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial- mesenchymal transition. Cancer Res 2008; 68: 7846-7854.
    • (2008) Cancer Res , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6    Goodall, G.J.7
  • 84
    • 54049089608 scopus 로고    scopus 로고
    • MicroRNAs as regulators of epithelialmesenchymal transition
    • Gregory PA, Bracken CP, Bert AG and Goodall GJ. MicroRNAs as regulators of epithelialmesenchymal transition. Cell Cycle 2008; 7: 3112-3118.
    • (2008) Cell Cycle , vol.7 , pp. 3112-3118
    • Gregory, P.A.1    Bracken, C.P.2    Bert, A.G.3    Goodall, G.J.4
  • 87
    • 77955497665 scopus 로고    scopus 로고
    • The role of the miR- 200 family in epithelial-mesenchymal transition
    • Mongroo PS and Rustgi AK. The role of the miR- 200 family in epithelial-mesenchymal transition. Cancer Biol Ther 2010; 10: 219-222.
    • (2010) Cancer Biol Ther , vol.10 , pp. 219-222
    • Mongroo, P.S.1    Rustgi, A.K.2
  • 88
    • 47249091921 scopus 로고    scopus 로고
    • The miR- 200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M, Lee ES, Hu G and Kang Y. The miR- 200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 2008; 283: 14910-14914.
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 90
    • 84856006660 scopus 로고    scopus 로고
    • MiR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition
    • Zhang Z, Liu S, Shi R and Zhao G. miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition. Cancer Genet 2011; 204: 486-491.
    • (2011) Cancer Genet , vol.204 , pp. 486-491
    • Zhang, Z.1    Liu, S.2    Shi, R.3    Zhao, G.4
  • 91
    • 77954445464 scopus 로고    scopus 로고
    • Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway
    • Su HY, Lai HC, Lin YW, Liu CY, Chen CK, Chou YC, Lin SP, Lin WC, Lee HY and Yu MH. Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway. Int J Cancer 2010; 127: 555-567.
    • (2010) Int J Cancer , vol.127 , pp. 555-567
    • Su, H.Y.1    Lai, H.C.2    Lin, Y.W.3    Liu, C.Y.4    Chen, C.K.5    Chou, Y.C.6    Lin, S.P.7    Lin, W.C.8    Lee, H.Y.9    Yu, M.H.10
  • 92
    • 49549086856 scopus 로고    scopus 로고
    • Epigenetic alterations of CDH1 and APC genes: Relationship with activation of Wnt/beta-catenin pathway in invasive ductal carcinoma of breast
    • Prasad CP, Mirza S, Sharma G, Prashad R, DattaGupta S, Rath G and Ralhan R. Epigenetic alterations of CDH1 and APC genes: relationship with activation of Wnt/beta-catenin pathway in invasive ductal carcinoma of breast. Life Sci 2008; 83: 318-325.
    • (2008) Life Sci , vol.83 , pp. 318-325
    • Prasad, C.P.1    Mirza, S.2    Sharma, G.3    Prashad, R.4    Dattagupta, S.5    Rath, G.6    Ralhan, R.7
  • 93
    • 54449085718 scopus 로고    scopus 로고
    • Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers
    • Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M and Tlsty TD. Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci USA 2008; 105: 14867-14872.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14867-14872
    • Dumont, N.1    Wilson, M.B.2    Crawford, Y.G.3    Reynolds, P.A.4    Sigaroudinia, M.5    Tlsty, T.D.6
  • 95
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL and Weinberg RA. A perspective on cancer cell metastasis. Science 2011; 331: 1559-1564.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 96
    • 23744452875 scopus 로고    scopus 로고
    • Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGFmediated signaling networks
    • Cheng N, Bhowmick NA, Chytil A, Gorksa AE, Brown KA, Muraoka R, Arteaga CL, Neilson EG, Hayward SW and Moses HL. Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGFmediated signaling networks. Oncogene 2005; 24: 5053-5068.
    • (2005) Oncogene , vol.24 , pp. 5053-5068
    • Cheng, N.1    Bhowmick, N.A.2    Chytil, A.3    Gorksa, A.E.4    Brown, K.A.5    Muraoka, R.6    Arteaga, C.L.7    Neilson, E.G.8    Hayward, S.W.9    Moses, H.L.10
  • 97
    • 0035999133 scopus 로고    scopus 로고
    • Critical determinants of metastasis
    • Fidler IJ. Critical determinants of metastasis. Semin Cancer Biol 2002; 12: 89-96.
    • (2002) Semin Cancer Biol , vol.12 , pp. 89-96
    • Fidler, I.J.1
  • 100
    • 80655149144 scopus 로고    scopus 로고
    • Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/beta-catenin signalling pathway
    • Fu L, Zhang C, Zhang LY, Dong SS, Lu LH, Chen J, Dai Y, Li Y, Kong KL, Kwong DL and Guan XY. Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/beta-catenin signalling pathway. Gut 2011; 60: 1635-1643.
    • (2011) Gut , vol.60 , pp. 1635-1643
    • Fu, L.1    Zhang, C.2    Zhang, L.Y.3    Dong, S.S.4    Lu, L.H.5    Chen, J.6    Dai, Y.7    Li, Y.8    Kong, K.L.9    Kwong, D.L.10    Guan, X.Y.11
  • 102
    • 77956472212 scopus 로고    scopus 로고
    • The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
    • Brabek J, Mierke CT, Rosel D, Vesely P and Fabry B. The role of the tissue microenvironment in the regulation of cancer cell motility and invasion. Cell Commun Signal 2010; 8: 22.
    • (2010) Cell Commun Signal , vol.8 , pp. 22
    • Brabek, J.1    Mierke, C.T.2    Rosel, D.3    Vesely, P.4    Fabry, B.5
  • 103
    • 84863229849 scopus 로고    scopus 로고
    • Matrix rigidity regulates a switch between TGF-beta1-induced apoptosis and epithelial-mesenchymal transition
    • Leight JL, Wozniak MA, Chen S, Lynch ML and Chen CS. Matrix rigidity regulates a switch between TGF-beta1-induced apoptosis and epithelial-mesenchymal transition. Mol Biol Cell 2012; 23: 781-791.
    • (2012) Mol Biol Cell , vol.23 , pp. 781-791
    • Leight, J.L.1    Wozniak, M.A.2    Chen, S.3    Lynch, M.L.4    Chen, C.S.5
  • 104
    • 79960835510 scopus 로고    scopus 로고
    • Hypoxic stress and cancer: Imaging the axis of evil in tumor metastasis
    • Avni R, Cohen B and Neeman M. Hypoxic stress and cancer: imaging the axis of evil in tumor metastasis. NMR Biomed 2011; 24: 569-581.
    • (2011) NMR Biomed , vol.24 , pp. 569-581
    • Avni, R.1    Cohen, B.2    Neeman, M.3


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